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Brit mum imprisoned in Iran for ‘secret plot’ loses final appeal to overturn five-year jail-term – The Sun

Posted: April 25, 2017 at 8:43 am

Nazanin Zaghari-Ratcliffe's husband said no more legal avenues wereavailable

A BRITISH-Iranian mum jailed for five years in Iran after being accused of plotting to topple the regime, has lost her final appeal.

Nazanin Zaghari-Ratcliffe, 37, was arrested in Tehran on April 3 2016 trying to return to Britain after visiting family with her daughter Gabriella, two.

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Nazanintook her case to Irans Supreme Court but the sentence was upheld and her husband saidno more legal avenues are available.

In September 2016 Richard Ratcliffe, of Hampstead, North West London said his wife had suffered weight loss, lost hair and became virtually unable to walk since being jailed.

After the latest ruling he said:This extinguishes the last hope we have had of legally overturning a punishment where the crime remains a mystery,

Weve had a year, the legal process is finished, so I think the (British) Government needs to step up, find a way to visit her, say that shes innocent and call for her release publicly.

Zaghari-Ratcliffes husband said she was feeling angry but determined after losing her final appeal and is hoping for intervention from the UK.

Britains foreign ministry said it was deeply concerned by reports the Supreme Court has upheld the sentence and said Prime Minister Theresa May and Foreign Minister Boris Johnson had raised the case with their Iranian counterparts.

We continue to press the Iranians for access and for due process to be followed, and are ready to help get her daughter back safely to the UK if requested, a spokesman said.

PA:Press Association

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Irans elite Revolutionary Guards accused Zaghari-Ratcliffe of having taken part in the sedition movement of widespread protests that followed the 2009 re-election of former hardline president Mahmoud Ahmadinejad, charges which she denies.

The couples daughter Gabriella, is being cared for in Tehran by her grandparents, who speak little English.

Gabriella has been able to visit her mother since she was moved from solitary confinement to the womans ward of Tehrans Evin prison.

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Brit mum imprisoned in Iran for 'secret plot' loses final appeal to overturn five-year jail-term - The Sun

Weight loss – girl shows the shocking TRUTH behind her impressive before and after picture – Express.co.uk

Posted: April 25, 2017 at 8:42 am

Imgur/issegal

Imgur user issegal shared two images of herself in a bikini which appear to show months of weight loss.

In the first picture, the girl can be seen standing in a red bikini which cuts in to her sides, causing a muffin top.

Her stomach protudes and does not appear to be flat at all.

In the second image - presumed to be an after shot - the girl wears the same red bikini top with a pair of black bottoms.

Her muffin top has completely disappeared, and her stomach is now completely flat. Her thighs also appear slimmer too.

But the photos have not been taken months or even days apart - but were in fact taken with just 15 minutes between them.

Captioning the post, issegal explained: Lose weight in only 15 minutes by changing your stance, hair, clothes, came zoom and filter.

The post has gone viral, with over 219,000 views and hundreds of comments.

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London

Finally a 15 minute weight loss program that works

One person joked: Finally a 15 minute weight loss program that works.

Another said: Everything else I understand, but how did the dreaded muffin top disappear, just looser pants?

One wrote: Black underwear is also very slimming.

One person noted: If its stupid but it works then its not stupid.

The shocking before and after pictures come as one common kitchen ingredient was revealed as a secret star for weight loss.

Scientists have been investigating the effects of apple cider vinegar on weight loss in recent years and there has been consistently encouraging evidence of its beneficial effect on the body.

Apple cider vinegar (ACV) is made from crushed apples combined with yeast and bacteria for fermentation.

The major active component of ACV is acetic avid, also known as ethanoic acid.

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Weight loss - girl shows the shocking TRUTH behind her impressive before and after picture - Express.co.uk

How Women Can Lose Weight After 40 (especially around the middle) – Huffington Post

Posted: April 25, 2017 at 8:42 am

Are you a woman over 40 and noticing its getting harder to lose weight? Got some extra stubborn fluff and puff around the middle? Maybe yourefinding that the diets you did in your 20s or 30s dont work as fast as they used to or donteven work at all! If youre already well past 40, chances are youve found its harder to lose weight. And, those inches around your waistline wont budge.

