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Category Archives: Sermorelin

The Benefits of Sermorelin Injections – Defy Medical

Posted: November 2, 2023 at 11:31 am

What is Human Growth Hormone?

Human Growth Hormone (hGH) is crucial to growth and development.

It controls functions like:

HGH levels are highest in our youth, while were still developing. Levels decreases as we get older, leading to symptoms often associated with aging. These include slower healing, difficulty recovering from exercise, fatigue and insomnia, changes in body fat and composition, and more.

By the time adults reach 55, HGH levels are typically one-tenth of the levels from their youth. This type of aging is sometimes called sarcopenia.

Sermorelin Acetate performs the same function as Growth Hormone Releasing Hormone (GHRH). GHRH is produced by the hypothalamus and is responsible for triggering the release of hGH. By causing a similar effect, Sermorelin is useful in elevating hGH levels.

Sermorelin is available as an injection. Its typically a subcutaneous injection, though your provider may recommend an intramuscular injection depending on your dosage and needs.

Studies have shown that Sermorelin and Growth Hormone Restoration have several benefits.

Sermorelin-stimulated hGH production seems to have a positive effect on the brain. Improved brain function has been observed shortly after administration of Sermorelin injections.

The tie between hGH and mental function has been established. In a study of patients who produced little to no hGH, providers saw decreased brain function, lowered work capacity, depression, self-isolation, mood swings, and anxiety. Study participants also struggled with retaining information, short-term and long-term memory, and motor skills like hand-eye coordination. 1

Another study reported that depressed men release much less hGH during the first three hours of sleep compared to non-depressed study participants. Sleep is the primary time when the body releases hGH.2

These studies, in addition to reports from men and women who experience benefits after increasing their hGH levels using Sermorelin injections, demonstrate that increased hGH affects the human brain in a positive way.

As we age and our hormone levels decrease, many patients find that Sermorelin injections alleviate aging symptoms.

Reported benefits include:

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Sermorelin Acetate Injection | Empower Pharmacy

Posted: March 24, 2023 at 12:10 am

Dosage Strengths of Sermorelin Acetate Injection

6 mg Lyophilized Vial9 mg Lyophilized Vial15 mg Lyophilized Vial

Sermorelin is the structurally truncated analog of Growth Hormone Releasing Hormone (GHRH). It consists of the first 29 amino acids of the naturally occurring neurohormone that is produced in the hypothalamus. Sermorelin is the most widely used member of the GHRH analogue drug class. It can significantly promote the synthesis and release of growth hormone (GH) from cells in the pituitary gland, improving the serum concentrations of GH and subsequently insulin-like growth factor 1 (IGF-1) in animals and humans. It is able to influence the concert of hormonal signals that affect GH secretion from the anterior pituitary including GHRH, somatostatin, and insulin like growth factor (IGF) and others. The positive and negative opposing regulation of growth hormone by GHRH and somatostatin, respectively, creates a rhythmic-circadian pattern of GH secretion. Thus, modification of both pulse amplitude and frequency of GH secretion results from Sermorelin administration. After sermorelin stimulates the release of GH from the pituitary gland, it increases synthesis of IGF-1 in the liver and peripheral tissues.

Sermorelin acts on the growth hormone releasing hormone receptor (GHRHr) in the pituitary to regulate cellular activities. GHRHr is the natural receptor for the endogenous hormone, GHRH, and for sermorelin. This receptor regulates growth hormone release directly by stimulation and indirectly by a feedback relationships with somatostatin.

Sermorelin is readily degraded after reaching the bloodstream, having a biological half-life of approximately 10-20 min. Due to the biological half-life and bioavailability of Sermorelin, administration for growth in childhood GHD must occur periodically several times a day as subcutaneous-injections. However, single daily dosing is sufficient to treat most cases of adult-onset GH insufficiency. Three (3) mcg/kg subcutaneous-injections of Sermorelin have been reported to simulate a naturally occurring GHRH mediated GH release responses.

In addition to increasing production and secretion GHRH also affects sleep patterns by increasing the amount of slow wave sleep (SWS) while augmenting sleep-related GH secretion and reducing cortisol secretion.

To exert all its beneficial effects, Sermorelin requires a functioning pituitary and a host of peripheral tissues. This is due to the reliance on endogenous receptors controlling hormone secreting glands and tissues. More precisely, functioning growth hormone releasing hormone receptors (GHRHr) are required on somatotrophs in a functioning anterior pituitary.

Sermorelin essentially mimics the hypothalamic peptide, GHRH. Sermorelin acts directly on the pituitary stimulating the somatotroph cells ability to produce and secrete GH. Sermorelin increases proliferation of somatotroph cells during development. With the increase of serum GH, downstream effects occur. A notable hormone that is commonly used as a surrogate for growth hormone therapy, insulin like growth factor 1 (IGF-1), is known to increase with the administration of Sermorelin. IGF-I negatively regulates GHRH-mediated GH secretion.

Sermorelin is able to influence the concert of hormonal signaling that effects the GH axis. GH secretion from the anterior pituitary is regulated by GHRH, somatostatin, and GH secretagogues. The positive and negative opposing regulation of growth hormone by GHRH and somatostatin creates a rhythmic-circadian GH secretion. GH asked by signaling target cells, most notably increasing the synthesis of IGF-1 in the liver and peripheral tissues.

Sermorelin acts on the growth GHRHr in the pituitary to regulate cellular actives. GHRHr is the natural receptor for the endogenous hormone GHRH, a signaling hormone produced by the hypothalamus. This receptor among many other functions, controls growth hormone release, mainly by inhibition of somatostatin activity.

Tell your doctor of all prescription and nonprescription medication you may use, especially: corticosteroids and thyroid medications. This drug may affect the results of certain lab tests (e.g., inorganic phosphorus, alkaline phosphatase). Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without approval from your healthcare provider. Hypothyroidism: Untreated hypothyroidism can jeopardize the response to Sermorelin. Thyroid hormone determinations should be performed before the initiation and during therapy. Thyroid hormone replacement therapy should be initiated when indicated. Intracranial lesions: Patients with GH deficiency secondary to an intracranial lesion were not studied in clinical trials; Sermorelin treatment is not recommended in such patients. Obesity, hyperglycemia or hyperlipidemia: Subnormal GH responses have been seen in obesity and hyperglycemia, and in patients with elevated plasma fatty acids.

FDA pregnancy risk category C. Exercise caution during lactation; it is not known if this drug is excreted in breast milk. Laboratory Tests: Serum levels of inorganic phosphorus, alkaline phosphatase, GH and IGF-I may increase with therapeutic use. Corticosteroids: Glucocorticoids may inhibit the response to Sermorelin. Controlled studies did not indicate an interaction of Sermorelin with drugs commonly used in the treatment of routine pediatric problems/illnesses. However, formal drug interaction studies have not been conducted

Call your doctor for medical advice if pain/swelling/redness occurs at the injection site (occurring in approximately 16% of patients). Other possible, but less common side effects of rhGH (not Sermorelin) are upper respiratory conditions, nerve sensitivity, insomnia, depression, nausea, hypothyroidism chest pain, gynecomastia, headache, flushing, dysphagia, dizziness, hyperactivity, somnolence, urticaria and sore bones. Call your health care provider immediately if you are experiencing trouble swallowing, vomiting, and tightness in the chest. Antibody formation to Sermorelin has been reported after chronic subcutaneous administration of large doses but their clinical significance is unknown. Antibodies do not appear to affect growth hormone release nor appear to be related to a specific adverse drug reaction profile. No generalized allergic reactions have been reported. A temporary allergic reaction described by severe redness, swelling and urticaria at the injection sites has been reported in one patient who developed antibodies. Additionally, its use may reduce insulin sensitivity, thereby raising blood sugar to levels which could be harmful to diabetes sufferers. It may also decrease triiodothyronine (T3) levels due to its tendency to reduce the bodily levels of sodium, potassium, and phosphorous.

