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DBV to Present Data at the 2017 AAAAI Meeting Highlighting the Therapeutic Potential of EPIT – Yahoo Finance

Posted: February 11, 2017 at 11:45 am

Press Release Montrouge, France, February 10, 2017

Eight abstracts, including detailed two-year follow-up data to the VIPES Phase IIb trial supporting the long-term efficacy and safety of Viaskin Peanut for the treatment of peanut allergy, will be presented during the meeting

DBV Technologies (Euronext: DBV - ISIN: FR0010417345 - Nasdaq Stock Market: DBVT), today announced that eight abstracts, seven of which will highlight data from the company`s Viaskin technology platform, were accepted for oral and poster presentation at the 2017 American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting in Atlanta, Georgia, March 3-6, 2017. These abstracts became available on the AAAAI meeting website at 9:30 AM CT on February 10 http://annualmeeting.aaaai.org/.

Detailed results from the OLFUS-VIPES trial, which followed patients for a total of 36 months, will be presented during the Late Breaking Oral Abstract Session on Sunday, March 5. Topline results from OLFUS-VIPES, which evaluated the long-term efficacy and safety of Viaskin Peanut for the treatment of peanut-allergic children, were previously announced in October 2016. Viaskin Peanut is the company`s lead product candidate based on its proprietary EPIT platform, which aims to deliver biologically active compounds to the immune system through the skin, and is currently being evaluated in a global, pivotal Phase III program in peanut-allergic children 4 to 11 years of age.

"The long-term clinical data we are presenting at AAAAI provide further insight into the promise of Viaskin Peanut as a potential treatment option for peanut-allergic children," said Dr. Lucia Septin, Chief Medical Officer of DBV Technologies. "These detailed results, combined with pre-clinical data that will be presented at the meeting, also underscore the tremendous potential of EPIT to help address a wide range of unmet medical needs."

Additional abstracts to be presented at the meeting include two pre-clinical studies, which tested the therapeutic potential of EPIT in type 1 diabetes and in the vaccination against respiratory syncytial virus (RSV).

Selected abstracts of interest: Peanut Allergy Data

FARRP (Food Allergy Research & Resource Program) Data

RSV Data

Type 1 Diabetes Data

EPIT Mechanism of Action Research

Full data will be shared following embargo lift; at the time the studies are presented. All abstracts are available online at http://annualmeeting.aaaai.org/, and will also be published in a supplement to the February Journal of Allergy and Clinical Immunology (JACI) at http://www.jacionline.org/.

About the PEPITES Study The Peanut EPIT Efficacy and Safety Study (PEPITES) is a global, pivotal, double-blinded, placebo-controlled Phase III trial designed to evaluate the safety and efficacy of Viaskin Peanut 250 mcg in children ages four to 11 years. During PEPITES, patients` response will be assessed using a double-blind, placebo controlled food challenge (DBPCFC). Patients are randomized 2:1 to receive either Viaskin Peanut 250 mcg or placebo for 12 months. The primary endpoint is based on a responder analysis after 12 months of treatment with Viaskin Peanut 250 g. For patients with a baseline peanut protein eliciting dose (ED) equal to or less than 10 mg, a responder is defined as a patient with a peanut protein ED equal to or greater than 300 mg of peanut protein after 12 months of treatment. For subjects with a baseline ED greater than 10 mg, a responder is defined as a patient with a peanut protein ED equal to or greater than 1,000 mg of peanut protein after 12 months of treatment. As a secondary efficacy endpoint, Cumulative Reactive Dose (CRD), will also be used in PEPITES to establish the total quantity of peanut protein that triggers patient reactions at month 12 of active treatment versus placebo. Serological markers will also be measured at baseline, 3, 6, and 12 months in order to characterize the immunological changes in patients. Following the completion of PEPITES, all patients are eligible to rollover into PEOPLE, a long-term, open-label extension study of Viaskin Peanut 250 g. In the PEOPLE study, patients who were randomized to active treatment during PEPITES will receive ViaskinPeanut 250 mcg for two additional years; patients who were previously receiving placebo during PEPITES will be treated with Viaskin Peanut 250 mcg for three years. Patients enrolling in the PEOPLE study will remain blinded to their respective treatment group in PEPITES until the PEPITES study results become publicly available.

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About the REALISE Study REALISE is a multicenter, randomized, double-blind, placebo-controlled Phase III study designed to assess the use of Viaskin Peanut 250 mcg in routine medical practice and generate safety data after six months of blinded treatment in patients four to 11 years of age. At the six-month time point, patients in both the placebo and active arms will be able to opt into an open-label portion of the study, which will continue monitoring patients for a total of 36 months of active treatment. Exploratory criteria will also include scores from subjects` Food Allergy Quality of Life Questionnaire (FAQLQ) and the Food Allergy Independent Measure (FAIM), as well as the evolution of peanut-specific serological markers over time. The study is expected to be conducted in approximately 30 to 40 centers in North America.No oral food challenges are required in REALISE. Patients in the study will be selected based on a well-documented medical history of IgE-mediated reactions to peanut, including children with a history of severe anaphylaxis, as well as analyses of peanut-specific immunological markers. During the first six months of trial, patients will be randomized 3:1 active versus placebo. Key assessments of safety parameters will include treatment-emergent adverse events observed in both the placebo and active treatment groups after the initial 6 months, which will continue to be monitored during the open-label portion of the study. DBV intends to enroll approximately 335 subjects in REALISE.