Yes ladies, Middle Age Spread is a real thing. Now before you click the little x on your browser to close this page and curse my name in disgust, sit tight. First, Im going to lay out the facts of why this happens to most women. Then, Im going to give you some action steps you can take tostart losing weight again!

Ok, no big surprise here. During perimenopause, our estrogen and testosterone levels start to drop. By menopause, they plummet. This is probably why approximately 30% of women between 50 and 59 are obese. http://www.womenshealth.northwestern.edu/blog/menopause-and-weight-gain

There appears to be a connection between estrogen and body weight regulation. With lowerestrogenlevels, lab animals tend to eat more and be less physically active. http://www.womenshealth.northwestern.edu/blog/menopause-and-weight-gain Levels that are too high or too low appear to lead to fat storage. And, lower estrogen levels may also slow down your metabolic rate (the speed at your body converts stored energy into working energy).

Many of us just slow down with age and exercise less. This is just bad all around. This is true for both men and women. Heres why:

Sarcopenia. Sar-who? Naturally as we get older, we gradually lose muscle mass a little bit every year. It actually starts happening as early as 30. The less muscle we have on our bodies, the slower our metabolism is and the easier it is to gain weight.

We also lose aerobic fitness as we age, further slowing down our ability to use up energy when we exercise. In other words, we burn less calories when we exercise.

If you were very active in your younger years, you may have had some injuries. Like a spicy pepperoni pizza does after dinner, those injuries from your carefree days can come back to haunt you. These ghosts of injuries past show up in the form of early arthritis, bone spurs, tighter muscles, pinched nerves, etc. After our 30s, new injuries also take longer heal. No wonder we slow down.

Not Getting Enough Quality zzzs.

Many women have troublesleeping during menopause due to hot flashes, night sweats, stress and the other fun stuff that goes along with low estrogen levels. Migraines anyone?? The bummer is poor sleep is linked to hunger and weight gain because of two more hormones: ghrelin (the feed me hormone) and leptin (the Im full hormone). Heres a short blog I wrote on that topic. If youre sleep deprived, these hormones get out of whack.

Increased insulin resistance.

As we age, we tend to become more insulin resistant which can put us at risk for type 2 diabetes. When you eat foods that break down into sugar, the pancreas pumps out insulin to escort the sugar out of your blood. People with Insulin resistance dont use insulin effectively so that cells have trouble absorbing sugar which causes a buildup of sugar and insulin in the blood. Researchers still arent 100% in agreement as to why, but at the end of the day, people with insulin resistance gain weight, particularly around the middle. And some research shows that lack of estrogen may cause insulin resistance.

1. Eat less added sugar, processed foods and refined grains (white bread, bagels, pasta, white rice, you know the drill). A lot less. According to the sugar science department at UCSF, added sugar is hiding in 74% of all packaged food. And, the majority of carbohydrates in the typical American diet is made of refined grains. This means reading labels folks and knowing how many different names there are for sugar. Just because its called agave nectar or cane juice crystals doesnt mean its any better for you than the white granulated stuff. Your body doesnt know the difference and once you eat it, its all the same to your pancreas (the organ that produces insulin in response to sugar). Click this link to see 61 different names of sugar then run to your pantry and read the ingredients on your packaged food.Prepare for a rude awakening!

http://sugarscience.ucsf.edu/

2. Exercise more. Contrary to what your body may want to do, you must exercise more regularly as you age, not less! If youre finding yourself slowing down, gradually start ramping it back up. Its not a good idea to go from taking an occasional walk to running a 10K. Thats a fast track to getting an injury. But start finding ways to fit more physical activity to your life. The more you exercise, the more insulin sensitive you become (thats the opposite of insulin resistant!)

Although your diet is the primary factor in weight loss (or gain), there are some sure-fire ways to speed up that weight loss though through exercise.

