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Aeglea BioTherapeutics to Present Topline Data from Phase 1 Trial of AEB1102 for Treatment of Arginase I Deficiency … – P&T Community

Posted: March 24, 2017 at 12:42 pm

Aeglea BioTherapeutics to Present Topline Data from Phase 1 Trial of AEB1102 for Treatment of Arginase I Deficiency ...
P&T Community
We are pleased with the data from our Phase 1 study which show that not only was AEB1102 administered safely, but it also rapidly reduced blood arginine levels to the normal range in these patients, said David G. Lowe, Ph.D., chief executive officer ...

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Aeglea BioTherapeutics to Present Topline Data from Phase 1 Trial of AEB1102 for Treatment of Arginase I Deficiency ... - P&T Community

Overweight Force India car forces Sergio Perez into ‘extreme diet’ – ESPN

Posted: March 24, 2017 at 12:41 pm

Sergio Perez has revealed Force India's overweight 2017 car has forced him into an "extreme diet" to shed pounds ahead of the new season.

Force India's underwhelming pre-season in Barcelona prompted questions about the team's competitiveness ahead of the new season, and soon reports surfaced of both drivers being asked to lose weight in a bid to help the team. Though all the drivers have been bulking up ahead of the new season in order to handle the bigger, faster 2017 cars, Perez confirms he has had to do the opposite since leaving Spain.

"I have tried so hard to lose weight in the last couple of weeks since Barcelona," Perez said, revealing he's already dropped two kilos since testing finished. "Obviously I increased my weight from last year purely by training harder, putting on more muscle, but I was on an extreme diet all last week and still now until Saturday [I will do the same].

"I am all the time very hungry. As much weight as I can lose, the better it will be for us."

Perez says Australia will be the first chance to properly test the car with his adjusted weight. The Mexican driver is not expecting his dramatic diet to be a long-term solution to Force India's problems.

"We haven't weighed the car actually, because in testing you have a lot of sensors and things on the car. Right now, considering that I lose two kilos or three since Barcelona, then probably we might be quite close [to the ideal level].

"I think the weight, sooner or later we will be on it. If not this weekend, then latest by Bahrain, so I don't think that is a big issue."

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Overweight Force India car forces Sergio Perez into 'extreme diet' - ESPN

11 Things You Might Think Are Terrible for Your Diet That Actually Aren’t – ScienceAlert

Posted: March 24, 2017 at 12:41 pm

I'm used to the shaming look I get from my peers when I crack open a can of sugar-free Red Bull. The questions - and judgment - never end. "That stuff'll kill you," someone said to me the other day, shaking his head. "So many chemicals!" was what I heard last week.

Truth be told, Red Bull (at least the sugar-free kind) isn't all that terrible for you. Besides having only 10 calories and no sugar, it has only 80 milligrams of caffeine, abouta thirdof the amountin a tall Starbucks drip coffee. As far as its other ingredients - namely B vitamins and taurine - go, scientific studies have foundbothtobe safe.

But my favorite source of caffeine isn't the only harmless food or drink that gets a bad rap. Here are some of the rest, along with the science behind their safety.

1. Gluten

The myth:As more and more of your friends go gluten-free, you may wonder: Is there something to this latest diet craze? Is gluten intolerance a thing?Is it getting more common?

Why it's bogus:Only about 1 percent of people worldwide haveceliac disease, the rare genetic disorder that makes people intolerant to gluten, according to the Celiac Disease Foundation.

For most of the rest of us, this doughy, chewy ingredient is simply how it tastes: delicious!

2. Eggs

The myth:The massive amounts of cholesterol in eggs will translate to a massive amount of cholesterol in your veins.

Why it's bogus:Even though eggs are high in cholesterol (a single egg packs roughly185 mg), eating them likely won't translate into higher blood cholesterol for you. The first studies that suggested that were done with rabbits,as my colleague Kevin Loria reported.

So go ahead, pop a perfectly poached egg on that avocado toast. You know you want to.

3. Caffeine

The myth:Caffeine stunts your growth and messes with your health.

Why it's bogus:According to the Mayo Clinic, the average adult can safely consumeup to 400 mg of caffeine daily. Most standard cups of coffee containbetween 90 and 120 mg.

So if you're limiting yourself to under four cups of joe a day, you should be relatively in the clear. Still, some java packs more of a punch than others.

A 12-ounce (375 ml) "tall" cup of Starbucks drip coffee, for example, hasabout 260 mg of caffeine- putting you well over the daily dose after two cups.

4. Carbonated water

The myth:Fizzy water is all the rage these days, showing up in grocery-store aisles in flavors like coconut or watermelon.