About the OLFUS-VIPES Study OLFUS-VIPES (Open-Label Follow-Up Study-Viaskin Peanut`s Efficacy and Safety), or OLFUS, enrolled 171 subjects who had previously received either placebo or one of three 12-month dose regimens administered during VIPES. During the first year of OLFUS, patients were to receive a daily application of Viaskin Peanut 50 g or Viaskin Peanut 100 g or Viaskin Peanut 250 g for 12 months. According to a study protocol change implemented in March 2014, all patients were switched to receive Viaskin Peanut 250 mcg during OLFUS. All patients in OLFUS maintained a peanut-free diet during the study. Baseline response levels in OLFUS were based on the results of the last double-blind, placebo controlled food challenge (DBPCFC) in VIPES, and adjusted by the number of patients enrolling in OLFUS. Responders in the OLFUS trial were defined as subjects with a peanut protein eliciting dose equal to or greater than 1,000 mg peanut protein or with a greater than 10-fold increase of the eliciting dose compared to their baseline eliciting dose observed in the VIPES study. Patients enrolled in OLFUS who received placebo in VIPES were analyzed separately from subjects who initially received Viaskin Peanut. At month 24 in OLFUS, patients who were unresponsive to a cumulative dose above 1,440 mg were eligible to discontinue study drug for two months while maintaining a peanut-free diet. Patients who opted to enter into this additional period performed a DBPCFC at month-26 to assess durability of response.

About DBV Technologies DBV Technologies is developing Viaskin, a proprietary technology platform with broad potential applications in immunotherapy. Viaskin is based on epicutaneous immunotherapy, or EPIT, DBV`s method of delivering biologically active compounds to the immune system through intact skin. With this new class of self-administered and non-invasive product candidates, the company is dedicated to safely transforming the care of food allergic patients, for whom there are no approved treatments. DBV`s food allergies programs include ongoing clinical trials of Viaskin Peanut and Viaskin Milk, and preclinical development of Viaskin Egg. DBV is also pursuing a human proof-of-concept clinical study of Viaskin Milk for the treatment of Eosinophilic Esophagitis, and exploring potential applications of its platform in vaccines and other immune diseases. DBV Technologies has global headquarters in Montrouge, France and New York, NY. Company shares are traded on segment A of Euronext Paris (Ticker: DBV, ISIN code: FR0010417345), part of the SBF120 index, and traded on the Nasdaq Global Select Market in the form of American Depositary Shares (each representing one-half of one ordinary share) (DBVT). For more information on DBV Technologies, please visit our website: http://www.dbv-technologies.com

Forward Looking Statements This press release contains forward-looking statements, including statements regarding the potential safety and efficacy of Viaskin Peanut and statements reflecting management`s expectations for clinical development of our product candidates and the commercial potential of our product candidates. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. Among the factors that could cause actual results to differ materially from those described or projected herein include uncertainties associated generally with research and development, clinical trials and related regulatory reviews and approvals, the risk that historical preclinical results may not be predictive of future clinical trial results, and the risk that historical clinical trial results may not be predictive of future trial results. A further list and description of these risks, uncertainties and other risks can be found in the Company`s regulatory filings with the French Autorit des Marchs Financiers, the Company`s Securities and Exchange Commission filings and reports, including in the Company`s Annual Report on Form 20-F for the year ended December 31, 2015 and future filings and reports by the Company. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. DBV Technologies undertakes no obligation to update or revise the information contained in this Press Release, whether as a result of new information, future events or circumstances or otherwise.

DBV Technologies Contact Susanna Mesa Senior Vice President, Strategy +1212-271-0861 susanna.mesa@dbv-technologies.com

Media Contact Andrea Fassacesia, Weber Shandwick +1212-445-8144 afassacesia@webershandwick.com

Media Contact Europe Caroline Carmagnol, Alize RP, Relations Presse +33 (0)6 64 18 99 59 caroline@alizerp.com

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This announcement is distributed by NASDAQ OMX Corporate Solutions on behalf of NASDAQ OMX Corporate Solutions clients.

The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein. Source: DBV Technologies via GlobeNewswire HUG#2077894

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DBV to Present Data at the 2017 AAAAI Meeting Highlighting the Therapeutic Potential of EPIT - Yahoo Finance

Global Wearable Security Devices Market to Be Worth USD 5.74 Billion by 2021: Technavio – Business Wire (press release)

Posted: February 11, 2017 at 11:45 am

LONDON--(BUSINESS WIRE)--According to the latest market study released by Technavio, the global wearable security devices market is expected to grow at a CAGR of close to 19% during the forecast period.

This research report titled Global Wearable Security Devices Market 2017-2021 provides an in-depth analysis of the market in terms of revenue and emerging market trends. This market research report also includes up to date analysis and forecasts for various market segments and all geographical regions.

Technavio analysts forecast the global wearable security devices market size to reach USD 5.74 billion by 2021. The increased adoption of Internet of Things (IoT) to manage the physical assets of an organization is one of the key drivers of the market.

Request a sample report: http://www.technavio.com/request-a-sample?report=56404

Technavios sample reports are free of charge and contain multiple sections of the report including the market size and forecast, drivers, challenges, trends, and more.

