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Dietary Interventions for Osteoporosis and Osteoarthritis – WholeFoods Magazine

Posted: April 16, 2020 at 11:41 pm

Osteoporosis (OP) and osteoarthritis (OA) are increasingly prevalent conditions that can lead to significant healthcare costs and disability. Osteoporosis is estimated to affect 200 million women worldwide, while osteoarthritis affects over 32.5 million U.S. adults, with symptomatic knee OA occurring in 10% men and 13% in women aged 60 years or older.(1,2)

The increase in the aging population and chronic disease rates serve as a precursor to loss of bone and joint degradation, increasing the risk of frailty. This loss of tissue integrity is not relegated to the elderly, as the preceding bone loss witnesses in osteopenia can begin to appear in the late 40s and early 50s, and the wear-and-tear of OA also occurring in middle age.

Osteoporosis is characterized by loss of bone mineral density (BMD) and deterioration of bone microarchitecture. This progressive deterioration increases susceptibility to fractures, with the most common occurring in the hip, wrist, or spine. Smoking, alcohol use, poor nutrition, hormones, and a sedentary lifestyle may all contribute to the development of OP.

Critical compounds that constitute bone and connective tissue decrease as disease progression occurs. Calcium, phosphorus, collagenous, and non-collagenous proteins (NCPs) in the extracellular matrix all play a pivotal role in bone integrity. Their loss through pathophysiological processes, as well as suboptimal nutritional intake, may exacerbate dysfunction in joints and bones.

Osteoarthritis initiates from mechanical stress on the joints that can cause progressive deterioration of cartilaginous structures. Ligaments and tendons can become inflamed while articular cartilage can break down, causing more irritation around joints. The catabolic processes that ensue can lead to pain and loss of mobility. Aging, overuse, and obesity are all factors that increase the potential for OA development.

Dietary Interventions

Joints and bones require an array of nutrients for healthy function. These foundational dietary components appear to provide benefits in the context of joint and bone disease as well. Dietary-derived sources of protein, collagen peptides, calcium, vitamin D, and anti-inflammatory compounds (e.g., omega-3 fatty acids) have shown promise as interventions in the context of OA and OP. Of these, collagen peptides are of interest to explore as consumer demand has increased in recent years, and clinical research demonstrates the efficacy of collagen in both OA and OP.

For example, a systematic review covering 20 years of literature investigated the therapeutic potential of collagen hydrolysate in bone and joint pathologies. In the studies examined, hydrolyzed collagen had a positive therapeutic effect on osteoporosis and osteoarthritis displaying a potential increase in bone mineral density, a protective effect on articular cartilage, and especially in the symptomatic relief of pain. (3)

In another randomized, placebo-controlled double-blinded investigation, researchers studied the role of specific collagen peptides (SCP) in postmenopausal women with a primary, age-related reduction of BMD. Supplementation with specific collagen peptides increased BMD in the cohort, and was associated with a favorable shift in bone markers, indicating increased bone formation and reduced bone degradation. (4)

Collagen peptides also show promise and clinical utility in OA. A randomized, placebo-controlled, double-blind study conducted at Penn State University showed statistically significant changes with the dietary supplement collagen hydrolysate (CH) compared with placebo in joint pain, mobility, and inflammation. (5)

Collagen peptides are not only a building block of connective tissues but possess anabolic signaling properties, essential for remediation of joint and bone loss. Examples such asWhole Body Collagenfrom Designs for Health, which offers three collagen peptides with specific molecular weights including one of the forms from the above mentioned Penn State study (as well as constituents studied at Harvard and Tufts), are viable solutions for practitioners seeking evidence-supported collagen.

In light of the prevalence of osteoporosis and osteoarthritis in the population, theres an increasing need and value in reliable joint and bone-related dietary interventions. Research points to collagen as a viable, cost-effective option that boasts benefits in addressing underlying mechanisms in both conditions, resulting in a viable candidate in patient plans.

Note: The views and opinions expressed here are those of the author(s) and contributor(s) and do not necessarily reflect those of the publisher and editors of WholeFoods Magazine.

References

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Dietary Interventions for Osteoporosis and Osteoarthritis - WholeFoods Magazine

Coronavirus Briefing: What Happened Today – The New York Times

Posted: April 16, 2020 at 11:41 pm

President Trump said the U.S. would reopen one careful step at a time, and told governors they would call the shots about when to lift restrictions in their states.

