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Food Not Bombs Marks 40th Anniversary, A Conversation With Local Co-Founder – 90.3 KAZU

Posted: June 9, 2020 at 5:45 pm

The volunteer organization Food Not Bombs just marked its 40th anniversary. The group collects vegan and vegetarian food from grocery stores that would otherwise be thrown out and shares it with those in need.

Keith McHenry was part of a group of activists living in Massachusetts when he co-founded the group. Now, he lives in Santa Cruz.

As Food Not Bombs celebrates this 40 year milestone, it now operates in over 65 countries. KAZUs Erika Mahoney spoke with McHenry about the virtual celebration that brought people together from around the world.

Erika Mahoney (EM): Let's go back to 1980. Walk me through the beginning of the organization and explain the significance of the name.

Keith McHenry (KM): I was in my early 20s and my friends were doing a lot of protests against nuclear power and nuclear weapons. I was an art student and I worked at a grocery store and I was just appalled at the amount of produce I was throwing away. So I started taking it to the housing projects to give to the people down there. And one day I'm talking to the residents, we're discussing this brand new building across the street, and they say that's where they design nuclear weapons. And I was like, oh, that's crazy you need food over here, but they've got all this money for nuclear weapons over there. And that's where the name Food Not Bombs came from. Then, we had started like doing street theater with the food. And we saw that really caught people's attention. And then we decided we would do a street theater outside the stockholders meeting of the Bank of Boston and we would dress up like hobos. It was just such an inspiring day that just changed my life. And the guys that were there said, you should do this everyday because there's no food for homeless people in Boston. We decided that night we would quit our jobs and do nothing but collect food, take it to housing projects and make meals that we'd share on the streets. And so that's what we did.

EM: Why do you focus on vegetarian and vegan food for distribution?

KM: I was vegan when we started Food Not Bombs, and that was the case for all eight of us. We thought, well, if we're going to be Food Not Bombs, and we're going to be against violence, we should also be against the violence towards animals and towards the environment and the earth. The other thing is, we were very poor. We had no money and we wanted to do this safely. The only way to really do that was to have the vegan diet and that way we wouldn't have to get special refrigeration units and heating tables and everything to safely feed lots and lots of people.

EM: So Food Not Bombs has gotten in trouble for distributing food to the homeless. Tell me about that.

KM: The original time we got arrested, and I was the first to be arrested, was at Golden Gate Park, August 15th of 1988. And nine of us were arrested that day. There was a photo that showed up the next morning in the San Francisco Chronicle. And that really encouraged people to join us the next Monday. So people like started writing us and leaving messages at our answering service that we had, which overwhelmed them, asking how they could start a Food Not Bombs chapter in their community. And so I had taken notes on how I started the second group in San Francisco, and I made a flier called Seven Steps to starting a Food Not Bombs. And I would mail that to you. By the next summer, there were groups in Prague, Czechoslovakia; Brixton in London; in Melbourne, Australia; Victoria, British Columbia; and also at Tompkins Square Park in New York City.

EM: What was the objection to feeding people?

KM: The objection is, and it's still to this day, a big, big issue, is that you see a large number of homeless people standing outside waiting in line to get food. And it highlights the failure of the local government to deal with a crisis that's at hand.(Click here to read a newspaper article published August 16, 1988.)

EM: In Santa Cruz, you work closely with homeless people. Homelessness is affecting all communities across California and the nation and the world. What's something youd like to share about unhoused individuals that maybe people don't see?

KM: Rather than just looking down on people living outside, people should really realize that these are our neighbors, our family members, our friends. And they're really a victim of an economic and political system that has forced people onto the streets.

EM: What do you believe is the best way for our country to deal with hunger?

KM: I think that we need to get to a point where we realize that food and shelter and education and health care are rights, basic human rights. Those things are being withheld for profit and that we need to turn around. And that's, I think where Food Not Bombs has been most effective, is in developing this idea that, it is one of our slogans, is "food's a right, not a privilege."

EM: Do you have a favorite memory over your time with Food Not Bombs?

KM: Here... this is an interesting one. It was a snowy day in Boston and I was trying to deliver to one of the shelters, the food, and they had not come back. I was just sitting there with our van open and I had buckets of tofu that were in ice that were part of what I was going to donate. And this woman, African-American woman, just silently walks up to the van and she points to the bucket of tofu and I say, well it's not cooked. You know, it's frozen. She just didn't say a word and insisted that I hand her the eight ounces of tofu, you know, a little block of tofu. So I hand it to her and before long, my van is surrounded by people eating frozen tofu. They were so hungry. So I think that was one of the most shocking things I've heard. But I could tell you many, many amazing stories about Food Not Bombs. And, you know, in 40 years, it's just, it's magical, the amount of things that have happened.

Keith McHenry co-founded Food Not Bombs, which just marked its 40th anniversary. McHenrys weekly food distributions in Santa Cruz have recently turned into daily ones due to the coronavirus pandemic.

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Food Not Bombs Marks 40th Anniversary, A Conversation With Local Co-Founder - 90.3 KAZU

Life after lockdown should start with this healthy to-do list – Cherokee Phoenix

Posted: June 9, 2020 at 5:45 pm

BYSTAFF REPORTS

06/09/2020 02:00 PM

And when it is safe, what should be on your post-lockdown health checklist?

As you prioritize your health to-do list, be aware of coronavirus rates in your area, your personal risk from COVID-19 based on your age and medical conditions, and what experts are advising in your area and for your personal care.

Reschedule missed procedures or screenings

Work with your health care team to reschedule high-priority procedures or screenings, where available.

In arecent report, 16 North American cardiovascular societies issued guidance for health professionals on safely reintroducing diagnostic tests and invasive cardiovascular procedures, with an eye to regions with lower rates of infection.

The pandemic has taken a toll on cardiovascular care, said cardiologist Dr. Robert Harrington,chair of the department of medicine at Stanford University in California. He coauthored the report as president of the American Heart Association.

"We've seen a large drop-off in patients seeking acute care for suspected heart attacks and strokes. There's been a decrease in more elective procedures such as exercise testing, cardiac catheterization and other procedures. Anecdotally, we also hear of people having worsening symptoms at home, with a reluctance to seek care for issues such as heart failure management."

