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Research Shows a Lower Protein Diet Could Be the Key to Healthier Eating Habits – SciTechDaily

Posted: July 24, 2022 at 1:57 am

By The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)July 18, 2022

By the time they were 18 months old, infants who began receiving taster portions of the new Nordic diet were eating 46% more vegetables than those who were fed a conventional diet.

Introducing infants and toddlers to a lower-protein Nordic-style diet that places an emphasis on plant-based foods could allow them to obtain healthy eating habits

New research recently presented at the 54th Annual Meeting of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)suggests that the key to healthier eating habits may be to introduce babies and toddlers to a lower protein Nordic-style diet with a greater focus on plant-based foods.

By the time they were 18 months old, infants who began receiving taster portions of the new Nordic diet, which includes fruit, berries, roots, and vegetables, along with breast or formula milk, were eating nearly twice as many vegetables (a 46 percent increase) as those who were fed a conventional diet.

As part of the OTIS experiment, researchers from the University of Umein Sweden, the Stockholm County Council Centre for Epidemiology, and the University of California in the United States studied two groups of infants from 4-6 months to 18 months. 250 infants in total participated, and 82% of them completed the study.

A graphic explaining the benefits of a Nordic-style diet. Credit: The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)

The toddlers in the 2 groups had quite different eating patterns, according to the study. Those who followed the new Nordic diet, who received Nordic home-made baby food recipes, protein-reduced baby food products, and social media support from other parents, ate 4245% more fruit and vegetables at 1218 months of age than those who followed the traditional diet currently advised by the Swedish Food Agency.

Although in the traditional diet group, fruit consumption remained constant, but between 12 and 18 months, infants receiving the traditional diet consumed 36% fewer vegetables.

Babies on the Nordic diet had an average protein intake 17-29% lower than those on the conventional diet at 12-18 months of age. This was still within recommended protein intake levels and the overall calorie count between the two groups was the same. The protein reduction in the Nordic diet group was replaced by more carbohydrates from vegetables, not more cereals, together with some extra fat from rapeseed oil.

Lead researcher Dr. Ulrica Johansson, a Medicine Doctor in pediatrics and registered dietitian at the University of Ume, Sweden, said there did not appear to be any negative effects from having a lower protein intake.

Commenting on the findings, Dr. Johansson says: A Nordic diet with reduced protein introduced to infants naive to this model of eating, increased the intake of fruit, berries, vegetables, and roots, establishing a preferable eating pattern lasting over a 12-month period.

There were no negative effects on breastfeeding duration, iron status or growth.

A Nordic diet reduced in protein is safe, feasible, and may contribute to sustainable and healthy eating during infancy and early childhood, she added.

The novel research could pave the way to broadening the taste spectrum in infants and potentially provide an effective strategy for instilling healthier eating habits early in life.

The Nordic diet has a higher intake of regionally and seasonally produced fruit, berries, vegetables, herbs, mushrooms, tubers, and legumes, as well as whole grains, vegetable fats and oils, fish and eggs, and a lower intake of sweets, desserts and dairy, meat, and meat products.

Typical Nordic fruits include lingonberry, buckthorn berry, cranberry, raspberry, and blueberry, as well as fiber-rich vegetables such as turnip, beets, swede, root celery, carrots, parsnip, cabbage, broccoli, cauliflower, and kale.

Chair of the ESPGHAN Nutrition Committee, Professor Jiri Bronsky, stated: The authors have shown a significant effect of the diet in 12 and 18 months of age of the children. The Nordic diet group consumed more fruit and vegetables and less protein than the control group. The Nordic diet was well tolerated and did not negatively affect the growth of the child or breastfeeding duration. Importantly, this research demonstrates that this diet is safe, feasible and exposes infants to a variety of flavors which may influence long-lasting food preferences.

Meeting: 54th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)

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Research Shows a Lower Protein Diet Could Be the Key to Healthier Eating Habits - SciTechDaily

Forget Fad Diets, Here’s the One You Need – Medscape

Posted: July 24, 2022 at 1:57 am

This transcript has been edited for clarity.

Hello. I'm Dr David Johnson, professor of medicine and chief of gastroenterology at Eastern Virginia Medical School in Norfolk, Virginia. Welcome back to another GI Common Concerns.

All of us routinely see diet recommendations on the Internet like TikTok or in new books. Every possible diet seems to receive this promotional push, although the evidence behind them is often lacking.

So what do we mean when we talk about a "healthy diet"?

Today, I'd like to spend a few minutes updating you on the current evidence and how I discuss it with my patients so that you can perhaps do the same in your own patient discussions.

The Western diet has really cannibalized the health of the United States and Western civilizations.

This diet is typically characterized by high intakes of processed and prepacked food items, red meat, dairy, and grains, consisting of high-fat, high-protein, and low-fiber components. These food items have become diets of convenience as opposed to diets potentially promoting health.