Based on application, the report categorizes wearable security devices into the following segments:

The top three revenue-generating application segments in the global wearable security devices market are discussed below:

Military

The military is a key application segment of the global wearable security devices market in terms of revenue. Several countries such as the US and the UK have adopted smart clothing for military applications, which are designed to provide both comfort and protection, says Abhishek Sharma, one of the lead analysts at Technavio for M2M and connected devices research.

This segment is also creating a demand for smart clothing designs, which can provide protection from hazards such as viruses and chemical weaponry. Agencies such as NASA, the Canadian Space Agency, and other military organizations seek the expertise of vendors like Hexoskin to design and manufacture smart shirts for health tracking.

Emergency services

The emergency services constitute the second largest application segment of the wearable security devices market. This segment has wearable devices, which can assist the elderly and differently abled people in carrying out routine tasks safely and effectively. They are also equipped with emergency contacts of first responders and alert them in the case of any shift in patterns recorded by the sensors. Additionally, wearable devices are being increasingly used to respond to emergency situations such as natural or human-made disasters and personal attacks.

Tracking

An increase in health awareness among people is reflected in the rapid growth in demand for hygienic and nutritious food, gym memberships, and diet programs. To keep track of all their activities throughout the day, the demand for fitness tracking devices have also increased, says Abhishek.

Individuals are adopting various fitness tracking devices such as fitness bands and sports equipment to track and control their health to reduce the risk of diseases. Smart wearable fitness devices monitor the fitness of individuals and measuring and eventually improving the performance of players and athletes. Additionally, the availability of low-cost tracking services is resulting in increased sales of these devices, resulting in high market growth.

The top vendors highlighted by Technavios research analysts in this report are:

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Become a Technavio Insights member and access all three of these reports for a fraction of their original cost. As a Technavio Insights member, you will have immediate access to new reports as theyre published in addition to all 6,000+ existing reports covering segments like cloud computing, IT hardware, and IT security. This subscription nets you thousands in savings, while staying connected to Technavios constant transforming research library, helping you make informed business decisions more efficiently.

About Technavio

Technavio is a leading global technology research and advisory company. The company develops over 2000 pieces of research every year, covering more than 500 technologies across 80 countries. Technavio has about 300 analysts globally who specialize in customized consulting and business research assignments across the latest leading edge technologies.

Technavio analysts employ primary as well as secondary research techniques to ascertain the size and vendor landscape in a range of markets. Analysts obtain information using a combination of bottom-up and top-down approaches, besides using in-house market modeling tools and proprietary databases. They corroborate this data with the data obtained from various market participants and stakeholders across the value chain, including vendors, service providers, distributors, resellers, and end-users.

If you are interested in more information, please contact our media team at media@technavio.com.

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Global Wearable Security Devices Market to Be Worth USD 5.74 Billion by 2021: Technavio - Business Wire (press release)

Mediterranean diet could lead to lower child obesity rates – wwlp.com

Posted: February 11, 2017 at 11:45 am

(CNN) The so-called Mediterranean diet has gained lots of followers because of its perceived health benefits; but what about having your children making the switch to its regimen of natural foods?

The Mediterranean diet is heavy in vegetables, fruit, unrefined grains, and other foods that are good for you. Its been linked to a host of benefits, including longer life, and better bone and heart health.

There are many positive aspects of this style of eating for adults. Nutrition experts say the Mediterranean diet is good for kids too, with some caveats.

The diet calls for skim or low-fat dairy products; pediatricians call for little ones to consume whole milk until age two.Nuts are also included in the diet, something doctors say could be a choking hazard for children under age four.

The Mediterranean diet calls for a moderate amount of wine, which is illegal to consume until age 21 in the United States. Apart from that, signs are emerging that the Mediterranean could be beneficial for children.

A study presented to the European congress on obesity in 2014, found that children who followed it were 15 percent less likely to be obese.Other studies have suggested the diet could lower rates of asthma and wheezing in children.

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Mediterranean diet could lead to lower child obesity rates - wwlp.com

Ask the Anytime Gal: What is the best diet to stave off heart disease … – Jacksonville Daily Progress

Posted: February 11, 2017 at 11:45 am

Question: With it being American Heart Month, Im curious what dietary changes I should make in order to stave off heart disease? Just trying to be proactive rather than reactive!

Answer: First of all, kudos for focusing on prevention! As far as diet is concerned, there are definitely some modifications you can make, but to be honest, they arent all that new. For starters, you could try following the DASH diet, which stands for Dietary Approaches to Stop Hypertension. This diet focuses on specific amounts of fruits, vegetables, whole grains, low-fat dairy products, and lean proteins. I follow a Whole-Food Plant-Based diet for disease prevention. The WFPB way of eating has even reversed heart disease in numerous studies. It focuses on whole grains, legumes (beans, lentils, and peas), vegetables, fruits, dark leafy greens, daily multivitamin, vitamin B12 supplement, and ground flaxseed. Sounds pretty healthy, right? In fact, the diet has been shown to reduce hypertension, and can also decrease the risk of heart disease and stroke over time. But even if you dont follow a comprehensive diet, you should still try to limit your sodium intake, reduce your intake of saturated and trans fats, moderate your alcohol consumption (no more than 2 drinks per day for men and 1 drink per day for women), and increase your intake of omega-3 fatty acids. All of these changes will go a long way in helping to protect your heart, and the rest of your cardiovascular system. If you want additional information, check out the American Heart Association website, http://www.americanheart.org, or consult with a registered dietitian.

