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Effect of a short-term vitamin E supplementation on oxidative stress in infertile PCOS women under ovulation induction: a retrospective cohort study -…

Posted: April 6, 2020 at 9:47 pm

Study design

The present study is a retrospective cohort study (Trial registration: ChiCTR-OOC-14005389, 2014). In this study, 321 PCOS cases was conducted from October 2015 to April 2017 to assess the effect of short-term vitamin E administration on infertile PCOS women undergoing ovulation induction with CC and HMG in the Reproductive Medicine Center, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China. This retrospective cohort study was approved by the Institutional Review Board of the Department of Chinese Medicine Hospital of Jiangsu Province.

The inclusion criteria of this study were as follows: (i) Undergoing ovulation induction with CC and HMG; (ii) no previous infertile treatment; (iii) age less than 40 years; (iv) normal in hysterosalpingography; and (v) normal in semen analysis. The diagnostic criteria of PCOS was according to the 2006 Rotterdam criteria [17]: (1) Anovulation or olig-ovulation, (2) Clinical evidence of hyperandrogenism (on the basis of hirsutism or an elevated testosterone level), (3) Polycystic ovaries (a more than 10ml ovarian volume or at least 12 antral follicles with 29mm in diameter). PCOS could be confirmed if any 2 out of the following 3 criteria were met and if any other diseases that caused hyperandrogenism or anovulation could be excluded.

Other disorders that mimic the PCOS, including hyperprolactinemia, thyroid disease, late-onset congenital adrenal hyperplasia, androgen-secreting tumors and Cushings syndrome were ruled out. The PCOS patients with the major myocardial, liver and renal disorders, and taking confounding medications (primarily sex steroids, other infertility drugs, and insulin sensitizers) were excluded. Patients were divided into 3 groups according to the vitamin E used.

In this study, as shown in Fig. 1a, 110 of 321 PCOS cases underwent controlled ovarian stimulation but without vitamin E administration (Group A, n=110). Based on previous clinical medication experience, a dosage of 100mg/day vitamin was selected. Two-hundred eleven of or 321 PCOS cases underwent controlled ovarian stimulation combined with vitamin E administration (100mg/day, p.o.) started from follicular phase (Group B, n=105) and luteal phase (Group C, n=106), respectively. Administration of vitamin E in follicular phase(Group B) began from the 3rd day of the menstrual cycle to 14th day of luteal phase. Administration of vitamin E in luteal phase (Group C) started when ovulation was confirmed, and lasted for 14 consecutive days. After 14days of the HCG administration, serum -HCG was measured. The presence of a gestational sac on ultrasound was performed at 6 and 12weeks of gestational age to determine clinical pregnancy rate and ongoing pregnancy. The women enrolled in this study were followed up until miscarriage or delivery.

Summary of patient flow diagram a and Vitamin E administration and stimulation protocol b. EV=estradiol valerate; HCG=urinary human chorionic gonadotropin; Pg=progesterone;CC=clomiphene citrate;VE=vitamin E;TVU=Transvaginal ultrasonography; HMG=human menopausal gonadotropin

As shown in Fig. 1b, the ovulation was stimulated with CC (Merck Serano, China) at 100mg/day for 5days starting on day 3 of a spontaneous menstrual cycle or withdrawal bleeding. Starting from day 8, HMG (Livzon, China) was injected at 75IU every second day and estradiol valerate (Progynova, Bayer, China) was administered at 2mg/day. Transvaginal ultrasonography was performed from day 10 to adjust the HMG dosage. When at least one follicle had reached a diameter of 18mm, 10,000IU urinary human chorionic gonadotropin (hCG) (Livzon, China) was administered. All patients received luteal phase support by oral administration of progesterone (Dydrogesterone, Abbott Biologicals B.V, China) at 10mg three time a day for 14days starting on the day of ovulation. In each cycle, medroxyprogesterone acetate was used to induce withdrawal bleeding in cases in which there was no response. The complete participation considered as pregnancy or anovulation within a total of 6 cycles.

Body mass index (BMI) was used to evaluate the body weight. According to World Health Organization(WHO) criteria [18], women with a BMI <18.5, 18.525, 2529 and30kg/m2 were defined as underweight, normal weight, overweight and obese, respectively. Scores on the modified FerrimanGallwey scale [19], range from 0 to 36, were used for hirsutism evaluation. Higher scores indicated a greater degree of hirsutism.