Among other concerns, the new report stresses the need for cardiovascular care providers to prioritize procedures or tests with the most benefit for the most people, and to balance risk of further care postponement against risk of further spreading COVID-19.

"Video and phone visits remain the preferred mode for care for the near future as social distancing,masksand good hand hygiene remain critical to prevent and reduce the risks of infection," Harrington said. "There should be local protocols for all of this in the clinical environment that also take into consideration recommendations from local public health departments."

The American Cancer Societyaddresses similar questionsabout resuming cancer screenings and exams, urging people to talk to health care providers about their personal situations and whether they're having symptoms. Among the considerations: balancing the risk of the cancer being screened for against the risk from COVID-19, how involved the screening is, how common coronavirus infections are locally and what local officials advise, and precautions taken by individual medical centers to prevent COVID-19's spread.

Make a catch-up appointment with your primary care doctor

People who have missed routine medical care can schedule a catch-up visit, including by telephone or video. Primary care providers will want updates on their patients' health during the pandemic, including any weight or diet changes, depression symptoms, sleep problems, and COVID-19 or other illness. They'll want to know how home monitoring of chronic conditions has been going.

Also, primary care providers can help people balance their personal health vulnerability against local COVID-19 infection trends to determine whether and when to pursue in-person visits for routine care like vaccinations and dental checkups.

It's safe for most people to return to health care facilities, said Mercedes Carnethon, an epidemiologist and vice chair of the department of preventive medicine at Northwestern University in Chicago.

"Health care delivery teams have been thoughtful about setting up their offices in a way to reduce the probability of exposure by wearing protective health equipment such as masks and gloves, reducing the number of patients in the waiting room at any single time and converting those visits that can be done remotely to telehealth. In most cases, the health care provider's office will welcome questions about safety from patients," she said.

Take care of your lungs

Given that COVID-19 is a respiratory disease, keeping the lungs healthy should be high on the to-do list, Carnethon said.

Because smoking and vaping cause lung damage that's preventable, she said, "Don't start smoking now, and search for resources to help with quitting."

Make a plan for future medical care

Any health care checklist can include discussions with family about future health decisions in the case of serious illness, with the goal of recording those wishes in advance health care directives.AARPand theAHAprovide resources to help.

Set and follow through on health priorities

"The same principles of a healthy lifestyle hold true in our post-COVID world as they did pre-COVID," Carnethon said. "Individuals will thrive by committing to a lifestyle where they are thoughtful about what they eat, how much they move and how much they sleep." In particular, physical activity can promote both physical and mental wellness, she said.

Harrington additionally advises people to take medicines as prescribed and reduce stress through yoga, meditation or other methods.

People ready to venture back to the fitness center should evaluate whether the risk of COVID-19 transmission is low or high in their community. Either way, Harrington said, "social distancing and masking when near others and using good hand hygiene remain important."

Editor's note: Because of the rapidly evolving events surrounding the coronavirus, the facts and advice presented in this story may have changed since publication. Visit Heart.org for the latest coverage, and check with the Centers for Disease Control and Prevention and local health officials for the most recent guidance.

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Life after lockdown should start with this healthy to-do list - Cherokee Phoenix

Gemma Collins looks unrecognisable in very slim throwback picture as she reveals battle with PCOS made her g – The Irish Sun

Posted: June 9, 2020 at 5:45 pm

GEMMA Collins has revealed her battle with polycystic ovary syndrome (PCOS) as she posted an unrecognisable throwback snap.

The 39-year-old said the condition made her gain weight as she shared a "very slim" snap of herself in her 20s.

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Gemma Collins said: "As you can see guys when I was in my 20s I was very slim then I was told I had PCOS and its been a struggle ever since however I make the most of myself and remain positive because its what in your heart counts the most sending love to all the PCOS sufferers its not easy and always be kind people people are not always over weight because of all the stereo typical bullying comments !!!

"I CHOSE to RISE ABOVE and continued to promote body confidence even when I had my own personal struggles and the secret to my success was just being ME !

"Lots of people have bullied me taunted me and also early on in the industry loose weight Your too fat to promote my brand !!! Its endless !!!

"Cough cough .... where are you people now. WHERE AM I, RISE HIGHER. Always BELIEVE IN YOU. my heart has always been the same no matter of my size."

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What is polycystic ovary syndrome?

POLYCYSTIC ovary syndrome affects one in five women and has an impact on how ovaries function.

According to the NHS, symptoms will often be experienced in early twenties or late teens and one of the symptoms is weight gain.

Sufferers can struggle to release an egg to be fertilised making it often extremely difficult to fall pregnant.

For many, the only hint of PCOS is irregular periods, while in more severe cases sufferers can be left with embarrassing hair growth on their faces, chest, back and backside.

Having polycystic ovaries also increases a woman's chance of developingtype 2 diabetes, depression, high blood pressure and high cholesterol and sleep apnoea later in life, the NHS warned.

Earlier today Gemma spoke out about her shrinking frame she told fans her "secret" to losing three stone is down to keeping up with her weight loss injections.

In June The Sun Online exclusively revealed The GC was on a new weight loss plan SkinnyJab, which are injections that act as an appetite suppressant.

Despite the temptation of ditching her diet and slacking on exercise, Gemma has maintained her weight loss - and fans have been desperate to know how.

"Lots of you been asking me how I am looking so good," Gemma said today.

"I need to tell about how amazing the team at Skinny Jab have been throughout lockdown.

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WHAT ARE WEIGHT LOSS INJECTIONS?

THE jabs act as an appetite suppressant, reducing hunger and cravings to ensure that users eat less.

SkinnyJab report that it takes three days for their clients to experience a loss of hunger when on the plan, with a three week plan costing 250, and repeat pens 135 after that.

Fasting diets can typically be dangerous, with your body entering ketoacidosis, or "starvation mode" when cells aren't able to get enough glucose (sugar) for energy.

However, SkinnyJab reassure users that the appetite suppresant used in their plan regulates glucose, allowing the body to use stored fat for energy.

The website states: "This means that you can safely consume small portions without experiencing the undesired effects of starvation mode."

The company also insist that side effects are limited, with mild nausea affecting less than 1% of their patients.

There is also an on-hand medical team available, with all clients undergoing a full clinical health screening before they are provided with the jabs.

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"I think its safe to say weve all had those days over these past month where weve felt very low with no motivation to do anything.

