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Arena transfers diet pill application to Eisai

Posted: July 30, 2012 at 4:10 pm

SAN DIEGO (AP) -- Arena Pharmaceuticals Inc. said Monday it transferred marketing rights for the diet pill Belviq to its partner Eisai Co. Ltd., which will market the drug in the U.S. and apply for approval in other North and South American countries.

Arena said it transferred the FDA application for the drug to the Japanese pharmaceutical company, which plans to submit it for approval in Mexico, Brazil, Canada and other countries.

The FDA approved Belviq in late June for adults who are obese or are overweight with at least one medical complication, such as diabetes or high cholesterol. It was the first FDA approval of a new drug for long-term weight loss in 13 years.

Arena's studies showed that patients taking Belviq, known generically as lorcaserin, had modest weight loss. On average patients lost 3 to 3.7 percent of their starting body weight over a year. About 47 percent of patients without diabetes lost at least 5 percent of their weight or more, which was enough to meet FDA standards for effectiveness.

Shares of Arena Pharmaceuticals fell 8 cents to $9.34 in morning trading.

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Arena transfers diet pill application to Eisai

Health coaches could be key to successful weight loss, study suggests

Posted: July 30, 2012 at 4:10 pm

Public release date: 30-Jul-2012 [ | E-mail | Share ]

Contact: Jessica Collins Grimes jgrimes2@lifespan.org 401-793-7484 Lifespan

(PROVIDENCE, R.I.) Coaches can help athletes score touchdowns and perfect their golf swing, but can they also influence weight loss? Researchers from The Miriam Hospital's Weight Control and Diabetes Research Center say health coaches could play an important role in the battle of the bulge, according to the findings of a pilot study published online in the journal Obesity.

In the first study of its kind, obese individuals participating in a low-intensity behavioral weight loss program who were supported by either a professional health coach or a peer coach lost clinically significant amounts of weight (at least 5 percent of their initial body weight). These weight losses are comparable to the amount of weight lost by patients participating in a more intensive behavioral intervention with twice as many treatment sessions.

"Our study suggests health coaches may not only yield impressive weight loss outcomes, but that lay or peer health coaching may be particularly promising as a cost-effective obesity treatment strategy," said lead author Tricia M. Leahey, Ph.D., of The Miriam Hospital's Weight Control and Diabetes Research Center. "Although these findings are only preliminary, it's encouraging that lay health coaches successfully supplemented a less intensive, lower cost behavioral intervention and that their weight losses were actually comparable to those produced by professional coaches something that could be critical in this changing health care landscape."

Obesity remains a common, serious and costly disease in the United States. About one-third of American adults are obese, according to the Centers for Disease Control and Prevention, and no state has met the nation's Healthy People 2010 goal to lower obesity prevalence to 15 percent. Obesity and its associated health problems, including heart disease and diabetes, continue to have a significant economic impact on the U.S. health care system, costing the nation hundreds of billions of dollars each year.

Health coaches have grown in popularity, yet empirical support is limited. In the health coach treatment model, health coaches supplement treatment by providing ongoing support, accountability and information to promote behavior change between treatment visits. Health coaches can be professional health care providers, such as nurses or social workers; peers, or individuals currently facing the same health problem who coach one another to support behavior change; and mentors, or master coaches, who have previously and successfully faced the same health situation.

In this randomized controlled pilot study, 44 participants took part in a group behavioral weight loss program that met for 12 times over the course of 24 weeks half the amount of sessions of a traditional treatment plan. Groups met weekly for the first six weeks, biweekly for the following six weeks and monthly thereafter.

Miriam researchers randomly assigned individuals to work with one of three different types of health coaches: a professional (behavioral weight loss interventionist), peer (a fellow group member) or mentor (a successful weight loser). During the weeks where there were no group meetings, participants emailed their weekly weight, calorie and physical activity information to their coach and received feedback. All coaches were trained on appropriate coaching strategies and feedback delivery.

While all three groups yielded clinically significant weight losses, participants guided by professional and peer coaches had the most success, losing more than 9 percent of their body weight on average, compared to just under 6 percent in the mentor group. At least half of the participants in the professional and peer coaching groups achieved a 10 percent weight loss, which research has shown can reduce the risk of a wide range of illnesses linked to obesity, including heart disease and diabetes. Only 17 percent of those in the mentor group accomplished this goal.