Store dry powder at 68F to 77F (20C to 25C) and away from heat, moisture and light. Once reconstituted keep this medicine in a refrigerator between 36F to 46F (2C to 8C). Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

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Sermorelin for Weight Loss: Does It Work? How Long To See Results?

Posted: March 24, 2023 at 12:10 am

Anyone considering sermorelin for weight loss, also known as sermorelin acetate, should know that its a peptide that aids in boosting the bodys release of human growth hormone via the pituitary gland and should only be used under supervision of a healthcare professional.

Peptides like sermorelin are short chains of amino acids that have a hand in metabolism and appetite, but since theres not much research on their effectiveness and safety.However, theres plenty of anecdotal evidence online that suggests it may be good for weight loss but deciding if its worthwhile or if another alternative such has human growth therapy (HGT) is better and/or safer.

So take glimpse into a few peoples journeys of using sermorelin treatment, view their before and after sermorelin results, and get science backed answers to the questions of does it work and how long results can take.

The human growth hormone (HGH) found naturally in the body functions to provide muscle development and regenerates cells. Though many people now use sermorelin for weight loss, sermorelin therapy was initially used for both children and adults who had growth deficiencies or developmental delays.1

Its primarily used in young children who have poor growth rates, but when the bodys natural growth hormones start to slow down (often around age 30), people may notice:

Due to these symptoms of less natural HGH production, some adults choose to turn to sermorelin as a better approach to management of adult-onset growth hormone insufficiency and to stimulate more natural HGH production from the pituitary gland.2

Although many artificial HGH products and treatments are available, sermorelin is not one of these; rather, its a natural peptide that stimulates the body to release more of its natural growth hormone.

Sermorelin, ipamorelin, and vitamin B are all similar treatments that can elevate the body up to par when it struggles to naturally keep up.

With certain therapies including sermorelin and ipamorelin, the goal is often to reduce body fat and increase lean muscle mass, among other benefits; vitamin B treatments are administered through a similar process and are identical to many sermorelin benefits including boosting energy levels, aiding in wound healing, treating anxiety, and improving overall well-being.

Those wondering how does sermorelin work must look no further: sermorelin injections for weight loss are administered subcutaneously and are recommended to be injected into the thigh or stomach areas where the body has more fat.

However, when it comes to sermorelin, weight loss is far from the only benefitin fact, sermorelin seems to help the body defy aging.

Sermorelin peptide benefits are abundant and include the following:

As with many peptides, theres both benefits and risks so be sure to see the risks section below to understand the pros and the cons of sermorelin.

Anyone on weight loss diets is tempted to ask how much weight can be lost on the program theyre on and those considering sermorelin are likely no exception. Unfortunately there is no universal answer because weight loss can vary greatly depending on countless factors including starting weight, calories burned, activity level, genetics, eating habits, and more.

Another important factor is ones frequency of use. Some recommend taking one dose (usually 0.2-0.3 mcg) each evening for a month, while others stand by a sermorelin cycle of 3-6 months being the most effective.

Furthermore, some dont recommend taking any breaks whatsoever and adamantly argue that its safe to use year-round.

The amount of weight loss on sermorelin therapy can vary just as much as the differing views on its usage. The best advice we have to offer is to err on the side of starting slowly as ones body adjusts and consulting a doctor to ensure proper use and dosages per person.

Its imperative to see how a growth hormone, athletic performance, and aging interact with one another when trying something like sermorelin and its natural to wonder how long does it take for sermorelin to work and on sermorelin, how long to see results?3

Sermorelins effectiveness kicks in almost immediately in terms of health benefits and stimulation of the pituitary gland, but most people feel their body reacting within the first month or so, then begin seeing true results within 3-6 months.

A loose timeline follows, but keep in mind that this will always vary from person to person based on their normal hormone levels and many other factors..

For some extra motivation and insight into what sermorelin injections for weight loss can do, we have a few examples of sermorelin weight loss results to share. Here are 3 sermorelin before and after results and pictures of different people who opted for sermorelin peptides for weight loss to assist them in their health and fitness goals.

Amber decided to give sermorelin a try and hasnt looked back since; she lost over 30 lbs in under 6 months after starting sermorelin injections paired with semaglutide for weight management. Shes not only lost an impressive amount of weight, but now feels energized, has improved complexion, and is sleeping better.

Source: @feelerconsulting from Instagram

After being a former athlete and letting life get in the way of her health goals, Amber used sermorelin to support her on her health journey and improved her diet. Her goals for sermorelin were better rest and recovery and burning more fat and sermorelin has served her well.

Before starting sermorelin therapy to increase his HGH production, Derek regularly overindulged in junk food, drank alcohol, slept a lot, and noticed he easily became breathless.

Source: u/Theenhancedman from Reddit

Source: u/Theenhancedman ong Reddit

After beginning his use of sermorelin and TRT, Derek soon began to notice subtle changes that quickly became much more drastic and within 6 months his physique changed in shockingly impressive ways.

Derek said that he now has enough energy to work out for 1 hour 7 days per week and fuels his body with frequent small meals and plenty of fruit and vegetable servings each day instead of junk food and alcohol.

He watches out for hidden sugars and noted that he actually sleeps less now but much more deeply and restfullyso much so that he doesnt even use an alarm clock anymore since his body is so attuned that his body clock does the job for him.

Note: These results may not be perfectly indicative of weight loss on sermorelin alone since Derek used TRT as well; the results are impressive regardless but be sure to have appropriate expectations if trying sermorelin therapy alone.

After mentioning that she didnt realize she had gained some weight until seeing photos of herself, Regina started her own round of sermorelin treatments and decided to stick with it after both feeling better and liking how she looked more. With more energy and clearer skin, Regina said that she couldnt be happier with her results.

Source: @feelerconsulting from Instagram

Whether trying peptides on their own, with other weight loss treatments or supplements, or paired with trending diets, its important to know if there are any potential risks. Its wise to ask if any potential sermorelin long term side effects exist, but we are happy to report that any negative impacts are extremely rare.

Not only is sermorelin highly effective in comparison to other hormone replacement therapiesit also causes far fewer side effects due to it being used to boost natural HGH instead of putting synthetic HGH into the body.

Notably, most negative reactions (if any) happen right away and are due to skin irritation or allergic reactions at the injection site. These can include pain, redness, or swelling at the site or occasionally a rash or hives.

If anyone has swelling of the tongue or difficulty breathing they should seek medical help immediately.

Other side effects are rare as well but may include:

Although sermorelin for weight loss may not be a good fit for everyone, overall it is healthy, has few negative health risks, and is very effective. Generally, sermorelin may be worth considering for healthy adults, however, only under the supervision of a healthcare professional. Its always best to consult a physician before making any major adjustments to your diet, lifestyle, supplementations or adding in peptides such as sermorelin.

Between sermorelin vs tesamorelin, our preference is sermorelin for weight loss.4 Although tesamorelin injections serve a similar purpose and are used to help reduce belly fat, increase energy, and boost metabolism, our top choice is sermorelin due to having much fewer side effects and seeming to work more efficiently in most people.5

Tesamorelin not only has been shown to take up to 26 weeks to reduce body fat in any significant way, but it also has much more severe potential side effects including swelling, fluid retention, numbness, blood glucose fluctuations and increased joint pain.

Whether wanting increased strength and lean muscle mass to improve ones powerlifting routine or simply wanting to reap other benefits such as weight loss, immune support, and increased energy, a clear winner for HGH-increasing peptides is sermorelin for weight loss and for general wellbeing.

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Where Do You Inject Sermorelin? | HealthGAINS

Posted: March 24, 2023 at 12:10 am

A study published in the BioDrugs journal supports that sermorelin is usually injected just under the skin, known as a subcutaneous injection. A Michigan University Rogel Cancer Center document states that this type of injection goes into the body fat, not the bloodstream or a muscle. Sermorelin therapy requires tiny needles.