"But keeping on track of my weightloss and continuing to stay motivated has never been easier with skinny jab on board.

"Honestly, Caroline and her team have been the best support! Not only have they kept my supply of jabs up to date, theyve also been providing me with meals plans and weekly check ups with how Im getting on.

"Please go check out their page if youre looking for a real solution to loosing weight! @skinnyjab. #ad I have always been body confident no matter of size."

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Gemma Collins looks unrecognisable in very slim throwback picture as she reveals battle with PCOS made her g - The Irish Sun

It is a national scandal that children will soon be able to go to Thorpe Park, but not to school – Telegraph.co.uk

Posted: June 9, 2020 at 5:45 pm

Driving past a school a few days ago, I stopped to let a group of children cross the road. There must have been ten of them, all in single file, wearing their plum and grey school uniform, with two teachers keeping guard at the front and the back. I stopped long enough to see what happened when they reached the other side.

The teachers made the children they were very young, maybe five or six years old open their arms wide to establish a distance between themselves and their neighbour on either side. Then, off they went, not laughing, skipping or whispering as small children do, but in a glum, stretched-out column, remote from one another.

The children were not the required two metres apart. How could they be? Their little arms were much too short to achieve that span. Still, if one of them had stumbled into the bus lane they were far away enough to mean that no adult could have got there in time. That was my Mummy Mind kicking in. If youve ever had small children of your own you never stop doing that kind of instant risk assessment.

Looking at that sad school crocodile, my Mummy Mind was telling me that those children were in danger. Not from a passing bus. The danger was from unnatural, anti-social distancing measures (SDs) which have been foisted upon them by adults who claim that its about keeping them safe from a virus which is fast disappearing and which doesnt harm children anyway. Its like that fairytale in which the wicked witch convinces Rapunzel that she must stay locked up in a tower for her own good. The witch is lying.

Is our Government lying about schools, children and Covid19? Has the fear they instilled through public health messaging worked so well that millions of parents, under the powerful spell of irrationality, are now too scared to send their kids to school so classrooms must be reordered to cope with an imaginary threat? Have the teaching unions seized this opportunity to bugger up Boris? (Silly question. Course they have.)

Could Matt Hancock be serious when he did a handbrake-turn on plans to get all primary-school pupils back for four weeks before the summer holidays? (A painfully modest ambition as it was.)

Astonishingly, the Health Secretary even hinted that secondary schools may not be ready to resume in September, thereby maiming the prospects of millions of teenagers who are already depressed, disheartened and zombified by a daily diet of Call of Duty.

If Hancock is serious, this is now a national scandal. It calls for legal action against the Government (one group of parents I know is already taking advice at the highest level), against the teaching unions and, quite frankly, against any of the wickedly useless adults who have failed to provide that service which is enshrined in Article 2 of the First Protocol of the Human Rights Act. A childs right to an education.

It is simply incredible that British schools will not be ready by the start of the autumn term. Why the hell not? Some 22 European countries have reopened their schools. That has not led to a spike in coronavirus infections. On the contrary, Frances education minister said it is more of a risk keeping children at home (Gavin Williamson, are you listening?).

Children, if they get corona at all, are asymptomatic and the World Health Organisation said this week that asymptomatic transmission is very rare. Teachers are more likely to get the virus from a supermarket trolley than a student. Normal flu poses a far greater threat (in an average year, flu kills twelve children under the age of 15, Covid has claimed 3.)

The worry now is that, after such a prolonged absence from school, and from bug-trading with snotty-nosed classmates, they will be even more vulnerable to infection. Some paranoid parents are unwittingly raising mini Howard Hugheses, a scientist friend observes, with a baseline psychology of isolation and greatly reduced exposure to the germs that teach their immune system while theyre learning. Its quite scary."

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It is a national scandal that children will soon be able to go to Thorpe Park, but not to school - Telegraph.co.uk

Adele weight loss diet plan: How to lose 7lb in 7 days following the Sirtfood diet – Express

Posted: June 9, 2020 at 5:44 pm

Adele, best known for popular hits like Someone Like You and Turning Tables, recently revealed photos that showed off her weight loss transformation. The London-born singer shared photos on Instagram showing off her slim figure after being out of the public eye for a few years. Heres how she lost the weight while following a super easy diet plan.

The Sirtfood diet is famous for allowing red wine and chocolate on the diet.

It encourages slimmers to eat plant based foods known as sirtfoods which can kickstart your metabolism, regulate your appetite, boost muscle tone and burn fat.

The diet is based on research on sirtuins, a group of seven proteins found in the body that has been shown to regulate a variety of functions, including metabolism.

In order to follow it correctly, you must stick to a calorie restriction which can help with weight loss.

READ MORE:Atkins diet: This diet plan can help lose weight faster than others - how does it work?

Nutritionist Aidan Goggins, co-author of The Sirtfood Diet explains: For the first three days, you restrict calorie intake to 1,000 calories a day, which includes drinking three sirtfood green juices plus eating a sirtfood-rich meal and snacking on antioxidant sirtfood bites.

For the last four days, you up the calorie intake to 1,500 calories a day by consuming two sirtfood-rich meals and two green juices, cutting out the bites.

Restricting your calorie intake to 1,000 calories a day will put your body into a calorie deficit, meaning you will most likely be burning more than you are consuming and even more if you exercise too.

The first phase lasts seven days and it can help you lose up to seven pounds in seven days by kickstarting your weight loss.

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During the first three days of phase one, you will be restricted to 1,000 calories and you can drink three green juices per day plus one meal.

Meal examples include miso-glazed tofu, the sirtfood omelet or a shrimp stir-fry with buckwheat noodles.

The second phase lasts for two weeks and the creators of the diet say this is when you should continue to steadily lose weight.

You may repeat these two phases as often as desired for further weight loss.

The top sirtfoods include:

Kale Red wine Strawberries Onions Soy Parsley Extra virgin olive oil Dark chocolate Matcha green tea Buckwheat Turmeric Walnuts Rocket Medjool dates Blueerries Capers Coffee

The majority of these foods have demonstrated health benefits in humans.

Not only for weight loss but lowering the risk of heart disease, help fight inflammation, reducing the risk of stroke and even lowering blood pressure.