Age, height, weight, waist, FerrimanGallwey hirsutism score, age of menarche, incidence of oligomenorrhea and amenorrhea, numbers of previous pregnancies and previous ovarian were obtained from patient medical records.

Levels of estradiol (E2), androstenedione (T), luteinizing hormone (LH), prolactine (PRL) and follicle-stimulating hormone (FSH) were tested by RIA (Beijing North Institute of Biological Technology of China and the CIS Company of France). Peripheral blood samples were taken on the 3th day of menstrual cycle after overnight fasting.

In this study, we measured four oxidative stress serum markers (malondialdehyde (MDA), ischemia modified albumin (IMA), total antioxidant capacity measurements (TAC), and vitamin E) in 3 time points (T0:before stimulation, T1: the day of HCG treatment, and T2: the day of complete participation) to evaluate the levels of oxidative stress. Serum levels of MAD, an end-product formed during lipid peroxidation that is released into the extracellular space and finally appears in the blood [20], were measured using a thiobarbituric acid-reactive commercial kit (Jiancheng Bioengineering Institute, China). Serum TAC, provided better information on antioxidant status than individual antioxidant compounds [21], were tested using an antioxidant assay kit (Jiancheng Bioengineering Institute, China). Serum levels of IMA, a novel marker of oxidative stress, were evaluated by cobalt to albumin binding capacity kit (CUSABIO, China). Serum contents of vitamin E were evaluated by colorimetric method using assay kit (Jiancheng Bioengineering Institute, China).

Statistical analysis was carried out by SPSS (version 23, USA). Data were presented as either median (Min-Max) or meanSD as appropriate. Quantitative data analyses were carried out by independent samples t-test or Mann-Whitney U-test depending on the normality of data. Categorical variables were compared with Chi-Square test. A P value <0.05 was considered as statistically significant.

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Effect of a short-term vitamin E supplementation on oxidative stress in infertile PCOS women under ovulation induction: a retrospective cohort study -...

Global Hormon replacement therapy Market Reports Deliver Insight And Expert Analysis Into Growth Opportunity, Driver, Key Trends and Restraints -…

Posted: April 6, 2020 at 9:47 pm

MarketResearch.biz, in its latest report titled, Hormon replacement therapy Market: Global Industry Analysis 20142020 and Forecast 20202029 provides a complete view of the market by assessing the impact of the technological advancements, changes in investment habits, and in-depth overview of competitive landscape and geographical regions. This report is a consolidation of primary and secondary research, which provides market size, share, trends, CAGR, revenue, dynamics, and forecast for various segments and sub-segments considering the macro and micro environmental factors.

This report focuses on the global Hormon replacement therapy industry status, presents volume and value, future forecast, growth opportunity, key market, product type, consumers, regions and key players.

The intelligence study of the Hormon replacement therapy market covers the estimation size of the market both in terms of value (Mn/Bn USD) and volume (x units). In a bid to recognize the growth prospects in the Hormon replacement therapy market, the market study has been geographically fragmented into important regions that are progressing faster than the overall market. Each segment of the Hormon replacement therapy market has been individually analyzed on the basis of pricing, distribution, and demand prospect for the global regions.

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Leading players covered in the Hormon replacement therapy market report:

Bayer Pharma AG, Inc., Orion Pharma AB, Allergan plc, Novo Nordisk A/S, Mylan Laboratories, Abbott Laboratories, Pfizer and AbbVie

Hormon replacement therapy market segmentation:

Global hormone replacement therapy market segmentation by product:EstrogenTestosteroneThyroidOther

Global hormone replacement therapy market segmentation by route administration:Oral tabletsParenteralTransdermal patchesOther

Global hormone replacement therapy market segmentation by disease:CancerMenopauseHypothyroidismMale hypogonadismGrowth hormone deficiency

Global hormone replacement therapy market segmentation by distribution:Hospital pharmaciesRetail pharmacies and drugstoresCompounding pharmaciese-CommerceOthers

Regional Fragmentation:

North America (the United States, Canada, and Mexico)

Europe (Germany, UK, France, Italy, and Russia, etc.)

