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Unilever eyes potential in wellness: ‘We are uniquely positioned to lead purposefully in the space of holistic health and immunity’ -…

Posted: June 13, 2020 at 10:51 am

The COVID-19 pandemic has encouraged shoppers to seek out food and drink that boosts the immune response, according to research from Unilevers CMI People Data Centre & CMI U-Futures.

The research reveals that interest in and consumption of foods that support the immune system, as well as supplements like vitamins C and D, has increased. Unilever suggests that this is a global trend. In the US, vitamin supplementation jumped 15% in the space of a month, in Brazil consumers are eating more fruit rich in vitamin C, while in Japan immune-boosting yogurts are proving popular. The desire for health and wellbeing post pandemic is a consistent trend across all markets, Unilever concluded.

According to the company, the connection people are making between what they eat and their personal health has reached new heights. Having an optimally working immune system is more important than ever. The way our body deals with an infection is influenced by many factors of which the nutritional status is a critical element, Dr Angelika De Bree, global nutrition director, explained.

And these changes are here to stay, Dr De Bree believes.

One of major lifestyle changes we see is an exponential growth in attention to health and wellbeing with immunity being the epicentre of this attention. We think that the heightened interest from consumers in staying healthy is here to stay. In that sense, we belief that health and wellness will indeed become more mainstream.

While trendy ingredients like turmeric or rhodiola might be making a big splash on social media in the short-term, Dr De Bree suggests that to tap into this demand in the longer-term food makers need to tackle the underlying consumer need-state through innovation.

While at the moment focus may shift to particular ingredients that are positively associated with immunity, experts highlight the complexity of the immune system which is a complex system of molecules, cells, tissues and organs, she noted.

Each element of this system is influenced by a wide range of health and wellbeing factors, the Unilever nutrition expert told this publication. This includes weight and physical fitness, mental health, sleep and nutritional intake, among other things.

Whilst some ingredients might be trending now, we can imagine that holistic health for holistic immunity is here to stay and thereby a new need state for consumers. We can help our consumers by providing relevant products and inspiring recipes that help them in a simple manner to support their immune system, she said.

Dr De Bree said Unilever has been working on this healthy shift for about one year.

A key element of our force for good strategy has been boldly healthier. This calls for more plant-based and fortified products and recipes, that at the same time have acceptably low levels of sugar, salt and fat, she elaborated.

COVID-19 has acted as an accelerator of these trends and Unilever intends to use its innovation might and powerhouse brands from Magnum ice cream to Knorr stocks - to respond.

Then came COVID-19, creating the biggest disruption in our lifetimes with tectonic shifts in consumer behaviours and reminding us of the importance of health. Our research shows this has resulted in a spiked interest by consumers for health and immunity.

Experts agree that a diet that is mainly based on plants, with some animal-based products delivers the key nutrients that are needed to optimally support the immune system. If eating such a diet is not possible, for example because it is not available, fortified products may be a good solution. This shows that with our strategy focused on positive, more plant-based nutrition, we are well positioned to serve the current needs of consumers.

Basing its approach on scientific consensus, Dr De Bree continued: We see various areas where Unilever can play an important role.

Unilever will further accelerate its plant-based offerings and leverage its shelf-stable brands such as packaged soups to deliver food that is rich in critical macronutrients.

The company has also set a target of providing 200bn servings of products that deliver at least one critical micronutrient that is important for holistic health and immunity, Dr De Bree revealed. Currently 2bn people around the globe suffer from malnutrition and as a consequence may be immuno-compromised. Vitamin A, D, zinc and iron are amongst these critical micronutrients. These are also the micronutrients that are heavily researched in light of preventing a severe COVID-19 infection and/or treatment when infected, she noted.

Across Unilevers Food and Refreshment business, the company is working to deliver products that are more nutritionally dense and support health and wellbeing.

Our Foods and Refreshment business is uniquely positioned to lead purposefully in the space of holistic health and immunity, Dr De Bree said.

Our biggest food brands (Knorr: Reinventing Food for Humanity; Hellmanns: Taste the Waste) offer thousands of products and recipes which are nutritious, affordable and made with sustainably sourced ingredients.

