Search Weight Loss Topics:

Page 649«..1020..648649650651..660670..»

Straight facts about Splenda and its affect on health – Insider – INSIDER

Posted: June 26, 2020 at 7:45 pm

Many people turn to artificial sweeteners in an attempt to cut calories from sugar out of their diets and lose weight. However, some of these sugar substitutes have been controversial for decades.

One sweetener, Splenda, has even raised concerns for causing cancer, though there's no substantial proof. Here's what researchers have actually found so far on Splenda's health effects.

Splenda is one of the brand names for sucralose-based artificial sweeteners. Other brands include Sukrana, SucraPlus, and Nevella. Sucralose was first approved as a general-purpose sweetener in 1999 by the FDA.

The Splenda-making process starts with sucrose, also known as table sugar. The chemical structure of sucrose is then altered into a new compound called sucralose, from which the human body cannot absorb any calories.

This result is an artificial sweetener that is extremely sweet 600 times sweeter than regular sugar and low-cal. One packet of Splenda contains 3.36 calories.

The FDA says that sucralose is safe capping the recommended maximum intake at 23 packets a day, or about the equivalent of 5.5 teaspoons. However, some nutritionists disagree with the FDA.

Danica Cowan, MS, RD, a dietitian at UCSF Osher Center for Integrative Medicine, strongly advises against using any chemical artificial sweeteners, not just Splenda. Cowan says that until we have unequivocal proof that chemically-altered artificial sweeteners are not harmful, everyone should err on the side of caution.

In fact, most of the research points to potentially adverse health effects. Here's what some of the research has uncovered, so far:

A study published in Cell Metabolism in 2020 found that consistently eating sucralose and carbs together for 10 consecutive days decreased insulin sensitivity in otherwise healthy adults. In other words, it's possible that consuming too much sucralose-based sweeteners may cause you to have higher blood sugar, which can increase your risk of prediabetes. However, this research is relatively new, and there are no other studies to confirm its conclusions.

There's talk that artificial sweeteners may have a negative impact on gut health. However, so far, the only studies on this effect have been done in animals and there's no proof that the results apply to human health.

That said, artificial sweeteners including mannitol and sorbitol have been shown to cause GI issues like diarrhea. Whether this has any long-term adverse effects on gut health, though, is unknown.

In 2016, a study published in the International Journal of Occupational and Environmental Health made media headlines for its supposed link between Splenda and an increased risk of cancer.

However, the study was performed in mice and the researchers reportedly fed the rodents at least 12 times more sucralose than what's recommended for human consumption. The mice were eating this amount every day until they died.

Later in 2016, a different group of researchers published an extensive review in the Journal Nutrition and Cancer concluding that, "sucralose does not demonstrate carcinogenic activity even when exposure levels are several orders of magnitude greater than the range of anticipated daily ingestion levels."

Artificial sweeteners, in general, can actually backfire for those who are trying to lose weight. According to a 2010 mini-review, artificial sweeteners affect the brain differently than true sugar, leaving it less satisfied which can spark additional sweet cravings.

When we eat sugar, reward pathways in our brain are activated, and they release hormones that make us feel good, which explains why we love sweets so much. On the other hand, when artificial sweeteners are consumed, those same pathways are activated only partially since they don't contain calories, meaning they can't be broken down into energy for the body. This can lead you to crave more, eat more, and possibly gain weight.

There is a deficit of studies that investigate the long-term health effects of Splenda consumption. From what researchers have found, Splenda isn't horrible for you, but it also isn't necessarily good for you, either. And it definitely doesn't add any nutritional value.

Cowan says that if you want to reduce your sugar intake, then start by cutting back slowly and steadily. "If you just begin to cut back on sugar and sweets in general, your body adjusts. Your taste buds adjust, and you crave sweets less and I think that's very beneficial."

If you have intense sugar cravings and aren't ready to cut back on traditional sweets just yet, Cowan says artificial sweeteners can have a place. But she suggests trying healthier sugar substitutes instead of Splenda. She highly recommends using Stevia or Monk Fruit, which are more natural than Splenda. Both of these sweeteners come from plants and are not artificially derived from other substances or chemicals.

Lastly, if you're trying to lose weight, take a hard look at your overall diet. Weight loss and health are about way more than just using an artificial sweetener or not. Cowan recommends focusing on having a healthy balanced diet of whole foods, and avoiding highly-processed foods.

For help with weight loss check out our guide on how to lose weight safely. You can also consult a doctor or dietitian for guidance.