Sermorelin injections are usually administered once a day, often before bedtime because it mimics the bodys natural cycle of growth hormone production. A doctor, however, may offer different advice. Sermorelin may interact with other hormones in the body, so it usually needs to be taken on an empty stomach.

Studies published in Pediatrics and Clinical Endocrinology in the 1980s and 1990s confirmed that subcutaneous injections are the best delivery route for sermorelin in children and adolescents who are receiving this hormone because of a problem with their pituitary gland or other growth restriction concern.

Some adults may use sermorelin injections as a part of a program to improve declining levels of human growth hormone as they age. Sermorelin usually gets injected into the stomach or thigh because a subcutaneous injection targets the fatty tissue just below the skin. Anywhere someone can pinch their skin and pull fatty tissue into a roll should work, though a doctor may recommend specific sites.

For a free consultation, call (305) 682-1818

Just like insulin-dependent diabetics who rotate the location on their body where they administer an injection, a person will want to alternate the site of sermorelin injections to avoid bruising and soreness. Some people like to keep a written record of where and when they took their injections to ensure a good rotation.

For example, a four-day rotation may include:

On the fifth day, someone would administer the injection into the abdomen again and repeat the rotation. Depending on their doctors advice, they can create this type of pattern to reduce the bruising and soreness they experience at each injection site.

Sermorelin stimulates the body to produce and secrete human growth hormone, a major hormone that continues to play a significant role in the way the body functions even after someone reaches adulthood. If a person has declining or low levels of human growth hormone, a program that includes sermorelin therapy may help them.

A study published in the journal Clinical Interventions in Aging reports that sermorelin injections for adults with declining levels of human growth hormone is an off-label use. However, people who participate in sermorelin therapy as a part of a comprehensive program report a wide range of positive effects that may include:

Sermorelin is often used in conjunction with additional hormone therapies as a key part of a larger protocol or program that can help users regain and maintain the levels of human growth hormone they previously had.

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Sermorelin is a medically proven, science-based therapy that addresses declining hormone levels and other concerns. Before treatment, a person must submit a blood sample for a laboratory panel. Bloodwork of this kind helps determine someones current hormone levelsthe potential cause of their decline in vitalityand the dose that may be necessary to improve their overall wellness.

If a persons bloodwork shows that they have declining or low levels of human growth hormone, they may be a good candidate for sermorelin therapy as a part of a comprehensive plan to address their lowered hormone levels. Testing is the only way to learn if sermorelin therapy might be effective for them.

Once tested, someone may receive a customized plan based on the results of a lab panel. If a persons results show decreased human growth hormone, sermorelin therapy may play a major role in their program. Because sermorelin is a prescription medication, they will not receive this type of therapy unless they have a deficiency.

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At HealthGAINS, health advisors can help people visualize their full potential and reach it through one of the optimal wellness solutions. HealthGAINS has individualized plans and bio-identical therapies designed for both men and women at every age and stage of life. These therapies are medically proven and scientifically based. HealthGAINS members also receive care in state-of-the-art facilities with the latest tech.

When patients enter a wellness clinic, they are greeted by a concierge health coach in spa-inspired surroundings. There is also no wait time when people come in for their therapy session, and HealthGAINS provides white-glove service to all members. Hotel-like amenities and plenty of attention to detail may help people feel at ease during their treatment.

To discuss individual needs and make an appointment to visit a facility, interested parties can reach out to a HealthGAINS health adviser who can explain relevant services, therapies, and programs. An adviser can help people understand their options for revitalization through human hormone growth treatments like sermorelin.

Call or text (305) 682-1818 or complete a Free Consultation Form

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Where Do You Inject Sermorelin? | HealthGAINS

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Sermorelin | Reviews, Dosage & Clinical Trials – Peptides

Posted: August 17, 2022 at 2:06 am

Effective treatment of adult-onset growth hormone insufficiency: Sermorelin is an effective and attractive treatment of adult-onset GH insufficiency. Unlike rhGH, sermorelin does not stimulate IGF-1 production in the liver and instead stimulates the pituitary gland to produce and secrete endogenous hGH, giving it a number of clinical advantages over exogenous hGH.

Notably, according to a 2006 article by Richard Walker, overdoses of endogenous hGH are difficult if not impossible to achieve as the effects of sermorelin are regulated by negative feedback involving the inhibitory neurohormone, somatostatin.

Sermorelin is not associated with the pro-cancer and pro-diabetes side effects linked to long-term hGH therapy, and is thus heavily researched to treat adult-onset GH insufficiency along with being used in longevity medicine for preserving youthful anatomy and physiology [5].

Positive effects on body composition: Sermorelin has been identified as one of several growth hormone secretagogues (GHS) that can help manage body composition in hypogonadal males. In a 2020 paper, Deepankar et al. noted that sermorelin can significantly improve body composition (in hypogonadal males) while ameliorating specific hypogonadal symptoms such as fat gain and muscular atrophy [6].

While the authors suggest that sermorelin could be used to achieve lean mass gain in both hypogonadal males and men with subclinical hypogonadism, to date, there is no published research that has investigated sermorelins effect on body composition in healthy subjects, highlighting an area for further research.

Potential anti-aging benefits: A 1992 study identified sermorelins potential anti-aging benefits after nine young male test subjects (22 to 33 years old) and ten elderly male test subjects (60 to 78 years old) were administered the peptide. The study found that short-term subcutaneous sermorelin injections enabled healthy male test subjects to reverse age-related decreases in GH and levels of IGF-I [7].

A 1997 single-blind randomized placebo-controlled trial found that elderly male and female test subjects who received nightly subcutaneous injections of sermorelin for 16 weeks experienced a significant increase in skin thickness. The peptide was found to produce significant increases in lean body mass in male test subjects and notable increases in libido and wellbeing. Male test subjects gained an average of 1.26 kg of lean body mass by the end of the trial [8]

Sermorelin and heart health: Sermorelin has been investigated alongside other GHRH agonists as a potential treatment for myocardial infarction scarring in swine [9]. The 2015 study found that sermorelin offered a number of benefits in post-heart attack animal models, which included:

As a result, there is research interest in sermorelins heart health-related benefits, namely in its potential to treat problems resulting from cardiac remodeling and ability to heal damage in myocytes following a heart attack.

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Sermorelin Therapy Benefits, Uses, Side Effects, Risks, More – Healthline

Posted: August 17, 2022 at 2:06 am

To properly grow and develop, your body needs human growth hormone (hGH). This is a peptide hormone produced in the tiny part of your brain called the pituitary gland. Although hGH plays its most crucial role during childhood and adolescence, it continues to maintain healthy tissues and organs throughout your life. Because of that, hGH levels that are lower or higher than typical can lead to health problems both in children and adults.

As often is the case with such complicated machines as our bodies, hGH does not act alone. A molecule called the growth hormone-releasing hormone (GHRH) controls hGH by releasing it from the pituitary gland into the bloodstream. If your blood test indicates low levels of hGH, your doctor may recommend injections of a synthetic form of GHRH, called sermorelin.

Keep reading to learn more about sermorelin, its benefits and risks, and when to consider using or avoiding sermorelin injections.

Sermorelin is used to diagnose and treat poor growth in children. Its also sometimes used off-label to treat hGH deficiency in adults. Some research has suggested that it can be beneficial in people with certain recurrent brain tumors.

Children usually benefit the most from sermorelin. One older study reported that a daily injection of sermorelin increased growth rate in 74 percent of children after just 6 months.

Studies investigating benefits of sermorelin in adults are scarce, but researchers have observed that sermorelin injection increases hGH levels in the bloodstream. These findings have led to widespread claims that sermorelin is an anti-aging therapy that can restore your bodys natural hGH production. Indeed, some older research suggests that sermorelin may increase:

However, definitive research to support the anti-aging effect of sermorelin is lacking. The use of sermorelin in healthy adults to reverse the effects of aging and in bodybuilding remains controversial.