Our tea and herbal category delivers healthy hydration through Earths most sustainable plant-based drinks. Our recently acquired Horlicks brand offers beverages designed to support the nutritional needs of children, supporting their growth and development; as well as adults. And also ice cream plays a big role in offering people a little happiness through responsible treats, she detailed.

Dr De Bree said that Unilever believes the majority of its brands are well-positioned to respond to health and wellness concerns. We believe the potential to leverage wellness sits in the balance within our portfolio, she explained.

Within its Foods portfolio, Unilever is focused on meeting growing demand for nutritious snacking options and plant-based alternatives.

The companys blockbuster brands have already responded by rolling out plant-based alternatives. Magnum Vegan ice cream and Hellmanns Vegan mayonnaise continue to be popular, the company noted.

It has also extended its reach in the meat-free space through the recent acquisition of The Vegetarian Butcher. This business is growing at a record rate, reflecting a sustained consumer trend, according to Unilever.

This does not mean Unilever is pivoting its portfolio towards plant-based at the expense of other options, Dr De Bree was quick to emphasise. Plant-based (or plant-forward) does not mean exclusivity. Moving towards more plant-based eating is generally healthier for people as well as for the planet. This does not mean that we will not offer choice. For example, as long as consumers still enjoy regular dairy ice cream, this will be something we will cater for.

Knorr is another brand that is focused on improving population health and here the company has seized the fortification opportunity. Last year, Knorr launched Future 50, an initiative that encourages consumers to eat a more diverse, plant-based diet by providing healthy and nutritious recipes. Knorrs Immunity Meals recipes are also a source of micronutrients to support the immune system, such as Vitamin C and D.

Meanwhile, in the groups Refreshment division, tea has seen a spike in demand as consumers turn to Liptons Immune and Daily Support, seen particularly in the US, and Pukkas immunity range, Unilever claimed.

Elsewhere, India and other South East Asian markets have seen a jump in demand for beverage-based nutrition brands, such as Boost and Horlicks. Both beverages are designed to support the nutritional needs of toddlers and children. They also fulfill an adults nutritional needs. Horlicks enhances womens bone health and contains zinc, which is clinically proven to boost the immune response.

Our brands are well suited to provide more plant-based products and inspire consumers to eat more plant-based through recipe suggestion.

Some products are specially formulated including fortification to meet nutritional needs that support health and immunity. Some are intrinsically good such as our [herbal] teas, Dr De Bree observed.

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Unilever eyes potential in wellness: 'We are uniquely positioned to lead purposefully in the space of holistic health and immunity' -...

Suffering from night anxiety? We tell you ways to control it – Times of India

Posted: June 13, 2020 at 10:51 am

The uncertainty of life due to the coronavirus scare has left all of us shaken. The growing numbers of infected cases every day, the Whatsapp forwards highlighting the instability and inefficiency of the medical set up, increasing work pressure, lack of personal space are some common concerns that are pulling us all down. Quite often we feel pangs of anxiety, not knowing how to calm our nerves.

For example, you are worried about losing your job, and then imagine that if it happens, how will you manage your finances, which snowballs into higher anxieties that get difficult to handle.

Mental health experts worldover are reporting a spike in calls and queries about anxiety, depression, feeling of loneliness and other issues, not only among adults but even the youth. And this sense of instability is disturbing our sleeping patterns too because bedtime is the time when your mind relaxes and focuses on what is worrying you.

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Suffering from night anxiety? We tell you ways to control it - Times of India

EDITORIAL: Where are the checks, balances on massive extra budget spending? : The Asahi Shimbun – Asahi Shimbun

Posted: June 13, 2020 at 10:51 am

A second extra budget to finance additional steps to ease the impact of the coronavirus pandemic in the current fiscal year that passed the Diet on June 12 comes to a whopping31.9 trillion yen ($297 billion).

It includes 10 trillion yen worth of reserve funds that can basically be used to cover any unexpected expenses.

This extra budget, formulated to cure the nations enfeebled economy, could give the government unprecedented funds to spend as it likes without being checked by the Diet.

By giving a free hand to the government in using such a vast amount of taxpayer money, the Diet has done something that blatantly violates the principles of fiscal democracy. It also negates thejustification for its own existence.

The Constitution requires any state budget to be authorized by the Diet. A reserve fund that can be spent upon the responsibility of the Cabinet is only allowed as an exceptional funding means to provide for unforeseen deficiencies in the budget.

