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Slimmer tried unusual weight loss method and lost 1.5st in four months – what she did – Express

Posted: October 4, 2022 at 2:05 am

As people grow older, losing weight can become more tricky. And for one slimmer, she found losing her baby weight was near enough impossible after having children later in life.

Maxine Booth, an Enfiled-based lymphatic drainage therapist and model, gave birth to her firstborn when she was 36 years old and welcomed her second when she was 41.

But she struggled to shift the post-baby weight, admitting she found it "very difficult", especially as she was also going through a rough time in her marriage.

According to Baby Centre, six months after giving birth some women retain an average of 11.8lb, meaning that they weigh almost 12lb more than they did before they were pregnant.

With life getting in the way, Maxine's diet and exercise routine went out the window, and she found she wasn't shifting the pounds by sticking to a plan.

READ MORE:Diet: Expert warns against common mistake

The technique can significantly reduce stubborn body fat and cellulite and help with muscle recovery, and Maxine found it worked wonders for her.

"After our interview, I decided to join her studio to see whether I could get some similar results," she said.

"I was amazed! I started losing weight and I had better skin and a lot more energy."

And it wasn't long before others began to notice a difference in Maxine as well.

"I had many people compliment me to the extent that I decided to open my own studio and help other women in my position and this is what I still enjoy doing today," she beamed.

And not only did she shed weight quickly and easily, but she maintained it too, something that was incredibly important to her after spending years being unhappy with how she looked.

She added: "In the end, I lost a whopping 1.5st in four months!

"After being the same weight for years, I have maintained that weight ever since."

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Slimmer tried unusual weight loss method and lost 1.5st in four months - what she did - Express

Here’s How to Lose Belly Fat After 50, Say Physicians Eat This Not That – Eat This, Not That

Posted: October 4, 2022 at 2:05 am

Getting older has its advantages, but one downside of hitting 50 is it becomes more challenging to lose weight, but it's not impossible. With a few positive lifestyle changes, you can lose that stubborn belly fat that's a health concern because it can lead to other serious issues like heart disease, stroke and premature death. So while it may be more difficult, don't get discouraged. Eat This, Not That! Health spoke with experts who reveal how to eliminate abdominal fat and help keep it off. Read onand to ensure your health and the health of others, don't miss these Sure Signs You've Already Had COVID.

Dr. Suzanna Wong. a licensed Doctor of Chiropractic and health expert with Twin Waves Wellness says, "It is harder to lose weight after 50 because your body has different requirements. It's most notable for women who are going through the menopause, but not impossible. Their body deals with carbs differently, and the loss in estrogen means their muscles break down much quicker unless they are doing resistance exercise and eating a higher protein diet. With less muscle your metabolism falls meaning it seems harder to lose weight."

Robert Herbst a personal trainer, weight loss and wellness expert, and powerlifter adds, "One of the reasons it is harder to lose weight after 50 is age related loss of muscle. As people get older, they start to lose muscle. Since muscle is metabolically active, the less they have the slower a person's metabolism and the fewer calories they burn. Also, with less muscle, people generally become less active so they burn even fewer calories. As they gain more weight they become even less active and the situation compounds. The solution for this is to do strength training. By lifting weights one prevents or reverses age related muscle loss so your general metabolism will be higher. Also, after a weight workout the body's metabolism is elevated for 48 to 72 hours afterwards as the body recuperates. Additionally, as one builds more muscle through weight training, they will feel better and be stronger and are more likely to be active and engage in sports and recreational pursuits and do chores. All this adds up to more calories burned and easier weight loss."

Dr. Wong says, "Count calories. Make sure you are in a calorie deficit and belly fat will start to fall."

Pam Sherman, a certified personal trainer with The Perfect Balance recommends "creating a small calorie deficit for overall weight loss. This is the best way to lose weight by being accountable for what a person is eating/drinking."

Dr. Wong suggests, "Drink enough water. For women 2-3 liters a day, for men 4 liters a day. This helps your body to work effectively and reduces your cortisol levels, helping you to drop body fat from your tummy."6254a4d1642c605c54bf1cab17d50f1e

Caroline Grainger, ISSA Certified Personal Trainer at FitnessTrainer.reminds us, "Belly fat is stubborn. You're not going to zap it with a quick diet or one neat trick. It's going to take sustained intentional eating that you can stick to in order to really succeed. Your ultimate goal comes down to creating a calorie deficit."

RELATED: Signs You're Being Medically Gaslit

Grainger states, "Good cardio workouts like walking, jogging, biking, swimming, and racket sports, are the best ways to burn calories quickly, and they're also the lowest-impact forms of exercise on your body, meaning you'll be able to keep up the habit."

Sherman emphasizes, "Get enough sleep! When our brains are tired, we crave sugar. Getting regular sleep can make it so much easier to keep your food on track!"

RELATED: Doing This After Age 60 is "Unhealthy," Say Physicians

Jesse Nicassio, former NFL player and CEO of Juke Gyms says, "Although fruit juice contains vitamins and minerals, it contains the same sugar as soda and other sweetened beverages. Drinking in high quantities may pose the same danger to belly fat growth. Unsweetened apple juice has 24 grams of sugar in an 8-ounce (240-mL) drink, half of which is fructose. Replace fruit juice with water, unsweetened iced tea, or sparkling with a wedge of lemon or lime to help reduce excess belly fat."

"This not only brings your calories down but more importantly will help to reduce your visceral fat, which is fat stored around your organs and always appears as belly fat," explains Dr. Wong.