Read the original:
Straight facts about Splenda and its affect on health - Insider - INSIDER

State rules on PPE will prevent people from seeing relatives in long-term care sites | News, Sports, Jobs – Fort Dodge Messenger

Posted: June 26, 2020 at 7:45 pm

Anyone paying attention to the news lately has seen both heartwarming and heartbreaking stories about residents in Long-Term Care (LTC) facilities, their homes, and their families. In our best efforts to protect LTC residents from COVID-19, we have created another health risk. Our safety measures to restrict visitation and communal activities the past three months have negatively impacted residents physical, mental and emotional health. In fact, residents have documented physical, mental and emotional decline due to the social distancing and isolation measures in place to keep them safe. Some residents have experienced weight loss as they have no socialization while eating.

I have been an infection preventionist in a hospital setting, currently working in an Adult Day Services program connected with a long-term care community. I am also an independent living resident on a continuing care campus. I am writing in support of both keeping our residents in LTC settings, many of whom are my friends, not only physically healthy and safe but also mentally and emotionally healthy. With everything going on in our country right now, LTC residents feel as though they no longer have rights and have been imprisoned in the name of safety. We have lost sight that this is their home and that they have a voice. They cannot have in-person visits with their families and are isolated from their friends in the place they call home.

I have to admit that I too have felt some frustration. In order to keep fellow residents in assisted living and LTC safe on campus, I have needed to limit my daily comings and goings off campus. Leaving campus is limited to trips for groceries, medications, and a drive in the country or a safely distanced walk to a park.

I, along with everyone on our campus, have been watching the rest of the state reopening on the news and have been looking forward to the states easing of restrictions in LTC so we too can socially distance on a visit with our families and friends and have limited communal dining. These small acts do wonders for residents well being.

Our campus has had one resident test positive for COVID-19, and that resident has recovered and returned to their neighborhood. If all goes as planned, we hope to meet the states requirements to progress to Phase 2 of the reopening plan on July 1. However, that progress is in jeopardy because our campus cannot obtain the amount of Personal Protective Equipment (PPE) to meet the additional precautions the state requires us to have in place. Having a background in infection prevention and employee health, I fully understand the need for PPE as it relates to transmission-based precautions. However, the state is requiring LTC facilities to go beyond precautions utilized in the past and to do so without any extended use or reuse of PPE.

Precautions should be based upon known or suspected likelihood of transmitting pathogens. With additional precautions applied to all residents, regardless of symptoms or their history of potential of exposure, it seems unnecessary and will require unlimited amounts of PPE that would be better saved for conventional situations.

Unless the state helps us find considerably more medical-grade PPE or addresses their PPE requirements for reopening, our campus, and Id venture to say almost every LTC in the state, will not be able to move to Phase 2. This means our vulnerable residents will continue to have limited interactions with people or, in their words, be locked away in jail. This is not what they signed up for, not even in the name of safety. Further, how can we ethically reopen the rest of the state while forgetting about our greatest generation?

Linda Opheim, RN, CIC, is a nurse at Schmoker Adult Day-Friendship Haven in Fort Dodge.

Today's breaking news and more in your inbox

Visit link:
State rules on PPE will prevent people from seeing relatives in long-term care sites | News, Sports, Jobs - Fort Dodge Messenger

Medical Professionals in the Ozarks – 417mag

Posted: June 26, 2020 at 7:45 pm

Eustasis Psychiatric & Addiction Health

417-322-6622| 3600 S. National Ave., Springfield

Eustasis Psychiatric & Addiction Health is pleased to announce construction of their brand new site in the heart of Medical Mile, opening in July! There is expanded access to medication management, psychotherapy, testing and advanced treatment options.

Dr. Alok Jain and his wife Breanna Jain started the clinic in 2018 with the mission of providing the highest quality psychiatric care to all patients. Since then they have put together an amazing team of board-certified providers and support staff who have tirelessly served the Springfield community.

We wanted to build something really vital for our patients. A place that everyone could come, regardless of age or diagnosis, says Dr. Jain.

Dr. Alok Jain has been honored as a 417 Top Doctor every year since 2007 and is 2020's top psychiatrist. He is a board-certified psychiatrist, member of the American Psychiatric Association and has an extensive background in consultation-liaison psychiatry and psychopharmacology.

Eustasiss immediate-access site has provided patients with an unprecedented way to receive psychiatric care without delay. Their walk-in and be seen model is changing the face of psychiatry. The new location has eight providers and room for growth! They are providing the most state of the art modalities, including ADHD testing and esketamine.

It is super exciting, says Breanna Jain, CEO, PMHNP-BC. We have patients who come in all hours of the day, pediatric or adult, all payor sources. They will ask, You mean I can really be seen right now? We can proudly tell them of course! This is just the way we believe mental health should be done.

Both Dr. Jain and Breanna know that people need options in this community. Patients struggles are numerous, ranging from addiction, bipolar, ADHD, trauma, anxiety and more. The Jains like to think of Eustasis as a one-stop-shop.

There shouldnt be high levels of bureaucracy. This is what overwhelms patients. Barriers have no place when it comes to mental health, the Jains explain.