Jill Brown

3. Keep a food journal (or use an app) to keep track of what you eat. As we get older, our metabolisms naturally slow down. That means you need less food. If youre still eating as much as you did in your 30s, youve probably had to buy a whole new wardrobe or 2 by now. Apps like My Fitness Pal or Lose It help making weight loss goals easier by keeping you on track. Or you can go old school and write everything down then look up the calories. Not all calories are created equal, but one is for sure, taking in more than you burn leads to more body fat.

Pay attention to how you feel after eating certain types of foods and notice what makes you good and what makes you feel crappy.

4. Take probiotics to help digestion.

5. Eat more anti-inflammatory foods high in omega-3s, along with garlic, turmeric, cocoa, tea and berries.

6. Eat more high-quality protein. Higher protein diets have been shown to help with weight loss.

7. Eat more soluble fiber. It fills you up so you feel less hungry, it can increase insulin sensitivity and you know the other reason.

8. Sleep more and stress less. Easy, right? This may be the hardest part. There are plenty of things you can try. Melatonin and or magnesium at night. Massages. Yoga. Meditation. Hot baths before bed. Black out windows and cooler temperature in your bedroom. A good shrink. Theres really no shortage of suggestions. It may be time to experiment if youre not getting enough good sleep.

9. Talk to your doctor about hormone replacement therapies. HRTs have been shown to help control weight gain.

Think of this as a quick start guide for what you can do to promote weight loss starting around the perimenopausal years. In future articles, I will go deeper into each of the topics mentioned to help you lose weight and feel better so we can enjoy what should be the best years of our lives! Stay tuned!

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How Women Can Lose Weight After 40 (especially around the middle) - Huffington Post

Food Choices Swayed by ‘Behavior’ Genes – Genetic Engineering & Biotechnology News

Posted: April 24, 2017 at 5:43 pm

Do you crave fatty foods or salty snacks? Does the thought of chocolate make you swoon? Or do youas you know you shoulddelight in fruits and vegetables? Whatever your food preferences, you are likely aware that theyre not strictly a matter of willpower. For better or worse, your diet is shaped by environmental, cultural, and social factorsand your genetics.

Although people with eating disorders such as anorexia and bulimia have been evaluated for genes that influence dietary behaviors, healthy people have often been overlooked. Consequently, little is known about the natural variations in the behavior-related genes that might affect eating behavior among people who simply hope to stick to healthier diets.

Working to fill in this gap is an international team of scientists that analyzed the genetics of 818 men and women of European ancestry, evaluating single-nucleotide polymorphisms (SNPs) within 38 loci (1359 SNPs) selected on the basis of previous associations with several behavioral and psychological traits (that is, stress, addiction, depression, impulsivity, novelty-seeking, aberrant eating) from genome genotype data. In addition, the scientists gathered information about their diet using a questionnaire.

Ultimately, the scientists found that the genes they studied did play a significant role in a person's food choices and dietary habits.

One team member, Silvia Berciano, a predoctoral fellow at the Universidad Autonoma de Madrid, presented the new findings during the Experimental Biology 2017 meeting, which is still being held in Chicago. The findings also appeared in an article (Behavior Related Genes, Dietary Preferences and Anthropometric Traits) that is in the April issue of the FASEB Journal.

Significant associations were observed for the FTO locus with vegetable and total fiber intake; the CREB1 and GABRA2 loci were associated with salt intake; and the SLC6A2 with total fat and monounsaturated fatty acids, wrote the articles authors. Finally, chocolate intake was associated with variation at the OXTR locus.

The authors noted that many nominally significant associations were observed between genetic variability at the selected loci and the consumption of specific foods and nutrients, but they emphasized that the most significant association with anthropometric traits was found with certain forms of the oxytocin receptor gene. This gene was not only linked with higher chocolate intake, but also greater waist circumference.

Our data indicate that genes implicated in behavioral and psychological traits drive a significant component of an individuals food preferences and dietary habits, the authors continued. This information will contribute to a better understanding of eating behavior and facilitate the implementation of personalized dietary advice that should result in better compliance and more successful prevention and therapy of chronic disorders.

The researchers plan to perform similar investigations in other groups of people with different characteristics and ethnicities to better understand the applicability and potential impact of these findings. They also want to investigate whether the identified genetic variants associated with food intake are linked to increased risks for disease or health problems.