They've led to an associated increase in so-called "diseases of civilization," including cardiovascular disease, obesity, and a variety of metabolic diseases and cancers.

Western diets have been also associated with a variety of microbial and gut integrity changes, which in turn, are associated with an assortment of bad outcomes. Specifically, they're associated with decreases in microbial diversity in the gut; upregulation of proinflammatory mediators, cytokines, and chemokines; and several changes to gut integrity, immunity, and pathways that are derivatives toward diseases and even promoting translocation of gut bacteria.

In contradistinction, we have the Mediterranean diet, which is often proffered as the good or healthy diet for most patients. This comprises a diet that's high in fiber and low in animal protein and saturated fat, and is characterized by a higher ingestion of vegetables, fruits, and healthy fat and a lower intake of red meat and dairy. The Dietary Guidelines for Americans recommend a Mediterranean diet for promoting health and minimizing disease.

The high fiber content of Mediterranean diets is a key reason behind that recommendation. Fiber comes in soluble and insoluble forms. Soluble fiber gets digested, whereas insoluble fiber moves through the gastrointestinal tract, bringing components of water absorption and promoting gut motility, particularly in the colon.

Insoluble fiber has a variety of ascribed benefits, particularly related to the changes in the gut production of short-chain fatty acids, which are incredibly important for optimizing intestinal function.

We know that short-chain fatty acids increase secretion of immunoglobulins, induce regulatory T-cell tissue repair, promote antimicrobial peptides and mucus production, and basically optimize intestinal function and the intestinal barrier integrity. This is all critically important in promoting health.

There are also some data on short-chain fatty acid production as it relates to crossing the blood-brain barrier. This association with the brain-gut axis potentially changes gut-related derivatives, driving mood and behavioral activities in the brain. Therefore, we can say that the short-chain fatty acid derivative from the intestinal microbiome does have central nervous systemrelated effects.

There are also some very interesting data in this area related to the progression of COVID to severe disease or long-haul COVID, or even the development of COVID. Enhanced microbial diversity seems to be somewhat protective and, if infected with COVID, predictive of a rapid response and resolution. Short-chain fatty acids also serve as a marker, particularly when they're reduced. Branch-chain shorty acid called L-isoleucine has been shown to be predictive of longer-term consequences and more-severe COVID. So diet may have a significant role in even in the COVID world.

There are other elements in the diet that may contribute to disease.

Some things commonly added to diets have been shown in animal models to have a significant impact in changing gut integrity. In particular, this is observed in prepacked foods that are often found in the Western diet, which incorporate things such as emulsifiers and food additives with a goal toward enhanced aesthetics and taste.

Some that we see routinely in popular food items are carboxymethyl cellulose and polysorbate-80. These are derivatives in a variety of dairy products. Interestingly, they decelerate the melting of ice cream. That may be good for your kids eating an ice cream cone in the backseat in the summer, but not so good potentially for the intestine.

The same is true as it relates to maltodextrin, which is a very common thickener and sweetener, but again decreases the mucosal layer thickness and increases gut permeability.

Carrageenan, which is made from red seaweed, is added to increase texture, primarily in dairy products and sauces. It also decreases gut integrity and permeability changes and antigenic translocation.

Another common food additive is high-fructose corn syrup, something we're seeing more and more data about. Its use in sugary beverages was once implied to have, and now clearly is associated with, an increased risk for nonalcoholic fatty liver disease, early colon cancer, and a variety of other cancer pathways. Recent animal model data have shown mechanistically how it contributes to colon cancer. It was also most recently associated with liver cancer in postmenopausal women ingesting one sugary beverage a day.

Almost all sugary beverages have shifted from using cane sugar to high-fructose corn syrup because it's cheaper and sweeter. Interestingly, as data have become more onerous regarding its disease associations, in 2012 the corn industry went to the US Food and Drug Administration and petitioned to change the name from high-fructose corn syrup to corn sugar. That term sounds a lot easier and maybe even sweeter when it comes to possible health implications, but the FDA said no.

Since then, the widespread use of high-fructose corn syrup has been described as a food public health crisis. High-fructose corn syrup is something that is very easy to avoid when you talk about sugary beverages.

When it comes to artificial sweeteners, the top three that have been studied to date are aspartame, saccharin, and sucralose (Splenda). They are not absorbed but rather are fermentable sugars that get to the gut and change the gut microbiome. In animal models, they have been shown to promote obesity and diabetes, which is very much paradoxical to what their advertised intent is. Again, this has only been studied for these three agents, and we also don't have data in lower-threshold exposures.

I think it's common sense to minimize the use of these things and instead ask patients to use natural sugars, consume water, and incorporate other strategies; that's what I discuss with my own patients.

We can go the wrong way and make our patients too rigid about reading nutritional labels. I want to caution you about emerging food restrictive disorders that very much can become an eating disorder. So we don't want to go the opposite way.