Twenty-two million American workers have filed new unemployment claims in the four weeks since pandemic-prompted shutdowns took hold.

The federal loan program intended to help keep small businesses afloat has run out of money.

Read the latest updates: World | U.S. | New York | Business

No matter how well we all practice social distancing, Covid-19 is unlikely to completely disappear. So to safely return to something like normalcy, society needs to be able to spot and swiftly contain new cases that pop up.

Rapid, widespread testing, once it becomes available, is the key to the spotting part. But since people can spread the virus before they know they have it, effective containment depends both on isolating those who test positive and on checking everyone theyve come in contact with recently.

Thats why public health officials say robust contact tracing is a must for reopening the economy, which President Trump hopes will start happening by May 1. But it will be a huge, expensive job.

Mr. Trump is expected to announce as soon as Thursday evening that the Centers for Disease Control and Prevention will hire hundreds of workers to perform contact tracing, and that the federal government will help states pay for their own expanded efforts.

Contact tracing has already helped in Asian countries like South Korea and Singapore, but their systems rely heavily on digital surveillance, using location data from smartphones and other digital footprints to automatically alert contacts a privacy intrusion that many Americans wouldnt accept.

So Massachusetts, the first U.S. state to invest in an ambitious new contact-tracing program for Covid-19, is doing it the manual way.

The state is spending $44 million and hiring 1,000 workers to reach out by phone to everyone who has had recent contact with a confirmed case. The workers explain the situation, ask about symptoms, go over quarantine requirements and arrange help if the person needs it.

This is where the human element of public health comes in, one of the states new contact tracers, David Novak, told our New England correspondent Ellen Barry. You can use technology to make the humans more efficient, but if you take the humans out of it, how do you ask questions?

Other places with the same idea: San Francisco is assembling and training 150 volunteers to augment its public health department. Ireland is deploying 1,000 furloughed government workers to do contact tracing.

The Times is providing free access to much of our coronavirus coverage, and our Coronavirus Briefing newsletter like all of our newsletters is free. Please consider supporting our journalism with a subscription.

More than 5.2 million workers filed new claims for unemployment benefits last week, bringing the four-week total to a staggering 22 million. Thats roughly the net number of jobs created in the decade since the last recession.

But that decade of economic growth was always somewhat misleading: While some people high on the income ladder became very rich, other Americans did not fare as well, and are now less able to weather the current storm. We spoke to Patricia Cohen, who covers the economy for The New York Times, about how workers are struggling in the coronavirus crisis.

How has the pandemic exposed hidden weaknesses in the U.S. economy?

Patricia: I think of it like an X-ray that is revealing all these stress fractures, which we couldnt see from the outside. On the one hand, weve had this record-setting economy, with the lowest jobless rate in 50 years. But the work available is often unsteady, insecure and low-paying. Minimum wage is not enough to support a family and cover the most basic necessities of food, rent and health care. And we have a just in time economy: Peoples hours fluctuate erratically. It helps businesses make money, but the worker loses that income.

Now that system is being tested in a way it hasnt before.

Exactly. Many people were already living on a precipice, and any shock can push them over the edge. So what youre seeing now is incredible hardship: Because they have no savings, they have nothing to fall back on.

What will the recovery look like for workers?

The economy is likely to slowly ramp up, in fits and starts, but a lot of businesses will not come back, and a lot of people will not be rehired. Most analysts think that at this point, well have an 8 or 9 percent unemployment rate into next year, which is where it was in the teeth of the recession.

Emerging research into severe coronavirus cases has found some surprises: Obesity appears to pose a much greater risk than expected, while asthma does the opposite.

People with obesity often have other medical problems as well, but new studies point to obesity itself as the second most significant complicating factor in severe coronavirus cases, after age. Young adults with obesity appear to be at particular risk, even if they have no other health issues.

Its not yet known why, though doctors note that abdominal obesity can compress the diaphragm, lungs and chest capacity.

Asthma, on the other hand, has turned up in an unexpectedly low percentage of severe cases just 5 percent in New York, officials said and European researchers called the scarcity striking.

Doctors stressed that people with asthma were still at risk, and said it was important that they continue taking medications that keep their symptoms in check.

Like all viruses, the novel coronavirus is mutating as it replicates in the body and passes from person to person which can make it harder to develop an effective vaccine.

An essay from our Opinion pages examines the two ways mutations can play out. With some diseases, like measles, a vaccine corners the virus for good, but with others, like influenza, scientists must continually develop new versions of the vaccine to keep up with new strains of the virus.