Andrea Ivins is the club manager and Zumba Instructor at Anytime Fitness in Palestine, TX. To submit a question for future articles, please contact the author at palestinetx@anytimefitness.com and thrivingivins.com.

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Ask the Anytime Gal: What is the best diet to stave off heart disease ... - Jacksonville Daily Progress

Newall: The pony of Port Richmond goes on a diet – Philly.com

Posted: February 11, 2017 at 11:45 am

The construction workers arrived at Kazs Tire Center in Port Richmond in need of some Goodyears and an answer to a burning question: Wheres the pony?

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Coco. The pony of Port Richmond. The delight of East Somerset Street. The chestnut gelding rescued from an abusive fairground who lived behind the tire shop and grew fat and happy from 15 years of love and attention lavished by Kaz Nabavi and his wife, Sedighah.

Too fat, unfortunately.

Kaz and the construction workers sat in the wood-paneled waiting room he keeps decorated with a shrine to his hero, John Wayne.

He would tell them the whole story. He always does.

The horse, said Kaz, solemnly, had to go on a diet.

I first met Kaz a few years ago on a whim. I heard a pony was living behind a tire shop. I met Coco. More importantly, I met Kaz, who is 72 and about as close to a living embodiment of joy as a human being can be.

An Iranian immigrant, he left his homeland in the early 1960s, fleeing the brutality of the shah. He loves his life in America. He loves Sedighah and their two children a doctor and a lawyer. He loves The Duke, and Teddy Roosevelt cowboys, he said. He loves working the polls on Election Day, with his carefully selected slate of candidates, both Republicans and Democrats. He loves the tire shop and the animals he keeps on his land behind it. His Chilean chickens that lay green eggs. His gorgeous peacock and dearly departed rescue goat. The parrot that liked to ride on Cocos back.

Sometimes, Kaz and I discuss politics. And sometimes when all the ugliness makes even Kazs smile fade, well talk about his pony. Kaz always returns to his pony.

Sitting under a portrait of the Duke, Kaz regaled his guests.

One afternoon in late summer, the story goes, Sedighah hurried into the shop. Coco had fallen. Or at least, lay down very fast. She wasnt sure. Kaz went to Coco. There was no just denying it anymore. The horse was too fat.

For months, he had been telling his wife as much.

One lap of hay in the morning, hed remind her. One lap of hay in the evening.

The horse doesnt like that, his wife would say, leaving Coco a feast of a whole bale.

At the market, for every piece of fruit his wife bought Kaz, shed buy two for Coco.

Watermelons and cantaloupes. Apples and carrots. Bananas even.

This is not a monkey, Kaz would say. This is a horse.

And exotic fruits that Kaz had never tasted, let alone name.

Who is the boss of this house? Kaz said. Is it the horse or me?

He tried spreading the hay out so Coco would walk for it.

The horse doesnt like that, Sedighah would say

Then there were the endless snacks from the neighborhoods kids who ignored Kazs sign: Please, do not feed the animal (Horse). Thank you.

Once, Kaz would ride Coco from Port Richmond to Penn's Landing, stopping along the way to give kids rides. Sedigah would ride him, too, with the parrot on the back.

But now, Coco was growing old and round enough that Kaz could no longer fit his legs around him.

He called a doctor.

Give him less food, otherwise hes going to die, the doctor said, prescribing a year of exercise.

Sedighah wasnt impressed.

The doctor doesnt know what hes talking about, she said. The horse likes to eat, give him food.

Kaz thought of a friend who owns a farm, near a lake, with a cozy barn and roomy paddock. Coco could get the exercise he needed.

We put it to pasture, Kaz said. Its the best thing. Of course, I miss him."

Kaz has visited Coco twice. He doesnt look like hes lost any weight. But they take good care of him. And that makes Kaz happy.

But without a pony things werent the same on East Somerset. Sedighah was sad. So was Kaz. And all the kids missed him, said Danny Beck, a roofer across the street, who liked to feed him apples despite the sign.

You got rid of my Coco, one little girl told Kaz, who tried to make her smile. I said, I didnt get rid of him. You did. You fed him too much food.'

Kaz knew what had to be done.

On Thursday, once the snow ended, Kaz put on his jacket and began to clean Cocos old stall. He wants it to be nice when he brings home the brown and white painted pony he bought for himself and Sedighah and East Somerset Street.

Beautiful, he called him. Hell bring him home when the weather breaks. He showed me a picture. It looked a little fat.

Published: February 10, 2017 6:57 PM EST | Updated: February 10, 2017 8:31 PM EST

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Newall: The pony of Port Richmond goes on a diet - Philly.com

So here it is: Don’t diet on the days leading up to a date. Drinking, dieting and dating is a terrible idea. – Elite Daily

Posted: February 11, 2017 at 11:45 am

Greetings, sweet kittens. It's me, Zara, your digital big sister.

While I love the weekend as much as the next free-wheeling, high heel-wearing, winged liner-sporting, booze-swilling, red-lipsticked PARTY GIRL, 99.9 percent of the mistakes I've made in my life have taken place during the weekend. I've spent one too many Mondays spiraling down the dark vortex of weekend guilt, regret and shame.

But hey, don't fret. Because I'm going to be here every Friday to stop you from the awful weekend fuckups that are screwing up your life. Here's this week's Very Important PSA.

Lets not waste time. This weekend PSA is so painfully real and happens all too often, so I feel VERY strongly about it.

So here it is: Dont diet on the days leading up to a date. Drinking, dieting and dating is a terrible idea.