Given this constitutional provision, there is no doubt that any reserve fund must be used in a restrained manner.

There is no legal provision that sets a clear ceiling on the amount of a reserve fund. Controversies flared in the past over the appropriateness of massive reserve funds.

A dispute raged, for instance, over a 1-trillion-yen reserve fund included in the initial state budget for fiscal 2009 as part of emergency financing measures in response to the economic downturn triggered by the collapse of U.S. investment bank Lehman Brothers in 2008.

Kaoru Yosano, the finance minister at the time, defended the fund, saying it was not outstandingly large (compared with past reserve funds) in terms of its ratio to the total budget, which amounted to 88 trillion yen.

But this time, the size of the reserve fund is by far the biggest in the nation's history. It is 10 times larger than the one in Yosanos spending plan.

Of this amount, 5 trillion yen is to be spent to support troubled small and midsize businesses and help companies avoid cutting jobs, according to the government. But no specifics have yet to be provided. The government has said nothing about the remaining 5 trillion yen except that the money will be used to deal with the effects of the new coronavirus pandemic.

Despite all this uncertainty and vagueness, all the opposition parties with the exception of the Japanese Communist Party voted for the second supplementary budget along with the ruling coalition.

Even though the spending plan includes outlays for measures that need to be implemented immediately, such as expenditures to subsidize rents paid by small and midsize firms, the opposition lawmakers, as well as the ruling camp, fully deserve to be criticized for defaulting on their constitutional responsibility as members of the Diet to check budgets.

In stressing the need for the gargantuan reserve fund, Prime Minister Shinzo Abe said the government needs to take unprecedented steps to ensure that the nation will overcome this once-in-a-century national crisis.

If so, the administration should first ask the Diet to extend the current regular session beyond the June 17 expiry of its term to ensure it can make a swift response to any emergency.

The Constitution mandates the Cabinet to get subsequent approval of the Diet for all payments from the reserve fund. But this 10 trillion yen appropriation is no ordinary reserve fund.

The government should clarify in advance how the money will be spent and obtain Diet approval. In case additional spending is necessary, the government will be able to submit a third extra budget to the Diet swiftly if it is in session.

Diet deliberations in recent days have underscored the vital importance of rigorous Diet monitoring for proper expenditures by the government.

Doubt is only deepening over the governments plan to contract out the administrative work for a program to help cash-strapped businesses survive the current crisis.

An appropriation to pay up to 300 billion yen in fees for a contractor to handle the administrative work for the Go To Campaign" to support the tourist industry, one of the hardest-hit sectors, has drawn much criticism, forcing the government to suspend the process of recruiting the contractor. But the government has yet to say how it will review the contract.

The first and second supplementary budgets allow the government to spend more than 57 trillion yen, a scale of extra expenditures without precedent, to cushion the economic impact of the COVID-19 pandemic. Such a tremendous amount of government spending outside the original state budget requires more transparency than ever before.

The Abe administration needs to continue responding to public doubts and suspicions over these spending blueprints without closing the session in haste.

--The Asahi Shimbun, June 13

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EDITORIAL: Where are the checks, balances on massive extra budget spending? : The Asahi Shimbun - Asahi Shimbun

Researchers Discover How to Turn On the Heat in Energy-Burning Fat Cells – SciTechDaily

Posted: June 13, 2020 at 10:51 am

Researchers have discovered a new set of signals that cells send and receive to prompt one type of fat cell to convert fat into heat. The signaling pathway, discovered in mice, has potential implications for activating this same type of thermogenic fat in humans.

Thermogenic fat cells, also called beige fat or beige adipocytes, have gained attention in recent years for their potential to curb obesity and other metabolic disorders, due to their ability to burn energy stored as fat. But scientists have yet to translate this potential into effective therapies.

The challenge of activating beige fat in humans arises, in part, because this process is regulated through so-called adrenergic signaling, which uses the hormone catecholamine to instruct beige fat cells to start burning energy. But adrenergic signaling also controls other important biological functions, including blood pressure and heartbeat regulation, so activating it in humans with agonists has potentially dangerous side effects.

Heat map of thermogenic fat cells (artistic rendering). Credit: Illustration by Life Sciences Institute multimedia designer Rajani Arora.