Sirtfood green juice:

75g kale30g rocket5g flat-leaf parsley5g lovage leaves (optional)150g celery, including leavesHalf medium green appleJuice half lemonHalf tsp matcha tea powder

Juice all of the ingredients together, except for the matcha tea powder and lemon. Pour the mix into a glass and then squeeze the lemon by hand and add the tea powder.

The juice is important for the first phase of the diet as it can kick start the metabolism which contributes to weight loss.

Experts recommend only using matcha in the first two drinks of the day as it contains the same caffeine content as a normal cup of tea.

Countries where people already consume a vast number of sirtfoods including Japan and Italy, which are both regularly ranked among the worlds healthiest countries.

Other celebrities who have loved the Sirtfood diet include Pippa Middleton, chef Lorraine Pascale and Jodie Kidd.

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Adele weight loss diet plan: How to lose 7lb in 7 days following the Sirtfood diet - Express

Mark Allen reveals weight loss success ahead of World Championship – Belfast Live

Posted: June 9, 2020 at 5:44 pm

Mark Allen has revealed how he has ditched beer and fast food to get in shape for next month's World Championship.

The Northern Ireland snooker star has gone on a strict diet ahead of his return to the Crucible.

And the Antrim man hopes his new healthy eating regime can fuel his quest for a first world crown.

"I've lost 22lbs in four weeks, it's been good although I'm missing a beer and I've been craving pizza," said the world number four.

"It started as a bet with four of my mates, that we could lose more weight that each other. It's all about the bragging rights.

"But Ive been enjoying it and for me it's part of the jigsaw about becoming a better player.

"I've been cutting out all the rubbish, so no takeaways, no crisps, chocolate or fizzy drinks.

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"I've been staying away from all the bad stuff, eating steaks, chicken and prawns. And I've been having smoothies every day.

"I'm going in the right direction, but I've still got a long way to go before I'm happy."

Allen added: "I had to pull my finger out, especially because you have to be fit to win in Sheffield.

"Stamina is a big test for 17 days in Sheffield. It's a tough test.

"In general, the winner of the World Championship keeps themselves fit, so this is the bit that I've got to try and crack.

"I'm trying to be a lot more disciplined off the table so I can reap the rewards on it."

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Mark Allen reveals weight loss success ahead of World Championship - Belfast Live

How effective is Cinnamon for weight loss? Know the facts – BOL News

Posted: June 9, 2020 at 5:44 pm

Stubborn belly fat and overall body fat is something we usually get worried about and people with much busy schedule dont get enough time to work on to reduce their body fat. This negligence causes increase in body weight and several health problems.

We have heard about many spices which are said to be very beneficial for weight loss in few days because they are natural substances and have no preserved ingredients.

Including all the natural spices, Cinnamon is one of the most beneficial spice for weight loss and other health benefits.

People have used cinnamon since 2000 BC in Ancient Egypt, where they regarded it highly. In medieval times, doctors used it to treat conditions such as coughing,arthritis, andsore throats.

It is now the second most popular spice, after black pepper, in the United States and Europe.

As a spice, cinnamon is available in powder form or whole, as pieces of bark. People can also use cinnamon essential oil and supplements.

Here we will discuss about the procedure to use Cinnamon in a drink to burn the body fat.

Step 1: Boil water till it boils ans use an inch of Cinnamon seed and soak it in the water for 2-3 minutes with a covered lit.

Step 2: Now drink a cup of that hot water when your stomach is empty, every morning for consecutive 40 days.

As for summers, those who want to avoid drinking hot water, can use Cinnamon soaked the whole night in a cup at room temperature and use it every morning.

You can throw the Cinnamon stick and can only get benefit from the enriched water. Also, it can be used in a sprinkle form on salads and desserts to get a fast weight loss result.

Moreover, various compounds in Cinnamon may benefit the cardiovascular system. Cinnemaldehyde, for example, lowered blood pressure in an animal study.

In a study, rats that received long-term treatment involving cinnamon and aerobic training had better heart function than those that did not.

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How effective is Cinnamon for weight loss? Know the facts - BOL News

5 Tried and tested ways to speed up weight loss – PINKVILLA

Posted: June 9, 2020 at 5:44 pm

Unable to lose weight? Then follow these proven and study backed ways and speed your weight loss.

Did you know that obesity is linked to several diseases and health disorders such as type 2 diabetes, high blood pressure, heart disease and strokes, osteoarthritis and fatty liver disease among others? Unfortunately, obesity has tripled between the years of 1975 and 2017. In 2016, 1.9 billion adults were overweight and more than 650 million adults were obese. Due to the sedentary living and lack of time for a healthy lifestyle, many are becoming overweight. As per WHO, overweight and obesity are defined as ''abnormal or excessive fat accumulation that presents a risk to health''.

If your BMI is greater than or equal to 25 then you are overweight and if your BMI is greater than or equal to 30 then you are obese. It not only impacts your appearance, but also physical and mental wellbeing and your daily chores. And that's why if you are overweight or obese then you should lose extra fat and others too, should follow healthy eating and exercise daily to prevent the same. Are you a weight watcher and want to optimize your weight loss regime, then read on as today we have listed some proven weight loss hacks.

1. A bowl of soup before your meals

A study revealed that eating a bowl of soup before a meal can help curb your appetite and over-eating.Also, this gives your brain, hormones, and your stomach enough time to coordinate a message of fullness. Over-eating leads to extra calories and when not burned these extra calories get stored as fat.

2. Snack it right

Waiting until you're extremely hungry is not a good idea, so make sure to have a moderate amount of meals and snacks throughout the day. If you starve then you will eat more and not feel satisfied. You will also end up eating too fast, which is again not advisable. So, when hungry instead of munching packaged foods, have healthy foods such as seeds, nuts, fruits, whole wheat crackers, and low-fat cheese among others.

3. Are you sleeping properly?

Sleep is very crucial for weight loss. As per a study, people who were on a diet consumed 6% fewer calories when they got enough sleep. Also, try to sleep in a cold environment as our body burns stored fats to keep the body warm. A study published in the journal Diabetes revealed that people who slept in rooms with a temperature of around 66 F burned 7% more calories than those who slept in warmer rooms.

4. Blue colored plates

As per research, people tend to eat less when eating from blue plates. Also, they found people eat 33% less in a blue room. Higher contrast in colors between the plate/room and the food works.