But many people worry the bubblescause kidney stones, leach calcium from your bones, and even strip the enamel from your teeth.

Why it's bogus:The bubbly stuff is just as good for you as plain water, Jennifer McDaniel, a registered dietitian and certified specialist in sports dietetics,told my colleague Dina Spector.

"Carbonated or sparkling water is made by dissolving carbon dioxide in water, creating carbonic acid," Spector wrote.

"This process just adds bubbles - it does not add sugar, calories, or caffeine. Tonic water, club soda, and mineral water are all types of carbonated water, but these have added sodium, vitamins, or sweeteners, so it's important to read the label."

5. Fatty foods

The myth:Fatty foods like avocados and olive oil will make you fat.

Why it's bogus:Although it makes intuitive sense, this myth is not borne by scientific research.

Arecent lookat the studies behind the dietary guidelines that suggested we cut back on fat found that there wasn't evidence to support those rules in the first place.

In the book Eat Fat, Get Thin, Mark Hyman, director of the Cleveland Clinic's Centre for Functional Medicine, talks about how heincorporated healthy fatsfrom foods like fish and nuts in his diet to lose weight.

6. Cheese

The myth:Some news outlets have reported thatcheese "is like crack"because it's "as addictive as drugs".

Why it's bogus:We tracked downthe studythat appears to lie at the root of these claims, and it found no such thing. Several University of Michigan researchers asked people to report which foods on a list they had the hardest time cutting out or eating moderately.

Cheese ranked toward the middle.

Nevertheless, since pizza, a cheesy food, ranked high on both lists, people speculated that cheese was the culprit, going as far to suggest something about the way one of its proteins breaks down in the body is addictive.

There's little to no evidence to back this up.

7. Artificial sweeteners

The myth:Artificial sweeteners like Splenda and Equal have been found to cause cancer.

Why it's bogus:The Food and Drug Administration has evaluatedhundreds of studieson sucralose (Splenda), aspartame (Equal), saccharin (Sweet' N Low) and more. So far, it has deemed all of them safe.

That said, somepreliminary researchsuggests artificial sweeteners may notsatisfy your craving for sweetsand therefore may not be effective at curbing your overall sugar intake.

8. GMOs

The myth: Genetically modified organisms cause cancer and wreak havoc on the environment.

Why it's bogus: GMO crops, which have been around since the 1980s, have been studied at length, and a recent report from theNational Academies of Sciences, Engineering, and Medicinefound that they aren't posing any greater risk to the environment than regular crops.

It also found no evidence that they "are less safe to eat than conventional food",my colleague Lydia Ramsey reported.

9. Salt

The myth: Salt causes heart problems and weight gain.

Why it's bogus:The science about whether eating salt in moderation has a net negative or positive effect on our health is somewhat unclear.

However, a2011 meta-analysis of seven studiesinvolving more than 6,000 people published in the American Journal of Hypertension found no strong evidence that reducing salt decreased people's risk of heart attack, stroke, or death - even in those who had high blood pressure.

"If the US does conquer salt, what will we gain? Bland french fries, for sure. But a healthy nation? Not necessarily," Melinda Wenner Moyer wrote in Scientific American.

10. All carbs

The myth: Carbohydrates - including rice, bread, cereal, and potatoes - contribute to weight gain.

Why it's bogus: While it's a good idea to limit your intake of processed carbs like white bread, white rice, and white pasta, not all carbs are bad for you. Some are healthy and a great source of energy. Take potatoes, for example.

"White potatoes are actually very good for you," Christian Henderson, a registered dietitian,told Health.

Potatoes pack potassium and vitamin C, and they have almost 4 grams of fibre - just cook them with the skins on.

11. Fish

The myth:Fish is high in mercury and will make you sick.

Why it's bogus:While mercury can build up in larger, older predator fish like marlin and shark, it's not generally a problem in smaller fish.

The FDA maintains ahelpful list of guidelines for mercury in seafood- salmon, trout, oysters, herring, sardines, and Atlantic and Pacific mackerel are all considered "good" or "best" choices, according to the FDA.

This article was originally published by Business Insider.

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11 Things You Might Think Are Terrible for Your Diet That Actually Aren't - ScienceAlert

Blood fatty acids reveal your child’s diet — ScienceDaily – Science Daily

Posted: March 24, 2017 at 12:41 pm

Eating lots of sugary candy may strain the liver, alter the body's fatty acid metabolism and increase the risk of cardiometabolic diseases already in childhood. Children's blood fatty acid composition reflects their diet -- but luckily this composition can be influenced by lifestyle interventions, say researchers from the University of Eastern Finland.