In a new study scheduled for online publication today (June 12, 2020) in the journal Developmental Cell, a team of researchers led by the University of Michigan Life Sciences Institute describes a pathway that can regulate beige fat thermogenesis independently of adrenergic signaling. Instead, it operates through a receptor protein called CHRNA2, short for Cholinergic Receptor Nicotinic Alpha 2 Subunit.

This pathway opens a whole new direction for approaching metabolic disorders, said Jun Wu, an assistant professor at the LSI and the studys senior author. Of course, this cholinergic pathway also is involved in other important functions, so there is still much work to do to really figure out how this might work in humans. But we are encouraged by these initial findings.

For their study, Wu and her colleagues blocked the CHRNA2 pathway only in adipocytes in mice, and then fed the mice a high-fat diet. Without the CHRNA2 receptor proteins, the mice showed greater weight gain than normal mice, and were less able to activate thermogenesis in response to excess food intake.

Wu believes the findings are particularly exciting in light of another research teams recent discovery of a new type of beige fat that is not regulated by catecholamine. This newest study from the LSI indicates that this subpopulation of beige fat, called glycolytic beige fat (or g-beige fat), can be activated through the CHRNA2 pathway.

Many patients with metabolic disorders have catecholamine resistance, meaning their cells do not detect or respond to catecholamine, said Wu, who is also an assistant professor of molecular and integrative physiology at the U-M Medical School.

So even if it could be done safely, activating that adrenergic pathway would not be an effective treatment option for such patients. This new pathway, with this new subtype of beige fat, could be the beginning of a whole new chapter for approaching this challenge.

###

Reference: Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation by Heejin Jun, Yingxu Ma, Yong Chen, Jianke Gong, Shanshan Liu, Jine Wang, Alexander J. Knights, Xiaona Qiao, Margo P. Emont, X.Z. Shawn Xu, Shingo Kajimura and Jun Wu, 12 June 2020, Developmental Cell.DOI: 10.1016/j.devcel.2020.05.017

The research was supported by the National Institutes of Health, American Diabetes Association, Chinese Scholarship Council and Michigan Life Sciences Fellows program.

Study authors are: Heejin Jun, Shanshan Liu, Jine Wang, Alexander Knights, Margot Emont, X.Z. Shawn Xu and Jun Wu of U-M; Yingxu Ma of U-M and Central South University, China; Yong Chen and Shingo Kajimura of the University of California, San Francisco; Jianke Gong of U-M and the Huazhong University of Science and Technology; and Xiaona Qiao of U-M and Fudan University, China.

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Researchers Discover How to Turn On the Heat in Energy-Burning Fat Cells - SciTechDaily

Knowing your BMR is crucial for losing weight — here’s how to find yours – CNET

Posted: June 13, 2020 at 10:50 am

BMR can be helpful is losing weight is one of your goals.

No matter what your goals, when it comes to nutrition and body recomposition, knowledge is power. And understanding a few key principles, like how to track macros, calories and how to exercise more effectively is especially important if weight loss is your goal.

If you want to lose body fat, gain muscle or maintain your weight, an important metric you should know about is Basal Metabolic Rate (BMR). Your BMR is the minimum number of calories that your body needs to function at rest. You may think you only need energy to exercise or complete tasks, but your body has a specific energy need just to complete basic functions like breathing and regulating your hormone levels.

Your BMR is not in itself a tool for weight loss, but it can be a helpful starting point for figuring out how to adjust your diet and exercise goals. The problem with a lot of diets and weight loss programs out there is that they are "one size fits all." But every person is different, so taking one meal plan and applying it to multiple people just does not work. Your BMR is calculated based on several different factors that are personal to you, like your age, gender, current weight and activity level.

Keep reading to find out about what BMR is, how to calculate it and how it can help you with your nutrition and exercise goals.

BMR calculators use several different factors, like age and gender, to determine your BMR.

Many people use BMR as a starting point to calculate their daily calorie needs and how to best adjust them to reach their goals. In fact, many macro calculators, like the popular IIFYM, incorporate BMR into their calculations for telling you about your calorie intake and macro needs based on your goals.

One common misconception about BMR is that it is the amount of calories your body burns at rest, but that is a different metric -- Resting metabolic rate or (RMR). Your BMR is what energy your body needs to perform basic functions, while RMR is the amount of calories that your body burns while at rest. Some people use the measurements interchangeably, but they aren't necessarily the same thing.