I tell my patients to be a good, conscientious thinker, look at your food, minimize the processed foods, and build your meals. The Western diet needs to go. The more we can use the Mediterranean diet, the better off we are. You can still have your occasional cheeseburger and French fries but use common sense.

The Mediterranean diet really is simple. I routinely recommend this to my patients with inflammatory bowel disease, obesity, nonalcoholic fatty liver disease, along with other inflammatory disease conditions. But I do think we can make this a general recommendation across all patients in our attempt to promote health and thereby prevent disease.

I hope this has been helpful.

I'm Dr David Johnson. Thanks for listening.

David A. Johnson, MD, a regular contributor to Medscape, is professor of medicine and chief of gastroenterology at Eastern Virginia Medical School in Norfolk, Virginia, and a past president of the American College of Gastroenterology. His primary focus is the clinical practice of gastroenterology. He has published extensively in the internal medicine/gastroenterology literature, with principal research interests in esophageal and colon disease, and more recently in sleep and microbiome effects on gastrointestinal health and disease.

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Forget Fad Diets, Here's the One You Need - Medscape

Diet, Exercise, and Logging Off? Rethinking Employee Wellness – MIT Sloan

Posted: July 24, 2022 at 1:57 am

Companies should think beyond traditional health care benefits and consider social medias impact on employees well-being.

Almost every large organization is trying to get employees to adopt healthful habits. Managers have long known that healthier employees are more productive, loyal, and, frankly, less expensive, given that healthy behaviors can lead to lower health care costs. Given the steeply rising cost of providing health insurance benefits, more companies have experimented with paying employees to start healthy habits. Adobes wellness reimbursement program compensates employees up to $360 each year for gym memberships, bike-share programs, fitness classes, massages, nutritional counseling, and more. Google has gone so far as to build out most of these amenities directly onsite at its main campuses.

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These organizations have a promising opportunity to broaden the types of wellness efforts in which theyre investing. Existing programs definitions of healthy habits are generally woefully limited to diet and exercise. While physical activity and nutrition are surely two significant factors affecting health (and insurance-related expenses to self-funded employers), such a narrow view misses myriad lifestyle choices we make every day that drastically affect our health. Social media use continues to be an ever more salient example.

A growing body of research confirms that the joys of social media come with drawbacks directly related to well-being, including disrupted sleep patterns, heightened anxiety, and increased depression. Managers cant shove this aside by categorizing employees online activity as starkly unrelated to work. Depression is the leading cause of disability inside and outside of the workplace, and rising generations of employees are particularly susceptible to health issues fueled by social media use.

To see the value of nudging employees to think carefully about how they use social media, consider a recent experiment conducted by researchers at Stanford and New York University, which found that paying participants about $100 to deactivate Facebook for four weeks reduced their overall online activities, increased their offline activities, and increased mental health measurements.

The research team recruited over 2,000 participants through Facebook ads, asking them baseline questions about their well-being, and had half of them deactivate their profiles. When the researchers checked back in with the participants about their well-being and their time use after a month, the results were striking: There were significant improvements in well-being, in particular in self-reported happiness, life satisfaction, depression, and anxiety, among the deactivators.

Overall, deactivation improved participants social well-being scores by 0.0

Karyn Georgilis-Becker is a design strategist at Fusion, a UnitedHealthcare accelerator.

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Diet, Exercise, and Logging Off? Rethinking Employee Wellness - MIT Sloan

Meal frequency and portion size: What to know – Medical News Today

Posted: July 24, 2022 at 1:57 am

It is widely accepted in modern culture that people should divide their daily diet into three large meals breakfast, lunch, and dinner for optimal health. This belief primarily stems from culture and early epidemiological studies.

In recent years, however, experts have begun to change their perspective, suggesting that eating smaller, more frequent meals may be best for preventing chronic disease and weight loss. As a result, more people are changing their eating patterns in favor of eating several small meals throughout the day.

Those who advocate for eating small, frequent meals suggest that this eating pattern can:

While a few studies support these recommendations, others show no significant benefit. In fact, some research suggests it may be more beneficial to stick with three larger meals.

Here is what the research says.

Early epidemiological studies suggest that increased meal frequency can improve blood lipid (fats) levels and reduce the risk of heart disease. As a result, many experts advise against eating fewer, larger meals a day.

Over the years, some studies have supported these findings, suggesting that people who report eating small, frequent meals have better cholesterol levels than those who consume fewer than three meals per day.

In particular, one 2019 cross-sectional study that compared eating fewer than three meals per day or more than four meals per day found that consuming more than four meals increases HDL (high-density lipoprotein) cholesterol and lowers fasting triglycerides more effectively. Higher levels of HDL are associated with a reduced risk of heart disease.

This study observed no differences in total cholesterol or LDL (low-density lipoprotein) cholesterol. It is important to note, however, that this is an observational study, meaning it can only prove association, not causation.

Additionally, one review published in the American Heart Associations journal Circulation concluded that greater eating frequency is associated with a reduced risk for diabetes and cardiovascular disease, according to epidemiological studies.