Heather Newgen

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Here's How to Lose Belly Fat After 50, Say Physicians Eat This Not That - Eat This, Not That

World Heart Day: Can quick weight loss lead to heart attack? Experts answer – Hindustan Times

Posted: October 4, 2022 at 2:05 am

World Heart Day 2022: Shedding kilos and achieving an ideal weight can help reverse a number of chronic health conditions from high blood pressure, diabetes, high cholesterol to even heart ailments. But rapid weight loss can do the opposite and may worsen the heart function let alone improving it. Weight loss for heart health should be done in a healthy, sustainable and steady manner to reap the maximum benefits of it, According to experts, the wrong methods to attain quick weight loss may work against our heart health. For instance fad diets or low-calorie diets can lead to heart function which may eventually lead to heart attack. Excessive exercise to lose kilos is also deterimental to heart health and it is increasingly becoming common for people to suffer heart attack in gyms. (Also read: World Heart Day 2022: Can screaming, losing temper trigger a heart attack? Experts answer)

"Low-calorie diets or crash or the starvation' diet for a rapid weight loss are becoming very popular these days, There is enough evidence that weight loss in overweight or obese person can reverse the effects of high blood pressure, diabetes, and high cholesterol on heart, with almost half of the patients being able to stop or reduce the medications. But the effects of crash diets or rapid weight loss on the heart have not been studied very well so far," says Dr Sanjeev Gera Director & HOD, Cardiology, Fortis Hospital Noida.

Dr Gera explains how a low-calorie diet could lead to heart enlargement and subsequent heart failure.

"The heart muscle prefers fats or sugar as its fuel for effective functioning. It takes up all the fats released into the blood circulation from adipose tissues or organs following a very low-calorie diet. So, rather than improving heart function, it worsens because of more fat than muscle with fewer blood vessels. That can lead to heart enlargement and subsequent heart failure when the heart becomes too weak and unable to meet the requirements of other organs, compromising its functions ultimately.

The sudden drop in heart function rate can lead to fatal heart rate and rhythm problems or arrhythmias, sometimes leading to sudden collapse and even a cardiac arrest. It can also cause low blood pressure due to dehydration and electrolyte loss, further compromising organ functions. Sudden malnutrition can also affect heart wellness," says Dr Gera.

People also take to excessive gymming to lose weight quickly in a short span of time. If you are not used to such routine, your heart function can be affected and this may lead to a heart attack.

"It is very common that people suffer heart attacks while exercising, in the gym or outdoor. While exercise keeps your body in good shape, and also cardiovascular condition, if youre not accustomed to a difficult routine and you try to do too much too soon, it may disrupt the way your heart pumps blood and oxygen through your system. More people die because of Cardiac arrhythmia. The term "arrhythmia" refers to any change from the normal sequence of electrical impulses. The electrical impulses may happen too fast, too slowly, or erraticallycausing the heart to beat too fast, too slowly, or erratically. This causes ineffective blood pumping leading to less blood supply to other vital organs. Always keep checking regularly with a cardiologist before starting or doing any exercise," says Dr. (Mr) Kiran Rukadikar, Bariatric Physician and Obesity Consultant, and founder of DietQueen App.

"Losing weight is a slow and conscience process. Rapid weight loss is not good for your heart. It can cause dehydration, low blood pressure, electrolyte imbalance which can further cause arrhythmia, exacerbate heart failure and even cause sudden cardiac arrest in some," says Dr. Aditya Kumar Singh, Sr Consultant & HOD, Adult Cardiac Surgery at Marengo QRG Hospital, Faridabad.

Losing weight too fast is putting yourself at risk. Crash diets can lead to irregular heart rate (abnormal electrical activity of heart), fluctuation in heart rate and blood pressure. By missing important nutrients in diet may increase the risk of heart failure. Rapid weight loss can lead to severe dehydration triggering blood clot formation in susceptible individual. This can lead to heart attacks and blood clot formation in great arteries of heart, says Dr. Vikrant Khese, Consultant Cardiologist, Apollo Clinic.

Dr Gera says weight loss should be gradual with the aim of losing around 500 gm every week but with proper care of fluid and nutrient intake.

"Before adopting a very low-calorie diet, one should consult a cardiologist for a safe diet and exercise prescription and also diagnose pre-existing silent heart ailments. Losing extra kilos is always a good idea for heart health but starvation may lead to serious and irreversible heart issues," says Dr Gera.

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World Heart Day: Can quick weight loss lead to heart attack? Experts answer - Hindustan Times

Want To Eat Carbs Without Gaining Weight? Health Experts Say You Should Follow This Rule – SheFinds

Posted: October 4, 2022 at 2:05 am

From pasta to potatoes, some of our favorite foods contain carbohydrates. For many, these foods have a reputation that involves sabotaging weight loss, but experts tell us this isnt necessarily true as there are different types of carbs. We checked in with registered nutritionists, dietitians and other health aficionados for tips regarding eating a balanced diet with fiber-filled carbs and still being able to lose weight healthily. Read on for suggestions and insight from Lisa Richards, registered nutritionist and creator of The Candida Diet and Emilie Rice, MS, RDN, LDN, CSCS, CPT, registered dietitian and health expert.

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An essential tip for a healthy diet with carbs and losing weight, Richards says, is knowing the difference between the types of carbs you consume. "Opposed to popular belief among health and fitness enthusiasts, carbs are not the enemy to weight loss," Richards explains, "In fact, the body requires carbs as its primary source of fuel. It is the quality of carbohydrates and how they are prepared that can make weight loss difficult."