There are many different calculators available online that can calculate your estimated BMR. Note that some of them will ask you to enter your body fat percentage, which many people do not know. If you don't, you can make an estimate or use the images provided (like IIFYM does) to guess.

Some of the best BMR calculators:

Once you start learning about your BMR, you will likely also find information on TDEE (total daily energy expenditure) since BMR is often calculated first to find TDEE.

Your BMR tells you your calorie needs, when you take that number plus how much you burn every day during normal activity and exercise, you get your TDEE. So really, TDEE is the number that you work off of for figuring out how to adjust macros or calories for body composition goals, according to IIFYM.

Weight loss is tricky, but using calculators that factor in your BMR are helpful for taking a more customized approach for your calories and macronutrient needs. The way that most macros and BMR-based calculators work is by factoring in your TDEE with your goals.

If you want to lose weight, you have to be in a calorie deficit, meaning the calculator will set your daily food intake to equal less calories than what you burn. Sometimes when you take an online quiz to find this number, you will be asked how fast you'd like to lose weight. Then the calorie deficit will be adjusted accordingly. The faster you want results, the more extreme you will have to be with cutting calories. But many experts say that slow and steady is optimal compared to trying to lose a lot of weight quickly.

If you want to maintain your weight instead of lose or gain, then knowing your BMR and TDEE can help you know how many calories you should aim to consume each day to maintain your weight. On the flipside of weight loss is gaining muscle mass. This too requires that you strategically approach your nutrition and add calories into your day (likely in the form of protein and carbs) to make sure you can gain muscle.

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The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

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Knowing your BMR is crucial for losing weight -- here's how to find yours - CNET

Running to weight loss? Accomplishes it truly work – Broadcast Cover – Broadcast Cover

Posted: June 13, 2020 at 10:50 am

Running is an extraordinary method to burn calories yet theres a whole other world to it on the off chance that you need to get more fit.

With rec centers despite everything shut due to the coronavirus pandemic, individuals are searching for simple, at-home exercise schedules.

Theres one compelling, gear free exercise that nearly anybody can take up: Running!

Versatile, flexible and genuinely simple to begin, running can help get in shape, particularly when joined with a solid eating regimen. TODAY addressed two nutritionists to locate the most ideal approach to join running with diet to arrive at your wellness objectives.

As indicated by Natalie Rizzo, a New York City-based enlisted dietitian who works with everyday athletes, running is an incredible method to get more fit since it consumes a ton of calories rapidly.

Youre burning more calories per minute with running than you are with quality preparing or cycling, Rizzo said.

Kristin Kirkpatrick, a dietitian and the chief of wellbeing nourishment administrations at the Cleveland Clinic Wellness Institute, included that the measure of calories you consume running can shift dependent on to what extent or exceptional your exercise does, and said that diet assumes a tremendous job in making the activity viable.

My husbands a trail runner, he will go out for a run and run 15 or 20 miles out in the mountains, Kirkpatrick explained. So that is very high intensity. If youre doing something like that, the chances of losing weight are pretty high, but if youre just someone who walks out the front door and runs three miles, that might not be enough for weight loss if your diet is still lousy.

One of the main goals, when it comes to weight loss, is that you want to burn calories, Rizzo explained. That has to go hand in hand with good nutrition.

The issue with unexpectedly expanding the measure of activity you do, Rizzo stated, is that individuals much of the time think they are consuming a greater number of calories than they are, and overcompensate with regards to eat less carbs.

Its really easy to overeat, she explained. Youre going to feel hungry when youre just starting to run Just because youre running and youre working out doesnt necessarily mean you can eat whatever you want. It really has to be a combination of exercise and diet. Eating healthy is generally whats going to make your weight loss goals happen.

Diet will almost always trump exercise, said Kirkpatrick.

Consolidate running with a sound eating routine to make a calorie shortfall, which Rizzo said is the thing that really makes weight loss goals happen. A calorie shortage basically implies that you are consuming a bigger number of calories than you expend, so its essential to fill your eating routine with lower-calorie nourishments that cause you to feel full.