Eustasis is committed to helping patients find the optimal balance of emotions during these difficult times. They have expanded their hours and have both in person and telemedicine options available. They are always accepting new patients!

Go here to see the original:
Medical Professionals in the Ozarks - 417mag

We need to talk about the 1994 Disney film ‘Blank Check’ – Yahoo Lifestyle

Posted: June 26, 2020 at 7:45 pm

In 1994, Walt Disney Pictures produced a PG comedy called

Blank Check about an 11-year-old boy who gets into a bike

accident with an escaped convict and ends up with $1 million.

Though the movie is generally fun in a

classic 90s fashion, with tons of hijinks

and corny jokes, theres one small problem: .

The 11-year-old main characters

love interest is an adult woman.

The 1994 film has recently found

itself back in the spotlight now that

its available to stream on Disney Plus.

On TikTok, user therjpowell recorded a

now-viral video addressing the controversial

kissing scene in the movie, calling it cringey.

Though the entire concept of an 11-year-old falling in

love with a grown woman is troubling, therjpowell

calls out one problematic scene in particular in his video: .

the one where the 11-year-old and

the grown woman an FBI agent

named Shay actually kiss on the mouth.

Disney WHAT ARE YOU DOINNNN???

one person asked.

When the film came out in 94, the

Chicago Tribune called it one of the

sleazier movies ever marketed to kids"

Link:
We need to talk about the 1994 Disney film 'Blank Check' - Yahoo Lifestyle

The Best Toners to Smooth and Brighten Every Skin Type – Yahoo Lifestyle

Posted: June 26, 2020 at 7:45 pm

Face toners have come a long way since the old-school dehydrating astringents made to control oily skin. Toners are water-based or water-alcohol based solutions or mixtures, says Good Housekeeping Institute Beauty Lab chemist Danusia Wnek, but "there are now formulas that are alcohol- and astringent-free and can be less drying, she says.

This new generation of toners are often labeled as essences, tonics, waters, or solutions. These versions contain treatment ingredients similar to serums and moisturizers, so theyre gentler, says Joshua Zeichner, M.D., Director of Cosmetic & Clinical Research in Dermatology at Mount Sinai Hospital in New York City.

The goal of a toner is to remove any excess residue from cleansing and prep the skin for other skincare products," says Wnek. Toners are traditionally applied on clean, dry skin using fingers, cotton, or a cloth after face cleansing and before other leave-on skincare treatments like serums and moisturizers. Incorporate a toner into your skincare routine if you want additional complexion-purifying or treatment benefits or want to swap out heavier skincare formulas for lighter liquids in warmer months.

When shopping for a toner, look for formulations tailored to your complexion type or primary skin concern or goal. Here are Wnek's suggetions:

Here, the best face toners you can buy for all skin types, from oily and acne-prone to combination, dry and sensitive, for hyperpigmentation and more, according to GH Beauty Lab scientists and experts.

Go here to see the original:
The Best Toners to Smooth and Brighten Every Skin Type - Yahoo Lifestyle

How a coat covered in asbestos led to one woman’s cancer diagnosis 30 years later – Yahoo Lifestyle

Posted: June 26, 2020 at 7:45 pm

Heather Von St. James was diagnosed with malignant pleural mesothelioma, a cancer of the lining of the lungs, not long after her daughter was born in 2005. She only gained five pounds during her pregnancy and noticed she lost weight really quick afterward. I was so tired, she says.

I went to my basement to get laundry and, halfway up the stairs, I could barely breathe, she explains. Then, I went and sat on the couch and I passed out.

Von St. James says she called her doctor right away, who did an X-ray of her lungs. Then, she was given her diagnosis. She was told that she had just 15 months to live if she didnt receive treatment.

Mesothelioma is often caused by exposure to asbestos, a heat-resistant mineral that has been used in a variety of construction materials for insulation. Von St. James says her doctor asked if her dad ever worked in construction or mining of any sort. I said, Well, yeah. He did both, she recalls.

I remembered I would wear his jacket and his jacket was covered in this grayish, whitish dust, says Von St. James. I would wear it when I had to go feed my rabbits, or rake the leaves or something because it was already dirty and it was my dads coat. Its this coat covered in asbestos that led to my mesothelioma 30 years later.

If I didnt do anything, I was only going to live 15 months.

Von St. James was given a tough decision. If I didnt do anything, I was only going to live 15 months, which I was not going to take as an answer, she says. Her other option: To have a groundbreaking surgery one of the most invasive surgeries there is, she says. It involved removing her entire left lung, the lining of her heart, the left half of her diaphragm and one of her ribs. She decided to have the surgery.