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Carbohydrates are classified into two categories, Richards adds simple and complex. "Simple carbohydrates include carbs from processed and refined foods like convenience snacks," she continues. Richards notes that the simple ones are considered "bad carbs, but also come from milk and some fruits." This form of carbohydrate, she goes on, is "broken down quickly and used immediately by the body for energy."Complex carbohydrates are considered "good and include whole grains like oats and plant-based carbs like quinoa or brown rice are more nutrient-dense," Richards stresses, and "offer the body more than a quick glucose spike and stored fat." The fiber content of whole grains alone will help you reach your weight loss goals, Richards points out.

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The first tip Rice offers when creating a healthy diet for yourself is to select "high-fiber carbohydrates." These, she says, are your fruits, vegetables, and whole grains. "Fiber helps you feel fuller sooner, which can help you consume fewer calories, thus helping you lose weight," she explains. Next, Rice says to snack smart by pairing carbohydrates with protein. "Think of a half banana with 1 tablespoon of almond butter, or 1/3c peaches with 1/2 c cottage cheese." The fruit, she suggests, provides fiber and high-quality carbohydrates, "satisfying your carb craving while the protein (almond butter and cottage cheese in these two examples) helps to slow the release of carbs into your bloodstream and help you feel full longer from your snack."

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Lastly, Rice recommends asking yourself if your eyes are bigger than your stomach when preparing meals or snacks for yourself. "Use your fist to monitor portion sizes, this way you can satisfy your carb craving and consume them in moderation," she offers. Rice concludes that chewing slowly can also help you on your weight loss journey. "Chew slowlya lot of us eat mindlessly or rush through eating. By slowing down, thoroughly chewing your food, and eating mindfully, you give your brain time to communicate with your stomach to recognize when it's truly full." This, Rice notes, can "reduce your chances of eating too many carbs (and overeating in general)."

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Want To Eat Carbs Without Gaining Weight? Health Experts Say You Should Follow This Rule - SheFinds

healthy oil free snacks that can help you lose weight quickly in hindi – Globe News Insider

Posted: October 4, 2022 at 2:05 am

Oil Free Snacks: If you are health conscious and want to use less cooking oil in your food, you can include these tasty healthy snacks recipes in your diet. These snacks are not only very tasty to eat but also very easy to make. To Ia Bina Deer Kie Jaan Layte Hain Yeh Oil Free Snacks Kya Hain Aur Kaise Bake Jaeta Hain.

green paneer-To make Hariyali Paneer, first add green chillies, green coriander, mint leaves and lemon juice in a mixer and grind them finely. Now add ginger and garlic paste, chaat masala, turmeric powder, black salt and thick curd to a paste and mix well. Mix paneer pieces in this paste and keep it in the fridge for 4-6 hours. After that time, put the marinated paneer in slices and place it on a baking tray and grill it at 180 degrees and serve.

Lemon Pepper Popcorn-To make popcorn in this way, first make the popcorn in the microwave and take it out in a bowl. Now in a separate bowl mix lemon juice, ground black pepper and amchur powder together and add popcorn to it and mix well. Garnish the popcorn with green coriander and serve.

khandvi-To make Khandvi, first add curd and water in a bowl and beat it well. Now in a non-stick pan mix gram flour, thin curd, lemon juice, turmeric powder, ginger and green chili paste and salt to taste and cook for 10 minutes. After this, spread this mixture in an inverted pot with the help of a spoon and roll it when it cools down. Finally, dry roast rye and a pinch of asafoetida and serve on khandvi with grated coconut and green coriander.

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healthy oil free snacks that can help you lose weight quickly in hindi - Globe News Insider

9 Fast-Food Breakfasts To Stay Away From Right Now Eat This Not That – Eat This, Not That

Posted: October 4, 2022 at 2:05 am

In a perfect world, there's always time to start the morning with a healthy breakfast. Yogurt, oatmeal, chia pudding, and a veggie omelet sound perfect, but sometimes you just don't have the time and energy to make a whole meal from scratch or even sit down and eat it.

Many of the top fast-food restaurants across America have found ways to fill this niche and give morning commuters something easy to eat on their way to work. While you shouldn't have a hard time finding a quick bite on the move, not every fast-food breakfast checks off all the nutritional boxes if you want to watch your diet. A ton of menu items pack in fat, carbs, sugar, and salt in order to help make certain items delicious. While these options have found their fair share of fans, these foods also can easily derail any eating plan.

With so many less-than-wholesome fast-food breakfast items on the market, trying to figure out which ones to avoid feels like a nightmare. Luckily, Eat This, Not That! consulted a handful of experts to narrow down the 9 worst menu items you need to cross off your list. If you don't have the time to start your day any other way, make sure you grab one of the 12 Healthy Fast Food Breakfasts Under 360 Calories next time you visit your favorite fast food restaurant in the morning.

PER 1 MUFFIN: 590 calories, 24 g fat (8 g saturated fat), 65 mg cholesterol, 370 mg sodium, 88 g carbs (2 g fiber, 51 g sugar), 7 g protein

"Not all muffins are created equal, and most are just chock full of refined carbohydrates, sugar, and fat," Trista Best, RD at Balance One Supplements, said. "While there are some versions of muffins that can help you in your health goals this is unfortunately not the case for the most popular."

The danger of the Dunkin' Coffee Cake Muffin lies in the massive amount of sugar packed into each pastry, in addition to the huge portion of refined carbs.

