ScienceDaily (Aug. 15, 2012)  A    study to be published in the Endocrine Societys Journal of    Clinical Endocrinology and Metabolism (JCEM) shows    consumption of a Mediterranean diet enriched with olive oil for    two years is associated with increased serum osteocalcin    concentrations, suggesting a protective effect on bone.  
    Age-related bone mass loss and decreased bone strength affects    women and men alike are an important determinant of    osteoporosis and fracture risk. Studies have shown that the    incidence of osteoporosis in Europe is lower in the    Mediterranean basin. The traditional Mediterranean diet, rich    in fruits and vegetables, with a high intake of olives and    olive oil could be one of the environmental factors underlying    this difference.  
    The intake of olive oil has been related to the prevention of    osteoporosis in experimental and in vitro models, said Jos    Manuel Fernndez-Real, MD, PhD, of Hospital Dr. Josep Trueta in    Girona, Spain and lead author of the study. This is the first    randomized study which demonstrates that olive oil preserves    bone, at least as inferred by circulating bone markers, in    humans.  
    The participants in this study were 127 community-dwelling men    aged 55 to 80 years randomly selected from one of the    Prevencion con Dieta Mediterranea (PREDIMED) study centers who    had at least two years of follow-up. The PREDIMED study is a    large, parallel group, randomized, controlled trial aimed to    assess the effect of the Mediterranean diet on the prevention    of cardiovascular diseases.  
    For this study, subjects were elderly without prior    cardiovascular disease but having a diagnosis of type 2    diabetes or harboring at least three cardiovascular risk    factors, namely hypertension, dyslipidemia, or a family history    of premature cardiovascular disease. Participants were randomly    assigned to three intervention groups: Mediterranean diet with    mixed nuts, Mediterranean diet with virgin olive oil, and a    low-fat diet.  
    Biochemical measurements of osteocalcin, glucose, total    cholesterol, HDL-cholesterol and triglycerides were performed    at baseline and after two year follow-up on fasting blood    samples. Researchers found that only consumption of the    Mediterranean diet with olive oil was associated with a    significant increase in the concentrations of total osteocalcin    and other bone formation markers. There were also no    significant changes in serum calcium in subjects taking olive    oil whereas serum calcium decreased significantly in the other    two groups.  
    Its important to note that circulating osteocalcin was    associated with preserved insulin secretion in subjects taking    olive oil, added Fernndez-Real. Osteocalcin has also been    described to increase insulin secretion in experimental    models.  
    Other researchers who helped with the study included Mnica    Bull, Jos Maria Moreno-Navarrete, Wifredo Ricart, Emilio Ros,    Ramon Estruch, and Jordi Salas-Salvad of Instituto de Salud    Carlos III in Madrid, Spain.  
    The article, A Mediterranean Diet Enriched with Olive Oil    is Associated with Higher Serum Total Osteocalcin Levels in    Elderly Men at High Cardiovascular Risk, will appear in    the October 2012 issue of JCEM.  
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Mediterranean diet enriched with olive oil may protect bone