5. Spice up your food

Spicy food can temporarily boost your metabolism by up to 8%. Also, eating spicy food encourages people to eat slowly and the same eventually boosts metabolism.

ALSO READ: Weight Loss: Try these 1 spoon hacks and lose extra fat

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5 Tried and tested ways to speed up weight loss - PINKVILLA

Karyopharm Announces Dosing of First Patient in a Phase 1/2 Study of Selinexor in Combination with Standard of Care Therapy for Patients with Newly…

Posted: June 9, 2020 at 5:44 pm

NEWTON, Mass., June 09, 2020 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), an innovation-driven pharmaceutical company, today announced dosing of the first patient in a Phase 1/2 clinical study evaluating oral selinexor in combination with standard of care therapy in patients with newly diagnosed or recurrent glioblastoma (GBM). This global study is expected to enroll approximately 400 patients at clinical sites in the U.S., Europe, and Israel.

Selinexor is an oral selective inhibitor of nuclear export (SINE) compound which blocks the cellular protein XPO1, whose function includes playing a key role in regulating the activity of tumor suppressor proteins and other oncoproteins relevant in cancer cell biology. XPO1 may be an important, novel target in the treatment of patients with GBM as it is frequently overexpressed in both GBM and in high-grade gliomas, and the degree of XPO1 over-expression correlates with higher tumor grade and poor overall patient survival. Nonclinical studies indicate that selinexor has potent anti-GBM activity as monotherapy and is synergistic when combining with radiation, temozolomide and lomustine. Additionally, in previous clinical studies (KING study/NCT01986348), selinexor has demonstrated that it crosses the blood-brain barrier with adequate intra-tumoral penetration and single-agent efficacy with durable response and disease stabilization in heavily pretreated GBM patients further supporting the rationale for clinical development of selinexor to treat patients with brain cancers.

The randomized, multi-center, Phase 1/2 study (XPORT-GBM-029/NCT04421378) will be conducted in two phases: a Phase 1 dose finding study followed by a Phase 2 randomized efficacy exploration study, designed to independently evaluate three different combination regimens in three treatment arms in patients with newly diagnosed GBM (Arms A and B) or with recurrent GBM (Arm C). Arms A and B will investigate selinexor in combination with radiation therapy with or without the addition of temozolomide, while Arm C will evaluate the combination of selinexor and lomustine. The primary endpoints in the study are progression-free survival in patients with newly diagnosed GBM and overall survival (OS) in patients with recurrent GBM.

Yazmn Odia, M.D., Chief of Neuro-Oncology at Miami Cancer Institute, Baptist Health South Florida (BHSF), and investigator in the study, stated, We are very excited about the launch of this innovative clinical trial on behalf of our patients who desperately need new treatment options for what is typically an incurable disease and given the few meaningful therapeutic advances in recent years.

We are hopeful that this study evaluating the activity of selinexor in combination with currently used standard treatments will help us further identify promising novel approaches for the treatment of patients with both newly diagnosed and recurrent GBM, commented Minesh Mehta, M.D., Chief of Radiation Oncology at Miami Cancer Institute, BHSF, and investigator in the study.

While selinexor has been most extensively studied in patients with hematologic malignancies, there is increasing evidence that selinexor may also play an important role in the treatment of a variety of solid tumors, including patients with GBM, said Sharon Shacham, PhD, MBA, President and Chief Scientific Officer of Karyopharm. We were highly encouraged by the results from our previous Phase 2 KING study, which evaluated selinexor as a single agent in patients with recurrent GBM and demonstrated clear anti-cancer activity. We now look forward to assessing selinexors activity in combination with currently used standard of care treatments where we hope it will prove to be synergistic and even more effective.

Selinexor, marketed as XPOVIO, is currently approved by the U.S. Food and Drug Administration (FDA) as a treatment for patients with relapsed or refractory multiple myeloma. Selinexor is currently the only XPO1 inhibitor approved by the FDA and has been extensively tested in clinical trials across numerous cancer indications worldwide since 2012. Karyopharm has also submitted two additional supplemental New Drug Applications for XPOVIO which are currently under review by the FDA; one is for an expansion of XPOVIOs label to include XPOVIO as a treatment for patients with multiple myeloma after at least one prior line of therapy and the other for the treatment of patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).

About GBM

Glioblastoma Multiforme (GBM) is one of the most common and particularly aggressive forms of brain tumors of primarily glial cell origin. GBM is diagnosed in patients at a median age of 64 years but can occur at any age, including in childhood. GBM is an incurable disease and the prognosis for patients is typically poor due in part to its aggressive and extensive infiltration of surrounding central nervous system tissue and its frequent inaccessibility for surgical resection within the brain. In addition, the blood-brain barrier presents an obstacle for many chemotherapeutic agents, with only small, lipophilic molecules able to reach the tumor. Median survival in patients with newly diagnosed GBM is approximately 15 months and approximately five to seven months in patients with recurrent disease.

About XPOVIO (selinexor)

XPOVIO is a first-in-class, oral Selective Inhibitor of Nuclear Export (SINE) compound. XPOVIO functions by selectively binding to and inhibiting the nuclear export protein exportin 1 (XPO1, also called CRM1). XPOVIO blocks the nuclear export of tumor suppressor, growth regulatory and anti-inflammatory proteins, leading to accumulation of these proteins in the nucleus and enhancing their anti-cancer activity in the cell. The forced nuclear retention of these proteins can counteract a multitude of the oncogenic pathways that, unchecked, allow cancer cells with severe DNA damage to continue to grow and divide in an unrestrained fashion. Karyopharm received accelerated U.S. Food and Drug Administration (FDA) approval of XPOVIO in July 2019 in combination with dexamethasone for the treatment of adult patients with relapsed refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is refractory to at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody. Karyopharm has also submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) with a request for conditional approval of selinexor. A supplemental New Drug Application was accepted by the FDA seeking accelerated approval for selinexor as a new treatment for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), and selinexor has received Fast Track and Orphan designation and Priority Review from the FDA with a scheduled PDUFA date of June 23, 2020 for this patient population. Selinexor is also being evaluated in several other mid-and later-phase clinical trials across multiple cancer indications, including in multiple myeloma in a pivotal, randomized Phase 3 study in combination with Velcade (bortezomib) and low-dose dexamethasone (BOSTON), for which Karyopharm announced positive top-line results in March 2020. In May 2020, Karyopharm submitted a supplemental New Drug Application based on data from the Phase 3 BOSTON study. Additional, ongoing trials for selinexor include as a potential backbone therapy in combination with approved myeloma therapies (STOMP), in liposarcoma (SEAL) and in endometrial cancer (SIENDO), among others. Additional Phase 1, Phase 2 and Phase 3 studies are ongoing or currently planned, including multiple studies in combination with approved therapies in a variety of tumor types to further inform Karyopharms clinical development priorities for selinexor. Additional clinical trial information for selinexor is available at http://www.clinicaltrials.gov.