Asia-Pacific (China, Japan, ASEAN, India, and Korea)

The Middle East and Africa (UAE, Egypt, South Africa, Saudi Arabia)

South America (Brazil, Chile, Peru, and Argentina)

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The main sources are industry experts from the Global Hormon replacement therapy industry, including administrative organizations, processing organizations, and analytical services providers that address the value chain of industry organizations. We interviewed all major foundations to collect and verify qualitative and quantitative information and to determine future prospects. The qualities of this study in the industry experts, such as CEO, Vice President, Marketing Director, Technology and Innovation Director, Founder and key executives of core companies and institutions in major Hormon replacement therapy around the world in the extensive primary research conducted for this study. We interviewed to acquire and verify both sides and quantitative facets.

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What isn’t seen isn’t heard: trans and non-binary health amid COVID-19 – The CT Mirror

Posted: April 6, 2020 at 9:47 pm

March 31 was International Transgender Day of Visibility. Minus a few posts online by media outlets, little was said about it this year. As a public health student, I have been wondering how marginalized communities will be negatively affected by COVID-19 and how some communities needs will be overshadowed as healthcare systems become overwhelmed and medical resources are focused on treating coronavirus patients.

Ryan Sutherland

One of the communities that will undoubtedly face increased pressure is the transgender and non-binary community as a result of restrictive coronavirus lockdowns, disrupted access to social services, barriers to prescribing and managing hormone therapy medications, and hospital decisions to halt gender-affirming surgeries.

And in some ways, stay-at-home orders and enforced social distancing policies, while they effectively reduce opportunities for viral transmission, also contribute to trans erasure and create more opportunities for the existence of members of the trans and non-binary communities to be ignored, denied or minimized. What isnt seen isnt heard, and only through increased visibility comes equal rights.

Recently, Gov. Brad Little of Idaho signed into law House Bill 500, the Fairness in Womens Sports Act, and House Bill 509, the Idaho Vital Statistics Act. H.B. 500 states that athletic teams or sports designated for females, women, or girls shall not be open to students of the male sex and that disputes can be resolved by inspecting the students reproductive anatomy, genetic makeup, or normal endogenously 19 produced testosterone levels, effectively banning female-identifying transgender athletes from performing on teams aligned with their chosen gender identity.

H.B. 509 prohibits transgender individuals from changing their gender on their birth certificates. These bills originated from complaints strikingly similar to those articulated in a recent lawsuit filed against the Connecticut Association of Schools, Connecticut Interscholastic Athletic Conference and the boards of education in Bloomfield, Cromwell, Glastonbury, Canton and Danbury aimed to block transgender athletes from participating in girls sports.

With more than 40 states that have introduced similar legislation this year, statewide stay-at-home orders and social distancing policies limit the ability for transgender activists to protest and overturn discriminatory legislation such as these bills. And the media focus on COVID-19 developments might allow this type of legislation to fall through the cracks.

Additionally, trans and non-binary workers are three times more likely to be unemployed compared to the general population, and a lack of employer-based insurance results in a disproportionate insurance coverage gap. The pandemic has only exacerbated existing disparities. The International Foundation for Employee Benefit Plans reported that transgender inclusive healthcare benefits are offered to less than one-third of U.S. employees. With widespread furloughing and unemployment in response to the pandemic, even those with insurance benefits that cover hormone replacement therapy (HRT), counseling, or gender-affirming surgery are at risk of losing coverage.

While over 3 million Americans filed for unemployment as a direct result of layoffs caused by COVID-19, applying for unemployment might create unique challenges for trans individuals who might be required to use their deadname, a name assigned at birth that has electively been changed to match their gender identity, to prove their identity on government forms this can undoubtedly be traumatizing. Furthermore, trans and non-binary individuals might be wary to seek unemployment help as waiting in long lines outside unemployment offices might put them at an increased risk of discriminatory violence.

And it is no secret that, as a result of social stigma and discrimination, the transgender population has a higher rate of unstable housing and homelessness. According to the Williams Institute, over 30% of individuals served by drop-in centers, street outreach workers, and housing programsidentified as LGBT. Unfortunately, those who are transgender and homeless are at increased risk of exploitation, violence, and abuse, and may be turned away from shelters as a result of their gender identities. As some homeless shelters close or limit occupancy to stop the spread of COVID-19, this further limits available housing options for unhoused transgender individuals.

Past negative experiences of being misgendered or refused service when seeking care or out of fears of contracting COVID-19 in healthcare settings may cause trans people to forego care. And trans individuals may be reluctant to go to hospitals and clinics to request hormone replacement therapy (HRT) treatment during the pandemic already overburdened hospitals might not have the capacity to provide sufficient social services or hormone treatments.