Look, if youre one of those amazing girl creatures who has an authentically ~positive relationship~ with her body and would never THINK to diet before a date or skipa meal because she wanted to feel prettier and who has never tugged at her flesh in the mirror repeating, I hate myself. I hate myself. I hate myself, then please feel free to click out of this article. It will probably irritate you.

For the record, Im very happy girls like you exist. But Im not a girl like you, even though Ive spent thousands of dollars in therapy and yoga to emulate your wellness. I guess Im just damaged goods or something.

However, I know Im not alone. I happen to know a lot of girls who do (or have done) this kind of destructive shit, too. And it always ends in a total, epic, shame-spiraling disaster.

Now, kittens, the time has come to close your eyes. Its (horror) story time.

A million years ago (OK, maybe like five), I was going to go on a date with a girl I was super excited about. I had been lusting after her from afar for years. When I was still closeted, I had sex dreams about her.

But finally, I was an out-and-proud lez, and eventually, I told a friend, who told a friend, who told her, that I was, uh, interested.

And apparently, she was down for a date!

My little gay boy compatriotMax* came rushing up to me during Drag Queen Bingo one night.

She says youre her type! he gasped.

My heart fluttered. Really?

Yes. Shes going to text you.

I felt sick with excitement. Thats cool, I said, puffing on casually on my ciggie. (Never let them see you sweat, girls.)

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Two nights later, Lana* sent me a text. Hey, Zara. Its Lana. Do you want to grab a drink after work Tuesday?

Bile roseup in my throat. I quickly called my best friend Ruba and screamed, WHAT THE HELL DO I TEXT HER BACK? I WANT TO SEEM CASUAL, BUT ALSO INTO IT BUT CASUAL BUT INTO IT.

Ruba and I agonized over thisuntil we finally crafted the perfectly calculated, seemingly effortless text to send to Lana.

This is sort of like beach waves isnt it? I said to Ruba as Isent the message.

What do you mean beach waves?

Like, when you style your hair into beach-y waves. You spend two hours trying to make it look like you just stepped off a beach on a windy day. So, you spend twice as long trying to make your hair look effortless and messy than you do when you try to make it look styled and sleek.

Oh yeah, Ruba agreed. Beach waves.

Anyway, Tuesday night the night of my date with Lana was only four days away. That was nothing!

So I did what I always do when Im nervous: I went to take a good look at myself in my bathroom mirror and engaged in what my shrinks call negative self-talk.

Youre so hideous. Look at your skin; its full of zits. Massive, open pores. How are you going to clear your goddamn skin up in time for this date? my negative self said to me.

I cant, I whimpered back.

Well, you know what you can do?

What?

You might not be able to clear up your skin by Tuesday, but you can TOTALLYlose weight by Tuesday. Youre looking a little thick.

I pinched the flesh on my upper arm. I am?

Yes. Its OK, though. Just be really strict for the next few days, so you can look good for this date with Lana.

Oh, God. Youre right. Ill only eat fruits and vegetables for the next four days! And Ill go running, too. I promised.

Maybe even throw in some hot yoga? That will get rid of your water weight.

Good idea. I nodded at my negative self in the mirror.

Look, I dont have the best track record when it comes to self-control, but when Im determined to do something, I do it full force, babe.

So for the next four days, I practically starved myself. At work, I would watch my co-workers gorge on pizza and donuts, my mouth watering as I sadly ate my lonely carrot sticks.

Finally, Tuesday came around. I slipped on my deliciously slutty, Courtney Love-looking slip dress, fishnet stockings, patent leather Doc Martin boots and stared at my reflection. I ran my hands across my stomach I had definitely lost some weight.

Well done. My destructive negative-self was pleased.

I looked at my phone. It was 9:00 pm, and I was set to meet Lana at 11:00 pm.

Confession: Im one of those idiots who completely loses her personality when shes attracted to someone.

Im a sassy, talkative bitch most of the time. But when I find you physically beautiful, I completely shut down. I forget words. Im not exciting. I do weird things, like let out horrible tinkles of hysterical laughter at things that arent even remotely funny.

But sometimes, I believed alcohol wouldhelp.

Ill just have a personality drink! I thought to myself as I poured a giant glass of white wine before my date.

And having no food to hold the wine, I felt tipsy off half a glass. I giggled to myself as I slid into a taxi to meet Lana downtown.

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The next morning, I woke up with my heart pounding outside of my chest and a head full of steel nails. I struggled to open up my eyes, asthey felt like they were sealed shut.

Literally, my lashes were stuck together from gobs of sticky mascara, I had to peel them open with my fingers.

OH GOD! I shrieked.

I had a hazy memory of Lana texting me that she was going to be a little late and another hazy memory of ordering a glass of wine and stumbling into the bathroom to apply lipstick.

Then, I had a traumatic, ugly, vile flashback: I remembered beingso wasted, I was holding on to Lanas jean pockets. Then, my memories went right to black.

Yup, thats right. I had a total blackout on my dream date. I couldnt remember a damn thing.

After hours and hours of beating myself up, I finally mustered up the courage to call Lana.

Im so sorry was all I could say.

Yeah, its OK. I just hope youre OK. You were really bombed.

I know. Im sorry. I didnt eat a lot that day. This doesnt usually happen, I lied. I had blacked out from not eating more times than I could ever count. It always ended horribly.