Family-based lifestyle interventions can have an impact on children's blood fatty acid composition, according to a new study from the University of Eastern Finland. The plasma fatty acid composition reflects not only the quality of dietary fat, but also the quality of dietary carbohydrate in children's diets. For example, the relative proportion of oleic acid was higher in children who consumed a lot of sugar, and lower in children who consumed plenty of whole grain products. The findings are in line with the known phenomenon in human body. Excessive intake of sugar stimulates the body's endogenous synthesis of fatty acids, which can be detected in the plasma fatty acid composition.

Lifestyle interventions recommending a higher consumption of foods containing plenty of unsaturated fat can have an impact on the quality of dietary fat in children's diets. A frequent consumption of vegetable oil-based margarines containing at least 60 per cent fat was associated with higher proportions of the essential polyunsaturated fatty acids, linoleic acids and alpha-linolenic acids in plasma. In addition, children who frequently used vegetable oil-based margarines had less saturated and monounsaturated fatty acids in their blood, which has been shown to be beneficial for health. The study associated a high proportion of saturated and monounsaturated fatty acids, and a low proportion of polyunsaturated fatty acids in blood with an increased risk of cardiometabolic diseases already in childhood.

Furthermore, a frequent consumption of sugary candy was associated with a higher estimated activity of the delta-9-desaturase in liver. The delta-9-desaturase is an enzyme that helps the liver form monounsaturated fatty acids from saturated ones. While it prevents saturated fatty acids from accumulating in the liver, it also promotes the excretion of fatty acids from the liver into the blood stream. Earlier research has associated a high intake of carbohydrates with a higher estimated activity of this enzyme in adults, but the phenomenon hasn't been studied in children until now. Moreover, the association between a higher estimated enzyme activity with an increased risk of cardiovascular diseases hasn't been established in children until now. An elevated enzyme activity suggests that the liver is forming saturated fatty acids from sugars at a higher pace, which is harmful for lipid metabolism and overall health.

The study was conducted at the University of Eastern Finland as part of the Physical Activity and Nutrition in Children (PANIC) study involving 512 children, 6-8 years old, who started in their first year of school in 2007-2009 in eastern Finland, and their families. The children and their families received nutrition and exercise counselling over a period of two years.. The PANIC study is an ongoing exercise and diet intervention study extensively focusing on the lifestyle habits, health and well-being of children. The consumption of foods was assessed by 4-day food records and the fatty acid composition in plasma was assessed by gas chromatography from a fasting blood sample.

The findings were presented by Taisa Venlinen, MHSc, in her doctoral dissertation entitled Plasma Fatty Acid Composition, Dietary Components and Cardiometabolic Risk Factors In Children -- Cross-Sectional Associations And Effect of a Lifestyle Intervention, available for download at http://epublications.uef.fi/pub/urn_isbn_978-952-61-2454-4/

The original findings were published in Lipids, Journal of Clinical Lipidology and American Journal of Clinical Nutrition.

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Materials provided by University of Eastern Finland. Note: Content may be edited for style and length.

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Blood fatty acids reveal your child's diet -- ScienceDaily - Science Daily

The Mediterranean Diet: The Answer To Rising Health Care Costs? – Forbes

Posted: March 24, 2017 at 12:41 pm


Forbes
The Mediterranean Diet: The Answer To Rising Health Care Costs?
Forbes
As I began writing this blog post, I found myself wondering how many people reading it will have actually bought a fresh turkey from the butcher, cleaned it and cooked it themselves from scratch? Not many, I'll wager, given the preponderance of ...

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The Mediterranean Diet: The Answer To Rising Health Care Costs? - Forbes

Ditch these running excuses to jump-start your weight loss – Fox News

Posted: March 24, 2017 at 12:41 pm

Exercise is a key ingredient in weight loss and maintenance. Running especially comes with a host of health benefits: It can give you more energy, boost your metabolism, improve your mood, and help release stress, Erica Stepteau, a health coach at the Cleveland Clinics Center for Functional Medicine, told Fox News.

5 POSSIBLE REASONS YOUR WEIGHT LOSS HAS PLATEAUED

But strenuous exercise like running can seem daunting, and we often like to tell ourselves certain very convincing reasons why we should skip the cardio for the day. Fox News asked Stepteau about some of these common excuses about running, and how to get over them:

1. Running is too hard. Running can be difficult, given that it uses every muscle group in your body, Stepteau said. However, there are ways to start gradually: Try one of the online couch to 5k programs, she suggested.

2. Running is lonely. Another common excuse Stepteau hears is running is too lonely or boring. But try to reconfigure your thinking around running: Look at it as your therapy and alone time, Stepteau said.

