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All About the Mediterranean Diet and Its Benefits – VIVA GLAM MAGAZINE – vivaglammagazine.com

Posted: December 9, 2020 at 4:01 am

For quite some time, the Mediterranean diet has maintained its popularity all over the world. One reason is due to the numerous perks you can get by following this meal plan. But, what are the eating habits involve in this regimen? Aside from that, what are the health benefits of the Mediterranean diet?

Basically, the Mediterranean diet has no specific meal plan because of the cultural differences of the countries in this region. However, this regimen emphasizes the following eating habits:

One of the most well-known health benefits of the Mediterranean diet is its ability to promote a healthy heart. This effect is due to the various food products included in this meal plan.

Take olive oil as an example. This healthy fat is rich in alpha-linolenic acid (ALA), a fatty substance that can help decrease your risk of cardiac death. Moreover, consuming extra-virgin olive oil regularly may also help maintain a healthy blood pressure and cholesterol levels.

Aside from olive oil, the Mediterranean diet includes numerous heart-friendly foods such as nuts, veggies, and whole grains. Despite its alcohol contents, red wine is another excellent product for your heart, especially if consumed in moderation.

In addition to a strong heart, the Mediterranean diet also promotes a healthy skin. This benefit is primarily due to the various anti-inflammatory foods in this regimen.

As you know, inflammation can cause various skin problems such as acne, eczema, and dermatitis. But, thats not all. Inflammation may also release enzymes that can break down collagen and elastin, resulting in premature aging. Because of these negative effects, the highly recommended diet hacks for radiant skin is to consume healthy fats and avoid refined products- eating habits encouraged in the Mediterranean diet.

Another great perk in this list of health benefits of the Mediterranean diet is preventing diabetes. As you know, a lot of people are at risk of developing diabetes because of our fondness for simple carbohydrates like pasta, white bread, and sugary products. Fortunately, you can do various healthy lifestyle choices like regular exercise to prevent or manage diabetes. Another good option is to try the Mediterranean diet.

Although most people living in the Mediterranean region frequently eat small portions of pasta and bread, most of them have an active lifestyle, which can prevent insulin resistance. Furthermore, most plant-based products specifically whole grains are rich in fiber, a substance that can help balance your blood sugar levels. Lastly, the healthy fats and anti-inflammatory foods in this diet plan can also help prevent or manage diabetes.

Aside from antioxidants, healthy fats are also essential nutrients for optimum brain health. For this reason, health experts recommend including foods rich in omega-3 fatty acids to your daily meals. Thankfully, the Mediterranean diet is rich in these kinds of products. If you prefer a plant-based diet, the best sources of beneficial fats are nuts, seeds, legumes, and olive oil.

An added benefit is that most of the products in this regimen can uplift your mood and energy due to the various essential nutrients such as magnesium, iron, and vitamin B.

Aside from those mentioned health benefits of the Mediterranean diet, this meal plan can also help you achieve or maintain your ideal weight.

As you know, most weight loss programs recommend eating more plant-based foods, avoiding products with empty calories (highly processed products), and exercising regularly . common practices in the Mediterranean lifestyle. But, theres more. Various substances included in this regimen can also increase your satiety and reduce food cravings such as the healthy fats in olive oil, proteins in legumes, and fiber in whole grains. By including these foods in your diet, you can lower your total calorie intake without feeling tired all the time.

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All About the Mediterranean Diet and Its Benefits - VIVA GLAM MAGAZINE - vivaglammagazine.com

Dietary phytase reduces broiler woody breast severity – Poultry World

Posted: December 9, 2020 at 4:01 am

The inclusion of phytase enzymes in the feed can have a positive effect on wooden breast development.

Potential modulation of breast muscle fatty acid profiles reduces the severity of the myopathy which often leads to meat condemnation. In 2014, the first publications appeared which described woody breast, a condition of broiler breast muscle characterised by visually hard, outwardly bulging and pale areas on the ventral surface of the pectoralis major muscle. Woody breast is now one of the most important myopathies challenging the poultry industry. It is of global concern, with incidences reported to affect 30-50% of broilers growing for 8 weeks to a live body weight of over 4.2kg. The myopathy constitutes a major animal health, welfare and economic concern causing enormous financial losses to the industry due to on-farm culling and mortality, downgrading, and condemnation at processing, as well as rejection from human consumption.