The recovery was brutal because I had to follow up surgery with chemotherapy and radiation, Von St. James says. She also had to learn to breathe with just one lung. Having one lung, your breathing capacity is literally cut in half, she explains. People often ask me how long before everything is back to normal and Im like, Never. You have to adjust your entire way of life after a cancer diagnosis.

Story continues

The median survival rate for people with pleural mesothelioma is 18 months, so to make it even five years is a big deal, Von St. James says. Its been 14 years since her diagnosis, which is kind of unheard of. Thats why she says its so important that I talk about it to bring awareness to the disease and offer hope to people who are newly diagnosed.

HEATHER VON ST. JAMES: You know, a day you lose your lung could really be a tragic day, and you could be really sad and depressed about it. But we decided to turn it around and turning it into a huge celebration, Lungleavin' Day, which is the day my lung left. They took out my lung, but I got my life back.

My little girl was born on August 4, 2005. But I only gained five pounds through the whole pregnancy. I was so tired. I was exhausted. But I was a new mom, and I was up at night feeding her. And then I was losing weight really quick. I had a really hard time breathing. I had went to my basement to get laundry. And halfway up the stairs, I could hardly breathe. And then I went and sat on the couch, and I passed out. I called my doctor right away. He had me come in and do an X-ray. You have a disease called malignant pleural mesothelioma. It's a cancer of the lining of your lung. Without any treatment, he goes, you have 15 months to live.

Mesothelioma's caused by asbestos exposure. The doctor asked me if my dad ever worked construction or mining of any sort. And I said, well, yeah, he did both. I remembered I would wear his jacket, and his jacket was covered in this grayish whitish dust. I would wear it when I had to go feed my rabbits or break the leaves or something, because it was already dirty. And it was my dad's coat. It was this coat covered in asbestos that led to my mesothelioma 30 years later.

If I didn't do anything, I would only live 15 months-- which I was not going to take as an answer-- or have this groundbreaking surgery, one of the most invasive surgeries there is, removal of my entire left lung, the lining of my heart, the left half of my diaphragm, and one of my ribs. The recovery was brutal because I had to follow up surgery with chemotherapy and radiation. Having one lung, your breathing capacity is literally cut in half. People often ask me, how long before everything's back to normal? And I'm like, never. You have to adjust your entire way of life after a cancer diagnosis.

My dad felt a lot of guilt. I said, Dad you're not at fault here. It's the asbestos companies that did this. It wasn't you. Second-hand exposure of asbestos-- we're the patient that they never wanted to admit there was. One fiber can make a person sick. They've known that it's caused cancer since the early 1900s. The asbestos companies said years ago, oh, if they make a good living by asbestos, they might as well die by it too.

The United States is one of the only industrialized country where it's still legal. The Trump administration tried to roll back protections for asbestos a few years ago. You need to make sure when you're electing officials that they're on the right side of history. It boils down to dollars over lives, and that's unconscionable in my opinion.

The median survival rate is 18 months. So to make it even five years is a big deal. 14 is kind of unheard of with pleural mesothelioma, which is why it's so important that I talk about it to bring awareness to the disease and offer hope to people who are newly diagnosed. I have my lighthouse tattoo over here. My dad told me I would be a beacon of hope. And even when he got sick, which we think was due to the asbestos, he told me, he's like, you're going to continue to be that lighthouse aren't you?

Go here to see the original:
How a coat covered in asbestos led to one woman's cancer diagnosis 30 years later - Yahoo Lifestyle

Here’s how to definitively tell how tall someone is based on their dating profile – Yahoo Lifestyle

Posted: June 26, 2020 at 7:45 pm

Unfortunately, its not uncommon for

dating app users to lie about their height.

In fact, its common enough that TikTok

users have taken to extreme measures

to see if the guy they just swiped right on

is really 60 or if hes actually 510.

The trend began when a user who goes by

the name ofgadelhahanoticed a Corona beer

bottle in the hand of one of her matches.

She easily found that each bottle

is 9.5 inches tall, then used a photo

editing app to replicate the bottle over

the original photo multiple times.

She then lined those bottles up to match

his height, counted them, and converted

it to feet, finding the man to be 511.25.

TikTok usernicccoyatook that a step

further, showing her followers a

mathematical equation they can use to

get the most accurate answer possible.

First, youll need to figure out

how tall the items in the photo

are in both real-life and in the

photo, in centimeters.

niccoyafound that the bottle is

1 cm tall in the photo, and the man is 7.5 cm.

Just multiply the size of the man

in the photo (7.5 cm) by the real-life

size of the bottle (24.13 cm).

Once you have that number, divide it by the

height of the bottle in the photo (1 cm).