"Refined carbs, also known as simple or processed carbs, are grains that have been stripped of their beneficial nutrients like fiber, B vitamins, and iron making them empty calories, Best continued. "They are quickly processed by the body which raises blood glucose and insulin rapidly after meals. These characteristics all lead to a slow metabolism and weight gain. As the body is not obtaining beneficial nutrients from the refined carb muffins, but rather inflammatory and gut damaging nutrients."

If you crave a muffin and need to stick to a healthy eating plan, you can't go wrong making these pastries at home. Opt for 16 Cozy Muffin Recipes That Are Perfect for Weight Loss and discover your new favorite muffin.

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PER 1 BAGEL: 450 calories, 9 g fat (2 g saturated fat), 0 mg cholesterol, 550 mg sodium, 83 g carbs (2 g fiber, 30 g sugar), 9 g protein

The Dunkin' Coffee Cake Muffin can't do your diet any favors, but it isn't the only fast food breakfast offering that loads up on a walloping amount of carbs. Einstein Bros' Apple Cinnamon Bagel ends up looking much closer to a pastry thanks to the massive amount of carbs and sugars the bagel packs in per serving.

"A bagel on its own is just empty carbohydrates with very little fiber," Juliana Tamayo, RD, MS at LDN at FitnessClone.com said. "Most people eat bagels with only cream cheese, which does not add any fiber or protein to your diet. In most cases, bagels are high in carbohydrates and are absorbed quickly, making your satiety short-lived." If you need to watch your daily diet, avoid this very sweet bagel.

PER 1 BISCUIT: 850 calories, 61 g fat (25 g saturated fat, 0.5 g trans fat), 365 mg cholesterol, 2,380 mg sodium, 46 g carbs (0 g fiber, 5 g sugar), 31 g protein

If you need to hit the road and don't have time for a proper breakfast, Carl's Jr. Monster Biscuit sounds tempting, especially if you wake up hungry. While this biscuit sandwich comes with sausage, bacon, cheese, and eggs, it also packs in almost half of a day's worth of calories and a ton of fat in each serving. The salt content of this biscuit sandwich exceeds the FDA recommendation of sodium you should eat each day, while the bacon in this sandwich takes the item to whole new unhealthy levels.

"Regular bacon is a fan favorite, but not necessarily a good breakfast option," Tamayo said. "It is high in sodium, saturated fats, and nitrites. Bacon is going to raise your blood cholesterol levels, while also causing fluid retention due to excess sodium. Nitrites are also known carcinogens present in deli meats and usually used [to] keep products from [spoiling]."

If you need a new breakfast sandwich, don't settle for a calorie-packed biscuit. Instead, reach for 16 Delicious Breakfast Sandwich Recipes You Won't Believe Are Healthy.

PER 10.2-OZ SERVING: 370 calories, g fat (4.5 g saturated fat), 15 mg cholesterol, 170 mg sodium, 65 g carbs (3 g fiber, 45 g sugar), 11 g protein

At first glance, this unassuming yogurt parfait might not seem that bad, especially in comparison to greasy breakfast sandwiches or sugar-packed muffins. Underneath this blueberry yogurt's healthy-looking exterior lurks a ton of sugar that can easily derail your day before it even starts.

"Although yogurt is usually recommended, there are some types you might want to avoid," Tamayo said. "In general, plain flavored yogurt is high in sugar and preservatives and has very little protein. Greek yogurt is the recommended kind because it contains more protein and probiotics. Regular yogurt is high in calories and will often have very little protein. It can cause high blood sugar and will not keep you full [for] long."

Steer clear from this sugar-packed yogurt, even if it sounds like a healthy option

PER 1 STICK: 540 calories, 30 g fat (15 g saturated fat), 30 mg cholesterol, 430 mg sodium, 66 g carbs (1 g fiber, 37 g sugar), 4 g protein

Few breakfast options pack in the sugar and fat like donuts. These calorie bombs have the potential to undo all of your weight loss progress and can leave you feeling sluggish. "[Donuts are] made of highly processed flour, cooked in oil and with added sugar," Blanca Garcia, RDN at Health Canal said. "So sugar on top of sugar on top of fat [is] just carbs and fat."

While single donuts on their own easily rank as one of the most unhealthy breakfast offerings out there, they aren't all created equal. Dunkin's Glazed Jelly Stick ranks as one of the worst out there, thanks to each item containing a whopping 66 grams of carbs, almost half of a day's worth of fat, and over half of a day's worth of sugar.

Donuts in general won't do your diet any good. In addition to ditching this Glazed Jelly Stick, make sure to avoid The Worst Fast-Food Donuts in America.

PER 1 SMOOTHIE WITH PEANUT BUTTER: 770 calories, 26 g fat (5 g saturated fat), 0 mg cholesterol, 150 mg sodium, 130 g carbs (15 g fiber, 95 g sugar), 14 g protein

On paper, a breakfast smoothie looks irresistibly healthy. After all, these drinks come loaded with fruit and other nutrients, making them seem like the perfect way to quickly drink your breakfast and get all the nutrition you need to start your day.6254a4d1642c605c54bf1cab17d50f1e

Unfortunately, many breakfast smoothies also come loaded with calories, fat, and sugar, and Tropical Smoothie Cafe takes the cake with their signature Chia Banana Boost with Peanut Butter. This morning smoothie finds a way to deliver almost half of a day's worth of calories in one serving, while easily loading you up on sugar before you even get to lunch. If you need a healthy breakfast smoothie, stay far away from this offering.