Wooden breast syndrome is of global concern with incidences reported to affect 30-50% of broilers growing for 8 weeks to a live body weight of over 4.2 kg. Photo: Hans Prinsen

The aetiology of the myopathy is still unknown, however, histological evidence of the haemorrhagic lesions indicates multifocal degeneration and necrosis of muscle tissue with infiltration of inflammatory cells, connective tissues and fat. Evidence is provided in the literature that woody breast myopathy is associated with systemic and local breast muscle hypoxia. Dietary supplementation with phytase reduced its severity. Dietary phytase enzyme is accepted in practice for the intestinal degradation of plant phytate and improvement of phosphorus digestibility and feed efficiency, but has also been shown to modulate oxygen-homeostasis-related pathways. Hypoxic conditions have been reported to limit the regenerative capacity of muscle fibres by favouring the replacement of degenerated muscle fibres with lipid and fibrotic tissues.

It has been suggested that woody breast is associated with lipid dysmetabolism, The present study was undertaken to determine the effect of dietary phytase on woody breast and breast muscle fatty acid profiles. The experiments involved male broilers subjected to 6 treatments, including 3 levels of dietary phytase supplementation (500, 1000, 2000 FTU).

Woody breast and white striping scores were recorded, and fatty acid profiles were determined using gas liquid chromatography. The fatty acid profile in the breast tissue of woody breast-affected birds had a significantly higher percentage of saturated fatty acids and a lower content of polyunsaturated fatty acids. Dietary phytase in high doses (1000 and 2000 FTU) significantly reduced the percentage of saturated fatty acids and increased that of polyunsaturated fatty acids compared with the control group. As woody breast myopathy seems to be associated with an imbalance of the fatty acid profiles, the supplementation of dietary phytase ameliorates its severity through modulation of saturated fatty acids and polysaturated fatty acid content.

Authors: Reagan Cauble, Elizabeth Greene, Sara Orlowski, Carrie Walk, Mike Bedford, Jason Apple, Michael T. Kidd, and Sami Dridi, Poultry Science

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Dietary phytase reduces broiler woody breast severity - Poultry World

This Eating Habit Can Help You Lose a Pound a Week, Say Experts – msnNOW

Posted: December 9, 2020 at 4:00 am

Provided by Eat This, Not That! woman adding pumpkin seeds to a salad bowl vegetables avocado plant based meal

Weight loss can feel overwhelming at times, so it's easier to take it one step at a time. It'll be even easier if your first step is one that can show big resultsfast. And we have the perfect step: a healthy eating habit that can help you drop nearly a pound a week. What's the eating habit, you ask? It's straightforward: eat your daily recommended intake of fiber, or 28 grams per day.

If it doesn't sound like a groundbreaking habit, that's because it shouldn't be! But the issue is that most Americans currently aren't eating enough of the satiating, digestive-health-supporting nutrient. The most recent statistics show that 95% of Americans don't eat enough fiber. (Related: 100 Unhealthiest Foods on the Planet.)

We're not just barely missing our daily recommended fiber intake, we're falling way short of the recommended 28 grams. Adult men consume just 18.4 grams of fiber per day while women consume 15.5 grams, according to the USDA.

This deficiency is exactly why a healthy eating habit of eating your daily recommended intake of fiber will have such a huge benefit for weight loss.

Increasing your fiber intake from 16 to 28 grams of fiber per dayan increase of 75%has been shown to stave off hunger, decrease energy intake, and promote weight loss.

A small study published in the journal ISRN Obesity tracked participants as they increased the fiber in their diets by 12 grams per day to the recommended 28 grams. Over the course of 4 weeks, participants either ate 1.5 cups of beans per day or other high-fiber foods such as fruits, vegetables, and whole grains. Both groups decreased their caloric intake by 250 to 350 calories per day, reported feeling less hungry and more full, and lost between 3 and 3.75 poundsthat's nearly a pound a week!