For more information about Karyopharms products or clinical trials, please contact the Medical Information department at:

Tel: +1 (888) 209-9326Email: medicalinformation@karyopharm.com

IMPORTANT SAFETY INFORMATION

Thrombocytopenia

XPOVIO can cause thrombocytopenia, leading to potentially fatal hemorrhage. Thrombocytopenia was reported as an adverse reaction in 74% of patients, and severe (Grade 3-4) thrombocytopenia occurred in 61% of patients treated with XPOVIO. The median time to onset of the first event was 22 days. Bleeding occurred in 23% of patients with thrombocytopenia, clinically significant bleeding occurred in 5% of patients with thrombocytopenia and fatal hemorrhage occurred in <1% of patients.

Monitor platelet counts at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Institute platelet transfusion and/or other treatments as clinically indicated. Monitor patients for signs and symptoms of bleeding and evaluate promptly. Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.

Neutropenia

XPOVIO can cause neutropenia, potentially increasing the risk of infection. Neutropenia was reported as an adverse reaction in 34% of patients, and severe (Grade 3-4) neutropenia occurred in 21% of patients treated with XPOVIO. The median time to onset of the first event was 25 days. Febrile neutropenia was reported in 3% of patients.

Obtain neutrophil counts at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Monitor patients for signs and symptoms of concomitant infection and evaluate promptly. Consider supportive measures including antimicrobials for signs of infection and use of growth factors (e.g., G-CSF). Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.

Gastrointestinal Toxicity

Gastrointestinal toxicities occurred in patients treated with XPOVIO.

Nausea/Vomiting

Nausea was reported as an adverse reaction in 72% of patients, and Grade 3 nausea occurred in 9% of patients treated with XPOVIO. The median time to onset of the first nausea event was 3 days.

Vomiting was reported in 41% of patients, and Grade 3 vomiting occurred in 4% of patients treated with XPOVIO. The median time to onset of the first vomiting event was 5 days.

Provide prophylactic 5-HT3 antagonists and/or other anti-nausea agents, prior to and during treatment with XPOVIO. Manage nausea/vomiting by dose interruption, reduction, and/or discontinuation. Administer intravenous fluids and replace electrolytes to prevent dehydration in patients at risk. Use additional anti-nausea medications as clinically indicated.

Diarrhea

Diarrhea was reported as an adverse reaction in 44% of patients, and Grade 3 diarrhea occurred in 6% of patients treated with XPOVIO. The median time to onset of diarrhea was 15 days.

Manage diarrhea by dose modifications and/or standard anti-diarrheal agents; administer intravenous fluids to prevent dehydration in patients at risk.

Anorexia/Weight Loss

Anorexia was reported as an adverse reaction in 53% of patients, and Grade 3 anorexia occurred in 5% of patients treated with XPOVIO. The median time to onset of anorexia was 8 days.

Weight loss was reported as an adverse reaction in 47% of patients, and Grade 3 weight loss occurred in 1% of patients treated with XPOVIO. The median time to onset of weight loss was 15 days.

Monitor patient weight at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Manage anorexia and weight loss with dose modifications, appetite stimulants, and nutritional support.

Hyponatremia

XPOVIO can cause hyponatremia; 39% of patients treated with XPOVIO experienced hyponatremia, 22% of patients experienced Grade 3 or 4 hyponatremia. The median time to onset of the first event was 8 days.

Monitor sodium level at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Correct sodium levels for concurrent hyperglycemia (serum glucose >150 mg/dL) and high serum paraprotein levels. Treat hyponatremia per clinical guidelines (intravenous saline and/or salt tablets), including dietary review. Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.

Infections

In patients receiving XPOVIO, 52% of patients experienced any grade of infection. Upper respiratory tract infection of any grade occurred in 21%, pneumonia in 13%, and sepsis in 6% of patients. Grade 3 infections were reported in 25% of patients, and deaths resulting from an infection occurred in 4% of patients. The most commonly reported Grade 3 infections were pneumonia in 9% of patients, followed by sepsis in 6%. The median time to onset was 54 days for pneumonia and 42 days for sepsis. Most infections were not associated with neutropenia and were caused by non-opportunistic organisms.

Neurological Toxicity

Neurological toxicities occurred in patients treated with XPOVIO.

Neurological adverse reactions including dizziness, syncope, depressed level of consciousness, and mental status changes (including delirium and confusional state) occurred in 30% of patients, and severe events (Grade 3-4) occurred in 9% of patients treated with XPOVIO. Median time to the first event was 15 days.

Optimize hydration status, hemoglobin level, and concomitant medications to avoid exacerbating dizziness or mental status changes.

Embryo-Fetal Toxicity

Based on data from animal studies and its mechanism of action, XPOVIO can cause fetal harm when administered to a pregnant woman. Selinexor administration to pregnant animals during organogenesis resulted in structural abnormalities and alterations to growth at exposures below those occurring clinically at the recommended dose.

Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential and males with a female partner of reproductive potential to use effective contraception during treatment with XPOVIO and for 1 week after the last dose.

ADVERSE REACTIONSThe most common adverse reactions (incidence 20%) are thrombocytopenia, fatigue, nausea, anemia, decreased appetite, decreased weight, diarrhea, vomiting, hyponatremia, neutropenia, leukopenia, constipation, dyspnea, and upper respiratory tract infection.

The treatment discontinuation rate due to adverse reactions was 27%; 53% of patients had a reduction in the XPOVIO dose, and 65.3% had the dose of XPOVIO interrupted. The most frequent adverse reactions requiring permanent discontinuation in 4% or greater of patients who received XPOVIO included fatigue, nausea, and thrombocytopenia. The rate of fatal adverse reactions was 8.9%.