Although long-term risks of sermorelin use are not known, its usually well-tolerated. However, as with any synthetic drug, its possible to have an allergic reaction. Let your doctor know about any allergies before taking this medication.

If you notice any of the following symptoms of a severe allergic reaction, call emergency medical services or go to the nearest emergency room:

The most common side effect of sermorelin is caused by its injection under your skin. You may experience any of the following at the site of injection:

These reactions are typically short-lived and disappear without any action. As you get better at self-administering the shots, these symptoms may stop for good.

Other, much less common side effects of sermorelin may include:

Sermorelin may interact with other medications. Drug interactions that may interfere with sermorelin include:

Make sure to let your doctor know about any medications and supplements you take (including vitamins) before starting sermorelin treatment.

Children and youths with poor growth are the primary candidates for sermorelin injections. In this group, sermorelin can help with both diagnosis and treatment of hGH deficiency.

Adults with diagnosed hGH deficiency can also benefit from sermorelin, according to older research. Healthy adults sometimes use this therapy for anti-aging and for bodybuilding; however this use remains controversial due to the scarcity of scientific evidence.

People with certain medical conditions may require additional screening before taking sermorelin and sometimes should avoid this therapy. These conditions include:

You dont need to visit a doctors office for sermorelin injections. Instead, you can self-administer injections at home. Sermorelin is injected subcutaneously, which means under the skin.

To prevent contamination, wipe the rubber vial stopper with an antiseptic before puncturing it with the needle. When injecting, target the fatty tissue just below the skin. Many people inject their stomach or thigh. To avoid bruising and soreness, its best to switch up the location of the injection site. Ask your doctor to show you the best injection technique.

Sermorelin is administered once a day, ideally at night. Your doctor will determine your dosage and length of treatment based on your individual factors.

You may be wondering: If the purpose of sermorelin therapy is to increase the levels of hGH hormone, why cant you just inject hGH? The answer is that many people do. In fact, research suggests that genetically engineered hGH is an effective treatment for both poor growth in children and hGH deficiency in adults. Unfortunately, hGH therapy is associated with numerous risks and side effects. Therefore, it may not be appropriate for some people.

Sermorelin helps your body produce more hGH. Children with growth delays and adults with hGH deficiency may benefit from this therapy. Although some healthy adults take it to prevent aging and for bodybuilding, there is no definitive research suggesting that sermorelin is effective for either of these purposes.

Although this medication is usually well-tolerated, tell your doctor about any allergies and medical conditions you have as well as medications and supplements you take. Check in regularly with your doctor while youre taking it.

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Diagnosis and Management of Growth Hormone Deficiency in Adults – Consultant360

Posted: July 16, 2022 at 2:00 am

AUTHORS:Alexandra Martirossian, MD1 Julie Silverstein, MD2

AFFILIATIONS:1Fellow, Division of Endocrinology, Metabolism, & Lipid Research, Washington University School of Medicine in St. Louis, St. Louis, Missouri

2Associate Professor of Medicine and Neurological Surgery, Division of Endocrinology, Metabolism, & Lipid Research, Washington University School of Medicine in St. Louis, St. Louis, Missouri

CITATION:Martirossian A, Silverstein J. Diagnosis and management of growth hormone deficiency in adults. Consultant.2022;62(6);e20-e27.doi:10.25270/con.2021.10.00004

Received July 25, 2021. Accepted August 27, 2021.Published online October 14, 2021.

DISCLOSURES:The authors report no relevant financial relationships.

CORRESPONDENCE:Julie Silverstein, MD, Washington University School of Medicine in St. Louis, 660 South Euclid Avenue, St. Louis, MO 63110 (jsilverstein@wustl.edu)

Growth hormone deficiency (GHD) is a clinical syndrome caused by decreased production of or decreased tissue responsiveness to growth hormone. The most common cause of GHD in adults is pituitary tumors and their associated treatments of surgery or radiotherapy. Clinical manifestations of adult-onset GHD are nonspecific and include central obesity, loss of lean muscle mass, decreased bone density, insulin resistance, cardiovascular disease, hyperlipidemia, decreased exercise tolerance, and decreased quality of life. Diagnosis of GHD is confirmed by stimulatory testing or a low insulin-like growth factor 1 (IGF-1) level in the setting of multiple pituitary hormone deficiencies and organic pituitary disease. Treatment involves replacement with recombinant human growth hormone, and goals of therapy include clinical improvement, avoidance of adverse effects, and normalization of IGF-1 levels. Recombinant human growth hormone should only be prescribed for its approved clinical uses by an endocrinologist, and the risks and benefits of therapy should be weighed on a case-by-case basis.1,2

Physiology

Growth hormone (GH) is a polypeptide hormone secreted by somatotroph cells in the anterior pituitary that exerts several anabolic effects throughout the body. The GH receptor is expressed in multiple tissues including the liver, cartilage, muscle, fat, and kidneys.1 Activation of the GH receptor in the liver leads to hepatic production of insulin-like growth factor 1 (IGF-1), a peptide important for mediating many of GHs effects. In children, GH and IGF-1 are required for chondrocyte proliferation and linear growth. In adults, GH promotes several primarily anabolic effects including breakdown of fat, muscle growth, hepatic glucose production, and bone formation.1,3 Growth hormone secretion is regulated by a complex mixture of signals from the hypothalamus, gut, liver, and gonads, with production stimulated by growth hormone-releasing hormone (GHRH) from the hypothalamus and inhibited by somatostatin, which is primarily secreted in the brain and gastrointestinal tract. Factors that stimulate GH secretion include deep sleep, fasting, hypoglycemia, -adrenergic pathways, ghrelin, sex steroids, stress, and amino acids (eg, arginine, leucine).3 Factors that suppress GH secretion include obesity, glucocorticoids, glucose, hypothyroidism, IGF-1 (negative feedback), -adrenergic pathways, and free fatty acids. GH secretion is episodic and exhibits a diurnal rhythm with approximately two-thirds of the total daily GH secretion produced at night triggered by the onset of slow-wave sleep.3 GH levels reach a nadir during the day and may be undetectable, especially in obese or elderly persons. Over the course of a lifetime, GH secretion gradually rises during childhood, peaks during puberty, then gradually declines through adulthood. The phenomenon of age-related decline in GH levels is sometimes referred to as somatopause.4

Causes of Growth Hormone Deficiency

GHD can occur at any age and results from both congenital and acquired disorders (Table 1). Congenital causes include gene mutations and structural defects. Mutations in the genes encoding GH, GH receptor, GHRH receptor, and various transcription factors can cause GHD. Structural defects include empty sella syndrome, septo optic dysplasia, hydrocele, and pituitary hypoplasia.2 Acquired causes include intracranial tumors (eg, pituitary adenoma, craniopharyngioma, Rathke cleft cyst, glioma/astrocytoma, metastasis), head trauma, central nervous system infection, infarction (Sheehan syndrome), and infiltrative/granulomatous disease (eg, sarcoidosis, Langerhans cell histiocytosis, tuberculosis). GHD can also result from treatments for some of the aforementioned conditions, particularly cranial surgery or irradiation. In adults, the most common cause of GHD is a pituitary adenoma or treatment of the adenoma with pituitary surgery and/or radiotherapy, with the risk of deficiency proportional to the size of the tumor and extent of treatment.2

Manifestations of GHD in adults may include central obesity, loss of lean muscle mass, decreased bone mass, insulin resistance, cardiovascular disease, hyperlipidemia, and decreased quality of life.1 Data supporting the benefits of GH replacement are mixed, with much of the data showing benefit coming from retrospective and open-label observational studies. Some, but not all, studies show that GH replacement is associated with an increase in strength and exercise capacity2 and is associated with an increase in bone mineral density5,6 and decreased fracture risk.7 In terms of cardiovascular disease, a metanalysis of randomized, blinded, placebo-controlled trials suggests that GH replacement increases lean body mass and decreases fat mass, has a beneficial effect on low-density lipoprotein cholesterol, and lowers diastolic blood pressure8, but there is no evidence that these changes are associated with measurable changes in cardiovascular function.9

Benefits of Growth Hormone Deficiency

The effect of GH replacement on glucose metabolism is complex. GH antagonizes the action of insulin, and evidence suggests that GH replacement may lead to a transient increase in fasting glucose10 but not necessarily an increased incidence of diabetes.11 Long-term observational studies of patients with adult GHD also suggest that GH replacement is associated with an improvement in quality of life when assessing parameters such as memory and concentration, fatigue, tenseness, socializing, and self-confidence.12,13

Diagnosing Growth Hormone Deficiency

Making the diagnosis of GHD is generally easier in children because the outcome of short stature is readily apparent. The task is more difficult in those with adult-onset deficiency because the symptoms are generally nonspecific, so a higher index of suspicion is required.