Furthermore, gender-confirmation surgeries, deemed non-essential and elective, have been delayed or cancelled at many U.S. hospitals due to coronavirus. Interruptions in HRT provision or postponing long-awaited gender-affirming surgeries could augment feelings of isolation and gender dysphoria and amplify psychological distress. The Trevor Projects 2019 survey reported that more than half of transgender and non-binary young people have contemplated suicide and one-third have attempted it.

The minority stress model, a social psychology theory widely adopted in public health, describes how extreme minority stress causes adverse health outcomes among stigmatized minority groups. Consistent stress, discrimination and internalized stigma faced by transgender people increases their risk of suicidality. And as health systems react to treat coronavirus patients and critical services previously available to transgender patients are interrupted or deprioritized, feelings of isolation and marginalization might further increase rates of suicide or affect transgender mental and physical health and wellbeing.

School closures might also pose unique challenges to transgender youth. With campus LGBTQ resource centers and peer support unavailable and the suspension of all school-based social activities, transgender students might feel unsupported. Furthermore, self-quarantining with abusive family members who do not affirm their trans identity can be extremely traumatizing to trans youth.

As one trans commenter pointed out on a recent Buzzfeed article, I have to make a decision about whether to stay in the UK where I study or fly back to the States to be with my parents, one of whom doesnt use my name or pronouns and has refused to do so. With campuses and dormitories closed to suppress viral transmission, some transgender students must return home to unsafe emotionally and physically abusive homes because they are left with nowhere else to go. And once there, due to enforced lockdowns, they potentially cannot leave.

Quarantine and lockdowns may also increase rates of domestic and intimate partner violence perpetuated against transgender individuals. According to conservative estimates, the National Coalition Against Sexual Violence reports that one in three women and one in nine men will experience sexual violence during their lifetime, and these estimates do not accurately capture the increased risk of sexual violence within the LGBTQ community. Lockdowns and social distancing policies, budget cuts to IPV-related social services and mental health counseling, and financial instability due to unemployment all create opportunities for abusers to perpetrate sexual violence and make it more difficult for transgender victims to leave abusive relationships or report abuse.

Lastly, conservative graphs from the Imperial College COVID-19 Response Team and others by the Centers for Disease Control and Prevention (CDC) show frightening estimates that up to 2.2 million Americans mainly older adults, those who are immunocompromised, or those who have other pre-existing health conditions such as diabetes or lung disease might die as a result of contracting COVID-19. Elderly trans individuals at higher risk of contracting COVID-19 might refuse help from aging providers such as meal delivery programs, senior centers, or other social programs because they are afraid of harassment or discrimination.

Furthermore, statistics show the LGBTQ community is 50% more likely to smoke than the general population, potentially resulting in increased susceptibility to respiratory failure brought on by COVID-19, a respiratory illness. Moreover, trans individuals are more likely than the general population to be diagnosed with cancer and HIV, and reduced immune function could put them at a higher risk to contract coronavirus and face harsher symptoms.

Overall, the coronavirus has not just affected the trans and non-binary communities by restricting access to gender-affirming surgeries or HRT, but has effectively reduced their visibility. Fears of being misgendered or mistreated when seeking unemployment benefits or care in healthcare settings may cause trans and non-binary people to forego seeking assistance during this crisis.

Disruptions in hormone replacement therapy (HRT), counseling, or gender-affirming surgeries and self-quarantining with abusive family members may increase psychological distress and can augment rates of suicidality. Widespread unemployment might result in a loss of employer-based insurance coverage of hormone therapy and gender-affirming surgeries and cause an increase in homelessness among this population. And transphobic legislation may pass in the absence of assembled protestors who remain sequestered at home due to public health efforts to stop the spread of the coronavirus.

While COVID-19 has had a pronounced effect on everyone, those most vulnerable, such as those in the trans community, are poised to receive the most collateral damage.

Ryan Sutherland is a Master of Public Health candidate at the Yale School of Public Health in the Social and Behavioral Science Department with a concentration in global health.

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What isn't seen isn't heard: trans and non-binary health amid COVID-19 - The CT Mirror

Global Testosterone Replacement Therapy Market Research Report By Key Players, Geographical Regions and Growth Analysis Outlook Up To 2025 – Fashion…

Posted: April 6, 2020 at 9:47 pm

Global Testosterone Replacement Therapy Market presenting the fundamental market overview, market trends, past, present and forecast data related to the Testosterone Replacement Therapy Market From 2020-2025. A complete analysis of the Testosterone Replacement Therapy based on the definition, product specifications, market gains, key geographic regions, and imminent Testosterone Replacement Therapy players will drive key business decisions.