There is a commonly held notion that more frequent meals can help influence weight loss. However, the research on this remains mixed.

For example, one study compared eating three meals per day or six smaller, more frequent meals on body fat and perceived hunger. Both groups received adequate calories to maintain their current body weight using the same macronutrient distribution: 30% of energy from fat, 55% carbohydrate, and 15% protein.

At the end of the study, researchers observed no difference in energy expenditure and body fat loss between the two groups. Interestingly, those who consumed six smaller meals throughout the day had increased hunger levels and desire to eat compared to those who ate three larger meals per day.

Although calorie intake was controlled in both groups, researchers hypothesized that those who consumed frequent meals would be more likely to consume more daily calories than those who ate less frequently.

Results of another large observational study suggest that healthy adults may prevent long-term weight gain by:

Moreover, according to the United States Department of Agriculture (USDA) Scientific Report of the 2020 Dietary Guidelines Advisory Committee, due to inconsistencies and limitations in the current body of evidence, there is insufficient evidence to determine the relationship between meal frequency and body composition and the risk of overweight and obesity.

Small, frequent meals are often touted as a cure-all for obesity. Many believe that eating every 2 to 3 hours can help boost metabolism.

Digestion of food does require energy. This is known as the thermic effect of food (TEF). However, it does not appear that meal frequency plays a role in boosting metabolism.

In fact, some studies suggest fewer, larger meals may increase TEF more than eating frequent meals.

Although evidence to support increased meal frequency in the general population remains mixed, several experts believe that eating small, frequent meals can benefit athletes.

According to the International Society of Sports Nutrition, athletes who follow a reduced-calorie diet may benefit from eating small frequent meals with adequate protein because it can help preserve lean muscle mass.

When prioritizing total daily calorie intake, limited evidence suggests that, in athletes, a higher meal frequency may increase performance, support fat loss, and improve body composition.

People who eat more frequently are more likely to have better diet quality. Specifically, those who consume at least three meals per day are more likely to have a greater intake of vegetables, greens, legumes, fruit, whole grains, and dairy.

These individuals are also more likely to consume less sodium and added sugars than those who consume two meals per day.

Similarly, another 2020 study published in the British Journal of Nutrition found that increased meal frequency approximately three meals per day is associated with higher diet quality.

Researchers found that snack frequency and diet quality varied depending on the definition of snacks.

Based on the presented studies, no substantial evidence supports one eating pattern over the other. Yet many of these studies also have limitations.

For example, there is no universally accepted definition of what a meal or snack consists of. This can have an impact on study outcomes.

With that said, both eating patterns can be beneficial as long the primary focus is on healthful eating habits.

A review published in Nutrition in Clinical Practiceshows that certain populations may benefit from six to 10 small, frequent meals. These include people who:

If your goal is to lose weight, it is important to be mindful of your portion sizes. Be sure to stay within your allotted daily calorie needs and divide them among the number of meals you consume.

For example, if you need 1,800 calories to maintain your weight and choose to eat six small meals daily, each meal should be around 300 calories.

Small, frequent meals often come in the form of ultra-processed foods and snacks that fall short in many vital nutrients your body needs. Thus, it is essential to focus on the quality of the foods you consume.

People who may benefit from three larger meals per day include:

Again, keeping diet quality in mind and prioritizing whole foods is essential. Fewer meals mean fewer opportunities to get in key nutrients the body needs.

While we do not have strong evidence to support the importance of meal frequency, substantial evidence supports the overall health benefits of following a well-balanced, nutrient-rich diet.

According to the Dietary Guidelines for Americans 20202025, a healthy diet should:

Evidence is mixed about the importance of food frequency. While there is no solid evidence to suggest that one eating style is superior to the other, both can offer health and wellness benefits if you follow a healthy eating pattern.

Thus, it ultimately comes down to personal preference and which approach works best for you. Additionally, if you have certain health conditions, one style may benefit you over the other.

As always, consult your healthcare provider before making any significant changes to your diet.

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Meal frequency and portion size: What to know - Medical News Today

Monsoon Diet: 5 Immunity-Boosting Fruits You Must Add To The Diet – NDTV Food

Posted: July 24, 2022 at 1:57 am

After suffering from the severe summer heatwaves, we all look forward to enjoying the monsoon season. And now the season has finally arrived, we look for the reasons to indulge in our favourite snacks with a piping hot cup of 'kadak chai' while enjoying the beautiful weather. Apart from this, there's one thing which we should never take for granted and that is our health. Monsoon season can really take a toll on your health, especially hampering immunity. So, it is mandatory to consume food that can make your immune system strong. A strong immune system can protect you from many unwanted diseases. Having said that, here we bring you a list of fruits that you must add to your diet to cope up with monsoon effects. Take a look.