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Health coaches could be key to successful weight loss, study suggests

Hydroxycut(TM): Food Journals May Make or Break Weight Loss Efforts

Posted: July 30, 2012 at 4:10 pm

NEW YORK, NY--(Marketwire -07/30/12)- A new study indicates that keeping a food journal can increase the effectiveness of weight loss efforts. The makers of Hydroxycut agree that maintaining awareness regarding caloric intake can contribute significantly to the achievement of a weight loss goal.

Weight loss is a common goal for many individuals across the United States, particularly during the summer months. With "bikini season" in full swing, NY Daily News has published an article stating that food journals may assist in shedding excess pounds. The makers of Hydroxycut, a weight loss supplement, agree that monitoring caloric intake can improve the success of weight loss efforts.

According to the article, the assertion regarding the value of a food journal comes from the results of a study conducted by researchers at the Fred Hutchinson Cancer Research Center, located in Seattle, Washington. These researchers analyzed the food intake of 123 women who had, before the study began, been overweight and led sedentary lifestyles. The study found that the use of a food journal assisted women in achieving their weight loss goals.

Reports the article, "Women who kept food journals and consistently wrote down the foods they ate lost about six pounds more than women who didn't. Women who reported skipping meals lost almost eight fewer pounds than women who did not, and those who ate out for lunch at least weekly lost an average five fewer pounds than those who brought in their lunch."

These results indicate that keeping a food journal is one of many best practices that should be incorporated into a successful weight loss strategy. The article goes on to provide several tips regarding the maintenance of a weight loss journal. These include writing down everything that is consumed throughout the day, not leaving it all to the end of the night; recording the feelings that accompany the activity of eating and how different foods evoke different emotions; and including how hunger levels change with different foods. Additionally, individuals are encouraged to be honest in their records, as it will only help them to achieve their ultimate health and fitness goals.

To maintain a healthy diet and accurately monitor the intake of calories, the makers of Hydroxycut agree with the article that individuals should measure their portions and read food labels. Additionally, they should pay attention to more than just the calories in each serving size, as fiber, carbohydrates, protein, and other nutrients are important in achieving weight loss.

Hydroxycut is a weight loss supplement that works in conjunction with diet and exercise. As such, users of this weight loss product are encouraged to maintain a regular exercise program and healthy meal plan to achieve their weight loss goals.

ABOUT:

Hydroxycut, America's #1 best-selling weight loss supplement brand, is a complement to regular exercise and healthy nutrition. The product's key ingredients (lady's mantle extract, wild olive extract, komijn extract and wild mint extract) have been proven to decrease BMI and, ultimately, enhance weight loss in dieting individuals. In fact, the average weight loss with these key ingredients was 20.94 lbs. in one 12-week study and 16.50 lbs. in one 8-week study. All groups followed a calorie-reduced diet. Hydroxycut is available in multiple forms, including Pro Clinical Hydroxycut Caffeine Free, Hydroxycut Herbal, and more.

For more information about this product, visit http://www.hydroxycut.com.

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Hydroxycut(TM): Food Journals May Make or Break Weight Loss Efforts

Mom-to-be diet tied to child hypertension

Posted: July 30, 2012 at 1:14 am

GALVESTON, Texas, July 29 (UPI) -- The offspring of mothers on a low-protein diet are more likely to develop hypertension as adults, U.S. researchers say.

Drs. Haijun Gao, Uma Yallampalli and Chandra Yallampalli of the University of Texas Medical Branch at Galveston said in rats, the high maternal testosterone levels associated with a low-protein diet are caused by reduced activity of an enzyme that inactivates testosterone.

This increased testosterone reaches the fetus and increases the offspring's susceptibility to adulthood hypertension.

The researchers hypothesized the increased testosterone levels were caused either by increased activity of an enzyme that produces testosterone or by decreased activity of an enzyme that reduces testosterone, specifically Hsd17b2, which converts testosterone to a less potent androgen, androstenedione.

The team found that Hsd17b2 expression in rats was affected by protein restriction in two parts of the placenta.