But this was the worst. I had totally blown it with someone I had liked because I had over-dieted and drank too much booze. My radical methods of achieving perfection had backfired once again.

That sleepless night, I really thought about my life. It seemed I was always doing things like this trying too hard to be thin, trying too hard to be liked and trying too hard to be pretty.

In turn, I was destroying myself and scaring away the healthy things I so desperately wanted.

And Lana was a healthy person. Thats why I liked her. Thats why I wanted to look good for her and impress her to begin with.

But healthy people arent drawn to unstable peoplewho starve themselves and black out on first dates.

Some people are drawn to that, like the people I had been attracting before. But those people were toxic energy vampires whogot off on rescuing helpless shits like me.

Two days later, I called Lana again. Look, Im so sorry. That was a huge wake-up call. Can I please have a do over?

Lana hesitantly agreed. And this time, I didnt listen to my negative-self talk. This time, I told her to shut the fuck up because her advice wasnt helping it was hurting me.

So, I ate a solid meal before our date and only had one drink over the course of five hours.

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Yes, I was awkward because Im an awkward person when Im sober, and yes, I felt bloated because I always feel bloated when I eat. But I was aware of everything that was going on.

I didnt realize that not only was booze putting a hazy filter over my feelings, but starvation was, too. When youre hungry, you have a desperation about you. And you cant tell what youre ravenous for another person or a cheeseburger.

And just so you know, Lana and I ended up dating for, like, two years.Though,we wouldnt have ever had a relationship had she not been so kind.

But I dont want you to put yourself in that position.

So eat,girl. Not only do you need to eat so you wont make a fool of yourself on the date, but you also need to eat to be safe.

My blackout that night with Lana was so bad, whoknows what couldve (or DID) happen to me? In fact, I think a lot of terrifying things have happened to me in my life as a result of not eating and drinking too much and then blacking out.

Sometimes, I get weird nightmares of hands grabbing at me and strange flashes of being pulled into cars, and I dont know if theyre a figment of my imagination or if theyre traumatic memories my subconscious is still tortured by.

But Ill never know, which is the most terrifying part.

And all of this is a result of me DIETING (or shall I say starving myself) so I could be prettier.

Really, Im not even pretty when Im dieting.You cant be pretty when youre not giving your body what it needs. And when youre not giving your body what it needs, your body doesnt give your brain what it needs.

And our brain is really the most beautiful part of ourselves. Our thoughts, our feelings, our perspectives on the world they all come from our brains.

Dont screw with your brain. Its too stunning to starve away.

So if youre getting ready for your date tonight, and you skipped dinner in an attempt to feel pretty, I want you to imagine me standing in your doorway.

Im holding up a gorgeous, silver platter from somewhere really bougie, like Tiffanys. On it is a gorgeous plate full of beautifully grilled vegetables, wild rice and sweet potatoes. Its healthy, but its hearty, like us, baby!

Eat this before you go out, honey, I say to you.

You take the plate from steady hands. You notice how happy and healthy I look. Ive been eating fucking MEALS! I say to you, reading your mind.

You eat the meal, and you feel fabulous. You feel ready for your date.

You took care of yourself, and when you take care of yourself, you radiate a really different, attractive energy. Its not needy. Its not desperate. Its balanced, self-aware and independent, and those are all qualities that draw in positive things and people.

And if you feel like you still wantto skip the meal, message me. Your internet lesbian big sister wont let you go on that date without eating. Promise.

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Zara Barrie is a senior writer for Elite Daily. She's consumed by style, sexuality, women, words, fashion and feelings. She identifies as a "mascara lesbian" and lives beyond her means on the Upper East Side of Manhattan.

Original post:
So here it is: Don't diet on the days leading up to a date. Drinking, dieting and dating is a terrible idea. - Elite Daily

Joe Coffee’s Jonathan Rubinstein Splurges on Pie and Cake for Birthdays – Grub Street

Posted: February 11, 2017 at 11:45 am

At Lilia one of his favorite restaurants. Photo: Miachel Breton

Its an exciting time for Jonathan Rubinstein, the owner of Joe, a highly respected coffee chain that has shops in New York and Philadelphia: Danny Meyers Union Square Hospitality has invested in his company, which means that Joe, which roasts its own beans in Red Hook, will soon pop up in additional cities across the country. This week, Rubinstein mixed business with pleasure eating a hazelnut doughnut at a strategy meeting, birthday cake for an employees birthday, and lamb rag at Lilia, where he collaborated on the coffee program. He also treated his daughter, Sally, to pie, chicken sandwiches, and homemade pasta with butter and Parmesan.

Thursday, February 2My morning coffee routine is definitely a ritual, and as a total morning person, I usually jump out of bed because I cant wait to take my first sip. By 6 a.m. I start boiling water in my kettle and eat a piece of fruit and have half a piece of toast with some peanut butter to put something in my stomach before coffee. Once the water boils, I make a pour-over coffee with beans from one of my Joe shops. Today it is a Brazilian coffee from Santa Ines that we just released. I sit on the couch and savor each sip before my 8-year-old daughter, Sally, wakes up and the day has officially begun. Sally jumps on the bus to school in Red Hook, and I leave our apartment in Brooklyn Heights and catch the train to our office in Chelsea.

By 8 a.m. Im at the office, but today I have an all-day strategy meeting with our new investors, Union Square Hospitality Group. Knowing the way they exceed expectations I have high hopes that they will feed me well. Exceed they do. When I walk into the conference room, there is a gorgeous spread of freshly baked sweet and savory pastries including a passion-fruit danish, a salted hazelnut doughnut with spiced sugar, a tomato-and-olive tart, and a baklava danish with orange blossom.