Global Testosterone Replacement Therapy market report presents a thorough and latest market insights in the form of graphs, pie charts, tables to provide a clear picture of the Testosterone Replacement Therapy Market. Global Testosterone Replacement Therapy report is divided into different chunks based on the type, diverse applications, key geographical regions, market share of each player, their production volume, and supply-demand ratio.

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Global Testosterone Replacement Therapy Market Report is Segmented Into Different Parts As Below:

Testosterone Replacement Therapy Market Details Based On Key Players:

AbbVieAllerganBayerEli Lilly and CompanyKyowa Kirin InternationalNovartisPfizer

Testosterone Replacement Therapy Market Based On Product Type:

General Type

Testosterone Replacement Therapy Market Based On Product Applications:

Medical

In this study, the years examined to evaluate the market size of Testosterone Replacement Therapy are as per follows:

History Year: 2014-2019

Base Year: 2019

Estimated Year: 2020

Forecast Year: 2020 to 2025

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The Global Testosterone Replacement Therapy Market Report Covers The Following Data Points:

Section 1: This section covers the Global Testosterone Replacement Therapy Market overview, including the basic market introduction, market analysis by its applications, type, and regions. The major regions of the Global Testosterone Replacement Therapy Market include, Europe, Asia, Middle East & Africa. Testosterone Replacement Therapy Market statistics and outlook (2020-2025) are presented in this section. Testosterone Replacement Therapy market dynamics states the opportunities, key driving forces, market risk are studied.

Section 2: This section covers Testosterone Replacement Therapy manufacturers profile based on their business overview, product type, and application. Also, the sales volume, Testosterone Replacement Therapy product price, gross margin analysis, and Testosterone Replacement Therapy market share of each player is profiled in this report.

Section 3 and Section 4: These sections present the Testosterone Replacement Therapy competition based on sales, profits, and market division of each manufacturer. It also covers the Testosterone Replacement Therapy market scenario based on regional conditions. Region-wise Testosterone Replacement Therapy sales and growth (2020-2025) are studied in this report.

Section 5 and Section 6: These two sections cover the Testosterone Replacement Therapy Market by countries. Under this, the Testosterone Replacement Therapy revenue, the market share of the countries like United States, Canada & Mexico are provided.

Section 7, Section 8 and Section 9: These 3 sections covers Testosterone Replacement Therapy sales revenue and growth in all the regions. Under these regions Testosterone Replacement Therapy report covered, the growth and sales in these regions are illustrated in this Testosterone Replacement Therapy Market report.

Section 10 and Section 11: These sections depict the Testosterone Replacement Therapy market share, revenue, sales by product type and application. The Testosterone Replacement Therapy sales growth seen during 2015-2020 is covered in this report.

Section 12 and Section 13: These sections provide forecast information related to Testosterone Replacement Therapy market (2020-2025) for each region. The sales channels include direct and indirect Testosterone Replacement Therapy marketing, traders, distributors, and development trends are presented in this report.

Section 14 and Section 15: In these sections, Testosterone Replacement Therapy market key research conclusions and outcome, analysis methodology, and data sources are covered.

*** Thank you for reading. You may also request custom information, such as chapter-wise or unique region-wise research, depending on your interest. ***

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Study Finds That Fad Diets Only Work For A Year – newstalkkit.com

Posted: April 6, 2020 at 9:46 pm

You're trapped at home. The Coronaviruspandemic has the gym shut down, the Yoga studio closed and even the hiking trails are no fun if you have to wear a mask.

So you are stuck and while there may be a shortage of some items like disinfectant wipes and hand sanitizers, there seems to be no shortage of food. So we eat out of boredom and when this medical crises is over, there may be more of us to love than there was before.

So in planning for the diet we will all surely need in a month or so, I found this from the Daily Mail.

A new study finds fad diets may come and go but they only work for about a year. McMaster University researchers analyzed 121 studies on 14 fad diets, including the Atkins and Paleo diets. They found across all diets, people following them managed to keep off 2.2 to 4.4 pounds over the course of 12 months.

The only diet that appeared to help people stay healthier a year later was the Mediterranean diet.

Study authors say various types of diet can cause moderate weight loss, reduce blood pressure and lower bad cholesterol but that weight loss and the benefits for blood pressure and cholesterol disappeared after a year.