5 MILITARY-INSPIRED MOVES FOR A FULL-BODY WORKOUT

3. The weather is bad. If its rainy or slushy, your desire to run may take a nosedive. But even if you arent usually a fan of treadmills, you can still use them to recreate an outdoor running experience, Stepteau said. Try changing the incline on the treadmill, and listening to noises like chirping birds to remind you of outside.

4. I dont have a runners body. Some people believe that if they dont have the idealized athletic, slim, and fit runners body, they shouldnt get started. But be gracious with yourself, said Stepteau, noting that aesthetics come into play later on but shouldnt stop you from getting started.

5. My knees will start hurting. Running is definitely high impact on the knees, but you can go to a running specialty store to get fitted for proper shoes, which should help minimize the impact, Stepteau said.

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6. I should have started when I was younger. While many people wish they had gotten started on their running goals earlier, there are still huge benefits of getting started mid-age, Stepteau said. She noted that you can still reduce your risks of cardiovascular disease, cancer, and diabetes just by moving an hour a day.

7. Ive been inactive for too long. Even if you feel like youre out of practice, increase your activities gradually, Stepteau said. Soon, youll start building your endurance

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Ditch these running excuses to jump-start your weight loss - Fox News

The newest weight-loss procedure – Buffalo Business First

Posted: March 24, 2017 at 12:41 pm

The newest weight-loss procedure
Buffalo Business First
How does this compare to other medical weight-loss options? Basically there are three weight-loss surgeries available: the gastric bypass, the gastric sleeve and the laparoscopic band. The band has problems, but the other two are done quite a bit ...

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The newest weight-loss procedure - Buffalo Business First

5 Popular Weight Loss Strategies That Can Backfire – Care2.com

Posted: March 24, 2017 at 12:41 pm

Just because a weight loss strategy has worked for someone else doesnt mean itll work for you. In fact, the most popular weight loss plans (discussed below) fail all the time.

Now, Im not saying you shouldnt experiment with these weight loss strategies, but you should be aware of the mistakes that cause them to backfire. Below are reasons why some strategies fail.

Cheat meals can be great. They allow you to eat the foods you enjoy and undo the effects of low calorie intake. But most people abuse them and end up gaining weight.

Dieters usually overindulge in cheat meals and regain all the weight they had lost. Others even continue bingeing days after the cheat day. Such habits make it virtually impossible to lose weight.

Unless you have self-control over your food intake, avoid cheat meals. Instead, reward yourself with other things like massage or a weekend trip.

Most people starve themselves in order to reach their weight goal fast. But this strategy rarely works. For one thing, low calorie intake makes you feel hungry all the time and slows down metabolism.

Extreme calorie deficits may work for a while but theyre impossible to maintain long-term. Maintain a moderate calorie deficit and incorporate strength training in your weight loss plan. Remember that eating high-fiber foods can help keep hunger at bay.

Cutting carbs is definitely a good idea for anyone who wants to lose weight. Sugars, starchy foods and sweetened drinks trigger weight gain. But eliminating all carbs from your diet can cause fatigue, low energy and so on.

Dont be fooled by the initial weight loss in low-carb diets. Its usually due to loss of water weight and youll regain the weight once you start consuming carbs again. At least 30 percent of the macronutrients in your diet should come from unprocessed carbs.

You dont have to avoid junk food for the rest of your life to stay healthy. Restricting yourself to healthy foods all the time can bring feelings of guilt every time you eat junk or sweet foods.

Frankly, its not possible to eat clean all the time in todays world. Just make sure at least 80 percent of your diet comes from healthy, unprocessed foods. And 20 percent can come from the not-so-healthy foods.

You dont have to eat after every 3 hours to lose weight. In fact, eating frequently can hinder weight loss. Research shows that most people dont account for calories from snacks and soft drinks. And these calories eventually add up and cause weight gain.

If you are a frequent-snacker, remember to account for calories from the snacks in your total daily calorie intake.

As you can see, there isnt a foolproof weight loss plan. But itll be easier for you to attain your weight goal if you avoid the mistakes mentioned above.

Have you had success with any of the above weight loss strategies?

Disclaimer: The views expressed above are solely those of the author and may not reflect those of Care2, Inc., its employees or advertisers.

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5 Popular Weight Loss Strategies That Can Backfire - Care2.com

Lena Dunham: Weight loss doesn’t make me a hypocrite – CBS News

Posted: March 24, 2017 at 12:41 pm

Lena Dunham speaks onstage at Reebok And Gigi Hadid Present #PerfectNever Revolution, celebrating the next stage of the brands #PerfectNever message which inspires women to challenge the notion of perfection as part of its Be More Human campaign on December 7, 2016 at Skylight at Clarkson Square in New York City.