The researchers propose the reduction in Hsd17b2 expression might allow more testosterone to reach the fetus and play a role in fetal programming of hypertension.

The findings are scheduled to be presented at the Society for the Study of Reproduction's annual meeting at State College, Pa.

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Mom-to-be diet tied to child hypertension

Your diet affects your grandchildren's DNA, studies say

Posted: July 28, 2012 at 2:10 pm

Your Diet Affects Your Grandchildren's DNA, Scientists Say

By: Christopher Wanjek, LiveScience Bad Medicine Columnist

Published: 07/27/2012 10:00 AM EDT on LiveScience

You are what you eat, the saying goes. And, according to two new genetic studies, you are what your mother, father, grandparents and great-grandparents ate, too.

Diet, be it poor or healthy, can so alter the nature of one's DNA that those changes can be passed on to the progeny. While this much has been speculated for years, researchers in two independent studies have found ways in which this likely is happening.

The findings, which involve epigenetics, may help explain the increased genetic risk that children face compared to their parents for diseases such as obesity and diabetes.

The punch line is that your poor dietary habits may be dooming your progeny, despite how healthy they will try to eat. [10 Worst Hereditary Conditions]

Epigenetics

Epigenetics refers to changes in gene expression from outside forces. Different from a mutation, epigenetic changes lie not in the DNA itself but rather in its surroundings -- the enzymes and other chemicals that orchestrate how a DNA molecule unwinds its various sections to make proteins or even new cells.

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Your diet affects your grandchildren's DNA, studies say

Study shows new weight-loss drug may help keep pounds at bay

Posted: July 27, 2012 at 1:12 pm

A potential new weight-loss drug created by scientists may help people shed pounds and keep them off, researchers say.

In the study, obese mice treated with the drug ate less, lost weight and experienced improved metabolic health, such as reduced insulin resistance, compared with obese mice not given the drug.

The drug appears to work by increasing the body's sensitivity to leptin, a hormone that suppresses appetite. It's thought that obese people become desensitized to leptin, meaning their bodies do not respond to it.

"By sensitizing the body to naturally occurring leptin, the new drug could not onlypromote weight loss, but also help maintain it," said study researcher George Kunos, of the National Institute on Alcohol Abuse and Alcoholism.

Because the study was conducted in mice, it's not clear whether the effects will translate to people. The researchers plan to start tests of the drug in people if it passes a safety test required by the National Institutes of Health, Kunos said.

New drug, tried method

Because obese people become desensitized to leptin, simply giving people supplements of the hormone does not promote weight loss, studies have shown. The desensitization process is thought to involve cannabinoid receptors the same receptors that are activated bychemicals in marijuana.

Activating cannabinoid receptors is known to promote feelings of hunger in marijuana smokers, and blocking these receptors has been shown to cause weight loss. However, a previously developedweight- loss drug, called rimonabant, that blocked cannabinoid receptors also caused serious psychiatric side effects, including anxiety and depression. Rimonabant was sold in Europe beginning in 2006, but was taken off the market a few years later.

The drug tested in the new study, called JD5037, was designed to not enter the brain as a way to reduce psychiatric side effects. The drug blocks cannabinoid receptors in other parts of the body, including the liver and muscle, Kunos said.

Obese mice given JD5037 daily for about a month lost 28 percent of their body weight, and reached the weight of a normal-size mouse, Kunos said. Moreover, the mice lost the weight while continuing to eat the high-fat diet that led to their obesity in the first place. The mice appeared to lose most of the weight in the first two weeks, and maintained it after that.

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hCGTreatments / Diet Doc Offers Weight Loss Pills to that Work to Suppress the Appetite and Burn Belly Fat

Posted: July 26, 2012 at 6:14 pm

Seattle, WA (PRWEB) July 26, 2012

hCGTreatments / Diet Doc now offers weight loss pills that complement their natural weight management programs. With weight gain and obesity on the rise, most people are taking various precautions to stay healthy while others are taking drastic measures to fix the problem. Bariatric surgery is one of the drastic measures that is on the rise. Invasive surgery should be the absolute last resort for overweight or obese patients, due to its traumatic effects on the body, after exhausting all other methods of weight loss but most are starting to look to these invasive procedures are their only option.

hCGTreatments / Diet Docs weight management programs is a natural alternative to invasive surgery and offer the same drastic results. Their programs use hCG treatments, a natural hormone that works to balance the hormones, combined with a low-glycemic diet that is found to be suitable for people with any health condition. A diet plan is created for each patient by a nutritionist after a thorough health evaluation from a doctor and is guided by a weight loss coach throughout the program. Diet Docs patients are advised to supplement their diet plan with essential vitamins and minerals that are suited to their body type to optimize their bodies through the program.