Also read:Monsoon Diet Tips: 7 Low-Cal Fruits And Vegetables For Monsoon Diet (Recipes Inside)

According to the USDA data, jamun consists of 1.41 mg iron, 15 mg of calcium and 18 mg of vitamin C. Besides, this seasonal delight is also rich in antioxidants that help boost immunity and formulate collagen resulting in glowing skin. For more benefits of jamun and healthy recipes, click here.

You must have heard the very popular saying ''an apple a day keeps the doctor away'. Well, that's true! Apples are rich in Vitamin C and flavonoids called quercetin that help in improving the immunity, keeping any ailment at bay. To know more benefits of apples, click here.

This fruit is known for its juicy pearls and extraordinary taste. Besides, it is loaded with antioxidants that help improve gut-health and immune system as well. These are some factors that can also help you in losing some extra kilos. According to Celebrity nutritionist and life coach Luke Coutinho, pomegranate might help you detox better than green tea. You can read the complete detailed study, click here.

Bananas are high in Vitamin B6 that helps in keeping the immune system function properly. You can use this fruit as a base to prepare delicious smoothies and shakes. For more banana benefits, click here.

Besides plenty of fibre and potassium, pears are rich in Vitamin C and also contain anti-inflammatory flavonoids in their peels-so make sure you consume the skin for the super nutrient boost. Click here.

So, what are you waiting for? Stock up these seasonal treats and add them to the diet now.

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Monsoon Diet: 5 Immunity-Boosting Fruits You Must Add To The Diet - NDTV Food

Kate Moss Takes Her Place as the New Queen of Diet Coke in Leopard – W Magazine

Posted: July 24, 2022 at 1:57 am

When it was announced earlier this month that Diet Coke queen, Kate Moss, would finally be taking her well-deserved place on the Coca-Cola throne as the UK creative director of the diet variety, fans of the supermodel rejoiced. Long has Moss been a champion of the beverage, and after the position sat empty for a decade following Marc Jacobs stint in the role, Moss seemed like the perfect replacement. As for what she would do as the creative director, that part was unclear. I'm looking forward to inspiring fans and celebrating the brand's 40th birthday in style, Moss said in the brands announcement, which also stated that Moss would continue to showcase the positive attitude of Diet Coke drinkers, throughout the summer.

On Wednesday, Moss duties as the queen of the no calorie Coke became clear(er) when the model hosted an event at London's 180 The Strand. It was there that Moss unveiled four newly-designed cans, each of which were inspired by some of Moss most iconic looks from throughout the years. Of course, one of those cans includes a leopard motif, referencing the models love for the animal print. Its fitting, then, that for the event, Moss opted to wear a leopard print blouse, which she paired with black tapered trousers, a large black belt, and some gold sandals. She finished off the look with a lip color which can only be described as Coke red.

David M. Benett/Getty Images Entertainment/Getty Images

Unfortunately, it seems like Moss creative director duties only reach across the UK, meaning American fans will likely have to travel abroad if they want to get their hands on a Moss-designed can. But thanks to the wonderful world wide web, we can still enjoy her reign from here, and sip on our non-Moss Cokes as a consolation.

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Kate Moss Takes Her Place as the New Queen of Diet Coke in Leopard - W Magazine

Hopes rise that world’s first appetite-suppressant pill will help thousands lose weight safely – iNews

Posted: July 24, 2022 at 1:57 am

An appetite-suppressant pill being developed by scientists could help thousands lose weight safely with no obvious side effects, scientists say.

Experts have created a new protein that has safely reduced the weight of obese mice, rats and monkeys by up to 12 per cent in eight weeks.

The protein works by stimulating hormones that make you feel fuller and less hungry. It also boosts healthy gut bacteria that fight obesity by reducing the amount of fat absorbed by the body.

Developers hope to start testing the tablet in clinical human trials as early as next year.

Scientists say the protein, which is known as D3, although it has no relation to vitamin D3, can be turned into cheap tablets that could safely help thousands of obese people lose weight.

It is derived from human defensins proteins, or antibiotics, that protect against bacteria, funghi and viruses and can be produced in large quantities.

We are very excited about D3. Our research shows it has a great potential to be developed as an oral weight-loss drug, which will undoubtedly benefit society, said Professor Fangqing Zhao, of the Chinese Academy of Sciences in Beijing.

We are going to conduct clinical studies after some essential pre-clinical tests [on toxicity and finding a suitable material for the protein to bind with in the drug] perhaps with small-scale clinical results in one or two years.

The main advantage of D3 is that it can be taken orally, which can greatly improve the patient compliance. There are currently no appetite suppressants in a tablet form on the market. We hope to develop D3 as the safest and cheapest weight-loss drug.

D3 can not only suppress appetite, but also increase the abundance of the weight-loss bacteria Akkermansia muciniphila, a star bacterium that is thought to be strongly associated with lean body mass.

The study found the number of Akkermansia muciniphila increased about 100 times during the D3 treatment. It is unclear exactly how this bacteria helps a person lose weight.