You want to make sure that youre still eating a healthy diet and following recovery nutrition tactics, Rizzo said. Look for foods that have hunger-fighting properties in them. Thats generally energy-dense foods like fruits and vegetables, legumes and whole grains, beans and things like that. Pack your plate with those. Its going to keep you from overeating things you dont necessarily want.

Kirkpatrick said that you may need to change your eating regimen a piece to ensure you are getting the supplements you need, particularly in case youre running a great deal.

An average person running three to four miles a day doesnt necessarily need to come from a run and immediately re-fuel, she said. You can probably have normal meals and snacks as you typically would. If youre doing five or six miles, youre probably going to have to have some sort of simple sugar to refuel with, and of course water and electrolytes. Complex carbohydrates and lean sources of protein are always a great option.

Rizzo suggests utilizing the right kind of fuel to ensure your body is upheld by your eating routine, yet you dont gorge.

Generally, think about food as fuel for a workout, Rizzo said. One of the main issues that I see with runners, in terms of losing weight, is that they want fuel for their workouts, which a lot of times requires eating a decent amount of carbs and things that theyve been taught are not necessarily the best foods for weight loss. Its almost like theyre fighting with themselves on figuring out what to eat.

On the off chance that you do choose to begin fusing running into your weight reduction venture, Rizzo prescribes beginning gradually and cautiously to stay away from any injury.

You want to make sure you have the right form, she said. And that you dont go out to fast. That can be as simple as Googling the right form. Make sure youre landing on a flat foot, that your arms are at your sides and not crossing in front of your body, because having the wrong form can really lead to difficult injuries.

In case you will be running a great deal, ensure that you have not too bad running shoes, says Rizzo, on the grounds that ill-advised footwear can prompt shin supports.

Another thing that can lead to injuries is going out too fast and trying to train too much, Rizzo clarified, adding that individuals should attempt to consolidate running with different types of activity like quality preparing.

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Action Bronson Just Shared an Update on His Weight Loss Journey – Yahoo Lifestyle

Posted: June 13, 2020 at 10:50 am

Photo credit: David M. Benett - Getty Images

From Men's Health

Rapper and TV host Action Bronson has been making some major changes to his lifestyle while in quarantine. Last month, he told TMZ that since becoming a father, he has been taking his health much more seriously, and that meant committing to exercising and eating differently. "I've been working out like crazy," he said, revealing that he had lost a staggering 50 pounds already through a combination of healthy eating and cardio.

Bronson, whose job as the host of Viceland's F*ck That's Delicious involves a whole lot of eating, just posted a gym video to Instagram, giving fans an update on his journey including the fact that he has now lost 65 pounds to date, and is getting a lot more intense in his training, adding more resistance to his workouts.

In the video, Bronson can be seen cranking out the pushup reps (after months of practice on his balcony), as well as putting everything into a core-busting, fat-burning session on the battle ropes.

"I was on a path that leads straight to the graveyard," he wrote in the caption. "Eating for sport took its toll but it's my fault and it's on me to fix me. I owe it to myself and my family. I reached 363 pounds and I'm down to 298. Then a good friend got me to the right spot now I'm training hard. This is week one."

Bronson's post was met with overwhelming support in the comments. "Let's go!!!" wrote retired Major League Baseball pitcher CC Sabathia, who has undergone his own fitness transformation this year. "Respect... u got this," said UFC fighter Shane Burgos, while his fellow MMA fighter Ilir Latifi said "Keep it up." "Let's go Bam Bam!!" wrote ESPN's Ariel Helwani.

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Action Bronson Just Shared an Update on His Weight Loss Journey - Yahoo Lifestyle

U-M researchers identify new approach to turning on the heat in energy-burning fat cells – University of Michigan News

Posted: June 13, 2020 at 10:49 am

Heat map of thermogenic fat cells (artistic rendering). Image credit: Life Sciences Institute multimedia designer Rajani Arora

Researchers have discovered a new set of signals that cells send and receive to prompt one type of fat cell to convert fat into heat. The signaling pathway, discovered in mice, has potential implications for activating this same type of thermogenic fat in humans.

Thermogenic fat cells, also called beige fat or beige adipocytes, have gained attention in recent years for their potential to curb obesity and other metabolic disorders, due to their ability to burn energy stored as fat. But scientists have yet to translate this potential into effective therapies.