Diet Docs newest addition the their line of weight loss products, however, are designed to make the diet easier by suppressing the appetite and burning belly fat. Abdominal, or visceral fat, actually plays a role in various types of diseases according to recent studies. In fact, a group of specialists that study the link between abdominal fat and disease called the International Chair on Cardio metabolic Risk held their third International Congress on Abdominal Obesity which present new research on topics relating to intra-abdominal, belly fat. Their researchers stated that it is critical to measure the waist circumference in patients with Type 2 diabetes because the greater waistline, the higher the risk will be of developing cardio-metabolic complications. Their studies also find the role between belly fat and inflammation, which is also a major factor for disease.

hCGTreatments / Diet Docs weight management programs aim to find the root of the problem and work to change it. Programs that promise fast weight loss solutions only provide a temporary fix to the problem. The hCG diet has been around for over 50 years and Diet Doc has worked to modernize the program to make it safer and more effective. Many of their patients claim to lose 14 pounds in two weeks, matching their results with those of the invasive procedures like the lap band or bariatric surgery. Diet Doc CEO, Julie Wright, states our weight management programs are safe and effective and work to change eating habits and body structure. These results are life-long and cannot be achieved through any surgery.

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hCGTreatments / Diet Doc Offers Weight Loss Pills to that Work to Suppress the Appetite and Burn Belly Fat

Med diet satisfies growing teens’ zinc requirements

Posted: July 25, 2012 at 11:13 pm

Young people aged 11-14 can eat a healthy Mediterranean diet and get all the zinc they need to help them grow, according to researchers.

The Mediterranean diet is high in vegetables, fruit and olive oil and low in meat

The research by Marta Mesias et al. published in the Public Health Nutrition Journal found that a diet high in cereals, legumes and veg and low in meat could provide adequate zinc amounts even though these foods have typically been thought to reduce the bioavailability of minerals.

Med diet meets needs

The Mediterranean diet has been proposed as one of the healthiest dietary models available, said the study.

Although a diet based on Mediterranean patterns is associated with factors which can affect Zn [zinc] absorption, such as high consumption of phytate, its consumption in adequate amounts allows Zn status to be maintained during adolescence.

The study found that a med diet could account for 76% of the Spanish recommended daily intake of zinc.

Although, the diet did not meet 100% of Spanish zinc standards, the researchers called Spains recommendations unnecessarily high.

Why zinc is important

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Med diet satisfies growing teens’ zinc requirements

Ancient diet offers clues to diabetes

Posted: July 25, 2012 at 11:13 pm

The ancient Native Americans of the desert Southwest subsisted on a fiber-filled diet of prickly pear, yucca and flour ground from plant seeds, finds a new analysis of fossilized feces that may explain why modern Native Americans are so susceptible to Type II diabetes.

Thousands of years of incredibly fibrous foods, 20 to 30 times more fibrous than today's typical diet, with low impact on the blood sugar likely left this group vulnerable to the illness when richer Anglo foods made their way to North America, said study researcher Karl Reinhard, a professor of forensic sciences at the University of Nebraska-Lincoln.

"When we look at Native American dietary change within the 20th century, the more ancient traditions disappeared." Reinhard told LiveScience. "They were introduced to a whole new spectrum of foods like fry-bread, which has got a super-high glycemic index."