Singapore announced a record jump in coronavirus cases, with most of the 447 new cases arising in crowded dormitories for migrant laborers.

In India, which has reported more than 12,000 infections and 414 deaths, health officials have been attacked while attempting to conduct health screenings.

Japan declared a national emergency and said it would provide individuals with cash payments of 100,000 yen, or nearly $1,000.

The official death count in Spain is closing in on 20,000, but there are signs that the true toll may be far higher. The country is recounting to include any deaths that may have been missed.

Regulate your diet. If the coronavirus has busted your diet and youve busted out the fat pants here are some tips to get back on track.

Send your condolences. In these times, emailed condolences are fine, but avoid texting; consider your tone, and be direct.

Single, or a single parent? Plan ahead so that friends, neighbors and relatives can help if you fall ill. Stock up on medicines, prepare a go-bag for a hospital stay, and get a medical bracelet if you have special medical conditions.

What if both parents get sick? Identify someone now who could step in, work out a plan for the caretaker, and if youre not hospitalized, balance your own recovery with child care.

The World Health Organization has drawn criticism, but a closer look shows that it responded to the epidemic more forcefully and faster than many national governments.

Chinas success in taming the coronavirus has given rise to an increasingly strident blend of patriotism, nationalism and xenophobia.

Heres how one small rural hospital with a single doctor on duty caring for inpatients handled a Covid-19 surge.

Delivering special education services online is exceedingly difficult. This is what it looks like in New York City, whose public schools serve roughly 200,000 students with disabilities.

Britain bought $20 million worth of coronavirus tests from China. They didnt work.

Colombia is trying gender-based social distancing: Men can leave the house to seek out essentials on odd-numbered days, women on even-numbered days.

They may be at the epicenter, but they still have their pride: Stuck-at-home New Yorkers compete to see who has the best New York accent.

I am a senior and my boyfriend is 81. He is very nervous about contracting the coronavirus. On Easter, we drove separately to a Thai restaurant and ordered our meals by phone. We picked up the prepared food at the door and ate it in separate cars with the windows rolled down, trying to talk car to car! After lunch, we took a walk and tried to stay six feet apart. Such is life now as a dating senior!

Marilyn Matteson, Beaverton, Ore.

Let us know how youre dealing with the outbreak. Send us a response here, and we may feature it in an upcoming newsletter.

Sign up here to get the briefing by email.

Jonathan Wolfe and Tom Wright-Piersanti helped write todays newsletter.

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Coronavirus Briefing: What Happened Today - The New York Times

Simple science communication helps ease fears and spread good information during the COVID-19 pandemic – Massive Science

Posted: April 16, 2020 at 11:41 pm

We are currently living in a situation of extreme uncertainty, and if you are like me, you may have noticed yourself feeling extra anxious lately. Maybe you feel a constant ache it in your shoulders and neck. Maybe you are compulsively checking your phone, unable to tear your eyes away from Twitter and Facebook, or maybe you're extra irritable. According to medical professionals, these are very normal responses to the coronavirus pandemic.

Luckily there are lots of things you can do on your own to help ease the stress. Here are a few that work for me personally (note: I am not a medical professional). Not all of these will work for everyone, so don't beat yourself up if you try something to lessen your anxiety and it doesn't do much. Each of us is unique in our experiences and reactions to stressors!

Create something: Make something with your hands. You can cook or bake, put together a puzzle, color or draw, work in your garden or yard (if you have one), or even clean out your car. Whatever you choose, try to really focus on what you are doing instead of letting your mind wander. Don't worry about making something perfect just enjoy the process!

Go outside or get moving inside: Unless you are currently under lockdown, and assuming you stay at least 6 feet from others, it is safe to go outside. Exercise can help you redirect nervous energy. It also gets your feel-good neurotransmitters flowing. By the way, dancing in your living room counts as exercise!

Step away from your phone: Put the phone down. Leave it in another room while go about your other activities. It will feel weird, but I promise you that logging off Twitter and other social media for half an hour will not harm you. To be clear, your phone isn't the root cause of your anxiety, but a constant barrage of COVID-19 related news isn't helpful, either.

Give yourself a break: If you are really feeling anxious and it is keeping you from your daily activities, try just letting yourself be. A lot of times the pressure we put on ourselves to stay productive, keep working, clean the house, and so on keeps us paralyzed. Banish the word "should" from your vocabulary for now, and just do the best you can. Sometimes just giving yourself permission to slack off is enough to get your motivation and focus back.