RELATED:5 Low-Sugar Smoothies for Rapid Weight Loss

PER 1 ORDER: 760 calories, 48 g fat (18 g saturated fat), 485 mg cholesterol, 1,530 mg sodium, 57 g carbs (3 g fiber, 3 g sugar), 26 g protein

"In general, the worst thing you can buy are the ultra-deluxe or premium-style breakfasts," Garcia said.

"For breakfast, the general rule is to eat well and heartily," Garcia continues. "The problem with these foods is that they are very high in fat, and the portions are too large. At home, you have more control over the fat and salt that is added to your meals, but not so much at fast food chains." The McDonald's Big Breakfast takes the cake when it comes to loading you up with poor nutrition in the morning. The item features about half of your day's worth of salt in one serving and doubles down with a ton of fat.

Certain McDonald's breakfast offerings prove better for your health than others. If you can't stand the idea of completely abandoning McDonald's in the morning but still want to eat healthy, make sure you select an item from McDonald's Entire Breakfast MenuRanked For Nutrition!

PER 5-PIECE ORDER: 500 calories, 19 g fat (3.5 g saturated fat), 0 mg cholesterol, 620 mg sodium, 74 g carbs (3 g fiber, 13 g sugar), 19 g protein

Whipping up a healthy French toast at home doesn't have to be impossible, but all bets are off when you grab French toast-themed items at fast-food restaurants.

"French toast typically [has] high amounts of sugar due to the syrups and toppings on [it]," Jesse Feder, RDN, CPT at My Crohn's and Colitis Team says. "Additionally [French toast does] not provide much in regards to nutritional value. [It is] usually made with highly processed ingredients that can spike your blood sugar and cause weight gain."

Carl's Jr. offers up one of the most unhealthy fast food breakfast options out there thanks to their French Toast Dips that come loaded with carbs and fat. While these French toast sticks offer up a quick bite in the morning, steer clear of these if you need to eat healthy.

PER 1 CRUNCHWRAP: 730 calories, 47 g fat (15 g saturated fat), 140 mg cholesterol, 1,290 mg sodium, 52 g carbs (4 g fiber, 3 g sugar), 20 g protein

Taco Bell struck gold when they put the Crunchwrap Supreme on its menu. Thanks to the item's popularity, it continued to evolve and Taco Bell even found a way to add it to their breakfast menu. While the Crunchwrap continues to win over morning commuters, it also finds a way to put a major dent in diets thanks to its massive fat, salt, and carb content. While the item comes loaded with cheese and sausage, the inclusion of fried potatoes doesn't make this item any healthier. "Fried potatoes [] have high amounts of fats, more specifically saturated fats, which can clog your arteries," Feder explains.

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9 Fast-Food Breakfasts To Stay Away From Right Now Eat This Not That - Eat This, Not That

CORRECTION — Marius Pharmaceuticals Receives FDA Approval of KYZATREX, an Oral Testosterone Replacement Therapy – GlobeNewswire

Posted: September 26, 2022 at 2:12 am

RALEIGH, N.C., Sept. 21, 2022 (GLOBE NEWSWIRE) -- In a release issued under the same headline on August 2, 2022 by Marius Pharmaceuticals, please note that the correct number for reporting side effects ofKYZATREX to Marius is 1-833-949-5040. The corrected release follows:

Marius Pharmaceuticals, a patient-centric healthcare company, today announced the approval of KYZATREX (testosterone undecanoate) by the U.S. Food and Drug Administration (FDA). KYZATREX is an oral testosterone replacement therapy ("TRT") indicated in adult males for conditions associated with a deficiency or absence of endogenous testosterone, also known as hypogonadism. The approval of KYZATREX provides an important option in treating hypogonadism or more commonly known as, Testosterone Deficiency, which affects approximately 40% of men older than 45 years of age and 30-50% of men with obesity or type 2 diabetes have hypogonadism1. KYZATREX has been approved in three dosage strengths, 100mg, 150mg, and 200mg.

I would like to congratulate our scientific team on this major milestone, and now it is up to our commercial team to make KYZATREX a leading therapy and a go-to brand for millions of hypogonadal men in the U.S. Low Testosterone affects numerous metabolic factors as well as often overlooked, true quality of life, hence annual testosterone testing should be mandatory for men over age 40, remarked Himanshu H. Shah, Chairman of Marius.

KYZATREX is a proprietary oral softgel capsule that is absorbed primarily via the lymphatic system, avoiding liver toxicity. The oral delivery method eliminates the risk of application site reactions common with intramuscular testosterone injections as well as potential transference to women or children that can occur with topical testosterone gels and creams. With daily dosing in the morning and evening (with food), KYZATREX more closely mimics the daily rhythm of natural testosterone production compared to long-acting therapies.

With so many men suffering daily effects of Testosterone Deficiency and often abandoning or not electing to get treatment, we see FDA-approved KYZATREX as a newly viable oral option that has demonstrated safety and effectiveness. Further, Testosterone Deficiency is a big blind spot in medicine today and our research will continue to explore the importance of testosterone in both male and female health, commented Shalin Shah, CEO of Marius.

KYZATREX has the potential to become the new gold standard of care for treating patients with hypogonadism. There are at least six million symptomatic men suffering from hypogonadism in the U.S., and over 100 million men globally.

Please see additional Important Safety Information for KYZATREX below.

