Researchers interested in experimenting with sermorelin may be curious about the best way to administer this peptide. This sermorelin dosage calculator and guide draws upon past research and summarizes the doses used in previous sermorelin studies. By consulting this data, peptide researchers may gain an insight into how to dose sermorelin in future experiments and trials.
For researchers unfamiliar with sermorelin, this guide will also offer a complete overview of the benefits and side effects associated with this compound and any statistically significant benefits observed in past research.
Those interested in pursuing sermorelin research can find details of our preferred peptide vendor at the end of this guide. This vendor can ship research-grade sermorelin to researchers worldwide and come highly recommended.
Lets get started.
Buy Sermorelin from the #1 online Peptides vendor in the world...
Disclaimer: Peptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Peptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. Peptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.
Sermorelin acetate is a peptide made up of a chain of 29 amino acids. It is commonly referred to as sermorelin and was previously sold under the brand names Geref and Gerel. It is synthesized to resemble endogenous growth hormone-releasing hormone (GHRH) [1].
Sermorelin works by interacting with the bodys endocrine system. Since it resembles endogenous GHRH, it produces a similar effect, which is to bind to receptors that tell the pituitary gland to release more growth hormone into the bloodstream.
The result? Growth hormone (GH) levels increase.
What is growth hormone? An essential part of the bodys tissue construction process.
Growth hormone, also called human growth hormone (HGH), is involved in many biological functions including the reproduction of cells and the repair of tissue [2]. Because GH is so important for the growth and repair of tissue, there is currently strong research interest in the extent to which HGH may improve body composition and performance.
However, administering exogenous HGH directly to test subjects can produce a range of serious side effects, including swelling, joint pain, carpal tunnel syndrome, and an increased risk of diabetes [3]. It may also increase the risk of certain types of cancer, such as Hodgkins Lymphoma [4]. These risks mean that HGH research is strictly regulated and tightly controlled.
Thats the beauty of sermorelin research.
Rather than administering HGH directly, researchers can use sermorelin to increase HGH levels in test subjects by naturally stimulating the pituitary gland to release more endogenous HGH. Instead of spiking HGH to supraphysiological levels, sermorelin is believed to produce a gradual increase in HGH in a stable, predictable way.
In the next section, well take a look at the main benefits and uses of sermorelin.
So, what are the Sermorelin benefits? Well, there are quite a few.
In 1997, sermorelin received U.S. Food and Drug Administration (FDA) approval for the treatment of growth hormone deficiency (GHD) in child and adult patients. It was available under the trade name Geref and was also used as a diagnostic agent to check pituitary gland function.
However, the USFDA withdrew approval for Geref in 2008 and it was subsequently discontinued. While the manufacturer stressed that this was for reasons unrelated to safety or efficacy, the simple fact is that sermorelin no longer has any recognizer therapeutic use. In other words, it is a research chemical and is not approved for human use.
As sermorelin is able to increase GH levels in human test subjects, there is strong interest among peptide researchers as to whether it may offer the following benefits:
In summary, while sermorelin is a research chemical and no longer has FDA approval, ongoing research indicates that it may offer a wide range of benefits. Hopefully, researchers interested in exploring sermorelin can consult the relevant literature when calculating sermorelin dosage.
Well now explore the documented sermorelin side effects.
Sermorelin appears to offer several benefits, but are there any sermorelin side effects?
Firstly, researchers need to know that the decision to withdraw sermorelins FDA approval was for reasons other than safety or efficacy. There is no research to date that has linked sermorelin to any clinically significant adverse effects in test subjects.
In general, sermorelin is considered by most researchers to be well-tolerated by test subjects [12]. Side effects from sermorelin administration are rare and not severe. Some of these more mild side effects include:
More rarely, some test subjects have reported the following side effects:
To minimize the risk of test subjects experiencing side effects as a result of sermorelin administration, researchers are advised to consult the relevant literature when designing an experiment.
In the following section, well outline how this research chemical has been used in past studies.
Researchers interested in working with sermorelin may use this sermorelin dosage calculator during the design and planning phases of the research process. Below, the main doses used in past sermorelin studies are highlighted along with any general guidance that researchers may need to be aware of.
Sermorelin acetate usually comes in powder form. Prior to administration, researchers must first reconstitute it with bacteriostatic water by injecting water with a large mixing syringe against the glass wall of the vial. This water must be swirled, gently, around the vial until all of the powder is dissolved.
Researchers should follow the directions for how much water to add. For a 15 mg vial of sermorelin acetate, 7.5 ml of bacteriostatic water is typically required. Note that 10 units on an insulin syringe usually equates to 200 mcg of sermorelin.
Reconstituted sermorelin must be refrigerated and kept away from heat, light, moisture. It can be stored for up to 90 days. Researchers are advised to discard any sermorelin that is cloudy or contains particles.
When sermorelin held FDA approval as a treatment for GHD, it was administered intravenously as a subcutaneous injection. However, sermorelin may also be administered into the muscle as an intramuscular injection.
In terms of the timing of these injections, sermorelin has been administered to test subjects In past studies at night, at least two hours after eating. As HGH levels naturally peak at night, this protocol is believed to enhance HGH secretion.
During the period when sermorelin held FDA approval and was used to diagnose idiopathic GHD in children, it was administered intravenously at a dose of 1mcg per kilogram of body weight.
To date, sermorelin has not been approved for any other purpose and is currently classified as a research chemical. Therefore, based on the available data, researchers interested in experimenting with sermorelin for its purported recovery benefits may administer it in the following way:
While there is strong research interest in the application of sermorelin to improve the appearance of skin and reduce body fat, there is no published research to indicate the dosage at which it may be administered to this end.
Researchers interested in experimenting with sermorelin may consult the available literature regarding the past use of sermorelin as a treatment for GHD. This research indicates that a dose of 1mcg/kg of body weight provides a clinically significant effect in test subjects.
As with anti-aging and weight loss, there is currently very strong research interest in the application of sermorelin to lean muscle increase and athletic performance in test subjects. However, to date, no research has been published to indicate the dosage at which sermorelin may be administered for this purpose.
Based on the available data, doses of 1mcg/kg of bodyweight appear to produce a discernible effect. Researchers interested in exploring these purported benefits of sermorelin may consider this as a starting dose for any experiment they decide to conduct.
Researchers interested in experimenting with sermorelin should note that while this peptide has previously held USFDA approval as a treatment for GHD, it is currently classified as a research chemical and has no recognized therapeutic use.
The best place to buy sermorelin online is Peptide Sciences, a U.S.-based company that provides high-quality, research-grade peptides without additives or fillers.
We love Peptide Sciences because they have a solid track record and get every batch of peptides tested by an independent lab before putting them up for sale.
Here are a few things they do exceptionally well:
Researchers interested in exploring the benefits and side effects of sermorelin may consult Peptides Sciences to discuss their needs.
Buy Sermorelin from our #1 recommended vendor...
Hopefully, this sermorelin dosage calculator and guide has provided a useful starting point for researchers interested in working with this peptide. Although sermorelin is no longer FDA approved, past research findings indicate that further research may be warranted, especially with regards to GHD treatment, long-term safety, and anti-aging effects.
Those interested in finding a reliable, trustworthy sermorelin vendor may consider contacting our preferred supplier, Peptide Sciences.
Read the original:
Sermorelin Dosage Calculator and Guide | What You Must Know