We have barely finished the pastries when lunch is served: Union Square Events family meal of mushroom, carrot, and fava-bean salad, salmon tartines, and hake with sweet potato pure. Some family meal!

We end the day with drinks and snacks at Porchlight, where I wind down with a pint of Other Halfs IPA, an amazing smoky beef jerky made in-house, and peanut hummus with vegetables.

I am pretty satiated from a full day of eating, so my late-night dinner is a pint of raspberries.

Friday, February 3 My morning routine is exactly the same as yesterdays, except my coffee of choice today is our Papua New Guinea from the Baroida Estate, roasted just yesterday at our roastery in Red Hook.

On my way into work, I stop by Daily Provisions for opening day. We are the wholesale partner working on their coffee program, so I wanted to stop by and taste for quality, which is spot-on. I also have a scrambled-egg-and-spinach gougres, which is super yummy, and they also send me off with a fresh loaf of rye bread by baker Justin Rosengarten, which my staff devours as soon as I step in the office.

At noon, I run to a meeting in the Village and take a quick detour on the way, to Citarella, which in my opinion has the best salad bar and is the best deal in the city. I know people are very into the designer-salad trend, but I still like making my own and only spending $6 on it.

At 2 p.m., Im back at Joe HQ. Today is our director of retails birthday, so we gather in our Pro Shop space for a quick celebration. He doesnt eat sugar or carbohydrates, basically just meat and vegetables, so we grill him a steak and the rest of us have vegan chocolate cake from Whole Foods.

Dinner tonight is at one of my favorite restaurants, Lilia. Missy Robbins has been a friend and a customer for many years and its incredible to see her vision turned into a reality, not to mention one of the most celebrated restaurants in the country. We collaborated on her coffee program for Lilia and I stop by the Caff whenever Im in the area. Tonight, for dinner with a friend, we go all-out: two glasses of wine, a grilled radicchio salad, roasted trumpet mushrooms, scallops, Missys famous and incredible lamb-rag pasta, and of course, an olive-oil cake with soft serve for dessert.

Saturday, February 4 Coffee ritual on repeat with a side of blueberries and raspberries. A few hours later, I have one scrambled egg and half an avocado, both of which have been rejected by Sally. Her birthday party is this afternoon so she cant think about anything else and I have to threaten to cancel it if she doesnt agree to eat breakfast. In between birthday-party errands, which take us to downtown Brooklyn, we grab lunch at Hill Country Chicken a chicken sandwich for Sally and a kale salad with grilled chicken, sweet potato, and pine nuts for me.

Sallys birthday party is at Karaoke Cave, which is connected to Le Midi, a classic-style French bistro near Union Square, which randomly also has karaoke rooms in the basement. Over the course of the party, while 24 8-year-olds are belting Taylor Swift, I am fairly sure I ate two full plates of their delicious bistro-style French fries and half of the chicken fingers I ordered for the kids.

Birthday cake is literally my favorite dessert and I could eat an entire cake from One Girl Cookies on a daily basis. Sally has never liked birthday cake and always insists on pie for her birthday. I know her birthday is supposed to be about her, but I cant help but indulge the child in me we splurge and serve both.

After the party, we drive out to New Jersey to for a sleepover with two families I have known since high school and who have kids that Sally loves. When we get there, my friends have ordered Mexican food from Tinga in Millburn and it is delicious.

Sunday, February 5 Naturally, I am on coffee duty and make four Chemexes of Joes house-blend for the parents who slept over. (Yes, I packed an entire suitcase of Chemexes, a grinder, a scale, an electric water kettle, filters, and a bag of beans.) For breakfast, I have both a bowl of cereal and leftover rice and beans.

When we get back to the city, Sally goes to see a play with her grandparents and I meet up with my friend Missy, who is in the process of expanding her new business, Fresh Coat Nails. I love talking with entrepreneurs about growth and new ideas. We have brunch at Soho House, and while Im really not a private club kind of guy, they do have the best brunch buffet on the planet. I have a little bit of everything: grain salad, oysters, shrimp, salmon, and vanilla layer cake. Yay, two consecutive days of cake, my favorite dessert!

Im too full to eat dinner tonight, but I make Sally the go-to meal that kids, and parents, love: pasta with butter and Parmesan cheese. I sneak a few bites.

Monday, February 6 Coffee ritual Grind. Brew. Repeat.

On my way to work, I stop by Pret a Manger for a Southwestern egg-white wrap, and after catching up on emails, I head out late morning to visit a few Joe shops. I have a taste of our house coffee at our Union Square shop on 13th Street between 5th Avenue and University Place, then I continue onto the West Village for a straight shot of espresso at our Waverly Place shop, the original Joe. The shop always feel like coming home to me.

Sallys favorite weekend hobby is playing store I pay her a $1 an hour and shell bus tables, give them refills on their water, wash dishes. Shes very proud of Joe and feels like she has ownership.

Lunch today is broiled chicken with sweet potatoes and roasted cauliflower from Whole Foods I do my best to keep my diet lean and clean during the week, and Whole Foods has so many tasty but healthy to-go options.