Because of the high financial cost of recombinant human growth hormone (rhGH) and possibility of adverse effects, it is crucial that the correct diagnosis is made and that treatment is only pursued in those adults who are truly GH deficient. This shrewdness is important for prevention of inappropriate treatment that is sometimes seen in nonmedical conditions such as aging and sports. In deciding who to screen, a clinical history guides the extent of required testing (Figure).

In adults with a history of organic hypothalamic-pituitary disease (eg, pituitary mass with previous surgery and cranial irradiation) with at least 3 hormone deficiencies (eg, hypothyroidism, adrenal insufficiency, and hypogonadism) and a low serum IGF-1 level (< 2.0 standard deviation score, also reported as a Z-score), no further testing is required, and treatment can be initiated.14 This also applies to adults who have congenital structural defects or genetic mutations affecting the hypothalamic-pituitary axes who have at least 3 other hormone deficiencies and low serum IGF-1 level. In adults who have a history of organic hypothalamic-pituitary disease with 2 or fewer hormone deficiencies, high clinical suspicion, and a low IGF-1 level (< 0 standard deviation score), provocative testing for GHD is indicated.14

In the absence of any of these risk factors, testing is not advised. It should be noted that 30% to 40% of patients with adult-onset GHD may have normal IGF-1 levels, so if clinical suspicion remains high, diagnostic testing should be pursued.15 In adults with idiopathic GHD in childhood, retesting should be performed because a significant proportion of this population may have normal GH secretion as adults.16-19

Figure. Algorithm for Stimulation Testing and Treatment in Adults With Suspected Growth Hormone Deficiency14

Measurement of random GH levels for the purpose of diagnosing GHD is not reliable for multiple reasons. First, GH has a short circulating half-life of only 10 to 20 minutes, and the pulsatility of GH secretion makes interpretation of single measurements difficult.20 Second, GH secretion is suppressed in the postprandial state, so timing of food consumption is important to know. Other factors associated with decreased IGF-1 levels that should be taken into consideration when interpreting laboratory test results include advanced age, obesity, poorly controlled diabetes, liver disease, renal failure, oral estrogen use, hypothyroidism, and critical illness.21 Additionally, assays for GH and IGF-1 have not been rigorously standardized, and normal baseline values for adults are often inadequate. To circumvent these diagnostic issues, GH stimulation tests are used. There are several GH provocative tests available in clinical practice (Table 2), each with its own advantages and disadvantages.

The insulin tolerance test (ITT), although not commonly used in the United States, is considered the gold standard for diagnosis of GHD.4,14,22 Insulin-induced hypoglycemia stimulates the release of GH. The ITT is performed by having the patient fast for at least 8 hours and then intravenous insulin is administered at a dose of 0.05 to 0.15 U/kg. Blood is drawn fasting and then 20, 30, 40, and 60 minutes after adequate hypoglycemia is achieved (blood glucose, < 40 mg/dL).22,23 The diagnostic cutoff for GHD is a GH level 5 g/L or lower after hypoglycemia is achieved. The positive predictive value is 93%, sensitivity is 96%, and specificity is 92%.22 Several drawbacks of the ITTincluding the requirement for close medical supervision by a physician throughout the test, the possibility of inducing severe life-threatening hypoglycemia, and the risk of causing seizures and altered consciousness in certain susceptible populationslimit its use. The ITT is contraindicated in individuals aged older than 65 years, those who are pregnant, and those who have a history of or are at risk for seizures and cardiovascular disease. Moreover, normoglycemic or hyperglycemic patients with obesity and insulin resistance may require higher doses of insulin (0.15-0.2 U/kg) to achieve target hypoglycemia, thus increasing their risk for delayed hypoglycemia.

Finding an alternative to the ITT for the diagnosis of GHD has been challenging. The GHRH-arginine stimulation test showed favor for some time because of its convenience, reproducibility, and discriminatory power. However, in 2008, the recombinant GHRH (ie, injectable sermorelin) was removed from the market, so the test could no longer be performed in the United States.14,22 Since then, the glucagon stimulation test (GST) has become a preferred alternative diagnostic test for GHD in the United States. The exact mechanism for how glucagon stimulates GH secretion is poorly understood, but it has been shown to be a more-potent stimulator of GH secretion than other agents, including arginine and clonidine.24,25 Glucagon is more effective at stimulating GH secretion when administered intramuscularly compared with intravenously.26 The GST is performed by first having the patient fast for 8 to 10 hours, and then intramuscular glucagon is administered (1 mg if weight is 90 kg, 1.5 mg if weight is > 90 kg). Serum GH and blood glucose levels are measured at 0, 30, 60, 90, 120, 150, 180, 210, and 240 minutes after glucagon is administered. A GH cutoff of 3 g/L has been shown to have sensitivity and specificity of up to 100% in lean subjects (body mass index, 25 kg/m2).22 However, because obesity blunts the GH secretion response to glucagon, a lower cutoff of 1 g/L is recommended in individuals who are overweight or obese (body mass index, > 25 kg/m2).22 Advantages of the GST include its availability, reproducibility, safety, lack of influence by gender and hypothalamic cause of GHD, and relatively few contraindications. Disadvantages include its long duration, the need for intramuscular administration and multiple blood draws, and gastrointestinal adverse effects. The test is contraindicated in malnourished individuals or individuals who have not eaten for more than 48 hours, as well as those with severe fasting hyperglycemia (> 180 mg/dL).22,23 Because late hypoglycemia may occur, individuals should be advised to eat small and frequent meals after completion of the test.

In 2017, the US Food and Drug Administration (FDA) granted approval for the use of macimorelin for diagnosing adult GHD.27 Macimorelin acetate is an oral ghrelin receptor agonist with GH secretagogue activity that is readily absorbed and effectively stimulates endogenous GH secretion in healthy volunteers with good tolerability.28 To validate the efficacy and safety of macimorelin in the diagnosis of adult GHD, Garcia and colleagues performed an open-label, randomized, multicenter, 2-way crossover study of the macimorelin test vs the ITT.29 Participants with high (n = 38), intermediate (n = 37), and low (n = 39) likelihood for adult GHD and healthy, matched controls (n = 25) were included in the efficacy analysis. The macimorelin oral solution was prepared at a dose of 0.5 mg/kg of body weight. Blood samples for GH serum levels were collected before and at 30, 45, 60, and 90 minutes after administration of macimorelin. Using a GH cutoff of 2.8 ng/mL for the macimorelin test and 5.1 ng/mL for the ITT, the sensitivity was 87% and specificity was 96%. In post-hoc analyses, increasing the GH cutoff for the macimorelin test to 5.1 ng/mL while maintaining the GH cutoff of 5.1 ng/mL for the ITT resulted in a sensitivity of 92% and specificity of 96%. A greater peak GH level was seen in all groups with the macimorelin test compared with the ITT. Reproducibility for macimorelin was high at 97%. The macimorelin test was well tolerated with no serious or frequent adverse effects reported. The most common adverse effect was mild and transient dysgeusia. Garcia and colleagues later performed post-hoc analyses to determine whether macimorelin performance was affected by age, body mass index, or sex and evaluated its performance vs ITT over a range of GH cutoffs.30 They found that macimorelin performance was not meaningfully affected by age, body mass index, or sex. Caution should be used in generalizing these results in pediatric, elderly, and severely obese patients, since the study population age range was 18 to 66, and the highest recorded baseline body mass index was 36.6 kg/m2, with most participants having a body mass index of less than 30 kg/m2. Of the 4 GH cutoffs evaluated (2.8 ng/mL, 4.0 ng/mL, 5.1 ng/mL, and 6.5 ng/mL), the cutoff of 5.1 ng/mL provided maximal specificity (96%) and high sensitivity (92%) and was in good overall agreement with the ITT at the same cutoff (87%). At present, the approved FDA cutoff is the lower value of 2.8 ng/mL.29 Compared with the ITT and GST, the macimorelin stimulation test has the advantages of being safer, well tolerated, easier to perform, and is less influenced by body weight, so its use in clinical practice may increase in coming years. A major factor currently limiting its widespread use is high financial cost.14