To put this healthy eating habit into practice, consume at least one high-fiber food (3 grams of fiber or more) at every meal, and you can add 12 grams of fiber to your daily intake. For starters, it'll help if you knew the best high-fiber foods to put on your plate. And for some examples, these are some of our favorite ways to add fiber to your diet:

Remember, you just need to eat an additional 12 grams of fiber per day to reap the weight loss benefits. You can reach that with the chia seeds and hummus alone! For fat burning reinforcements, you can also stock up on The 12 Best Foods That Speed Up Weight Loss.

For more healthy eating news, make sure to sign up for our newsletter!

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This Eating Habit Can Help You Lose a Pound a Week, Say Experts - msnNOW

From acrylic shields to plastic bubbles, how Santa is staying safe in the Chattanooga area – Chattanooga Times Free Press

Posted: December 9, 2020 at 3:58 am

Turns out, COVID bubbles aren't just for professional athletes. When Santa Claus visited kids at the Tractor Swing in Collegedale over the weekend, he was safely ensconced inside a life-size snow globe.

"I knew we were going to need something outside the box," said Traci Bennett-Hobek, parks and recreation director for the city of Collegedale, which co-sponsored the Christmas-themed salute to farmers. "The bubble solved a lot of problems."

Keeping Santa safe has put many an elf on desperate missions this year. With COVID-19 rates rising and Santa at increased risk of infection thanks to his age and cookie diet, his helpers have scrambled to find ways to keep Santa front and center while safe and secluded for his photo-ops.

In many cases, Santa is hearing wish lists and even posing for photos virtually. Santas at Bass Pro Shop and Northgate and Hamilton Place malls are separated from visitors by clear acrylic shields. At Rock City, they're trying social distancing at an extra-large desk.

It's just one of several changes Rock City has made this year to safeguard guests, employees and its main emissary from the North Pole.

"We do not have live entertainment. We don't have the plethora of elves and other costumed characters. The things that rely on that very close, interpersonal exchange are not things that make sense for us this year from a safety perspective," said Susan Harris, president and CEO of the Lookout Mountain attraction.

Yet, Santa Claus found a way to be present. This year he greets children inside his workshop, "a really big, airy space," Harris said. "And with the volume of children that Santa keeps up with, he needs a really large desk for the naughty and nice lists."

At Bass Pro in East Ridge, general manager Bill Van Kampen said the two Santas that swap out photo duties appreciate having the acrylic shield as a safety measure because it allows this revered tradition to continue. For photos, children are seated in front of Santa, instead of on his lap, and Santa can hear what's on their wish lists.

"It's important, especially for kids," Van Kampen said. "With everything going on, there needs to be a sense of normalcy somewhere."

A spokesman for Cherry Hill Programs, which supplies the Santa setup at Northgate and Hamilton Place, said organizers are strictly adhering to Centers for Disease Control and Prevention guidelines, including the wearing of masks by Santa, staff and guests throughout the visit.

"Children will still be able to have a magical visit with Santa and share their wish list, but the experience will be contactless, and children will not sit on Santa's lap," said Matt Windt, chief marketing officer for the New Jersey-based company.

Mike Anderson, a Santa from LaFayette, Georgia, said he and his wife, Mary (a.k.a. Mrs. Claus), "canceled everything" they had on their schedule this year, including two parades, soon after the pandemic emerged. They have selectively agreed to a couple of events, including appearances for the Tennessee Valley Railroad Museum's Polar Express train rides.

"We stand about 50 feet from the train when it pulls into the North Pole," Anderson said. "We're waving and greeting the kids, but that's as close as we get."

Anderson, 68, said he's dressed as Santa the past 17 years, the last seven professionally, and knows that parents don't let a child's cough or runny nose stand in the way of the prized annual photo.

"It was rare that I went through a season without at least catching a cold," he said.

Anderson said he fears his age and past health issues, including a heart attack, stroke and open-heart surgery, put him at increased risk of coronavirus complications, so he opted for caution this season.