In this case,niccoyafound the answer to

be 180.975 cm. She quickly converted cm to inches

by asking Siri for the answer 511.25

Visit link:
Here's how to definitively tell how tall someone is based on their dating profile - Yahoo Lifestyle

Impact Analysis of Covid-19 On Testosterone Replacement Therapy Market Driver, Trends, Applications & Business Strategy Forecast 2027 | Endo…

Posted: June 25, 2020 at 10:54 pm

A new business intelligence report released by CMI with title Global Testosterone Replacement Therapy Market Insights, Forecast to 2027 that targets and provides comprehensive market analysis with future prospects to 2024. The analysts of the study have garnered extensive research methodologies and data sources (i.e. Secondary & Primary Sources) in order to generate collective and useful information that delivers latest market undercurrents and industry trends.

If you are involved in the Global Testosterone Replacement Therapy industry or intend to be, then this study will provide you comprehensive outlook. Its vital you keep your market knowledge up to date segmented by major players. If you have a different set of players/manufacturers according to geography or needs regional or country segmented reports we can provide customization according to your requirement.

We Do Offer Sample of this report. Kindly go through the follow information in order to access sample copy.

Note- This report sample includes:

Brief Introduction to the research report.

Table of Contents (Scope covered as a part of the study)

Top players in the market

Research framework (structure of the report)

Research methodology adopted by Coherent Market Insights

Request Sample Report @ https://www.coherentmarketinsights.com/insight/request-sample/2024

This study categorizes the global Testosterone Replacement Therapy breakdown data by manufacturers, region, type and application, also analyzes the market status, market share, growth rate, future trends, market drivers, opportunities and challenges, risks and entry barriers, sales channels, distributors and Porters Five Forces Analysis. Global Testosterone Replacement Therapy market size will increase to Million US$ by 2027, from Million US$ in 2017, at a CAGR of during the forecast period. In this study, 2017 has been considered as the base year and 2020 to 2027 as the forecast period to estimate the market size for Testosterone Replacement Therapy. This report focuses on the top manufacturers Testosterone Replacement Therapy capacity, production, value, price and market share of Testosterone Replacement Therapy in global market. The following manufacturers are

Competition Analysis:

Some of key competitors or manufacturers included in the study are AbbVie, Inc., Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin International plc, Pfizer, Inc., Acerus Pharmaceuticals Corporation, and Perrigo Company plc.

Detailed Segmentation:

By Active Ingredient TypeTestosteroneMethyl TestosteroneTestosterone UndecanoateTestosterone EnanthateTestosterone CypionateBy Route of AdministrationInjectablesParenteral

Market Analysis by Geographies:

This report is segmented into key Regions to identify significant trends and factors driving or inhibiting the market growth. To analyze the opportunities in the market for stakeholders by identifying the high growth segments., To strategically analyze each submarket with respect to individual growth trend and their contribution to the market. & to analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market. With Production Development, Sales, and Regional Trade & Forecast.

Stay up-to-date with Global Testosterone Replacement Therapy market research offered by CMI. Check how key trends and emerging drivers are shaping this industry growth as the study avails you with market characteristics, size and growth, segmentation, regional breakdowns, competitive landscape, shares, trend and strategies for this market. In the Testosterone Replacement Therapy Market Analysis & Forecast 2020-2027, the revenue is valued at USD XX million in 2017 and is expected to reach USD XX million by the end of 2027, growing at a CAGR of XX% between 2020 and 2027. The production is estimated at XX million in 2017 and is forecasted to reach XX million by the end of 2027, growing at a CAGR of XX% between 2020 and 2027.

Get PDF Brochure Report @https://www.coherentmarketinsights.com/insight/request-pdf/2024

Some of the Points cover in Global Testosterone Replacement Therapy Market Research Report is:

Chapter 1: Overview of Global Testosterone Replacement Therapy Market (2020-2027)

Chapter 2: Market Competition by Players/Suppliers 2015 and 2020

Chapter 3: Sales (Volume) and Revenue (Value) by Region (2015-2020)

Chapter 4, 5 and 6: Global Testosterone Replacement Therapy Market by Type, Application & Players/Suppliers Profiles (2015-2020)

Chapter 7, 8 and 9: Global Testosterone Replacement Therapy Manufacturing Cost, Sourcing & Marketing Strategy Analysis

Chapter 10 and 11: Testosterone Replacement Therapy Market Effect Factors Analysis and Market Size (Value and Volume) Forecast (2020-2027)

Chapter 12, 13, 14 and 15: Global Testosterone Replacement Therapy Market Research Findings and Conclusion, appendix and data source

Some of the key questions answered in this report:

Note: Access insightful study with over 150+ pages, list of tables & figures, profiling 20+ companies.

Buy This Complete A Business Report @https://www.coherentmarketinsights.com/insight/buy-now/2024

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia.

About Us:

Coherent Market Insights is a prominent market research and consulting firm offering action-ready syndicated research reports, custom market analysis, consulting services, and competitive analysis through various recommendations related to emerging market trends, technologies, and potential absolute dollar opportunity.