Treatment of Growth Hormone Deficiency

Once the diagnosis of GHD has been made, treatment is initiated with rhGH, which contains the identical sequence of amino acids found in HGH. For many years, the only rhGH product on the US market was somatropin, a once-daily injection. In September 2020, the FDA approved once-weekly somapacitan for the treatment of adult GHD, but it is not yet available on the market.31,32 It is hoped that the decreased frequency of injections should lower the burden of treatment and improve treatment adherence. Multiple brands of somatropin are available, and there is no evidence that one commercial product is different or more advantageous than another, apart from differences in pen devices, electronic autoinjector devices that are user-friendly, dose per milligram adjustments, and whether the product requires refrigeration.14

In adults, the typical dose of somatropin ranges from 0.1 to 0.4 mg/d and is influenced by age, sex, comorbidities, and concomitant medications. Per the 2019 guidelines published by the American Association of Clinical Endocrinologists (AACE), the recommended starting dose for patients aged younger than 30 years is 0.4 to 0.5 mg/d, aged between 30 to 60 years is 0.2 to 0.3 mg/d, and aged older than 60 years is 0.1 to 0.2 mg/d. In patients transitioning from pediatric to adult care, rhGH should be continued at 50% of the dose used in childhood and then gradually adjusted. In patients with concurrent type 2 diabetes, previous gestational diabetes, and obesity, lower doses of 0.1 to 0.2 mg/d are recommended. Women tend to require higher doses than men to achieve the same IGF-1 level, especially if they are taking oral estrogen.33,34 Approximately 85% of circulating IGF-I is liver derived, and oral estrogen, which undergoes first pass metabolism, suppresses hepatic production of IGF-1. rhGH dose reduction is often necessary when oral estrogen is stopped or switched to transdermal. Most adverse effects of treatment are dose related. The most common adverse effects are related to insulin resistance and fluid retention and include hyperglycemia, paresthesias, joint stiffness, peripheral edema, arthralgias, myalgias, and carpal tunnel syndrome.2 Contraindications to treatment include active malignancy and active proliferative or severe nonproliferative diabetic retinopathy.

After GH replacement therapy is initiated, it is recommended that patients follow-up in 1- or 2-month intervals at first, which can later be spaced out to 6- or 12-month intervals once a stable dose has been reached.14 Determination of the appropriate dose is influenced by multiple factors, including clinical improvement in symptoms, avoidance of adverse effects, and IGF-1 level. Assessment of fasting glucose, hemoglobin A1c, fasting lipids, body mass index, waist circumference, waist-to-hip ratio, and quality of life should be performed at least once per year. Assessment of other pituitary hormone deficiencies and structural pituitary lesions with laboratory and imaging studies, respectively, should be performed as clinically indicated. If the initial bone density scan is abnormal, repeat evaluations at 2- to 3-year intervals are recommended. IGF-1 levels are commonly used to guide the adequacy of rhGH dosing, and the general recommendation is to target a level within age-adjusted reference ranges (standard deviation score, 2 and +2). However, studies have shown varying benefits and drawbacks to targeting IGF-1 levels in the upper or lower half of this range. Targeting IGF-1 levels in the upper range of normal (standard deviation score, 1-2) has shown benefits in body fat composition, waist circumference, and microcirculatory function but at the expense of increased insulin resistance and myalgias.35,36 Targeting IGF-1 levels in the lower range of normal (standard deviation score, 2 to 1) is more often associated with fatigue. Women may have a narrower therapeutic dose window than men. In a study by van Bunderen and colleagues, a high-normal IGF-1 target level in female study participants was associated with impaired prefrontal cognitive functioning, whereas a low-normal target IGF-1 level was associated with decreased vigor.37

The question of how long to continue GH replacement therapy is frequently debated. If clinical benefits have resulted from treatment (eg, improved quality of life, body composition, cardiovascular health, bone density), rhGH can be continued indefinitely presuming there are no contraindications. If there are neither subjective nor objective benefits after at least 12 to 18 months of treatment, the option of discontinuing GH replacement should be discussed with the patient.2,14 Since GH promotes cellular proliferation and tissue growth, there has been a longstanding theoretical concern that rhGH leads to increased risk of malignancy. Although studies show no increased risk of malignancy in hypopituitary patients on long-term growth hormone treatment, an abundance of caution should be exercised when deciding whether to start rhGH in patients with GHD and a history of or genetic predisposition to malignancy.38 It has been suggested that in adult patients with a history of cancer, low-dose rhGH should only be initiated 5 years after cancer remission is achieved.14,39 The patients oncologist should be in agreement and closely involved in follow-up care while the patient is taking therapy. In all patients, regardless of cancer risk, cancer screening guidelines should be followed.

A topic that has gained much attention in our culture is the use of GH for antiaging, with some citing it as a fountain of youth.40 Despite the popularity of this idea, no studies have assessed long-term (> 6 months) efficacy or safety of rhGH administration for this purpose in humans.14 Paradoxically, studies performed in mice have shown that mice with isolated GHD caused by GHRH or GHRH receptor mutations, combined deficiency of GH, prolactin, and thyroid-stimulating hormone, or global deletion of GH receptors live longer than their normal siblings and exhibit multiple features of delayed and/or slower aging.41-43 Liu and colleagues performed a meta-analysis of 31 studies describing the use of GH in healthy elderly adults and found that GH use was associated with small changes in body composition but increased rates of adverse events.44 In the United States, off-label distribution or marketing of rhGH to treat aging or aging-related conditions and for the enhancement of athletic performance is illegal. Given the clinical concerns and legal issues involved, it is strongly recommended that rhGH only be prescribed for the well-defined approved uses of the medication, which are GHD and HIV-associated lipodystrophy.14,45,46

Conclusions

Growth hormone replacement therapy in adults with confirmed GHD has been shown to be associated with improvement in multiple aspects of health, including body composition, muscle mass, cardiovascular health, bone density, and quality of life. The clinical manifestations of GHD in adults are often nonspecific, so diligence to confirm an accurate diagnosis is essential for avoiding the costs and ethical dilemmas of inappropriate treatment. There are multiple GH stimulatory tests available, each with its own benefits and caveats. Once the diagnosis of adult GHD is established, rhGH should be initiated at low doses and uptitrated based on IGF-1 levels and symptoms, while avoiding adverse effects. Research into longer-acting rhGH formulations and enhanced diagnostic testing is ongoing and will be essential for guiding the management of adult GHD.