"Most years we've done between 120 and 130 visits," he said. "We're kind of enjoying the slowdown this year."

Gordon Hewes, who portrayed Santa in Collegedale, said this was his first time donning the red suit. He hadn't even considered it until Bennett-Hobek and a colleague approached him in a Dollar Tree store and asked if he'd be willing to climb inside an inflatable snow globe in a Santa suit and pose for photos.

Bennett-Hobek had tried that same conversation starter with a couple of other candidates and gotten nowhere.

"My regular Santa was unavailable, and I'd already asked two other men," she said. "At this point, I was getting desperate. I turned a corner to go down this aisle, and there he was. He looked like Santa."

Hewes, 70, said he had about three months to grow his beard longer, and the Parks and Recreation Department supplied the suit. There was a settee where he could sit, scoop up snow and interact with kids on the other side of the plastic bubble.

"The blower that kept the plastic up was fairly loud, so it was hard to talk to them," he said. "That's why I got into 'Give me five.' I knew they'd understand that."

Email Lisa Denton at ldenton@timefreepress.com.

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From acrylic shields to plastic bubbles, how Santa is staying safe in the Chattanooga area - Chattanooga Times Free Press

All school exams in Scotland cancelled next year – BreakingNews.ie

Posted: December 9, 2020 at 3:58 am

All exams in Scotland have been cancelled because of the disproportionate impact of coronavirus on pupils, the country's Education Secretary John Swinney has announced.

Mr Swinney told the Scottish Parliament on Tuesday that Higher and Advanced Higher exams are being cancelled for the second year in a row after an earlier decision to scrap tests at National 5.

He explained the level of disruption to learners has not been equal, with pupils from poorer backgrounds more likely to miss school to self-isolate.

Mr Swinney said: I will not stake the future of our Higher pupils whether they get a place at college, university, training or work on a lottery of whether their school was hit by Covid.

Exams cannot account for differential loss of learning and could lead to unfair results for our poorest pupils.

This could lead to pupils futures being blighted through no fault of their own. That is simply not fair.

The question is less whether we can hold the exams safely in the spring and more whether we can do so fairly

He added: While we hope that public health will improve in the coming months, we cannot guarantee that there will be no further disruption to pupils learning.

In light of this, the question is less whether we can hold the exams safely in the spring and more whether we can do so fairly.

However, there is no getting around the fact that a significant percentage of our poorest pupils have lost significantly more teaching time than other pupils.

Changing the exams for all does not and cannot address that. Instead, we need a model that is more flexible to the specific circumstances of the individual pupil.

Mr Swinney previously announced the National 5 exam diet, which was due to take place in the spring of 2021, was being cancelled as a result of Covid-19, with grades to be decided by teacher judgment supported by assessment.

No algorithm will be used to adjust results after the backlash at this years moderation process that disproportionately downgraded pupils from poorer backgrounds, Mr Swinney said.

He added: We will adopt the new model that has been developed and base awards on teacher judgement of evidence of learner attainment.

This is safe. It is fair. And it better recognises the reality of the disruption so many pupils have already had to their learning.

The decision follows a similar move by the Welsh Government to cancel its exam diet for 2021 in November. The UK Government has confirmed exams in England will go ahead in May.

Scottish Conservative education spokesman Jamie Greene criticised the governments months of dither and delay before making the announcement, which he described as an admission of complete failure .

Scottish Labours education spokesman Iain Gray said: These decisions make sense, but yet again, they are made very, very late."

World

Coronavirus restrictions to be eased for majority...

Scottish Green MSP Ross Greer said the announcement is overdue but welcome, adding: It provides the clarity that teachers, parents and, most importantly, pupils had demanded."

EIS teaching union general secretary Larry Flanagan, said: The EIS has every confidence in the ability of teachers to make professional judgments based on pupil evidence and in the circumstances believes that cancelling the exam diet in favour of an alternative model is the correct decision, one which could have been made earlier."