Try mindfulness: Mindfulness seems like the hip, hot thing to do lately, but there's a reason for that it works. There are tons of online resources and apps for learning mindfulness. I am most familiar with Headspace, and the thing I like most about it is that students (including grad students!) can get access to the full app for $10/year (usually $70). There is a lot of material in the app, and in my opinion it's worth it.

If full-on mindfulness isn't for you, but you need a way to stay calm when it feels like the world is falling apart around you, the 54321 method of grounding yourself is a good place to start. Take a deep breath, then look around you for five things that stick out to you in the moment, and say them out loud. Then repeat that with four things you can feel, three sounds you hear, two things you can smell, and one thing you can taste. Then take another deep breath.

We're all in this together. While you may have to stay physically distant from people right now, don't forget to connect socially in any way you can. And if you are feeling totally overwhelmed or depressed, please reach out to a mental health professional.

Originally posted here:
Simple science communication helps ease fears and spread good information during the COVID-19 pandemic - Massive Science

Digestive Enzymes and Weight Loss: Do They Help? – Healthline

Posted: April 15, 2020 at 7:46 pm

Digestive enzymes are often used to support healthy digestion and increase nutrient absorption.

Studies show that they may benefit conditions like lactose intolerance and irritable bowel syndrome (IBS) (1, 2).

In addition, many people wonder if digestive enzymes could help them lose more weight.

This article reviews whether digestive enzymes can promote weight loss.

Digestive enzymes are compounds that help break down foods into smaller components that your body can absorb (3).

The three main types are:

Your body naturally produces digestive enzymes, but theyre also available in supplement form.

These supplements are often used to improve conditions like lactose intolerance and other digestive issues like celiac disease and IBS (1, 2).

Digestive enzymes help break down proteins, fats, and carbs into smaller components. Theyre produced naturally by your body and are also found in supplement form.

Some studies show that digestive enzymes may enhance the health of your gut microbiome the microorganisms that live in your digestive tract (4).

In one study, administering digestive enzymes to mice promoted the colonization of beneficial gut bacteria (5).

Plus, a test-tube study showed that pairing a probiotic supplement with digestive enzymes could help protect against changes in the gut microbiome caused by chemotherapy and a type of antibiotic (6).

Interestingly, some studies have found that the gut microbiome may play a role in weight control (7).

In fact, one review of 21 studies reported that enhancing the beneficial bacteria in your gut may reduce body mass index, fat mass, and body weight (8).

That said, more studies on the effects of digestive enzyme supplements on weight control in humans are needed.

Some test-tube and animal studies show that digestive enzymes may improve the health of your beneficial gut bacteria bacteria that may be involved in weight control.

Lipase is a digestive enzyme that boosts the absorption of fat in your body by breaking it down into glycerol and free fatty acids (9).

Some studies show that supplementing with lipase may decrease feelings of fullness (10, 11).

For example, one study in 16 adults found that those taking a lipase supplement before consuming a high fat meal reported significantly decreased stomach fullness after 1 hour, compared with a control group (10).

On the other hand, lipase inhibitors which decrease lipase levels have long been used to promote weight control by increasing the excretion of fat (12).

While more research is needed, increasing your lipase levels by taking digestive enzyme supplements could potentially increase fat absorption, thus contributing to weight gain.

Lipase may decrease feelings of fullness. On the other hand, decreasing lipase levels can promote weight loss by reducing fat absorption.

Although research shows that digestive enzymes may or may not directly increase weight loss, they could improve gut health and digestion.

They may also alleviate bloating and promote regularity, especially for those with conditions like IBS (3, 13).

Most digestive enzyme supplements contain a combination of lipase, amylase, and protease. Some types also contain other specific enzymes that can be beneficial if you have difficulty digesting certain ingredients.

Other common enzymes found in digestive enzyme supplements include:

Supplements are derived from microbial or animal sources. Although animal-based digestive enzymes are more common, microbial-based supplements may be an effective, vegan-friendly alternative (14, 15).

To ensure quality, check the ingredients label and steer clear of supplements high in fillers, additives, and preservatives. Plus, opt for supplements that have undergone third-party testing and are certified by organizations like the United States Pharmacopeia (USP).

Be sure to talk to your healthcare provider before taking a new supplement, especially if you have any underlying health conditions or are taking any medications.

Additionally, note that you should always take digestive enzymes with food to maximize their effectiveness.