Contacts US:

Mr. ShahEmail:[emailprotected]Phone: US +1-206-701-6702/UK +44-020 8133 4027

Follow this link:
Impact Analysis of Covid-19 On Testosterone Replacement Therapy Market Driver, Trends, Applications & Business Strategy Forecast 2027 | Endo...

Alzheimers Disease Affects More Women Than Menand Some Experts Think The Reason Why Lies in the Gut – Well+Good

Posted: June 25, 2020 at 10:53 pm

Alzheimers diseasea progressive mental deterioration that can occur in middle or old ageis what experts call a complex medical condition. It isnt caused by one singular factor, like a caffeine-induced headache or a broken bone caused by an injury. Complex diseases involve multiple genes and environmental factors. In other words, its complicatedvery complicated, which has long hindered our understanding of the disease.

Further complicating matters is the fact that Alzheimers disease affects upwards of 5 million Americanstwo-thirds of whom are women, per the Womens Alzheimers Movement (WAM). While the disproportionate effect of Alzheimers on women has long been known, scientists and doctors are only relatively recently starting to understand why. Answering the why just may change the course of action in terms of both prevention and treatment.

But what do you focus on when it comes to a disease that has myriad risk factors, including genes, hormones, diet, stress, and environmental factors? For some of the leading experts in Alzheimers research, theyre choosing to focus on the gut.

Alzheimers is a deterioration of the brain, so it can be a little confusing to know why exactly the gut is taking center stage. As with seemingly everything else in health these days, it all comes down to the microbiome.

The microbiome is all the bacteria, fungi, and viruses that live in the gut, says Laura Cox, PhD, an instructor at the Ann Romney Center for Neurologic Diseases at Brigham and Womens Hospital and Harvard Medical School. (She received a grant from WAM in 2020 to fund her research.) Its important to have a high population of certain good bacteria strains and fungi in the gut. The good guys are linked to a variety of health benefits, including thriving brain health, while bad bacteria is linked to (amongst other health problems) deteriorating brain health.

Heres why: What happens is that as we age, everything starts to break down. This is normal and natural, and we try to fight it, Dr. Cox says. This is called inflamm-aging, aka inflammation due to age. The gut barrier (which lines the inside of the gut and prevents harmful substances from being absorbed by the body) and the blood-brain barrier (the protective blood vessels surrounding the central nervous system) are included in this gradual systemic breakdown.

This is problematic for two reasons. One, these barriers become less able to block harmful microbes, pathogens, and other substances from circulating through your system. Second, since inflamm-aging impairs the immune system, the body is less able to kill harmful bacteria and pathogens that escape through the gut. So you could have increased exposure to microbial products that are getting from the gut to the brain, Dr. Cox says. Both of these factors can lead to further bodily inflammationand experts believe that inflammation in the brain lays the groundwork for Alzheimers.Given that the majority of your immune function happens in the gutand that your microbiome supports said immune function as well as the integrity of the gut barrierand you can see why researchers are interested in the relationship between the brain and the gut.

Hemraj Dodiya, PhD has been studying the differences between the microbiome-brain connection as it relates to Alzheimers in women versus men for three years at the University of Chicago. He says that sex hormones and physiology in men and women affect the gut bacteria in the microbiome. The main question Dr. Dodiya and his team are working to answer is what bacteria strains in the gut are linked to amyloid deposits, which are buildups of plaque in the brain increasing the risk of Alzheimersand what strains are linked to reducing these deposits.

One study showed that a cocktail of five different antibiotics worked to reduce amyloid deposits in male mice, but not female mice. We can attribute this to the male mice having a protective bacteria in the gut, while the female mice could potentially have a pro-inflammatory type of bacteria in the gut, Dr. Dodiya says. Male and female mice have completely different reactions to antibiotic treatment that allows colonization or growth of certain bacterial species.

Dr. Dodiya says hes now exploring in several different experiments exploring how reproductive hormones interact with the bacteria in the gut and immune cells, in order to see if that explains the above-mentioned sex differences in the guts of mice. [This communication] could then modulate what bacteria live and what bacteria die, he says. One experiment involves castrating male mice and studying how that changes their microbiomes. In another experiment, testosterone supplements are given to female mice to see how that affects their microbiome. One experiment that Im working on is taking good bacteria from male [mice] and giving it to female mice, Dr. Dodiya says.

Dr. Cox has seen promise with female mice going a different route: reducing carbohydrate intake. What was surprising about the study was that reducing carbs [to less than 30 percent of the overall diet] showed to be effective in reducing amyloid deposits in female mice, but not male mice, Dr. Cox says. Another surprise from the study is that the microbiomes of the female mice aged faster than the males (meaning they started to break down sooner). But restricting carbs helped slow that aging process in the female mice, she says.