However, a 2020 study in the journal Nutrition & Metabolism, that Professor Zhao was also involved in, concluded that it may play a decisive role in reducing the burden of obesity, via modulation of glucose metabolism and low-grade inflammation both of which are factors in obesity.

Experts in the field, who were not involved in the D3 project, welcomed the findings as extremely promising, while cautioning that the benefits have yet to be proved in humans.

This is an exciting novel study showing D3 acts to reduce obesity by stimulating the gut microbiome targeting healthy microbes like Akkermansia muciniphila, said Professor Tim Spector, of Kings College London, who runs the ZOE app, the worlds largest nutrition study and the worlds largest Covid study.

It may also work to reduce fat absorption and appetite. So far, it has only been shown to work in mice, rats and small monkeys but is a potentially very useful therapeutic if it also works in humans, as it doesnt need to be injected.

Professor Ted Dinan, an expert in the brain-gut-microbe axis at University College Cork, added: This is indeed an interesting series of studies. The weight reduction in the various animal models is impressive.

The fact that the gut microbiota is altered with increases in Akkermansia muciniphila strengthens the view that D3 has significant positive metabolic effects.

The weight-loss area is full of false positive findings in animals that fail to translate. The results are promising but require human replication.

If all goes well, however, Professor Dinan says D3 pills could be available for people to use in seven to 10 years.

The development puts its scientists at the forefront of fledgling field weight-loss pills and injections.

In the UK, just two anti-obesity medicine have been approved, neither of which is an appetite-suppressing pill.

They are orlistat, a weight loss pill that works by reducing fat absorption and liraglutide, an appetite-suppressing injection.

The US Food and Drugs Administration has approved three additional anti-obesity drugs but none of those are in tablet form while there are a handful of other promising trials of anti-obesity drugs that, as with D3, are at the animal-testing stage.

Among the drugs currently approved by the FDA for clinical use in the treatment of obesity, it seems that most of them have side effects. Common adverse reactions to these weight-loss drugs include gastrointestinal reactions, such as nausea and vomiting, Professor Zhao said.

Notably, no obvious side effects were observed in our study in mice, rats or macaques. But considering that our experiment was conducted only for 10 to 12 weeks, a longer experimentation period is needed for verification of the results, he added.

The study is published in the BMJ journal Gut microbiota.

Having demonstrated the safety and effectiveness of D3 in mice, rats and small monkeys, Professor Zhao and his fellow researchers are busy preparing a series of pre-clinical trials ahead of tests in people to see if it works as well in them.

These include tests to determine whether the new protein they have developed could be poisonous to humans and to work out what would constitute a safe, yet effective, dose.

The pre-clinical studies for drug registration require a long period of time, including druggability, pharmacological toxicology and pharmacokinetics, said Professor Zhao who is nonetheless hopeful of beginning small-scale human tests in the next year or two.

Druggability refers to finding the right molecules or drug material to successful bind to the D3 protein to produce a tablet that can hold together outside the body and break down inside it.

Pharmacokinetics, meanwhile, is concerned with the movement of drugs within the body.

If things go well, the scientists will conduct a series of human trials of various sizes in the next few years to demonstrate safety and effectiveness.

After that, they will seek approval from a regulatory probably the FDA in the US, which would typically be followed shortly after by the UK approval by the The Medicines and Healthcare products Regulatory Agency (MHRA).

If all continues to go well, a table could be available in seven to 10 years most likely on prescription for people with obesity.

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Hopes rise that world's first appetite-suppressant pill will help thousands lose weight safely - iNews

Weight loss of residents at care home in Walsall put them ‘at risk of harm’ – Birmingham Live

Posted: July 24, 2022 at 1:56 am

A damning inspection found residents lost 'significant' weight and were put at harm at a specialist dementia care home in Walsall. Anson Court Residential Home was given the lowest rating of 'inadequate' by the Care Quality Commission (CQC) which raised serious concerns about the safety, effectiveness and leadership of the service.

A report said the home, in Harden Road, Walsall, had been inspected in November last year and rated as 'requires improvement' but had deteriorated further since then. Among the concerns highlighted now were three people losing significant weight in six months, unsafe practices in moving two residents, people trying to get into others' rooms at night and a half-chewed tablet being found on the floor and handed to an inspector.

Despite the issues raised by the CQC, people and their relatives gave positive feedback about staff and the home, saying they were treated with respect and dignity. A spokesperson for Anson Court said they were disappointed with the findings of the report but were working to address concerns and improve services provided.

READ MORE: 'Marvellous' development to transform crumbling buildings in Willenhall

When discussing safety at the home, the report said: "Since our last inspection in November 2021, we saw three people had lost significant weight over the last six months. The provider had failed to identify the weight loss and no action had been taken to check people were not malnourished or the weight loss was being caused by other health conditions.