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All school exams in Scotland cancelled next year - BreakingNews.ie

Weight loss story: The diet I followed to lose 30 kilos and also fight type-1 diabetes! – Times of India

Posted: December 9, 2020 at 3:57 am

My breakfast: I have a slice of brown bread, with a piece of paneer and tea. Later, if I have a smoothie which contains flax seeds, some fruit in half a glass of milk.

My lunch: Chapatis made out of overnight soaked lentils (2) with any sabzi made at home and a bowl of curd.

In the evening, I have a banana or black tea.

My dinner: Before dozing off, I drink a glass of turmeric milk and half a spoon of homemade peanut butter!

Pre-workout meal: Black coffee

Post- workout meal: I have started supplementing with whey protein now, but never had anything special during my transformation.

I am never once cheated on my diet. In fact! I carry my own lunch box whenever I go out, even if I am going to attend a marriage function.

My workout: I workout for six days a week, spending 1.5 hours in the gym (focussing on abs training) and go for a 5km run every alternate day.

Low-calorie recipes I swear by: Nothing in specific. Everything can be eaten, as long as you follow the rule of moderation.

Fitness secrets I unveiled: Dinners should be kept as light as possible and portion control should be strictly practiced, no matter how tempting the food looks!

It is important to determine a balanced diet for yourself which fulfils all your requirements of protein, fibre, vitamins, essential fats and carbohydrates.

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Weight loss story: The diet I followed to lose 30 kilos and also fight type-1 diabetes! - Times of India

Holy weight-loss, the Wyze Scale is an amazing deal at $19.54 shipped – CNET

Posted: December 9, 2020 at 3:57 am

For just $25, the Wyze Scale measures not only weight, but also body fat, BMI, heart rate and more.

Friends, let us not be ruled by the bathroom scale. Must we define our self-worth by a number at our feet? Are we to let our days be ruined upon discovering we've gained a pound? Nay, I tell you. Nay! Cast your scales into the river and look upon them no more.

Wait a sec... scale deal! The Wyze Scale normally sells for $20, plus $9 for shipping -- or $29 shipped if you buy it from Amazon. For a limited time, however, you can get the Wyze Scale for $19.54 shipped. Sure, that's only about a $9 savings, but when a product is this affordable to begin with, a discount is a discount. Plus, it's the lowest price on record.

Subscribe to CNET's Cheapskate newsletter and save on everything from phones to gadgets and more.

Wyze is the company behind a growing catalog of crazy-inexpensive smart home products, including the$20 CNET-favorite Wyze Cam, $7 Wyze Bulb and$100 Wyze Lock.

Like many of its smart ilk, the Wyze Scale pairs with your phone so you can track various metrics: weight, of course, but also things like body-fat percentage, muscle mass, metabolic age and half a dozen others. It even measures heart rate. All this happens courtesy of electrical signals sent through your feet. Thankfully, it has weight-only safety modes for pregnant women and people with pacemakers.

Read more:The best smart scales for 2020

What impressed me most about the scale is the design: It's really pretty, looking like something that could easily cost $100, and it has heft. (You can't begrudge Wyze charging a shipping fee for this.) I also like that it supports up to eight users, though that means each person in your family needs a phone, the Wyze app and a Wyze account.

It can integrate with Apple Health and Google Fit now; Fitbit and Samsung Health support are in the works (and have been since the product launched in May, so it's anybody's guess when that will actually happen).

The only real downside I can see is the IPX3 waterproof rating, meaning you shouldn't step out of the shower and directly onto it. Anything more than a small splash could be trouble.

But for $20 out the door? When some smart scales sell for as much as $100 to $150? Heck, you'd be hard-pressed to find a "dumb" scale this cheap.

First published earlier this year. Updated to reflect new pricing.