Please see XPOVIO Full Prescribing Information available atwww.XPOVIO.com.

About Karyopharm Therapeutics

Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is an innovation-driven pharmaceutical company dedicated to the discovery, development, and commercialization of novel first-in-class drugs directed against nuclear export and related targets for the treatment of cancer and other major diseases. Karyopharm's Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1 (or CRM1). Karyopharms lead compound, XPOVIO (selinexor), received accelerated approval from the U.S. Food and Drug Administration (FDA) in July 2019 in combination with dexamethasone as a treatment for patients with heavily pretreated multiple myeloma. In May 2020, Karyopharm submitted a supplemental New Drug Application requesting approval for XPOVIO as a new treatment for patients with multiple myeloma after at least one prior line of therapy based on the data from the Phase 3 BOSTON study. A Marketing Authorization Application for selinexor is also currently under review by the European Medicines Agency. A supplemental New Drug Application was also accepted by the FDA seeking accelerated approval for selinexor as a new treatment for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). In addition to single-agent and combination activity against a variety of human cancers, SINE compounds have also shown biological activity in models of neurodegeneration, inflammation, autoimmune disease, certain viruses and wound-healing. Karyopharm has several investigational programs in clinical or preclinical development. For more information, please visit http://www.karyopharm.com.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding Karyopharms expectations and plans relating to selinexor as a potential treatment for patients with GBM; the design and execution of a global randomized clinical trial to study this potential application of selinexor and the therapeutic potential of and potential clinical development plans for Karyopharms drug candidates. Such statements are subject to numerous important factors, risks and uncertainties, many of which are beyond Karyopharm's control, that may cause actual events or results to differ materially from Karyopharm's current expectations. For example, there can be no guarantee that Karyopharm will successfully complete necessary clinical development phases of selinexor in this indication; that data from a clinical trial of selinexor would support its use in treatment of patients with GBM; or that regulators will approve the use of selinexor in patients with GBM. Further, there can be no guarantee that any positive developments in the development or commercialization of Karyopharms drug candidate portfolio will result in stock price appreciation. Managements expectations and, therefore, any forward-looking statements in this press release could also be affected by risks and uncertainties relating to a number of other factors, including the following: the risk that the COVID-19 pandemic could disrupt Karyopharms business more severely than it currently anticipates, including by reducing sales of XPOVIO, interrupting or delaying research and development efforts, impacting the ability to procure sufficient supply for the development and commercialization of selinexor or other product candidates, delaying ongoing or planned clinical trials, impeding the execution of business plans, planned regulatory milestones and timelines, or inconveniencing patients; the adoption of selinexor for treatment of GBM in the commercial marketplace, the timing and costs involved in commercializing selinexor for such indication or any of Karyopharms drug candidates that receive regulatory approval; the ability to retain regulatory approval of selinexor for such indication or any of Karyopharms drug candidates that receive regulatory approval; Karyopharm's results of clinical trials and preclinical studies, including subsequent analysis of existing data and new data received from ongoing and future studies; the content and timing of decisions made by the U.S. Food and Drug Administration and other regulatory authorities, investigational review boards at clinical trial sites and publication review bodies, including with respect to the need for additional clinical studies; the ability of Karyopharm or its third party collaborators or successors in interest to fully perform their respective obligations under the applicable agreement and the potential future financial implications of such agreement; Karyopharm's ability to obtain and maintain requisite regulatory approvals and to enroll patients in its clinical trials; unplanned cash requirements and expenditures; development of drug candidates by Karyopharms competitors for indications in which Karyopharm is currently developing its drug candidates; and Karyopharms ability to obtain, maintain and enforce patent and other intellectual property protection for any drug candidates it is developing. These and other risks are described under the caption "Risk Factors" in Karyopharms Quarterly Report on Form 10-Q for the quarter ended March 31, 20, which was filed with the Securities and Exchange Commission (SEC) on May 5, 2020, and in other filings that Karyopharm may make with the SEC in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and, except as required by law, Karyopharm expressly disclaims any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.

Contacts:

Investors: Karyopharm Therapeutics Inc. Ian Karp, Vice President, Investor and Public Relations857-297-2241 | ikarp@karyopharm.com

Media:

FTI ConsultingSimona Kormanikova or Robert Stanislaro212-850-5600 |Simona.Kormanikova@fticonsulting.com or robert.stanislaro@fticonsulting.com

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Karyopharm Announces Dosing of First Patient in a Phase 1/2 Study of Selinexor in Combination with Standard of Care Therapy for Patients with Newly...

Soup Diet Review: Do They Work for Weight Loss? – Healthline

Posted: June 9, 2020 at 5:43 pm

A soup diet is generally a short-term eating plan thats designed to help individuals lose weight quickly.

Instead of one official soup diet, there are several soup-based diets. While some involve only eating soup for the duration of the diet, others also include a limited list of allowable foods.

As the idea is to lose weight quickly, most of these diets are only meant to last for 510 days.

This article reviews different types of soup diets, pros and cons of these diets, and whether a soup diet is effective for weight loss.

There are many types of soup diets, with some of the more popular ones listed below. Just keep in mind that theres currently no research on the effectiveness of these specific diets.

Broth-based soup diets generally last for 7 days. However, some can last as long as 1014 days. Over that time, proponents of a broth-based diet claim you can lose up to 10 or even 20 pounds (4.5 to 9 kg).

On a broth-based soup diet, cream-based soups are restricted, as theyre higher in calories and fat. Instead, youre encouraged to consume homemade or canned broth-based soups that include vegetables and protein.

While some programs recommend only consuming broth-based soups, others may allow for small amounts of low calorie options like lean proteins, non-starchy vegetables, and nonfat dairy.

One of the more popular bean soup diets is from Michael Greger, MD, author of How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease.

The diet encourages eating Dr. Gregers Champion Vegetable Bean Soup up to twice a day. In addition to the soup, youre allowed to consume any oil-free, plant-based foods, like whole grains, fruits, and vegetables.

While theres no calorie restriction, the diet recommends limiting intake of calorie-dense foods like dried fruits and nuts for optimal weight loss results.

Unlike other soup diets, Gregers is meant to be a lifelong shift to a plant-based diet.