1 Endocrine Society

About Testosterone and Hypogonadism

Hypogonadism, often referred to as Testosterone Deficiency, is a condition that occurs when the body does not produce adequate levels of testosterone. Primary hypogonadism (testicular failure due to certain conditions) and hypogonadotropic hypogonadism both result in low serum testosterone concentrations. In addition to testosterones widely accepted role in sexual and reproductive function, it also has important roles in numerous other metabolic and inflammatory process and is one of the most common causes of secondary osteoporosis in men. Patients with hypogonadism may experience fatigue, low energy, decreased muscle mass, weight gain, low libido, poor cognition, difficulty sleeping, and other mood disorders, such as depression and anxiety. Because low levels of testosterone can also increase the risk of developing type 2 diabetes and obesity, hypogonadism is a common comorbidity in a broader set of conditions, including type 2 diabetes and Non-Alcoholic Steatohepatitis (NASH).

About KYZATREX

KYZATREX is a proprietary softgel oral formulation absorbed primarily via the lymphatic system (meaning it is not toxic to the liver) indicated in adult males for conditions associated with a deficiency or absence of endogenous testosterone. The safety and efficacy of KYZATREX was demonstrated in a phase 3, multi-center, open-label, six-month study in 155 hypogonadal males between 18 and 65 years of age with documented hypogonadism, as defined by a below normal serum testosterone level (281 ng/dL) and at least one sign or symptom of testosterone deficiency. In the efficacy population (n=139), 88 percent of hypogonadal men treated with KYZATREX achieved a mean plasma total testosterone concentration (Cavg) over 24 hours within the normal range (222-800 ng/dL) on the final pharmacokinetic (PK) visit of the study at Day 90 (primary endpoint). Based on exploratory endpoints, patients who received KYZATREX reported improvements in quality of life, energy/fatigue, erectile function, intercourse satisfaction, and positive mood. The most common side effect reported in 2 percent of KYZATREX patients was increased blood pressure (2.6%). The safety and efficacy of KYZATREX in males less than 18 years old have not been established.

Please see additional Important Safety Information below, including Boxed Warning for potential increased blood pressure, for KYZATREX.

About Marius Pharmaceuticals

Marius Pharmaceuticals is a patient-centric healthcare company focusing on therapies designed for hypogonadism or Testosterone Deficiency. The companys mission is to improve the functional lives of patients by reducing the downstream effects of Testosterone Deficiency, which include multiple comorbidities, such as type 2 diabetes and obesity. For more information, please visit http://www.mariuspharma.com

Important Safety Information for KYZATREX (testosterone undecanoate)

Use

KYZATREX (testosterone undecanoate) is a prescription drug that is used to treat adult men who have low or no testosterone levels due to certain medical conditions. KYZATREX is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. KYZATREX is not meant for use by women.

Important Safety Information for KYZATREX

KYZATREX can increase blood pressure, which can increase the risk of having a heart attack or stroke and can increase risk of death due to a heart attack or stroke. Your risk may be greater if you have already had a heart attack or stroke or if you have other risk factors for heart attack or stroke.

Do not take KYZATREX if you: have breast cancer; have or might have prostate cancer; are a woman who is pregnant (KYZATREX may harm your unborn baby); are allergic to KYZATREX or any of its ingredients; or have low testosterone without certain medical conditions (e.g., do not take KYZATREX if you have low testosterone due to age).

Before you take KYZATREX, tell your healthcare provider about all of your medical conditions, including if you: have high blood pressure or are treated for high blood pressure; have a history of diabetes; have heart problems; have high red blood cell count (hematocrit) or high hemoglobin laboratory value; have urinary problems due to an enlarged prostate; have liver or kidney problems; or have problems breathing while you sleep (sleep apnea).

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking KYZATREX with certain other medicines can affect each other. Especially, tell your healthcare provider if you take: insulin; medicines that decrease blood clotting (blood thinners); corticosteroids; or medicines that increase blood pressure, such as some cold medicine and pain medicines.

KYZATREX may cause other serious side effects including:

Call your healthcare provider right away if you have any of the serious side effects listed above.

The most common side effect of KYZATREX is high blood pressure. Other side effects may include headache, joint or back pain, diarrhea, increased red blood cell count, anxiety, constipation, swelling of the legs, and increased prostate specific antigen (PSA) levels.

These are not all the possible side effects of KYZATREX. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Marius by calling 1-833-949-5040.

Keep KYZATREX and all medicines out of the reach of children.See Full Prescribing Information and Medication Guide for KYZATREX.

Media Contact:Lilly Washburn lilly@mariuspharma.com

Photos accompanying this announcement are available at:

https://www.globenewswire.com/NewsRoom/AttachmentNg/ba2569ca-0922-4b49-8d68-49424b5e44d4

https://www.globenewswire.com/NewsRoom/AttachmentNg/f825d70b-874a-4cef-9160-429f83bbfc66

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CORRECTION -- Marius Pharmaceuticals Receives FDA Approval of KYZATREX, an Oral Testosterone Replacement Therapy - GlobeNewswire

Endometriosis Diet: Foods to Eat and Avoid Cleveland Clinic

Posted: September 26, 2022 at 2:10 am

Heavy periods, pain and nausea. The symptoms of endometriosis arent just distressing, they interfere with your day-to-day life.

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When you have endometriosis, cells that are very similar to the cells from your endometrium (lining of your uterus) grow in other parts of your body. The cells may stick to your bladder, fallopian tubes or other organs. Then, the cells try to shed during your period but the blood has nowhere to go.

The trapped blood from the misplaced cells causes inflammation of nearby organs and tissues. This inflammation can lead to endometriosis symptoms like pain, fatigue and digestive problems, as well as, in some cases, infertility.

But an endometriosis diet could be the key to relief from the agony. Registered dietitian Courtney Barth, RD, explains which foods could help fight endometriosis symptoms and which ones make them worse.