Most digestive enzymes contain a combination of protease, lipase, and amylase, but they may also contain other specific enzymes to promote healthy digestion. Supplements are derived from both animal-based and microbial sources.

While digestive enzymes may not directly boost weight loss, research shows that enzyme inhibitors might.

Digestive enzyme inhibitors decrease the absorption of certain macronutrients and are sometimes used in the treatment of obesity to increase weight loss (16).

According to a review of 14 studies, supplementing with an amylase inhibitor extracted from white beans may increase both weight loss and fat loss in humans (17).

Another study showed that blocking the effects of trypsin, a protease enzyme that breaks down proteins, decreased food consumption and weight gain in rats (18).

Additionally, lipase inhibitors are used to reduce the absorption of fat, which could also result in significant weight loss (19, 20).

In particular, the lipase inhibitor called orlistat may reduce fat absorption by 30%. It does this by decreasing the production of lipase in the stomach and pancreas, resulting in weight loss (19).

One study in 40 women with obesity also found that long-term use of orlistat increased levels of certain hormones that suppress hunger and appetite (21).

However, other studies have found that orlistat could decrease these hormones and instead speed up the emptying of the stomach (22, 23, 24).

Aside from potentially affecting hormone levels, other common side effects of lipase inhibitors include diarrhea, stomach pain, and fat in the stools (19).

Enzyme inhibitors block the activity of digestive enzymes, which could promote weight loss and fat loss. However, studies have had contradicting results.

Digestive enzymes are substances that help break down macronutrients into smaller compounds to promote their absorption.

Some test-tube and animal studies show that they could improve the health of your gut microbiome, which may affect weight control.

On the other hand, digestive enzyme inhibitors have been shown to reduce food intake and increase weight loss and fat loss.

While digestive enzyme supplements may or may not directly boost weight loss, they could promote healthy digestion and regularity, especially for those with certain gastrointestinal conditions.

Originally posted here:
Digestive Enzymes and Weight Loss: Do They Help? - Healthline

Using AI, Yes Health cuts costs, improves adherence for weight loss and diabetes treatment – TechCrunch

Posted: April 15, 2020 at 7:46 pm

Using a combination of machine learning and computer vision, Yes Health claims it can cut costs and improve adherence for behavioral-based treatments targeting diabetes, obesity and other chronic conditions.

Those claims, and the companys technology-based approach, has netted the company a new $6 million in funding led by Khosla Ventures .

The companys technology automates patients reporting requirements by allowing them to take a picture of their meals rather than entering their daily food intake into a system. The companys software recognizes meals from the images and converts that information into data that physicians and patients can use to monitor their progress.

If the ease of use for patients is one selling point, then the companys automated messaging service is another. Using computer-generated prompts instead of human consultations reduces the cost of the service and ultimately the price that folks have to pay.

Founded by Alexander Petrov, a former PayPal executive who is, himself, pre-diabetic, Yes Health takes the therapies that have been pioneered by companies like Virta Health and Omada and makes them easier for patients to manage.

The biggest difference is that we have a level of personalization that then translates into engagement that is very unique, says Petrov. We are doing it through what we call an image-based in-the-moment approach We capture, analyze and share data not just through text but through images.

The company, which launched six years ago, is working with Blue Shield of California and other healthcare partners. Yes Health has tens of thousands of paying members, according to Petrov, and the vision is to reach millions of people.

Yes Health sells through both healthcare plans and direct to consumers and the market the company hopes to address is huge. Roughly 34 million Americans had diabetes in 2018, according to data from the CDC, and another 88 million are considered pre-diabetic. The cost of caring for these conditions in the U.S. is an astonishing $327 billion each year. Healthcare costs for these patients can also reach more than 230% of the average Americans healthcare expenditures.

These issues take on new significance given the COVID-19 epidemic. Conditions like diabetes or obesity are linked to increasing chances of fatality from COVID-19 infection, according to reports.

Americans are more conscious than ever about their health, and digital health has become one of the most important markets for innovation, said Samir Kaul, founding partner and managing director of Khosla Ventures, in a statement. Yes Health is proven to tackle difficult and costly chronic conditions through an AI-augmented and all-mobile solution, aligning it with our firms thesis in healthcare.