"This meant people were put at risk of potential, avoidable harm because any underlying health condition, contributing or causing the weight loss, had not been considered or referred for further consultation with health professionals, such as the GP or dietician.

"Prior to the inspection we had received information of concern relating to the moving and transferring of people who required the support of a hoist or similar equipment. Conversations with staff confirmed unsafe practices had been used to move two people."

It added: "A situation had developed in the home which had the potential to put people at serious risk of harm. Two people told us how unpleasant it was at night for them with people banging on their bedroom doors trying to get in. A relative told us, "It's like living on a knife edge" when they visited the home.

"A number of incidents had occurred and staff did not have the necessary knowledge and skills to support the people involved safely. One person found a half-chewed tablet on the floor and gave it to the inspector. It could not be confirmed what the tablet was, who it had been administered to or how long it had been on the floor."

Inspectors also concluded the home was not well led with records not always complete and care plan reviews being poor. In the areas of whether the services were caring and responsive, inspectors said they required improvement.

A spokesperson for Anson Court said: "Anson Court Residential Home is a long-standing member of the Walsall community and remains committed to the ongoing provision of safe, high-quality, person-centred care for all residents. Anson Court Residential Home has reviewed the CQC Inspection Report published on 16 July 2022.

"The home is disappointed at the findings of this report, however takes all concerns raised seriously and continues to work in consultation with the CQC and the local authority to address these. The home continues to receive support from expert healthcare consultants in shaping ongoing care quality improvements to continue to meet the needs of all residents."

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Weight loss of residents at care home in Walsall put them 'at risk of harm' - Birmingham Live

Innovative therapy for Type 2 diabetes management – Firstpost

Posted: July 24, 2022 at 1:56 am

T2DM therapy is primarily aimed towards controlling blood glucose levels, holistic management of the condition is the need of the hour

India is unfortunately known as the diabetes capital. Pixabay

According to the latest estimates, a whopping 537 million adults or 1 in 10 people are living with diabetes globally. India, unfortunately, is home to the worlds second-largest population of people with diabetes at 74.2 million. While Type 2 diabetes mellitus or T2DM, the most prevalent form of diabetes, is one of the most common health problems today, we often fail to take into consideration the seriousness of the disease. Compared to those without diabetes, people with this disorder are at a higher risk of developing several disabling and life-threatening health problems.

Uncontrolled Type 2 diabetes enhances the risk of complications

T2DM occurs when the body doesn't produce enough insulin or when it is unable to use the insulin it produces effectively. Since insulin is responsible for converting the sugar (glucose) in your food into energy, its insufficiency and underutilisation lead to high blood glucose levels. Patients with T2DM need to control their blood glucose levels since consistently high levels can lead to serious diseases that affect the kidney, eye, nerves, heart, blood vessels and brain. Nearly 0.6 million deaths in India are attributed to diabetes. Compared to individuals without diabetes, the risk of cardiovascular complications such as unstable angina (pain in the chest), heart attack, heart failure and stroke increases by 53 per cent, 54 per cent, 56 per cent and 72 per cent, respectively in those with T2DM.

Additionally, diabetes coexists with several other disorders, increasing the overall risk of complications. The combination of diabetes and obesity is termed diabesity and mortality risk in such individuals increases by 7 times. While weight gain is common in T2DM, the reverse is also true i.e. every kilogram gained increases diabetes risk by 4.5%. Obesity also affects the kidney with individuals living with obesity being 2.5 times more likely to suffer from kidney problems. Similarly, nearly 40 per cent of individuals with T2DM have kidney complications. Hypertension, itself a risk factor for heart disease, is also 2 times more common in those with T2DM than in individuals without diabetes.

Type 2 diabetes management in the current era of multiple comorbidities

Though T2DM therapy is primarily aimed towards controlling blood glucose levels, holistic management of the condition is the need of the hour. Though lifestyle changes such as weight control, appropriate diet and cessation of smoking and alcohol consumption can make a difference, most T2DM patients eventually need treatment with antidiabetic medications (ADMs). Though older agents such as sulphonylureas, insulin and thiazolidinediones help control blood glucose, they also result in side effects such as hypoglycaemia (glucose levels lower than normal) and weight gain which offset their beneficial effects.

The need to explore other avenues of treatment has led to the development of drugs such as sodium-glucose cotransporter-2 (SGLT2) inhibitors, dipeptidyl peptidase (DPP)-4 inhibitors and Glucose-like peptide (GLP-1) receptor agonists (RAs). GLP-1 RAs especially offer blood glucose control coupled with weight loss and lack of hypoglycaemia, tackling the twin hurdles of T2DM and obesity safely while reducing the overall risk of complications. However, their availability as injectables was a challenge for T2DM patients.