Inflammation and high estrogen levels can make endometriosis symptoms worse. And your diet can influence both factors.

Food plays an important role in helping your body fight inflammation and balance estrogen, says Barth. Many people find that the right diet can significantly reduce endometriosis symptoms.

Estrogen is a key hormone, and you need some of it for normal functioning. But too much estrogen can aggravate endometriosis symptoms like cramping and pain. Thats where food and fiber can come to the rescue.

Your body gets rid of excess estrogen in the stool, explains Barth. You should have a healthy bowel movement every day. If you dont, you probably have constipation, and your estrogen levels could be too high.

Kick constipation and extra estrogen to the curb by filling up on fiber. Adults should eat 35 grams of fiber every day, says Barth.

You can boost your fiber by eating more:

Just be sure to increase your fiber intake gradually. Adding a lot of fiber at once can cause bloating, gas and digestive discomfort, says Barth. Raise your fiber intake slowly and drink plenty of water to minimize these side effects. Ground flaxseed is packed with fiber, so dont eat more than 3 tablespoons per day.

Endometriosis is an inflammatory condition, so inflammation makes symptoms worse. Omega-3 fats can calm inflammation from endometriosis. Good food sources of omega-3s include:

Monounsaturated fats also have anti-inflammatory power. Theyre found in:

Calcium gets a lot of attention as an important mineral. But if you have endometriosis, make sure youre also getting magnesium and zinc.

Magnesium helps with menstrual cramps, says Barth. Its a natural muscle relaxer. Magnesium-rich foods include:

Zinc regulates your menstrual cycles, which is important for hormonal balance. Zinc helps your body ovulate, or release an egg, explains Barth. When you ovulate, you produce progesterone, which balances out estrogen. Ovulating is also necessary if youre trying to get pregnant.

The highest sources of zinc are animal sources. So if you eat a vegetarian or vegan diet, ask your doctor if you should take a zinc supplement. Good sources of zinc include:

Certain foods can worsen endometriosis pain by boosting inflammation or estrogen levels. Limit or avoid:

Some people with endometriosis find that a gluten-free or dairy-free diet helps them feel better. But it depends on the person.

If youve tried eating healthier and its not enough, then cutting out gluten or dairy is often the next step, says Barth. I usually recommend going gluten-free or dairy-free for at least a month. Then slowly add it back into your diet and see if your symptoms come back.

You can also pinpoint problem foods with the low-FODMAP diet. The low-FODMAP diet is designed for people with irritable bowel syndrome, but it can work with endometriosis, too, says Barth. If you follow it closely, you might find that certain foods trigger your endometriosis symptoms.

It might be tempting to pop some pills instead of updating your diet. But dont be quick to try supplements for endometriosis unless your doctor gives you the go-ahead.

Your doctor can run tests to see if youre deficient in certain nutrients, says Barth. Then, if your doctor recommends it, take supplements to fill any nutritional gaps. Supplements should be based on your health needs, not a one-size-fits-all approach.

Looking for some endometriosis-friendly meals? Try these recipes:

Endometriosis can be debilitating, but one part of managing it could be as close as your kitchen. If endometriosis is interfering with your life, try changing your diet, says Barth. It wont hurt, and it could really help.

Continued here:
Endometriosis Diet: Foods to Eat and Avoid Cleveland Clinic

What Is the GOMAD Diet? The Hype, the Risks, and More – Bon Appetit

Posted: September 26, 2022 at 2:10 am

The GOMAD diet probably will lead to muscle gains when paired with weight lifting, according to dietitians. But itll likely also increase fat stores as the body struggles to use all that consumed energy. And the results are going to be temporaryas soon as you stop drinking honking loads of dairy, any muscular gains will reverse.

Consuming a gallon of milk every day can lead to numerous problems, and not just for your butthole. A gallon of milk provides nearly 85% of a days worth of sodium, 600% of the recommended daily saturated fat intake, and enough calcium to potentially impair kidney function and form stones. Some studies have also found that people who consume too much of the mineral might be at higher risk of prostate cancer and heart disease.

Then theres the gastrointestinal distress. Consuming that much dairy when you are lactose intolerant is masochistic. If your body doesnt produce enough lactase, the enzyme that breaks down the sugar in dairy, drinking a gallon of milk is probably going to lead to bloating, nausea, and some serious farts, at minimum.

Even if youre not full-blown lactose intolerant, drinking too much milk can contribute to a leaky gut. This increased permeability of the intestinal lining can cause an imbalance of good and bad bacteria in the stomach, which might lead to chronic diarrhea or constipation, as well as fatigue and headaches.

Cows milk is nutrient-dense. It provides 18 of the 22 essential nutrientssuch as B vitamins, vitamin D, zinc, and potassium. It also contains magnesium (which is good for bones and muscles) and whey and casein proteins (which can supposedly lower blood pressure). On the other hand, downsides include excess of saturated fat and gastro issues, especially if youre lactose intolerant.

In the US, the recommended daily dairy intake is two to three cups. Many dietitians are petitioning to change those standards, which are the result of Big Dairys lobbying efforts and backdoor politics. The bottom line: You should not drink a gallon of milk in one day, and even two cups of dairy is most likely too much for some people. But enjoying the odd cup of cows milk probably wont do much harm. Plus, you can always opt for one of the many dairy-free alternatives out there.