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Using AI, Yes Health cuts costs, improves adherence for weight loss and diabetes treatment - TechCrunch

‘Mama June: From Not To Hot’: Jessica Credits Weight Loss To BoomBod After Plastic Surgery – TV Shows Ace

Posted: April 15, 2020 at 7:46 pm

Mama June: From Not To Hot recently started airing a new season. And, fans know that Mama Junes daughter Jessica features in it. Jessica, like her mom, struggled with weight problems, and ahead of the premiere, fans heard she and her sister Anna went for plastic surgery. Jessica weighed in 45 pounds lighter after her surgery. Now she credits her weight loss to BoomBod on Instagram.

Fans of the WEtv show speculated that Jessica and her sister Anna might show up in the new season, Family Crisis. TV Shows Ace repeated that fans saw Jessica complaining to her sisters, Alana and Pumpkin, that her mom pawned her car and it got repossessed. Mama June helped pay for it, apparently. Anyway, old fans of the series seemed pleased that Jessica appeared back on their screens, albeit, angry with her mom.

Back with the show, Jessica seems a bit more active on her social media these days. Like her sisters and her mom, she often promos the BoomBod products. Actually, Pumpkin gets flack for it as Mama June: From Not To Hot, fans say she lost no obvious weight and sells a product that doesnt work. But when Jessica shared a promo on April 14, they raved about how good she looks these days. Perhaps they forgot Jessica just spent a fortune on plastic surgery.

Daily Mail UK revealed that Jessica and Anna underwent expensive surgery. Their article dated March 17 says that Jessica spent over $80k on herself as she also got a balloon implanted in her tummy. That helps people regulate their appetites. Plus, she received liposuction on her back, flanks and bra area. Further in the article, they noted that the 350 liposuction procedure also included a tummy tuck. Loads of removed fatty stuff featured in a photo showing how much that comprised.

Jessica started off at 230 lbs. before the procedure and a short time later weighed in at 185 lbs. Thats a difference of 45 lbs. Now on her Instagram, Jessica wrote, A little consistency + my @boombod shots, and I am definitely feeling it! Then she added, 2020 [got] off to a rocky start. Then, she talked about a push in the right direction. So, she explained thats why BoomBods great for her.

Impressed fans of Jessica reacted to the two comparison photos she shared. One showed her now, holding her BoomPod product. The other one showed her pre-surgery. One fan said, Awesome job girl! Then, another fan commented, Omg congrats . One wrote, Omg YES Jessica!!!!!!!!!! U look amazing. Many other fans used the words, beautiful, fantastic, and great, to describe Jessicas weight loss. But maybe they never heard that the Mama June: From Not To Hot star just paid over $80k for plastic surgery.

What do you think about Jessica crediting her weight loss to BoomBod? Did you know she underwent expensive surgery? Sound off your thoughts in the comments below.

Remember to check back withTV Shows Aceoften for more news aboutMama June: From Not To Hot.

Woryn is a writer who started a small book publishing company. She wrote three books, one of them published by Domhan. Woryn also writes as Jane Flowers for The Destination Seeker and Blasting News.

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'Mama June: From Not To Hot': Jessica Credits Weight Loss To BoomBod After Plastic Surgery - TV Shows Ace

Will Novos big thinking in obesity pay off? – Vantage

Posted: April 15, 2020 at 7:46 pm

A sideways shift into obesity is a logical move for diabetes players, particularly those with substantial GLP-1 agonist franchises, which have a proven metabolic impact. Novo Nordisk is the biggest player here, and has led the drive to push these drugs into the weight loss space but the company's ambitions extend beyond this mechanism.

In the coming months several mid-stage projects are slated to yield datathat variously promise to suppress appetite or increase energy expenditure; Novo believes that a combination approach will ultimately be needed to match the sort of reductions that can be achieved through bariatric surgery. The biggest pending readout is from the pivotal Step programme with semaglutide, the company's newest GLP-1 agonist, which could well form the backbone of any treatment regimen.

Phase II trials suggest that semaglutide can produce double the level of weight loss seen with liraglutide, Novo's older GLP-1 agonist, marketed in obesity as Saxenda.Saxenda is associated with 5-7% weight loss, while bariatric surgery has been shown to help patients lose 12-45% of their body weight, over three years.

Despite bestowing what appears to be a marginal benefitSaxenda, which was launched in 2015,had a 55% share of the global obesity market at the end of 2019, Novo claims. The product generated revenue of $852m last year, and the company aims to double itsobesity sales by 2025. This target will be much more easily hit if semaglutide raises the game.

Data from four late-stage studies in the Step program are expected around the middle of the year. Novo has not indicated that the coronavirus pandemic has changed this timeline, noting recently that no significant delaysare expected in trials already close to finalisation.