Bryan Bedder/Getty Images

Lena Dunham says that her weight loss doesnt mean she cant advocate for body positivity anymore.

The controversial Girls creator appeared on Ellen and said fans have called her a hypocrite.

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Actress Lena Dunham is now apologizing after saying "I wish I had an abortion" on her podcast. She calls it "a distasteful joke." CBSN's Reena Ni...

I had this experience of my body changing and suddenly I got all of these people being like, Youre a hypocrite. I thought you were body-positive. I thought you were a person who embraces bodies of all sizes, she said. I do, I just understand that bodies change, we live a long time. Things happen.

Dunham said the criticism is sexist.

It really was evidenced that as a woman in Hollywood, you just cant win, she said.

The writer and actress said that she started working out because of her endometriosis, and emphasized that she did not lose weight to please other people.

I also just never felt self-conscious about [my weight], she said. I was like: Anyone who was going to take the time to say something negative about my weight on the Internet wasnt someone I was particularly keen to impress anyway.

2017 CBS Interactive Inc. All Rights Reserved.

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Lena Dunham: Weight loss doesn't make me a hypocrite - CBS News

5 habits that foster weight loss – Harvard Health (blog)

Posted: March 24, 2017 at 12:41 pm

Posted March 23, 2017, 9:30 am

Lets face it: the hardest part about losing weight isnt knowing what to eat. Youve heard it a thousand times: eat lots of vegetables, fruits, whole grains, and lean protein. The real challenge is changing your habits to make those healthy choices part of your everyday routine without feeling too deprived.

The late Dr. George L. Blackburn, who directed the Center for Nutrition Medicine at Harvard-affiliated Beth Israel Deaconess Medical Center, treated countless overweight and obese people over his 40-plus-year career. The following are five proven strategies that many of his patients have found helpful toward their goal of lasting weight loss:

1. Make time to prepare healthy meals. Home-cooked food tends to be far lower in calories, fat, salt, and sugar than restaurant food and most processed food. But it takes time and effort to choose recipes, go to the store, and cook. Take a close look at your weekly schedule to see if you can carve out a few hours to devote to meal planning and shopping, which is more than half the battle. It could be on Sunday afternoon or in 15- to 30-minute increments throughout the week.

To save time in the kitchen, take advantage of pre-cut vegetables and cooked whole grains (like brown rice) from the salad bar or freezer case. And stock up on easy, wholesome snacks like fruit, nuts, and low-fat cheese sticks.

2. Eat slowly. The next time you sit down for a meal, set a timer (maybe the one on your kitchen stove or smartphone) for 20 minutes. Thats about how long it takes the Im full message sent by the gut hormones and stretch receptors in your stomach to reach your brain. If you can spend a full 20 minutes between your first bite and your last, youll feel satisfied but not stuffed. Eat too quickly and youre more likely to overeat. Tips for stretching out your mealtime include chewing each bite a little longer than usual, setting down your fork between each bite, and taking frequent sips of water during your meal.

3. Eat evenly sized meals, beginning with breakfast. Most people tend to eat a small breakfast (or none at all), a medium-sized lunch, and a large dinner. But you may be better off spreading out your calories more evenly throughout the day. For one thing, a small or nonexistent breakfast can leave you ravenous by lunchtime, which may lead you to overeat. A morning meal also helps rev up your metabolism for the day, stimulating enzymes that help you burn fat. Whats more, eating at least 450 calories per meal can help you avoid hunger between meals. If you eat a light supper (and avoid grazing late into the night; see tip 4), you may eat fewer calories overall and actually be hungry for breakfast.

4. Dont skimp on sleep. When you burn the midnight oil, youre probably not also burning calories, but instead consuming too many. Many studies have linked shorter sleep duration with a higher risk of being overweight or obese. A recent review article suggests why: people who sleep fewer than six hours a night tend to have irregular eating habits including more frequent, smaller, energy-dense, and highly palatable snacks (read: fatty, sugary foods like chips, cookies, and ice cream).

5. Weigh yourself often. If you dont already have one, get a digital scale. Hang a calendar and pen above it, right at eye level, as a reminder to record your weight every day. Doing so only takes a few seconds and will keep you heading in the right direction. Most people find it difficult or tedious to track their calories, both from the foods they eat and those they burn via exercise. But a daily weigh-in tells you all you need to know and the scale doesnt lie. Also, research shows that people who weigh themselves often are more likely to lose weight and keep it off.

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5 habits that foster weight loss - Harvard Health (blog)


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