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What Is the GOMAD Diet? The Hype, the Risks, and More - Bon Appetit

What’s this ‘longevity’ diet, and will it really make you live longer? – The Conversation Indonesia

Posted: September 26, 2022 at 2:10 am

You may have heard about the longevity diet, and its promise of an extended life span but what exactly is it and is it any different to other diets promoting good health?

The longevity diet is a set of eating recommendations compiled by a biochemist called Valter Longo, director of the University of Southern Californias Longevity Institute. He is known for his research on the role of fasting, the effects of nutrients on your genes and how these may impact ageing and the risk of diseases.

While the longevity diet has been targeted to older adults, it is also recommended for younger people. Longo has said he plans to live to 120 by following this diet.

Foods in this diet are vegetables, including leafy greens, fruit, nuts, beans, olive oil, and seafood thats low in mercury.

So most foods in the longevity diet are plant based. Plant-based diets are generally higher in vitamins and minerals, dietary fibre, antioxidants and lower in saturated fat and salt, which lead to health benefits.

Foods that are discouraged are an excess of meat and dairy, and those high in processed sugar and saturated fats.

For people who dont want to go without dairy, the longevity diet recommends switching from cows milk to either goats or sheeps milk, which have a slightly different nutrient profile. But there is little evidence sheeps and goats milk provide more health benefits.

Including fermented dairy (such as cheese and yoghurt) in your diet, as recommended in the longevity diet, is beneficial as it provides a more extensive microbiome (good bacteria) than any milk.

Read more: Why you should eat a plant-based diet, but that doesn't mean being a vegetarian

Many of you may recognise this as a familiar dietary pattern. It is similar to the Mediterranean diet, especially as both feature olive oil as the oil of choice. The Mediterranean diet is promoted and backed by a considerable body of evidence to be health promoting, reducing the risk of disease, and promoting longevity.

The longevity diet is also similar to many national, evidence-based dietary guidelines, including Australias.

Two-thirds of the recommended foods in the Australian dietary guidelines come from plant-based foods (cereals, grains, legumes, beans, fruits, vegetables). The guidelines also provide plant-based alternatives for protein (such as dried beans, lentils and tofu) and dairy (such as soy-based milks, yoghurts and cheeses, so long as they are supplemented with calcium).

Another aspect of the longevity diet is the specified periods of fasting, known as intermittent fasting. The diet advocates eating in a 12-hour time-frame, and not eating for three to four hours before bed time.

Typically with intermittent fasting people fast for 1620 hours with a four to eight hour window of eating. Another intermittent fasting option is the 5:2 diet, in which eating is restricted to about 2,0003,000 kilojoules for two days of the week and for the other five days, eating normally.

The evidence indicates intermittent fasting may lead to improvements in insulin resistance, which leads to better blood glucose control. This can reduce your risk of type 2 diabetes and other chronic diseases, such as heart disease and obesity.

Read more: Is intermittent fasting actually good for weight loss? Here's what the evidence says

The longevity diet recommends that people who are overweight eat only two meals a day breakfast and either a midday or evening meal plus just two low-sugar snacks. This is to try to reduce kilojoule intake for weight loss.

Another important aspect of this recommendation is to reduce snacking, particularly of foods high in saturated fat, salt or sugar. These are the foods we typically refer to as discretionary/sometimes foods, or ultra-processed foods. These offer little nutritional value, and in some cases are linked to worse health outcomes.

Read more: Ultra-processed foods: it's not just their low nutritional value that's a concern

The longevity diet recommends eating foods rich in nutrients, which most national dietary guidelines also advocate. This means eating a diet rich in plant foods, and a variety of foods within each food group.

Each colour fruit and vegetable contains different nutrients, so eating a range of coloured fruit and vegetables is recommended. The recommendation to select a range of wholegrains over refined cereals, breads, pasta and rice also reflects the best nutritional evidence.

Read more: How to get children to eat a rainbow of fruit and vegetables

This diet recommends a restricting protein intake to 0.68-0.80g per kilogram of body weight per day. This is 47-56g of protein a day for a 70kg person. For reference each of these foods contains about 10g of protein: two small eggs, 30g cheese, 40g lean chicken, 250mL dairy milk, 3/4cup lentils, 120g tofu, 60g nuts or 300mL soy milk. This is in line with government recommendations.

Most Australians easily consume this level of protein in their diet. However it is the elderly population, to whom the longevity diet is targeted, who are less likely to meet their protein requirements.

In the longevity diet it is recommended most of the protein comes from plant sources or fish. This may require special planning to ensure a complete range of all the nutrients needed if the diet is missing red meat.

Read more: How to get the nutrients you need without eating as much red meat

This diet recommends taking a multivitamin and mineral supplements every three to four days. Longo says this prevents malnourishment and wont cause any nutritional problems.

However, many health bodies including the World Cancer Research Fund, the British Heart Foundation and the American Heart Association do not recommend taking supplements to prevent cancer or heart disease.

Supplements should only be taken on your doctors advice, following a blood test showing a deficiency in a specific nutrient. This is because some vitamins and minerals may be harmful in high quantities.

If you are eating a variety of foods across all food groups, you are meeting all your nutrient requirements and shouldnt need supplements.

Read more: Vitamins and minerals aren't risk-free. Here are 6 ways they can cause harm

This longevity diet is a compilation of many aspects of evidence-based healthy eating patterns. We already promote these as they improve our health and reduce the risk of developing chronic diseases. All of these aspects of healthy eating could lead to increased longevity.

Whats not mentioned in the longevity diet is the importance of exercise for good health and a long life.

Link:
What's this 'longevity' diet, and will it really make you live longer? - The Conversation Indonesia


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