They call it "unfortunate, but thats life. Plan B?

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Study Finds That Fad Diets Only Work For A Year - newstalkkit.com

5 tips to actually make your keto diet work – Times of India

Posted: April 6, 2020 at 9:46 pm

A favourite among people trying to lose weight is the ketogenic diet which limits the intake of carbohydrates and concentrates on increasing intake of fats (mostly) and proteins. Like with all kinds of diet, the results begin to show only after a few months of diligent practice of the diet. It is mostly during this time that people often lose steam and begin cheating their diet.It is the same with the keto diet. Even though it might seem difficult and frustrating in the beginning, these five hacks might help you get through the initial phases of the diet and see more satisfactory results faster. These tips will also help you maintain your weight loss journey as you go ahead with your diet.Create a keto environmentPreparation is the key to success in everything you do. The same is with your diet. Creating a suitable environment for your diet will help you stick to it for longer. There is always a war between your emotional brain and your rational brain, especially when you are following a strict diet. It helps at this time to not give your mind any kind of stimulus that may trigger a wrong eating choice. Make your environment force you to make healthier food choices. Here are a few things you can do to change the food environment at home Stop storing carb-heavy and unhealthy food. If you have to keep such food at home, keep it at a place that is out of your reach and sight Keep all keto-friendly foods close at hand Reduce your portion size to make sure you eat only the amount that is essential Also, prepare for your sweet cravings. They are bound to happen and being prepared in advance will help you keep up your diet and fulfill your cravings. You can keep keto-friendly sweeteners and desserts ready for whenever you have those uncontrollable cravings.

Add friendly fat to your dietIt is proven that adding friendly fats or medium-chain triglycerides (MCTs) is actually beneficial for people on a keto diet. These kinds of fats are easier to digest as compared to other forms of fat. Also, they go straight to the liver where they are converted to ketones. This helps you reach ketosis faster which is responsible for increased energy and feeling less hungry.

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5 tips to actually make your keto diet work - Times of India

Diets high in fiber linked to reduced risk of breast cancer – ConsumerAffairs

Posted: April 6, 2020 at 9:46 pm

Photo (c) bit245 - Getty ImagesHealth experts constantly stress the importance of consumers getting enough fiber in their diet, and now a recent study is lending additional weight to that advice.

Researchers from the Harvard T.H. Chan School of Public Health recently compiled data from 20 separate observational studies with the goal of seeing how fiber affected the risk of breast cancer. They found that the dietary staple lowered the chance of developing the disease by 8 percent.

The team found that soluble fibers -- which can be found in oat bran seeds, beans, lentils, and some fruits and vegetables -- lowered the overall risk of breast cancer. Higher total fiber intake (both soluble and insoluble) lowered risk in both premenopausal and postmenopausal women.

"Our study contributes to the evidence that lifestyle factors, such as modifiable dietary practices, may affect breast cancer risk," said Dr. Farvid.

"Our findings provide research evidence supporting the American Cancer Society dietary guidelines, emphasizing the importance of a diet rich in fiber, including fruits, vegetables, and whole grains."

While optimizing your diet can help reduce the risk of breast cancer, researchers have also been hard at work trying to find ways to catch the disease at its earliest stages when it is most treatable. One research team from the National Cancer Research Institute recently announced that they were in the process of developing a blood test that could do just that.

The researchers said that initial trials of their blood test were successful because it allowed them to differentiate between participants who had breast cancer and those who didnt. They hope that continuing to work on the method will eventually give medical professionals another tool to fight disease.

These results are encouraging and indicate that its possible to detect a signal for early breast cancer. Once we have improved the accuracy of the test, then it opens the possibility of using a simple blood test to improve early detection of the disease, said researcher Daniyah Alfattani.

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Diets high in fiber linked to reduced risk of breast cancer - ConsumerAffairs

The JavaScript Framework That Puts Web Pages on a Diet – WIRED

Posted: April 6, 2020 at 9:46 pm

Websites are too damn big.

The average web page is about 2 megabytes, according to HTTP Archive, a site that tracks the performance of websites and the technologies they use. Sure you can download 2 megabytes in less than a second on a good 4G mobile connection. But todays web pages are problematic for people on slow connections or with small bandwidth caps. Not all that long ago, a complex game or software program fit on a 1.4-megabyte floppy disk.