The glycemic index of a food is a measure of how fast its energy is absorbed into the bloodstream. It's measured on a scale of 1 to 100, with 1 being the slowest absorbing with the least effect on blood sugar. The native people who lived in the deserts of Arizona would have likely eaten traditional stews with glycemic indexes around 23, Reinhard found. Foods scoring lower than 55 are considered "low-GI" foods. [ 7 Perfect Survival Foods ]

Modern food and modern disease Members of Southwest Native American tribes are more susceptible than Caucasians to Type II diabetes, which happens when the body either doesn't produce enough insulin to break down sugar from food, or when the body's cells fail to recognize the insulin it does produce.

Researchers have long hypothesized that a "thrifty gene" (or, more likely, genes) acquired through feast and famine makes Native American populations more prone to this chronic disease. The idea is that people who were able to rapidly adapt to both lean times and times of plenty would have done better in ancient times. Today, the modern diet has rendered famine rare in the developed world, but the body continues to respond to times of plenty as if starvation is around the corner. Diabetes and obesity can result.

Reinhard and his colleagues now suggest that feast and famine may not be necessary for the "thrifty gene" hypothesis to make sense. Basically, Reinhard said, an extremely low-calorie, high-fiber diet made the ancient Native American gut a paragon of efficiency. With the arrival of whites, the diet changed faster than physiology could keep up with it. In other words, the digestive system didn't evolve for abundant, high-GI foods.

High-fiber diet To find solid evidence of what ancient Southwestern tribes actually ate, Reinhard turned to what he called "the most intimate residues from archaeological sites" fossilized poop. Known as coprolites, these fossils contain a record of their creator's most recent meals.

The researchers analyzed 25 coprolites from Antelope Cave in northwestern Arizona, a dwelling that was seasonally occupied for thousands of years. These particular coprolites (20 of which turned out to be human) date back to at least A.D. 1150 and earlier. The dates make the cave a perfect time to look at the transition from a total hunter-gatherer lifestyle to one supplemented by some agriculture, Reinhard said.

"It bridges two different dietary traditions, one which has been around for several thousands of years with one that was relatively newly introduced at the time the cave was occupied," he said.

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Dancing With The Stars’ Kirstie Alley Sued Over Weight Loss Claims

Posted: July 25, 2012 at 2:18 pm

Hells Kitchen Recap: Gordon Ramsay Hands Out The Black Jackets | Home

July 25, 2012 06:00 AM by Stephanie Gustafson

Remember how Kirstie Alley lost a massive amount of weight while she was on Dancing with the Stars?At the time, the Fat Actressstar was using Organic Liaison, a special weight loss product that she just happened to be endorsing. We all suspected that the weight loss had something to do with Kirstie Alley dancing several hours each day, but now, an unhappy Organic Liaison customer is suing Alley for making false and misleading advertising claims. Is there something to this argument? Keep reading for the details!

Dancing with the Starscould easily switch its format to a weight loss competition. After all, several alums have successfully dropped extra pounds while competing on the show. Kirstie Alleys DWTSweight loss story was especially impressive, as the actress lost over 60 pounds while on the show. Alley, however, credited much of this weight loss success to Organic Liason, a weight loss company that she was endorsing at the time. Now, another Organic Liaison user is suing the DWTSalum for misleading customers.Marina Abramyan tried Organic Liason and had little success, probably, because, believe it or not, weight loss supplements are (gasp) not magic! Most of us would have realized this before wasting our money, but Abramyan believes that she was purposefully misled by Kirstie Alley.

Marina Abramyans legal filing company points specifically to Kirstie Alleys claim that, I am proof of its success; I lost one hundred pounds on Organic Liaison. Abramyan argues that Organic Liaison was not behind the incredible weight loss; Dancing with the Starswas! According to the suit, Alleys weight loss is not due to the Organic Liaison Program, but rather, is the result of an above average exercise regimen and extremely low calorie diet, including her time on the television program Dancing with the Starswhere she spent five to seven hours a day exercising as part of the competition.

Well, yeah, most of us suspected that dancing seven hours a day might lead to weight loss. Thats called common sense! Does this sound to you like a ploy for money? Leave your comments below!

Want more? Follow our tweets onTwitterand like us onFacebook!Click here for more information aboutDancing With The Stars. For other great reality TV news, please feel free to check outSirLinksALot: Dancing With the Stars.

Photo Credit: ABC

Topics: ABC Reality TV Shows, Dancing with the Stars |

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