The pivotal programme testsonce-weekly subcutaneous injections of 2.4mg of semaglutide. Previouslyin a phase II study a 0.4mg daily dose of semaglutide produced 16.2% weight loss after one year, an effect that did not show signs of plateauing. The most common adverse events were dose-related gastrointestinal symptoms, primarily nausea, something to watch for with the higher dose used in the Step program.

Bernstein analysts have written that 12% or greater weight loss would be ideal in the phase III studies, and they assume that Novo will use its priority review voucher to get semaglutide on the market as soon as possible before the Saxenda patent expires in 2022/23.

If semaglutide lives up to expectationsit could provide a big improvement on currently available therapies. However, Novo ultimately wants to be able to offer a result closer to that seen with bariatric surgery, which, despite having very successful results, is a complex intervention that carries risks, and tends to be restricted to severly obese patients.

Getting up to 30-40% weight loss will involve adding in another mechanism, although of course these have to prove themselves in monotherapy first.One of the companys biggest hopes involves targeting amylin;AM833 is a long-acting human amylin analogue that in phase I demonstrated around 7% weight loss over eight weeks. A phase II dose-ranging study is expected to report in the first half of the year, and Saxenda is used an active comparator.

Other groups have had little luck in targeting amylin, including Amylin Pharmaceuticals with pramlintide, whose development in obesity was discontinued in 2011. Previously Novos chief science officer, Mads Krogsgaard Thomsen, told Evaluate Vantage that Novo had made improvements to AM833 that should help avoid the nausea seen with pramlintide.

The real potential of this mechanism could be revealed in a trial that combines semaglutide with AM833, a regimenthat could generateweight loss of at least 25%, according to Mr Thomsen. A phase I combination study is due to report in the second half of the year.

Semaglutide and AM833 both serve as appetite suppressors, as do Novos two phase I candidates LA-GDF15 and PYY 1875. Boosting energy expenditure is the other side of the coin, and this is where Novos GLP1/glucagon-targeting doublet, and its triplet, which adds a GIP agonist, come in.

Still, as these are very early projects itis not entirely clear whether Novo will say much about the results from ongoing trials, as these are probably not considered material to the group as a whole. Progression into larger studies might be the best indication that signals have been seen.

Semaglutide is a different story, of course, and the Step readout is one of the biggest events on Novo's horizon. The sellside already has high hopes: the product is projected to become market leader in obesity by 2024, according to EvaluatePharma.

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Will Novos big thinking in obesity pay off? - Vantage

Coffee Lovers, Try This Lemon Coffee For Your Caffeine Hit And Weight Loss Benefits – NDTV Food

Posted: April 15, 2020 at 7:46 pm

Lemon coffee will give your day a great start.

Highlights

In the throes of Coronavirus crisis, if there's anything that is helping us keep going, it is our favourite coffee. Lethargy is bound to creep in when we are in our bed all the time. The frequent rounds of instant pick me up' drink is all we need to work from home and do all that home ka work'. But, if you are bored of the same old taste of coffee in each cup, try lemon coffee. This all-new version of coffee will not only give you much-needed caffeine hit but may also help you prevent weight gain that you are likely to get after lazing around and munching all day.

(Also Read:Coconut Water Coffee - A Refreshing Drink You Would Love To Have Every Morning)

Coffee works as a great stimulator.

Coffee is known to improve digestion, which helps in breaking down of food and prevent accumulation of fat. It also contains some biologically active compounds apart from caffeine that are said to accelerate weight loss. Not just this, coffee may also break down fat cells that the body uses in the form of energy.

Lemon juice is known to stimulate metabolism rate of the body that greatly helps one shed extra kilos. It induces satiety and may also help in improving the digestive system.

(Also Read:Give Your Regular Coffee A Spin With These 4 Interesting Coffee Recipes)

Lemons are good for digestion.

It is best to have this drink the first thing in the morning. Remember, it is only black coffee without milk and sugar that you must make for weight loss. Pour about half teaspoon of coffee in a cup. Pour hot water over it and juice of a quarter part of lemon. Stir well and warm up for the day ahead with this warm drink.

If taste matters more to you, make lemon coffee just the way you would like it.

1. Make iced lemon coffee by mixing brewed coffee with crushed or cubed ice, some sugar, cold water and a dash of lime juice.