All these mice experiments have some big takeaways for the future of Alzheimers prevention and treatment, particularly in women. Dr. Dodiya says that he could see it leading to the development of probiotic supplements formulated to prevent Alzheimers, with different stains for women than men. This is an outcome Dr. Cox says she could see too; designer probiotics that work as different drug therapies for men and women. But she emphasizes that more research needs to be done to pinpoint exactly what bacteria strains can cause Alzheimers, as well as which strains could play a role in prevention. Were still several years off from that knowledge.

Another possible treatment method could lie in fecal transplants, pending how the experiment taking good bacteria from male mice and giving it to female mice turns out. (Yes, the idea of it may take some getting used to, but fecal transplants are already showing success when it comes to improving someones microbiome.)

In terms of the carb reduction study, thats something Dr. Cox says women can consider putting into practice now with doctor supervision, though she emphasizes that the takeaway shouldnt be confused with reducing calories to an unhealthy level. After all, your brain needs sufficient vitamins and nutrients to function properlyand carbohydrates are the brains preferred source of fuel. Malnutrition in the elderly is already a problem, so its important to be mindful of this, she says. Its more about eating fewer carbs and enough other beneficial macronutrients like protein, fat, and fiber.

Whats clear is that while all of this research is promising, more needs to be doneespecially on humans, not just mice. But whats encouraging is that researchers are really honing in on the differences between what causes Alzheimers in men versus women, something that was long ignored. And addressing those differences lies a prevention plan that could be affective for everyone.

Follow this link:
Alzheimers Disease Affects More Women Than Menand Some Experts Think The Reason Why Lies in the Gut - Well+Good

COVID – 19: Is There Healthily Thereafter? – Patch.com

Posted: June 25, 2020 at 10:53 pm

As SARS-CoV-2 virus spread throughout the globe and caused the largest amount of COVID-19 cases and deaths in the US, there is hardly a person on this planet who is unaware of the coronavirus.

While ending the lockdowns across the country with safety precautions and making sure hospitals are not overwhelmed, public officials and physicians alike are waiting to see the way coronavirus behaves in the next several months. Will we see a substantial increase in the cases during the summer or will the hot weather keep it at bay? Rising number of cases in Florida and Arizona despite the heat is certainly concerning and our eyes are on them, waiting to see how the situation progresses. Will SARS-CoV-2 return in the fall and winter months causing another spike in cases in New York and New Jersey?

With each day we learn more about the virus and about the ways to treat it.

Doctors gain experience, share knowledge and are now better prepared to treat the sick. There are many treatment protocols used in various countries, different hospitals, medical wards and intensive care units, although uniformed guidelines are still lacking.

The controversy about the Hydroxychloroquine, the drug to treat malaria and rheumatoid arthritis, continues, with some randomized studies about it withdrawn from the most respected medical journals (NEJM and Lancet), but some others still ongoing. New medication Remdesivir recently received emergency use authorization by FDA. Old medicine Dexamethasone (a familiar glucocorticoid) was recently shown in a UK-based trial to improve survival of hospitalized patients on mechanical ventilation by 30% and of hospitalized patients on oxygen by 20%. Some other off-label medications include Ivermectin, colchicine, antibiotics, antiretrovirals, immunoglobulins, convalescent plasma, and Toclizumab (an IL-6 inhibitor which can prevent the cytokine storm).

We discovered that COVID-19 not only affects the immune system, gastrointestinal and respiratory systems, causing bronchitis, pneumonia, and acute respiratory distress syndrome. It also produces hematological complications causing widespread blood clotting. Specifically, COVID-19 has been shown to cause dysfunction in the inner lining of the arteries (endothelium) and the treatment for blood clots (anti-coagulants) is now used to avoid life threatening complications. An important observation, shared by many physicians across several states, has been that in the newly diagnosed cases of the last several weeks, including June of 2020, we see that patients are not as sick, outcomes are better even with hospitalized patients. We also observe better survival rates. It is too early to say if the reason behind it is mutation and weakening of the virus or if there are other factors contributing to improved outcomes. Infection fatality rate (defined as deaths among all diagnosed, undiagnosed and asymptomatic individuals) seems to be between 0.4-1% according to various epidemiological reports. While it is still higher than influenza which carries about 0.1% death rate, the risk of dying from COVID-19 turns out to be much less than initially feared and estimated in March-April of 2020 when the case mortality rate (defined as deaths among those who were diagnosed with disease) was thought to be up to 5%.