Making an innovative leap in comprehensive Type 2 diabetes management

The need to bridge the gap between comprehensive T2DM management and convenience led to the development of an oral form of the GLP-1 RA, semaglutide. Oral semaglutide provides patients with efficacy, safety, weight loss and minimal side effects, all in a convenient pill form. Clinical studies conducted with oral semaglutide affirmed its impact on blood glucose levels and weight loss (up to 5 kgs) along with cardiovascular safety. Moreover, the effect was greater than that seen with other ADMs. The product of 15 years of research, oral semaglutide offers a novel and efficacious option for the holistic treatment of T2DM, thereby improving patient outcomes.

The writer is MBBS, MD- General Medicine, DM- Endocrinology. Views are personal.

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Innovative therapy for Type 2 diabetes management - Firstpost

Surgery gave Rehoboth man the tools to lose weight – Coastal Point

Posted: July 16, 2022 at 2:05 am

Mike Killmon doesnt hesitate when he says Dr. Tarek Waked, MD, saved his life. The Salisbury, Md., native, who now resides in Rehoboth Beach, has been on a journey since 2020, when he decided that surgical weight loss was his best option to return to a healthy life.

He is an active figure in the entertainment industry, representing some of the top talent across the globe. The fast-paced and demanding nature of his job, paired with the shutdown during the COVID-19 pandemic, resulted in weight struggles and its related diseases. With additional health issues piling up by the end of 2020, he realized that he could not manage those struggles on his own and turned to weight-loss surgery to help.

I didnt have a roadmap before I met Dr. Waked, in terms of how to live a healthy lifestyle, he said. And its not just about food. Its a whole personal reset, reinvention. Its a process. Its trial-and-error. With Dr. Waked, I have a blueprint now for what works for me, thats customized to my lifestyle, life, to the work that I do.

His lifestyle transformation, like many bariatric patients, didnt change overnight with his gastric sleeve surgery. That is where he said board-certified surgeon Waked, Kim Hyatt, MPH, RD, LDN, and the rest of the Beebe Center for Weight Loss team helped him make permanent changes for the future.

You always hear people say weight loss surgery is the easy way out, because they think, OK, Im going to get the weight loss surgery and thats the easy way out. You know, everything from now on, its going to be so easy. And thats a huge misconception, said Waked. You know, I call it the healthy way out. Thats how it is, because you still have to put in a lot of work after surgery.

The surgery provides patients tools so that they are biologically equivalent to someone who doesnt struggle with weight. But Waked said one then must put in the extra effort after that.

You have to follow a healthy nutrition plan, Waked said. You have to be more active. You have to deal with all the stressors that you have in life. You have to watch which medications you take, a lot of them. Theres a lot of what you, as the patient, have to put into it. And I see that daily in my patients. They put forth a lot of effort. And I always say I do the easy part. The surgery is the easy part. You do the hardest part, which is, changing your lifestyle for the years to come after surgery.

Beebes Center for Weight Loss Surgery is led by Waked, an experienced surgeon who trained at the Mayo Clinic and has performed more than 2,000 successful weight-loss procedures.

The Center is designated as a Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) an accreditation recognizing centers that set national standards for care with quality and safety measures.

In September 2021, Christopher Manieri joined the center alongside Waked and Hyatt to make up the centers team.

Hyatt, a registered dietitian, guides bariatric patients through their pre- and post-operative period, which includes classes, support groups, and addressing any questions or concerns that patients may have along their journey.

Seeing the results

Once the surgery was complete, the real work began. Killmon said he understood that the surgery was just the beginning, and the tools to succeed were provided by the Beebe team to successfully lose weight.

It is this long-term relationship with his care team that helped him not only get back to a healthy weight, but also adopt and embrace meaningful holistic lifestyle changes that has permanently impacted his outlook on health and well-being. His Beebe team has collaborated closely with his fitness trainer, Eli Lynn, to provide a healthy balance of nutrition and a physical regime that has been paramount in his journey, its all about partnership and not isolated to a single surgery, or diet plan; Wakeds program is dynamic, multi-faceted, collaborative and long term oriented.

With Dr. Waked and with Kim, they are always available to talk, and its comfortable and its easy because they care, he said. Its rare, you know. I mean, before I started seeing Beebe providers, it was nearly impossible to get in touch with my physicians.

The Beebe team has taken the time to get to know him not only as a patient, but as a person to understand the unique challenges he will continue to face due to the nature of his work and associated lifestyle.

Rather than simply telling him to change, they have worked closely with him to come up with effective and simultaneous realistic plans that work for him and allow him to do what he loves without compromising his health.

With Dr. Waked and Kim, even though their schedules are chaotic and busy, it doesnt feel that way. Its very personalized, and I feel very privileged and Im sure that they make everybody feel like that, Killmon said. When Im in the office or talking to them, its genuine energy and it makes me want to be a better patient and it makes me want to live a better lifestyle its inspiring.

Mikes transformation isnt complete. It is a lifelong journey filled with ups and downs. In addition to the motivation from the Beebe Center for Weight Loss team, he draws upon his career experiences, too, for inspiration every day.

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Surgery gave Rehoboth man the tools to lose weight - Coastal Point


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