CNET's Cheapskate scours the web for great deals on tech products and much more. For the latest deals and updates, follow the Cheapskateon FacebookandTwitter. Find more great buys on theCNET Deals pageand check out ourCNET Coupons pagefor the latest promo codes fromBest Buy,Walmart,Amazonandmore. Questions about the Cheapskate blog? Find the answers on our FAQ page.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

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Holy weight-loss, the Wyze Scale is an amazing deal at $19.54 shipped - CNET

Weight Loss: All The Reasons Why You Should Be Eating Eggs In Winter – NDTV

Posted: December 9, 2020 at 3:57 am

Eggs can help in boosting your immunity

Eggs are an excellent source of protein, a nutrient you need for losing weight and building muscles. According to nutritionist Divya Sobti says that eggs must be a part of your diet in winter, as it helps in building your immunity. Speaking of the nutrition profile of eggs, well they're a complete powerhouse! One egg can provide you with 7 gms of good quality protein and 5 gms of good fat. It is also provides iron, carotenoids, Vitamin A, folate, Vitamin B5, Vitamin B12, phosphorus, selenium and traces of Vitamin D, E, K, B6, calcium and zinc.

According to Sobti, we should be eating eggs in winter as they help in keeping us warm. Eggs contain good fats which support cell growth, protect organs and help in keeping the body warm. Here are other reasons to eat them regularly in the chilly winter months:

Eggs are known to contain zinc, a mineral which can help in fighting common winter diseases like cold or flu.

Also read:Try This Quick And Easy Eggs And Avocado Keto Breakfast For Quick Weight Loss

Eggs are amongst the rare food source of Vitamin D or the sunshine vitamin. Vitamin D is known to play an important role in building immunity. A strong immunity can protect the body from infections and diseases and improve body's ability to fight them as well.

You can eat eggs every dayPhoto Credit: iStock

Both these vitamins play a role in further strengthening the immune system.

Also read:Beetroot Health Benefits: Here's How This Root Vegetable Can Help Boost Immunity

Eggs are a weight loss friendly food. They are versatile in nature, in the sense that they are cheap and easily available. Not just in winter, but you can eat eggs throughout the year as they are available throughout the year. What's more, there are several ways to eat eggs. You can boil them or make an omelette, scrambled eggs and sunny side up to name a few.

Eggs are the ideal food on a keto diet. And no, you don't need to separate out the yolks and eat just the whites. Eat the whole egg to get complete and wholesome nutrition.

Also read:Weight Loss: Is Eating Roti Better Than Eating Rice For Losing Weight?

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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Weight Loss: All The Reasons Why You Should Be Eating Eggs In Winter - NDTV

Weight loss: Reset these hormones to lose stubborn belly fat – TheHealthSite

Posted: December 9, 2020 at 3:57 am

From exercise to eating healthy food, you have been doing everything right, but youre still not losing weight. So, whats going on? As it turns out, weight gain or loss isnt limited to eating and exercising. There are several reasons behind that expanding waistline, and you could be affected by any one of these. Case in point your hormones. Also Read - Your stubborn belly fat isn't going away? Try these workouts and lifestyle changes

Your hormones play a pivotal role in maintaining your weight. It influences your appetite, the fat your body stores in it and much more. It can be gruelling to lose weight if your hormones are out of whack. To help you understand and control the outcome, it is important to manage these 5 hormones. Also Read - Age is no barrier when it comes to weight loss

Insulin is a hormone produced by the pancreas, which helps regulate blood sugar. When there is an imbalance, it could lead to insulin resistance. What this means is that your body is unable to process insulin, which can make it more difficult for you to lose weight. You can manage insulin levels by avoiding added sugar, cut back on carbohydrates, eat a rich a diet rich in protein, healthy fats, and exercise. Also Read - Vitamin A induces weight loss in cold conditions: Know how

Cortisol is the stress hormone that controls your mood, motivation and fear. This hormone is also linked with insulin, the hormone that controls your blood sugar levels. An increase in your cortisol levels can lead to insulin resistance, which can cause weight gain. High cortisol levels can make your body store visceral fat around your abdominal area. So, try not to stress, sleep well and meditate!

Ghrelin, also known as hunger hormone, which is produced by the enteroendocrine cells of the gastrointestinal tract. It gets triggered when you are hungry. Blood levels of ghrelin are highest before meals and go back to normal after mealtime. Studies have shown that ghrelin levels are often lower in obese and overweight people. This means that your brain might not receive a signal to stop eating, which can lead to overeating. This could sabotage your weight loss plans.