Traditional medicine still does not recommend much for mild to moderate disease, as the majority of people will recover from COVID-19 without intervention. However, learning that there are delayed complications, such as prolonged fatigue, lingering cough, blood clots, and rashes, maybe we should be paying more attention even to the seemingly mild and moderate cases, those which do not require hospitalization. It is not uncommon for the patients to have persistently elevated levels of inflammatory and blood clotting markers and develop depressed mood and anxiety. The latter two can happen with any serious medical illness. Some physicians treat mild and moderate cases with off-label medications and supplements based on experiences with MERS and SARS and anecdotal reports from colleagues all over the world. We have observed a lot of positive progress with the use of off-label medications and natural supplements based on collective experience of many physicians, but without a gold standard randomized control trial it is impossible to definitely state whether these patients would have recovered by themselves without any intervention.

It is currently believed based on epidemiological models, that during the pandemic, the novel virus will continue to infect the world's population until about 70-80% of people are infected and herd immunity is achieved. Short of a rapidly produced vaccine or natural weakening of the SARS-CoV-2, it will mean that most of us will be exposed to the coronavirus at some point, regardless of the length of the quarantine. If and when that happens, one of two things will take place. If our immune system is stronger than the virus, we will be able to inactivate it with our own immune cells. Those people may become infected but be asymptomatic or have very mild symptoms. If our immune system is weaker than the virus's ability to enter our cells and replicate can overwhelm our defenses, leaving a person very sick, possibly progressing to life threatening complications. Research on hospitalized patients with COVID-19 revealed that older individuals, people with pre-existing conditions, such as hypertension, obesity, diabetes and cancer develop more severe disease and are at higher risk of death.

In the absence of a vaccine or a proven cure, strengthening one's immune system and practicing social distancing may be the only preventative strategies we have while the pandemic runs its course. Much like people have been preparing and stocking up on groceries and household supplies, we should be taking care of our immune system and prepare now. Our immune system is very complex and the process of becoming the healthiest version of yourself is not overnight, but simple steps can be employed right away to start the journey.

Getting adequate sleep, about 7-8 hours, will improve the body's response to illness. Decreased sleep duration has been linked to increased inflammation. Even mild sleep deprivation can cause elevation in pro-inflammatory markers, such as c-reactive protein, and cause immunodeficiency, thus decreasing the response of our body to several antigens. For example, only six days of restricted sleep tends to decrease immunity against influenza vaccination and enhances susceptibility to the common cold.Getting adequate sleep improves not only our cellular function and immunity but also helps to eliminate toxins from our body.

Eating a diet rich in fruits, vegetables, lean proteins, which constitute a healthy antiinflammatory diet, provides minerals, nutrients, and vitamins for proper cellular function. Studies show that only one meal full of refined sugars and trans-fats produces abnormal insulin response which, in turn, decreases function of macrophages. Targeted supplementation with vitamins and minerals which may specifically improve immunity can also be helpful. Zinc helps decrease viral replication, Vitamin D helps immunity, Vitamin C works as an antiviral and an antioxidant, Vitamin A helps the cells in the respiratory tree, flavonoid quercetin is also a potent antioxidant. Prior studies have shown the efficacy of Zinc in reducing colds caused by other coronaviruses. Antioxidant, antimicrobial and antiviral roles of Vitamin C are also well documented. Many of these supplements can be taken orally and some can be given intravenously, such as Vitamin C, which has decades of research showing its safety and efficacy. Higher doses of vitamin C have been given by doctors in Wuhan when the outbreak started and some hospitals and clinics in the US have also followed suit. Longer term preparedness would include seeing your doctor for a check up, getting routine blood work done, including immune markers, microbiome markers and micronutrients in order to target supplementation for deficiencies appropriately and to monitor optimal levels for the future.

Keeping mental health a priority is another important aspect of our daily activities during pandemic. With pandemic and economic uncertainties, physicians are seeing more complaints of anxiety and depression. In addition, breaking daily news around the country and the world creates negative emotions that impact hormones, releasing adrenaline and cortisol which can impair immune cells. Taking control of the information overload and limiting TV and social media to a daily minimum of 20-30 minutes can help balance our thoughts, increase parasympathetic nervous system response which will, in turn, improve mood, sleep and health.

Breaking the tradition of making health resolutions for the New Year's, we should take a closer look at what we can do this summer to help nurture our emotional resilience and strengthen our immune system. As we tame our anxieties, safely ending the lockdowns, these health optimizing strategies, whether holistic or medically supervised, can prove to be lifesaving. Going outside for a walk, normalizing sleep hygiene, enjoying the sun for a natural dose of Vitamin D, practicing mindfulness, swimming in the ocean or going for a hike for a minimum of 150 minutes per week are tools in our wellness toolbox which can allow us to ride the wave of COVID-19.

This post is an advertorial piece contributed by a Patch Community Partner, a local sponsor. The views expressed in this post are the author's own.

To learn more about becoming a Community Partner, click here.

Excerpt from:
COVID - 19: Is There Healthily Thereafter? - Patch.com


Page 649«..1020..648649650651..660670..»