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27. Macrilen (macimorelin) for Oral Solution. US Food & Drug Administration. Published January 31, 2018. Accessed March 14, 2021. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/205598Orig1s000TOC.cfm

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31. FDA approves weekly therapy for adult growth hormone deficiency. News Release. US Food & Drug Administration. Published September 1, 2020. Accessed March 27, 2021. https://www.fda.gov/drugs/drug-safety-and-availability/fda-approves-weekly-therapy-adult-growth-hormone-deficiency

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38. Child CJ, Conroy D, Zimmermann AG, Woodmansee WW, Erfurth EM, Robison LL. Incidence of primary cancers and intracranial tumour recurrences in GH-treated and untreated adult hypopituitary patients: analyses from the Hypopituitary Control and Complications Study. Eur J Endocrinol. 2015;172(6):779-790. https://doi.org/10.1530/eje-14-1123

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43. Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A. 2001;98(12):6736-6741. https://doi.org/10.1073/pnas.111158898

44. Liu H, Bravata DM, Olkin I, et al. Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Ann Intern Med. 2007;146(2):104-115. https://doi.org/10.7326/0003-4819-146-2-200701160-00005

45. Clemmons DR, Molitch M, Hoffman AR, et al. Growth hormone should be used only for approved indications. J Clin Endocrinol Metab. 2014;99(2):409-411. https://doi.org/10.1210/jc.2013-4187

46. Burgess E, Wanke C. Use of recombinant human growth hormone in HIV-associated lipodystrophy. Curr Opin Infect Dis. 2005;18(1):17-24. https://doi.org/10.1097/00001432-200502000-00004

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Diagnosis and Management of Growth Hormone Deficiency in Adults - Consultant360

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Sermorelin Dosage Calculator and Guide | What You Must Know

Posted: June 26, 2022 at 1:56 am

Researchers interested in experimenting with sermorelin may be curious about the best way to administer this peptide. This sermorelin dosage calculator and guide draws upon past research and summarizes the doses used in previous sermorelin studies. By consulting this data, peptide researchers may gain an insight into how to dose sermorelin in future experiments and trials.

For researchers unfamiliar with sermorelin, this guide will also offer a complete overview of the benefits and side effects associated with this compound and any statistically significant benefits observed in past research.

Those interested in pursuing sermorelin research can find details of our preferred peptide vendor at the end of this guide. This vendor can ship research-grade sermorelin to researchers worldwide and come highly recommended.

Lets get started.

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Disclaimer: Peptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Peptides.org makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments publicly available or that may be made available. However, research is not considered conclusive. Peptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials.

Sermorelin acetate is a peptide made up of a chain of 29 amino acids. It is commonly referred to as sermorelin and was previously sold under the brand names Geref and Gerel. It is synthesized to resemble endogenous growth hormone-releasing hormone (GHRH) [1].

Sermorelin works by interacting with the bodys endocrine system. Since it resembles endogenous GHRH, it produces a similar effect, which is to bind to receptors that tell the pituitary gland to release more growth hormone into the bloodstream.

The result? Growth hormone (GH) levels increase.

What is growth hormone? An essential part of the bodys tissue construction process.

Growth hormone, also called human growth hormone (HGH), is involved in many biological functions including the reproduction of cells and the repair of tissue [2]. Because GH is so important for the growth and repair of tissue, there is currently strong research interest in the extent to which HGH may improve body composition and performance.

However, administering exogenous HGH directly to test subjects can produce a range of serious side effects, including swelling, joint pain, carpal tunnel syndrome, and an increased risk of diabetes [3]. It may also increase the risk of certain types of cancer, such as Hodgkins Lymphoma [4]. These risks mean that HGH research is strictly regulated and tightly controlled.

Thats the beauty of sermorelin research.

Rather than administering HGH directly, researchers can use sermorelin to increase HGH levels in test subjects by naturally stimulating the pituitary gland to release more endogenous HGH. Instead of spiking HGH to supraphysiological levels, sermorelin is believed to produce a gradual increase in HGH in a stable, predictable way.

In the next section, well take a look at the main benefits and uses of sermorelin.

So, what are the Sermorelin benefits? Well, there are quite a few.

In 1997, sermorelin received U.S. Food and Drug Administration (FDA) approval for the treatment of growth hormone deficiency (GHD) in child and adult patients. It was available under the trade name Geref and was also used as a diagnostic agent to check pituitary gland function.

However, the USFDA withdrew approval for Geref in 2008 and it was subsequently discontinued. While the manufacturer stressed that this was for reasons unrelated to safety or efficacy, the simple fact is that sermorelin no longer has any recognizer therapeutic use. In other words, it is a research chemical and is not approved for human use.

As sermorelin is able to increase GH levels in human test subjects, there is strong interest among peptide researchers as to whether it may offer the following benefits:

In summary, while sermorelin is a research chemical and no longer has FDA approval, ongoing research indicates that it may offer a wide range of benefits. Hopefully, researchers interested in exploring sermorelin can consult the relevant literature when calculating sermorelin dosage.

Well now explore the documented sermorelin side effects.

Sermorelin appears to offer several benefits, but are there any sermorelin side effects?

Firstly, researchers need to know that the decision to withdraw sermorelins FDA approval was for reasons other than safety or efficacy. There is no research to date that has linked sermorelin to any clinically significant adverse effects in test subjects.

In general, sermorelin is considered by most researchers to be well-tolerated by test subjects [12]. Side effects from sermorelin administration are rare and not severe. Some of these more mild side effects include:

More rarely, some test subjects have reported the following side effects:

To minimize the risk of test subjects experiencing side effects as a result of sermorelin administration, researchers are advised to consult the relevant literature when designing an experiment.

In the following section, well outline how this research chemical has been used in past studies.

Researchers interested in working with sermorelin may use this sermorelin dosage calculator during the design and planning phases of the research process. Below, the main doses used in past sermorelin studies are highlighted along with any general guidance that researchers may need to be aware of.

Sermorelin acetate usually comes in powder form. Prior to administration, researchers must first reconstitute it with bacteriostatic water by injecting water with a large mixing syringe against the glass wall of the vial. This water must be swirled, gently, around the vial until all of the powder is dissolved.

Researchers should follow the directions for how much water to add. For a 15 mg vial of sermorelin acetate, 7.5 ml of bacteriostatic water is typically required. Note that 10 units on an insulin syringe usually equates to 200 mcg of sermorelin.

Reconstituted sermorelin must be refrigerated and kept away from heat, light, moisture. It can be stored for up to 90 days. Researchers are advised to discard any sermorelin that is cloudy or contains particles.

When sermorelin held FDA approval as a treatment for GHD, it was administered intravenously as a subcutaneous injection. However, sermorelin may also be administered into the muscle as an intramuscular injection.

In terms of the timing of these injections, sermorelin has been administered to test subjects In past studies at night, at least two hours after eating. As HGH levels naturally peak at night, this protocol is believed to enhance HGH secretion.

During the period when sermorelin held FDA approval and was used to diagnose idiopathic GHD in children, it was administered intravenously at a dose of 1mcg per kilogram of body weight.

To date, sermorelin has not been approved for any other purpose and is currently classified as a research chemical. Therefore, based on the available data, researchers interested in experimenting with sermorelin for its purported recovery benefits may administer it in the following way:

While there is strong research interest in the application of sermorelin to improve the appearance of skin and reduce body fat, there is no published research to indicate the dosage at which it may be administered to this end.

Researchers interested in experimenting with sermorelin may consult the available literature regarding the past use of sermorelin as a treatment for GHD. This research indicates that a dose of 1mcg/kg of body weight provides a clinically significant effect in test subjects.

As with anti-aging and weight loss, there is currently very strong research interest in the application of sermorelin to lean muscle increase and athletic performance in test subjects. However, to date, no research has been published to indicate the dosage at which sermorelin may be administered for this purpose.

Based on the available data, doses of 1mcg/kg of bodyweight appear to produce a discernible effect. Researchers interested in exploring these purported benefits of sermorelin may consider this as a starting dose for any experiment they decide to conduct.