The challenge of activating beige fat in humans arises, in part, because this process is regulated through so-called adrenergic signaling, which uses the hormone catecholamine to instruct beige fat cells to start burning energy. But adrenergic signaling also controls other important biological functions, including blood pressure and heartbeat regulation, so activating it in humans with agonists has potentially dangerous side effects.

In a new study scheduled for online publication June 12 in the journal Developmental Cell, a team of researchers led by the University of Michigan Life Sciences Institute describes a pathway that can regulate beige fat thermogenesis independently of adrenergic signaling. Instead, it operates through a receptor protein called CHRNA2, short for Cholinergic Receptor Nicotinic Alpha 2 Subunit.

This pathway opens a whole new direction for approaching metabolic disorders, said Jun Wu, an assistant professor at the LSI and the studys senior author. Of course, this cholinergic pathway also is involved in other important functions, so there is still much work to do to really figure out how this might work in humans. But we are encouraged by these initial findings.

For their study, Wu and her colleagues blocked the CHRNA2 pathway only in adipocytes in mice, and then fed the mice a high-fat diet. Without the CHRNA2 receptor proteins, the mice showed greater weight gain than normal mice, and were less able to activate thermogenesis in response to excess food intake.

Wu believes the findings are particularly exciting in light of another research teams recent discovery of a new type of beige fat that is not regulated by catecholamine. This newest study from the LSI indicates that this subpopulation of beige fat, called glycolytic beige fat (or g-beige fat), can be activated through the CHRNA2 pathway.

Many patients with metabolic disorders have catecholamine resistance, meaning their cells do not detect or respond to catecholamine, said Wu, who is also an assistant professor of molecular and integrative physiology at the U-M Medical School.

So even if it could be done safely, activating that adrenergic pathway would not be an effective treatment option for such patients. This new pathway, with this new subtype of beige fat, could be the beginning of a whole new chapter for approaching this challenge.

The research was supported by the National Institutes of Health, American Diabetes Association, Chinese Scholarship Council and Michigan Life Sciences Fellows program.

Study authors are: Heejin Jun, Shanshan Liu, Jine Wang, Alexander Knights, Margot Emont, X.Z. Shawn Xu and Jun Wu of U-M; Yingxu Ma of U-M and Central South University, China; Yong Chen and Shingo Kajimura of the University of California, San Francisco; Jianke Gong of U-M and the Huazhong University of Science and Technology; and Xiaona Qiao of U-M and Fudan University, China.

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U-M researchers identify new approach to turning on the heat in energy-burning fat cells - University of Michigan News

Beyond Meat gets ready to feed China and the world – New Hope Network

Posted: June 13, 2020 at 10:49 am

Ethan Brown can't wait to go to China.

The founder and CEO of Beyond Meat was scheduled to take the trip in March, but the coronavirus pandemic put a stop to that plan.

Related: Beyond Meat captures triple-digit revenue growth in fiscal 2019

As soon as he can safely travel, though, he'll be there. He wants Beyond Meat to be a major player as more people there begin eating meat.

"It's a really exciting market for us," Brown said this during the William Blair 40th Annual Growth Stock Conference, which of course was conducted via the internet.

Jon Andersen, a research analyst at William Blair, interviewed Brown and tossed in some questions submitted by the company's investors.

Even before Brown can cross the Pacific, Beyond Meat is working toward its goal of selling the plant-based alternative meat at a price lower than animal-based beef is sold.

Since coronavirus triggered the closing of numerous meatpacking plants across the country, the cost of beef skyrocketedjust as Memorial Day kicked off summer grilling season.

Beyond Meat is taking the opportunity to grab more consumers with its new, value pack of 10 frozen patties at price that, by pound, is about half of its other retail offerings, Brown said.

"This summer, we decided to hold our breath and lean in, because of the very rapid increase in beef pricing on the wholesale and, subsequently, retail markets," he said. "We said this would be a good opportunity for us to invest in pricing.

"It's not going to underprice beef, even at these historic highs, but it will come within striking range, and that's what's important," Brown said. The company's goal is to cost less than animal beef within three-and-a-half years. "We want to see how the consumer reacts to that this summer."

Beyond Meat also plans to start selling its products directly to consumers. Brown didn't give a specific date but said the initiative would launch soon. Although consumers will order via the company's website, it has contracted with a third party to fulfill the orders.