There are many reasons todays web is so bloated, including the ads and tracking scripts that saddle so many pages. Another reason is that websites do much more than just display text and images. Many sites now look and feel like full-blown desktop applications.

To build these interactive sites, many web developers turn to open source packages that handle common tasks. These tools liberate programmers from a lot of grunt work, but they can add heft to a project. Facebook's popular open source React library for building user interfaces, for example, weighs in at 100 kilobytes. Throw in some other tools and graphics, and soon youre talking many megabytes.

The up and coming JavaScript framework Svelte, created by visual journalist and software developer Rich Harris, aims to make it easier to write faster, smaller interactive websites and applications. Web developer Shawn Wang says he cut the size of his personal website from 187 kilobytes to 9 kilobytes by switching from React to Svelte.

"It was a big 'wow' moment," Wang says. "I wasn't even trying to optimize for size and it just dropped."

Harris, a graphics editor for The New York Times, created and released the first version of Svelte in 2016 while working for The Guardian. Many of his projects involved interactive graphics and animations, but he worried that the graphics could take too long to load or would chew through users data limits.

Frameworks add heft to websites because they traditionally serve as a middle layer between an app's code and the user's browser. That means developers need to bundle the entire framework, in addition to their own code, with an app, even if they don't use all of the framework's features. Wang compares this to a rocket ship that needs massive fuel tanks to launch into space.

Harris took a different approach. Svelte performs its middle-layer work before a developer uploads code to a web server, well before a user ever downloads it. This makes it possible to remove unnecessary features, shrinking the resulting app. It also reduces the number of moving parts when a user runs the app, which can make Svelte apps faster and more efficient. Svelte is like a space elevator, Wang says. The framework was tricky to create, but advocates say it makes it easier for developers to build efficient apps.

Everything you ever wanted to know about Linux, GNU, and how big companies are making money off of free, collaboration-based software.

Wang says he likes to use Svelte for web pages, but he still uses React for larger applications, including his professional work. For one thing, the larger an app, the more likely a developer will use all of React's features. That makes it less wasteful. In fact, some Svelte apps are bigger than apps made with React or similar tools. And theres much greater demand for React developers than Svelte developers.

In the State of JavaScript 2019 survey of more than 21,000 developers, 88 percent of respondents who had used Svelte said they were satisfied with it, giving it the second-highest satisfaction rating in the survey, just behind Reacts 89 percent satisfaction rate. But only 7.8 percent of respondents had used Svelte, and 24.7 percent had never heard of it. Meanwhile, 80.3 percent had used React.

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The JavaScript Framework That Puts Web Pages on a Diet - WIRED

A Quarantine Media Diet – The Free Press of the University of Southern Maine

Posted: April 6, 2020 at 9:46 pm

By: Cormac Riordan, Staff Writer

Like a lot of us, one solace in this new era for me has been Animal Crossing: New Horizons. This peaceful world of foraging and animal pals is both escapist and rewarding, something that has united my recent film, music, and book selections. From the island paradise of Portrait of a Lady on Fire to the sense of community fostered by the March sisters in Little Women, my current media diet is not just calming visions but works that encourage a sense of community.

Its hard not to see the March sisters, and others like Marmee and Laurie, in the helpful and loving visages of your animal companions. Although when Louisa May Alcott wrote her magnum opus in 1868/9, I dont think digital frogs and bears were on her mind, both communities have similar ethea. The chapter in which the sisters desire a world where they can do as they please and ignore their chores strikes the most similarities. Their mother agrees and allows herself and the help to take care of the work around the house, only for the girls to realize that a balance of work and play is what makes the downtime special. New Horizons works in a similar way, combining tasks like cleaning up your island with a rewards system and an arrestingly adorable style. Just like how doing chores, more or less, in Animal Crossing becomes less chore-like and more rewarding, one can imagine having to work becomes much more pleasant when joined by Jo or Beth.

Sharing the island aesthetic with New Horizons and the bond between women of Little Women, Cline Sciammas newest feature, Portrait of a Lady on Fire, is now available on Hulu. I caught up with it last year, but have been waiting anxiously for it to be widely available to revisit. It packs just as much emotional punch the second time, the setting as lush and picturesque as my memory served. Theres so much to praise about Sciammas vision of two women finding each other in the late 1700s, from the incredibly sparse yet devastating diegetic score to way the cinematographer, Claire Mathon, captures the two leads surrounded by this natural beauty. But it is in those two lead performances that the movie stands almost completely. Nomie Merlant is wonderful as the hired portrait maker, quiet and subdued by never vage. Who really steals the show, however, is Adle Haenel as the woman Merlants character is hired to paint. Haenel is Sciammas ex, and that energy both informs and compliments the film. There is a final moment, quite literally the last shot of the film, that I wont spoil here, but I cant imagine anyone coming away from that long take on Haenel and be able to doubt her incredible talents.