Researchers interested in experimenting with sermorelin should note that while this peptide has previously held USFDA approval as a treatment for GHD, it is currently classified as a research chemical and has no recognized therapeutic use.

The best place to buy sermorelin online is Peptide Sciences, a U.S.-based company that provides high-quality, research-grade peptides without additives or fillers.

We love Peptide Sciences because they have a solid track record and get every batch of peptides tested by an independent lab before putting them up for sale.

Here are a few things they do exceptionally well:

Researchers interested in exploring the benefits and side effects of sermorelin may consult Peptides Sciences to discuss their needs.

Buy Sermorelin from our #1 recommended vendor...

Hopefully, this sermorelin dosage calculator and guide has provided a useful starting point for researchers interested in working with this peptide. Although sermorelin is no longer FDA approved, past research findings indicate that further research may be warranted, especially with regards to GHD treatment, long-term safety, and anti-aging effects.

Those interested in finding a reliable, trustworthy sermorelin vendor may consider contacting our preferred supplier, Peptide Sciences.

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90 Day Fianc: Stephanie Davison Reveals The Secrets To Her Youthful Looks – Screen Rant

Posted: January 14, 2021 at 8:53 pm

Skin Envy owner Stephanie Davison often makes many 90 Day Fianc fans envious of her youthful looks. The TLC star, 52, has now confessed her secrets.

Although Stephanie Davidson from 90 Day Fianc is making waves for her relationship with her Belize boy toy Ryan Carr, it's also her looks that have fans saying "wow." Sure, being the face of a business that makes one "remove fat" helps, but what is that keeps Stephanie looking so good at 52? The 90 Day Fianc star Stephanie has revealed what is her fountain of youth on her Instagram page.

As fans try to decipher why a successful, independent woman like 90 Day Fianc's Stephanie could choose to date someone like Ryan, they also have started guessing the relationship won't last long. With Stephanie mentioning that Ryan had been talking to other women in spite of her paying for his bills for three years, the possibility of her choosing his cousin Harris might become a reality. A traumatic childhood and then loveless adulthood is what Stephanie finally left behind when she decided to couple up with Ryan. But a recent episode saw the 90 Day Fianc star shocking her friends with the revelation that she pays for Ryan's salary too. Of course, her sleeping with Ryans cousin could have made her guilty enough to pay his bills but TLC viewers couldnt help wondering if Stephanie was getting played. After all, a Maserati-driving, successful boss woman who looks way younger than her years could date anyone, right? Especially if the self-proclaimed sugar mama whose Instagram comments are filled with 90 Day Fianc fans asking Stephanie for her secret to looking half her age.

Related:90 Day Fianc: Throwback Video Shows Stephanie Selling Sermorelin Injection

Not surprisingly, 90 Day Fiancs Stephanie has been a fan-favorite since season 8s premiere even though she appeared on the reality show weeks later. Fans were curious about this cat-lady who was calling herself a cougar and Ryan her cub as she sent him expensive watches in the trailer. The Grand Rapids lady soon gained more interest by hosting expensive giveaways for handbags on her Instagram, which some 90 Day Fianc couldnt help but love her for. However, it was Stephanies weigh-loss spa Skin Envy that made her much more interesting. As expected, the 90 Day Fianc stars age-defying routine owes a lot to her own business.

When asked by an IG follower, How can I look like you? 90 Day Fiancs Stephanie replied, Well, the Youth Serum Sermorelin/Ipamorelin shots are $4500 a year. But Stephanie also gave an alternative option by suggesting, dont drink much alcohol, get at least 8 hours of sleep at night. Ryans Michigan lover also revealed that she drinks at least 8 glasses of PURIFIED water daily. And for exercise, 90 Day Fiancs Stephanies go-to is a hula hoop.

The curious TLC viewer further enquired Stephanie about her injections as she wrote, can I buy them from your store, and can you ship them? And the marketing maverick that she is, 90 Day Fianc star Stephanie shared, Call my medical assistant Pam. Spoilers suggest that Stephanie will be dumping Ryan while in Belize next and coming back to America with cousin Harris. But while that may take a while to happen on 90 Day Fianc, one things for sure, Stephanie is surely going to get a lot of calls at Skin Envy, all due to the fans who are in awe, if not envious of her own beauty.

Next:90 Day Fianc: Shocking Details Of Jovi Dufren's Criminal Past Revealed

90 Day Fianc airs Sundays at 8pm EST on TLC.

Source: Stephanie Davison/Instagram

90 Day Fianc: Skinny Angela Deem Posts Jaw-Dropping Christmas Look

Saylee Padwal is a Reality TV Features Writer for Screen Rant. When she's not thinking about pop-culture or food, you can always find her "investigating" her way through Instagram, reading mysteries and thrillers, and listening to BTS on loop.

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90 Day Fianc: Stephanie Davison Reveals The Secrets To Her Youthful Looks - Screen Rant

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Sermorelin Therapy for Anti-Aging & Weight Loss | Diet Doc

Posted: December 19, 2020 at 1:54 pm

What is Sermorelin?

Sermorelin is a formula created to fight the effects of aging and promote weight loss. This treatment has the potential to slow the effects of aging in humans by spurring the growth of new tissue, muscles, and synapses in the brain. It even has the potential to help patients think more clearly while elevating their mood and energy levels.

Sermorelin injections encourage the body to increase the production of human growth hormone (hGH) naturally. Prescription Sermorelin, a proven therapy for low growth hormone levels, is different from many similar treatments because it stimulates a natural process rather than requiring patients to add hormones to their body directly. This distinction makes our Sermorelin therapy much less likely to lead to complications.

Reduced hormone production is considered one of the principal medical signs of aging. The decrease in human growth hormones causes the changes in appearance that we associate with aging, such as wrinkles and loose or droopy skin. When your hormones decrease, you also experience the physical effects of aging, including weakening muscles, loss of energy, and a decrease in stamina. Sermorelins anti-aging properties naturally restore the bodys human growth hormone production to more youthful levels without the potentially dangerous side effects of actual hormone injections.

Studies have shown that adults who struggle with obesity and losing weight can have lower hormone levels than adults with a healthy weight. Sermorelin can help overweight adults lose weight by stimulating the body to naturally increase hormone production. Sermorelin therapy and an increase in growth hormones have also been linked to increased muscle mass and bone density and decreased fat storage. While weight loss results vary significantly between patients, Sermorelin can help reduce the physical effects of aging, such as weakened muscles and bone mass. Contact a weight loss physician at Diet Doc today to see if Sermorelin could be right for your weight loss journey.

Clinical studies have shown that Sermorelin anti-aging treatment is associated with a range of physical and mental benefits. Benefits of Sermorelin include:

Sermorelin injections yield results quickly. Patients report feeling and looking younger soon after beginning therapy, with fewer wrinkles, smoother and more youthful skin, elevated mood, and an improved feeling of overall wellness.

Patients typically experience few to zero side effects when participating in Sermorelin injection therapy. However, every persons body is unique, which is why it is imperative to consult your Diet Doc physician to determine if Sermorelin therapy is right for your needs. Some patients could experience adverse side effects such as allergic reactions at the injection site, headaches, dizziness, hives, or nausea. Contact your Diet Doc physician if you experience any complications while taking Sermorelin injections.

Diet Doc specializes in personalized medical weight loss programs customized specifically for your unique needs. If you struggle with weight loss or aging as a result of hormone reduction, the knowledgeable doctors at Diet Doc can help formulate a unique plan for using Sermorelin injections. We make it easy to buy Sermorelin injections online with permission from a doctor. This is just one of the many solutions we offer as part of our medical weight loss program at Diet Doc. Contact us if youre interested in seeing what Sermorelin can do for your health or want to learn more about our anti-aging and weight loss therapies. We will provide a confidential, no-obligation consultation to find out more about you and your priorities, and we will help you move forward to meet your goals.

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