The established retail market has benefited Beyond Meat as the pandemic forced restaurants and other food service outlets to limit sales or close, Brown said. Retail sales haven't completely replaced the lost institutional sales, but they have helped keep the company moving forward.

Europe and Asia are both important markets for Beyond Meat. During Wednesday's conversation, Brown said the European market is better developed than the U.S. market, but that the company needed a production facility there to reduce costs.

The next day, Beyond Meat announced it has contracted with Zandbergen, located in the Netherlands, as a co-packer. The new facility will produce Beyond Burger and Beyond Sausage products. It also will debut a sustainable package that features recyclable trays and less paper and plastic, according to a statement from the company.

Beyond Meat also has acquired a manufacturing plant in the Netherlandsits first outside of Missouri. The plant is expected to be fully operational by the end of the year, the company reported.

The company has been importing supplies from Europe, making the product in the United States, then shipping it back to Europea process Brown said was ridiculous during Wednesday's discussion.

But even without Brown's visit, Beyond Meat is starting to put down roots in Asia. Yum Brands, which owns Taco Bell, KFC and Pizza Hut, has launched Beyond Meat brands there.

"It's kind of a dream come true for a company like mine," Brown said.

But to enter the retail market there, Beyond Meat has some work to do, he said. Asian consumers have a different palate than American consumers, and they use social media differently, as well. But as more residents of China become affluent, they will be more interested in eating meat, Brown said.

"As more meat consumption comes online we hope to benefit from that by providing a plant-based meat," Brown said. He wants to capture the market before consumers make a habit of eating animal meat, so they simply move from a plant-based diet to a diet with plant-based alternative meat, he explained.

"To what extent can we be super aggressive in Asia to help usher in a new era of plant production?" Brown asked rhetorically.

If Beyond Meat can match the taste and nutrition of animal meat, while beating it on price, Brown said he expects consumers in Asia, Europe and the United States to be very attracted to the product.

Link:
Beyond Meat gets ready to feed China and the world - New Hope Network

The CDC Recommends Wearing Face Masks at Any Type of Gathering, Big or Small – Yahoo! Voices

Posted: June 13, 2020 at 10:49 am

MINNEAPOLIS, MN - MAY 26: Protesters march on Hiawatha Avenue while decrying the killing of George Floyd on May 26, 2020 in Minneapolis, Minnesota. Four Minneapolis police officers have been fired after a video taken by a bystander was posted on social media showing Floyd's neck being pinned to the ground by an officer as he repeatedly said,

As states are reopening and lifting social distancing restrictions amid the ongoing COVID-19 pandemic, some communities have begun to host gatherings again. The Centers For Disease Control and Prevention (CDC) is recommending all Americans to continue wearing cloth face coverings, among other guidelines, to help lower the risk of spreading the virus during gatherings and events.

In its updated guidelines, the CDC "strongly encouraged" cloth face coverings in settings where "individuals might raise their voice," citing shouting, chanting, and singing as examples. These settings might include protests, concerts, conferences, and weddings, or any other gatherings where physical distancing may be difficult. As a reminder, wearing a cloth face mask isn't necessarily meant to protect an individual from getting the virus, but rather to protect them from unknowingly spreading the virus to others, if they aren't showing any symptoms, according to the CDC.

Related: Experts Agree That Swimming Is Safe During COVID-19, but You'll Need to Take Precautions

While the World Health Organization (WHO) recently said the asymptomatic spread of coronavirus is "very rare," the CDC advises event organizers and attendees to continue to exercise caution, and prioritize outdoor activities as much as possible. "The more people an individual interacts with at a gathering and the longer that interaction lasts, the higher the potential risk of becoming infected with COVID-19 and COVID-19 spreading," the CDC states.

In addition to wearing face masks, the CDC recommends washing hands often and maintaining distance when possible, and discourages individuals from exchanging physical interactions, like handshakes, fist bumps, and high-fives at events. If you believe that you're infected with the coronavirus, are showing symptoms, or have been in close contact with someone showing symptoms within the past 14 days, you should stay home, especially from gatherings. If you have COVID-19 symptoms, here's how you can take care of yourself at home.

Read more:
The CDC Recommends Wearing Face Masks at Any Type of Gathering, Big or Small - Yahoo! Voices


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