Heaven/Heaven is a place/a place where nothing/nothing ever happens is a line David Byrne sings on a Talking Heads song called Heaven. The second song in the bands incomparable concert film Stop Making Sense, when I heard those lyrics early this week two things struck me. Firstly, how Byrnes words almost seem mocking right now, when we are all pretty much forced to do nothing. But secondly, how right he is about this idea of blissful emptiness, and how the film Portrait of a Lady on Fire, the book Little Women, and the video game Animal Crossing: New Horizons reflect that idea. All of these works have quiet, peaceful moments where little happens, but the audience understands the significance of moments like when the women in Portrait argue over a Greek myth or in Little Women when much is made about pickled limes. One could argue in the case of the whole Animal Crossing franchise, that nothing does ever happen. But isnt that kind of calming?

Excerpt from:
A Quarantine Media Diet - The Free Press of the University of Southern Maine

Lifestyle changes are important even if you take medications – Harvard Health Blog – Harvard Health

Posted: April 6, 2020 at 9:46 pm

A friend of mine takes a statin medication each day to lower his cholesterol. More than once Ive heard him say I ate too much! Im going to have to take an extra pill.

Never mind that it doesnt work that way a single additional statin pill wont make much difference to his cholesterol or his health. And never mind that you shouldnt self-adjust the dose of your medications (talk to your doctor before making any changes in medication dosing).

But my friends overindulging does bring up the question of whether starting medications for conditions like high blood pressure or high cholesterol might lead people to pay less attention to healthy lifestyle choices. Would my friend have been as likely to overeat before he was started on a statin?

The thinking might go like this. If your cholesterol or blood pressure is not ideal, your doctor will likely recommend changes in your diet, regular exercise, and loss of excess weight, as these measures will lower cholesterol and blood pressure in many people. But if that doesnt work well enough, a medication may be prescribed. Once the medicine is doing its job, it may seem like its not so important to continue with the diet and exercise routine.

A new study published in the Journal of the American Heart Association suggests that this way of thinking might be widespread: people with hypertension (high blood pressure) or high cholesterol seem to let their healthy habits slide once they start taking medications.

Researchers collected data on weight, smoking, physical activity, and alcohol use among more than 40,000 adults with no history of cardiovascular disease. Compared with people who were not prescribed medications for high cholesterol or high blood pressure, those who were prescribed medications

The news wasnt all bad. Those starting medications tended to drink less alcohol and to quit smoking more often than those not taking medicines.

These results can be interpreted in a number of ways. Perhaps people who start taking medications assume they no longer need to be as careful with how they eat or other lifestyle choices. Its also possible that people who ultimately needed medications were less careful with following a healthy lifestyle even before medications were prescribed and that may explain, at least in part, why they needed medications in the first place. Or, it could be that those destined to require medication therapy inherited more high-risk genes for future obesity.

Whatever the explanation, people with high blood pressure or high cholesterol should maintain a healthy weight and get regular physical activity, regardless of whether medications are prescribed. In fact, it may be even more important for those who were prescribed medications, because if their conditions were severe enough to warrant a prescription, they may be at higher risk for complications (such as heart attack or stroke) than those able to avoid medications.

For many conditions, a medication can only do so much. Healthy lifestyle habits can improve the chances that a medication will be effective.

For people with high blood pressure, high cholesterol, and many other conditions, medications should be in addition to lifestyle changes, not instead of them. Not only will these lifestyle choices improve the chances your medicines will work to lower blood pressure or improve cholesterol, they come with a long list of other health benefits, such as improved mood, a reduced risk of diabetes, and a lower risk of certain cancers. And if you stick with the lifestyle changes, theres a chance you will be able to stop the medication in the future.

If youve been prescribed a medication after trying diet, exercise, or other lifestyle changes, ask your doctor whether its still important to focus on these lifestyle factors. And dont be surprised if the answer is yes.

Follow me on Twitter @RobShmerling

Link:
Lifestyle changes are important even if you take medications - Harvard Health Blog - Harvard Health


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