Sally has a doctors appointment in Park Slope, the last appointment of the day, and we are both famished when we arrive. I think I may be the only person in the history of the world to order ramen delivered to a doctors office, but I do it. Its my first time ordering from Wasan, a Japanese restaurant on Bergen Street, but we will definitely add it to our list of delivery go-tos.

Tuesday, February 7 Coffee routine, of course.

Lunch from Whole Foods again: braised chicken, steamed broccoli, and some arugula.

I realize I havent been cooking as much as I should lately, so for dinner I make Sally some broiled salmon with soy sauce, maple syrup, garlic, and sesame oil, plus Brussels sprouts and mashed potatoes. Its one of her favorite meals and we both feel good about eating it.

My family situation is unique because Im a single father by choice. Im a gay dad who had a baby by surrogate, and I try to make our lives as normal as I can in a lot of ways, and cooking is a big part of that, especially in New York. My job is demanding and its a demanding time because we just closed on the investment and were expanding a lot and as a parent, I try to get as much quality time with her as I can.

Once she falls asleep, I open a bottle of cabernet and start to binge-watch Difficult People. I fall asleep on the couch soon after.

An industry insider calls it probably one of the biggest numbers Ive heard.

Birthday cake is literally my favorite dessert I cant help but indulge the child in me.

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Joe Coffee's Jonathan Rubinstein Splurges on Pie and Cake for Birthdays - Grub Street

New weight loss method requires patients to get over ‘ick’ factor … – myfox8.com

Posted: February 11, 2017 at 11:44 am

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ST. LOUIS --Losing weight isa struggle for many people, but a new weight loss device recently approved by the FDA may be the easiest way ever to shed pounds.

Washington University Medical School helped develop the device, the Aspire Assist, but one doctor warnedit may gross some people out.

Its a feeding tube that removes some of the ingested food, Washington University Medical School Doctor Vladimir Kushnir said.There is a significant ick factor to aspiration therapy that you have to get over.

Eric Wilcoxon from Poplar Bluff, Missouri, once weighed more than 400 pounds.

I lost close to 100 pounds within the first year, he said.

Wilcoxon now weighs 268 pounds. Even better, he can eat whatever he wants.

If I want to go out to dinner and have a steak, Im going to eat a great big meal, he said.

Wilcoxon credits the Aspire Assist for his miraculous weight loss turnaround.

About 30 minutes after a meal Wilcoxon pumps out one third of the food from his stomach or about one third of the calories hes consumed.

I was fat, I was obese and I was sick of being that, he said.

The device is connected to a port on the skin, which is secured to a tube inside the stomach. When the port is opened, the stomach contents empty into the toilet. The process takes about 10 minutes. Wilcoxon has a port on his stomach; he connects the device to his port and siphons or aspirates the food into the toilet. He does this faithfully.

With every meal Wilcoxon drinks lots of water and he chews the food into tiny pieces so it can flow throw the small exit tube. He eats less because it takes him so long to eat.

People dont grasp how much you have to chew your foodin order to aspirate (it), Wilcoxon said.

Not only has Wilcoxon lost weight, he no longer is required to take blood pressure, diabetes or heart medicine. And life with his family is so much better.

Its been life-changing, definitely, said Christy Wilcoxon, Erics wife.

Doctor Kushnir said the Aspire Assist is for people who are moderately to severely obese. Most insurance companies do not cover the cost, which is about $8,700.

For more information, click here.

38.627003 -90.199404

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New weight loss method requires patients to get over 'ick' factor ... - myfox8.com

Commercial weight-loss drug could help treat opioid addiction – Science Daily

Posted: February 11, 2017 at 11:44 am

Commercial weight-loss drug could help treat opioid addiction
Science Daily
... aid hospitals, doctors and public health officials in this fight. Now one team reports that the commercial weight-loss drug lorcaserin, when given to rats who had been self-administering oxycodone, appeared to reduce their use of and craving for ...

and more »

Read more:
Commercial weight-loss drug could help treat opioid addiction - Science Daily

Mama June’s Weight-Loss & Surgery Show Looks INTENSE – Refinery29

Posted: February 11, 2017 at 11:44 am

The first sneak peek at June Shannon's new reality show is here. Over seven episodes, WE tv's Mama June: From Hot to Not will chronicle the inner and outer (but probably mostly outer) transformation of the reality star as she diets, exercises, and undergoes plastic surgery to achieve an "unrecognizable" appearance.

The goal of the show is, clearly, massive weight loss. In the teaser, we see Shannon weighing in at 354 lbs, while the stated goal is for her to become a size four. "There is a skinnier person inside of me," Shannon says. We see her drill sergeant-style trainer berate her for stocking pints of Ben & Jerry's and gently waking her up with a blow horn. (Seems like a fun guy, no?)

We also get a glimpse at daughter Alana, a.k.a. Honey Boo Boo, telling her mom to cut back on the cheese and asking her to forgo surgery. (Whether it's cosmetic or something like a gastric bypass is not clear.) "I think you look fine the way you are," Alana says. Um, anybody else feel like the 12-year-old is the only voice of reason here?

Like many weight loss reality shows, the focus on pounds shed and dress sizes dropped is worrisome, as approaching fitness from that angle has the potential to lead to an unhealthy fixation on numbers, not wellness. We have to admit that we are curious, though if only for a little more screen time with Honey Boo Boo.

Watch the trailer below, and tune in to the premiere on WE at 10 p.m. ET on Friday, February 24.

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Mama June's Weight-Loss & Surgery Show Looks INTENSE - Refinery29


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