Proponents of this diet claim you can lose 916 pounds (47 kg) in just the first week.

Theres currently no research on Gregers bean soup diet. However, plant-based diets have been linked to benefits for weight loss and heart health (1, 2).

One of the most popular soup diets, the cabbage soup diet is a 7-day eating plan that involves eating a chicken- or vegetable-broth-based soup that contains cabbage and other low carb vegetables.

In addition to cabbage soup, you can also have one or two other low calorie foods, such as skim milk or leafy greens.

If following the meal plan closely, the diet claims you can lose up to 10 pounds (4.5 kg) over the 7 days.

The chicken soup diet is a 7-day weight loss diet that involves eating chicken soup for every meal except breakfast.

For your morning meal, you can pick from five low calorie options, which include foods like nonfat milk and yogurt, fat-free cheese, whole-grain cereal or bread, and fresh fruit.

For the rest of the day, the diet recommends consuming frequent small portions of homemade chicken soup throughout the day. By eating small, frequent portions of soup, the diet claims it will help reduce cravings and encourage feelings of fullness.

The soup itself is low in calories and carbs, as its made with broth, cooked chicken, aromatics like garlic and onion, and plenty of non-starchy vegetables, including carrots, turnips, broccoli, and collard greens.

Designed for those following the ketogenic (keto), paleo, Whole30, or another low carb diet, the keto soup diet claims it can help individuals lose up to 10 pounds (4.5 kg) in just 5 days.

As with the general keto diet, the soup version is a low carb, high fat, moderate protein eating plan. The program provides 1,2001,400 calories per day, limits carbs to 20 grams per day, and restricts nuts, dairy, and artificial sweeteners.

The plan recommends eating the same breakfast each day, which consists of eggs, butter, bacon, avocado, and unsweetened bulletproof coffee. One low carb, high fat snack is also allowed, such as celery with keto-friendly tuna salad.

The rest of the day, you eat four cups of the keto soup, split between lunch and dinner. The soup recipe includes ingredients like chicken, bacon, olive oil, chicken stalk, sun-dried tomatoes, mushrooms, and other low carb vegetables and herbs.

Similar to the cabbage soup diet, the Sacred Heart soup diet is a 7-day eating plan that consists almost entirely of a broth-based soup with non-starchy vegetables.

While other low calorie foods are allowed, the diet is very specific as to which foods can be included each day.

When followed closely, the Sacred Heart soup diet claims to help you lose 1017 pounds (4.58 kg) in 1 week.

There are several types of soup diets. While some are more restrictive in what you can eat, like the cabbage soup diet, others allow for more flexibility, like the bean soup diet.

Observational studies have found individuals who regularly consume soup tend to have a lower body mass index (BMI) and are less likely to have obesity, compared with those who dont eat soup at all (3, 4, 5).

The reason why soup is linked to lower body weight is unknown. Some studies suggest that soup may help increase feelings of fullness. Thus, regularly eating soup may help reduce the number of calories you eat per day (5, 6).

Its also important to consider other factors that could explain this relationship, such as cultural or genetic differences between individuals who regularly eat soup and those who dont (7).

Overall, more rigorous and long-term studies are needed to confirm the potential weight loss benefits of eating soup.

One other thing to note is that soup consumption hasnt been shown to reduce the risk of metabolic syndrome, a group of conditions that increase your risk for developing heart disease and type 2 diabetes (3, 8).

As for specific soup diets, theres currently no scientific evidence on their effectiveness for weight loss.

Yet, as most soup diets result in a significant reduction in calories, following them will likely help you lose weight (9, 10).

And the fewer calories you eat on a soup diet, generally the more weight youll lose.

Just keep in mind that as with other low calorie diets, most of the weight lost over the 510 days is likely due to water rather than fat loss (11).

Furthermore, as the diets are generally for only a week or less, youll likely regain the weight you lost unless youre able to transition into a more sustainable weight loss eating plan (12).

As the bean soup diet recommends transitioning into a plant-based eating pattern, it may have better long-term success than the others.

Regularly consuming soup has been linked to a lower body weight. However, theres insufficient research on the benefits of soup diets for weight loss. Still, due to the low calorie nature of these eating plans, youll likely lose some weight in the short term.

In addition to helping you lose weight quickly, soup diets may offer additional benefits, including:

However, keep in mind that just 1 or 2 weeks of increased vegetable, fiber, and water intake is unlikely to have any meaningful benefits for long-term weight and health, unless following the diet helps you make lasting lifestyle changes.

Soup diets are generally easy to follow and can help increase your intake of water, fiber, and vegetables. While these changes can be beneficial, you would need to maintain these increases to reap the long-term effects.

With the exception of Gregers bean soup diet, one of the biggest downsides to soup diets is that most of them arent meant to be followed for more than 510 days.

Therefore, unless you have a more sustainable diet to transition to, youll likely regain any weight you lose on the diet.

Furthermore, studies suggest that when you greatly restrict calorie intake or lose a sustainable amount of weight quickly, theres a reduction in your metabolic rate. This means that your body begins to burn fewer calories per day than it did before (11, 19, 20).

As a result, after going off the diet, your lowered metabolism may make it harder to maintain your weight loss.

Additionally, as soup diets like the cabbage soup diet and Sacred Heart diet are quite restrictive in the types and amounts of foods allowed, theres a concern for nutrient deficiencies.

While eating a restricted diet for just 5 to 10 days is unlikely to result in serious nutrient deficiencies, especially if taking a multivitamin, significantly reducing calorie intake can lead to side effects, such as dizziness, weakness, or fatigue (21).

As most soup diets are only designed to last for 5 to 10 days, they arent sustainable weight loss solutions. Furthermore, the severe and rapid reduction in calories and weight can slow your metabolism, making it even harder to maintain your weight loss.

Soup diets have become popular for their ability to help you shed a significant amount of weight in just 5 to 10 days.

However, most of the weight lost on these diets is largely due to a loss of water rather than fat.

Furthermore, as these diets are only designed to be followed for a short period, youll likely regain any weight you were able to lose.

Instead, as eating soup may help curb your appetite and reduce calorie intake over the day, youre likely better off simply incorporating soups into a balanced, less restrictive weight loss eating plan for long-term success.

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Soup Diet Review: Do They Work for Weight Loss? - Healthline


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