Known as the satiety hormone, leptin is produced by your fat cells. It tells your brain that you have enough stored fat in the body, which regulates your appetite and helps prevent overeating. An imbalance in this hormone sends the wrong signal to the brain, which pushes you to eat more. Elevated insulin levels and inflammation in the hypothalamus are two of the common causes of leptin resistance.

The female hormone, estrogen also plays an important role in weight loss. Having too much or too less of estrogen can lead to weight gain. Estrogen, along with other hormones, helps you respond to different foods. In other words, the lack of estrogen can cause the body to use blood sugar and starches less effectively, which could make it harder for you to lose weight.

Published : December 9, 2020 1:21 pm | Updated:December 9, 2020 1:26 pm

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Weight loss: Reset these hormones to lose stubborn belly fat - TheHealthSite

Innovative Peptide Study Evaluates Reduction in Liver Fat and Increased Weight Loss – Precision Vaccinations

Posted: December 9, 2020 at 3:57 am

Maryland (Precision Vaccinations)

A clinical-stage biopharmaceutical company announced that it has commenced dosing in a Phase 1 single ascending dose (SAD) and multiple ascending dose (MAD) clinical study of ALT-801.

Altimmune, Inc. stated in a press release that ALT-801 is a long-acting GLP-1/glucagon receptor dual agonist being developed for the treatment of non-alcoholic steatohepatitis (NASH), which is expected to affect more than 13 million adults in the USA.

Altimmune believes the treatment of obesity is the cornerstone of treating NASH and the principal morbidities of NASH, added this press statement.

The Phase 1 clinical trial is designed to evaluate the safety, pharmacokinetics, and activity of ALT-801 over 6-weeks of treatment in overweight and obese but otherwise normal volunteers, located in Australia.

Readouts from the trial, including initial weight loss and liver fat reduction, are expected in the second quarter of 2021.

This 6-week study will be followed by a 12-week Phase 1b study in volunteers with non-alcoholic fatty liver disease (NAFLD) and is expected to commence in the third quarter of 2021.

There is a significant need for an effective, well-tolerated treatment for NASH, commented Scott Harris, M.D., Chief Medical Officer of Altimmune. Unlike other metabolic approaches to treat NASH, ALT-801 combines the balanced, equipotent effects of GLP-1 and glucagon activities into a single peptide.

The approach is expected to provide optimal effects in activating both a satiety signal to reduce appetite while also stimulating energy expenditure to promote a reduction in liver fat and increased weight loss.

The Company anticipates that ALT-801, administered once-weekly, will have a favorable pharmacokinetic profile and improved gastrointestinal (GI) tolerability due to the proprietary EuPort domain, which slows the entry of the drug into the circulation.

As GI intolerability is a significant limiting factor with all current GLP-1 based treatments, and improved tolerability profile is expected to be regarded favorably among clinicians. We look forward to a readout from the study in the second quarter of 2021, which could support strong competitive positioning for ALT-801 in the NASH treatment landscape.

ALT-801 is a novel peptide-based dual GLP-1/glucagon receptor agonist that is designed to treat the obesity and metabolic dysfunction that causes NASH. As the most severe form of non-alcoholic fatty liver disease, or NAFLD, NASH involves multiple metabolic pathways leading to the abnormal accumulation of liver fat, toxic lipid metabolites, and inflammation, resulting ultimately in fibrosis (cirrhosis) or liver cancer.

As observed in a well-established preclinical model of the disease, ALT-801 was capable of inducing significantly greater weight loss compared to semaglutide, a GLP-1 receptor agonist, along with significantly greater decreases in liver fat, plasma ALT, and other markers of NASH.

Altimmune is a clinical-stage biopharmaceutical company focused on developing intranasal vaccines, immune-modulating therapies, and treatments for liver disease.

PrecisionVaccinations publishes research-based news.

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Innovative Peptide Study Evaluates Reduction in Liver Fat and Increased Weight Loss - Precision Vaccinations


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