2.Blend coffee with sugar. Add soda, water, cinnamon and lime juice. Enjoy this great cocktail.

3.And, if you want something boozy', add espresso coffee shot to a glass of gin/whisky/rum, sugar, and crushed ice. Drizzle some lime juice to enjoy this caffeinated cocktail.

Make lemon coffee whichever way you like, we are sure you'll love it. If you do, don't forget to tell us in the comments section below.

About Neha GroverLove for reading roused her writing instincts. Neha is guilty of having a deep-set fixation with anything caffeinated. When she is not pouring out her nest of thoughts onto the screen, you can see her reading while sipping on coffee.

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Coffee Lovers, Try This Lemon Coffee For Your Caffeine Hit And Weight Loss Benefits - NDTV Food

Weight Loss Supplement Market To Witness Robust Expansion Throughout The Forecast Period 2019 2025 – Curious Desk

Posted: April 15, 2020 at 7:46 pm

Weight Loss Supplement Market

UpMarketResearch, 15-04-2020: The research report on the Weight Loss Supplement Market is a deep analysis of the market. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. Experts have studied the historical data and compared it with the changing market situations. The report covers all the necessary information required by new entrants as well as the existing players to gain deeper insight.

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Contact Info UpMarketResearchName Alex MathewsEmail [emailprotected]Organization UpMarketResearchAddress 500 East E Street, Ontario, CA 91764, United States.

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Weight Loss Supplement Market To Witness Robust Expansion Throughout The Forecast Period 2019 2025 - Curious Desk

Mama Junes daughter Jessica, 23, shows off 50-pound weight loss in new pics after plastic surgery makeover – The Sun

Posted: April 15, 2020 at 7:46 pm

MAMA June's daughter, Jessica Shannon, showed off her 50-pound weight loss in a series of new pictures.

The reality TV star, along with her sister Anna Caldwell, underwent $120k worth of plastic surgery where they got liposuction and veneers.

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The 23-year-old has been proudly showing off her summer-ready bod on social media after dropping more than 50 pounds.

In her most recent post, she shared before and after pictures where the weight loss was evident.

She was advertising Boom Bod, a brand her mom also uses: "A little consistency + my Boom Bod shots, and I am definitely feeling it!

"2020 might have gotten off to a rocky start, and sometimes a push in the right direction is needed - thats what this program is for me.

"Anyone who has goals they want to get on top of, try out my fav program while it's buy one get one free right now."

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She had previously shared a bikini picture of when she visited her sister, Anna, at her new trailer home and the two sunbathed by the lake.

Along with the picture, she wrote: "Feeling really good lately!"

In another post, she also thanked Boom Bod for helping keep her cravings at bay and urged her fans to join in her weight loss journey.

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Jessica recently underwent plastic surgery to get the curvy body she wanted in order to start modeling as a plus-size model.

A source close to the sisters exclusively told The Sun: "[Jessica and Anna] feel amazing in their new bodies.

"Jessica would never wear a two-piece bathing suit and now she just wants to show off her new figure.

"She is still losing weight everyday."

But apparently she's not finished updating her look just yet.

The source said of Jessica, who was nicknamed Chubbs as a child: "She wants more liposuction and a breast lift and implants this summer."

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Jessica had her surgery done with Dr. Samuel Kashani of Beverly Hills, who inserted the Orbera Balloon into her stomach to help with her journey to a slimmer self.

The cost of that surgery was $17,000.

Dr. Michael K. Obeng also performed liposuction on her abs, flanks, back and bra area as well as a tummy tuck.

Jessica lost 40 pounds just from the $30,000 surgery.

The reality star also now has a Hollywood smile after having eight veneers fitted to her top teeth and laser whitening on the bottom teeth.

The cost of that treatment was $17,000, and was completed by Dr. Aamir Wahab of Beverly Hills.

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As the sisters show off their makeovers, the family is coping withMama June's recent troubles, including herarrest last yearfor possession of crack cocaine with herbad news boyfriend, Geno Doak.

The matriarch, 40, faces a year in prison if found guilty of the charges.

The troubles will play out on this season ofMama June: From Not to Hot, airing Fridays on WE tv.

Do you have a story for The US Sun team?

Email us at exclusive@the-sun.com or call 212 416 4552.

Like us on Facebook at http://www.facebook.com/TheSunUS and follow us from our main Twitter account at @TheSunUS.

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Mama Junes daughter Jessica, 23, shows off 50-pound weight loss in new pics after plastic surgery makeover - The Sun


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