"Most people have a hard time modifying their dietary habits, even if they know it is in their best interest," said Berciano. "This is because our food preferences and ability to work toward goals or follow plans affect what we eat and our ability to stick with diet changes. Ours is the first study describing how brain genes affect food intake and dietary preferences in a group of healthy people."

"The knowledge gained through our study, Berciano asserted, will pave the way to better understanding of eating behavior and facilitate the design of personalized dietary advice that will be more amenable to the individual, resulting in better compliance and more successful outcomes."

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Food Choices Swayed by 'Behavior' Genes - Genetic Engineering & Biotechnology News

4 Ways You’re Eating Your Way Toward an Anti-Inflammatory Diet – Verily

Posted: April 24, 2017 at 5:43 pm


Verily
4 Ways You're Eating Your Way Toward an Anti-Inflammatory Diet
Verily
"Increasing these nutrients in the diet, specifically omega-3 polyunsaturated fatty acids, ascorbic acid (vitamin C), vitamin E, polyphenols, prebiotics, and probiotics, help defend against chronic inflammation." In her work, she finds, more and more ...

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4 Ways You're Eating Your Way Toward an Anti-Inflammatory Diet - Verily

Agropur’s Glycomacropeptide Wins Breakthrough Award for Dairy Ingredient Innovation – Yahoo Finance

Posted: April 24, 2017 at 5:42 pm

EDEN PRAIRIE, Minn., April 24, 2017 /PRNewswire/ --Agropur has received the Breakthrough Award for Dairy Ingredient Innovation for its development of highly pure glycomacropeptide (GMP). The first annual honor, presented in Chicago on April 24 at the American Dairy Products Institute's annual meeting, is awarded in cooperation with Dairy Foods magazine.

GMP is a casein-derived protein fraction produced during the cheesemaking process. In 2016, Agropur introduced high purity whey protein isolate with more than 95% of the total protein in GMP form. No similar ingredient commercially available reaches the same purity.

"To our knowledge, only one other dairy ingredient company manufactures a whey protein concentrate with 60% GMP," said Anand Rao, vice president of research and development, Agropur Ingredients. "GMP extends our protein's reach to pharmaceutical applications."

GMP is an ideal dietary tool for people with phenylketonuria, a birth defect that inhibits the body from digesting the amino acid phenylalanine. People with phenylketonuria have to follow diets that restrict phenylalanine ingestion, leading to difficulty consuming enough protein. Agropur GMP's high purity results in just 1-2 milligrams of phenylalanine per gram of protein, making it highly functional for phenylketonuria-friendly products. So, phenylketonuria patients can safely follow a nutritious, high-protein diet.

"We are incredibly honored to receive this award from Dairy Foods and the American Dairy Products Institute," said Doug Simon, president of Agropur U.S. Operations. "As a global leader in protein isolation, Agropur is well-suited to formulate more innovative products like GMP for years to come."

Agropur's highly pure GMP also has applications in the dental industry. GMP's properties protect against tooth decay and plaque formation, so it's an ideal ingredient to be used in dental hygiene products like toothpaste and mouthwash.

Agropur started producing GMP at its award-winning Jerome, Idaho facility in December. The product is already being used in commercial formulations.

ABOUT AGROPURAgropur Cooperative is a North American dairy industry leader founded in 1938. With sales of nearly $6.0 billion in 2016, the Cooperative is a source of pride to its 3,345 members and 8,000 employees. Agropur processes more than 13 billion pounds of milk per year at its 39 plants across North America and boasts an impressive roster of brands and products. Agropur Inc. is a subsidiary of Agropur Cooperative.

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/agropurs-glycomacropeptide-wins-breakthrough-award-for-dairy-ingredient-innovation-300444548.html

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Agropur's Glycomacropeptide Wins Breakthrough Award for Dairy Ingredient Innovation - Yahoo Finance

Whole Cuisine Getting Runners Ready For The 10K One Meal At A Time – Vancouver Sun

Posted: April 24, 2017 at 5:42 pm

Whole Cuisine Getting Runners Ready For The 10K One Meal At A Time
Vancouver Sun
As the clinics are helping me learn to run 10k safely, the food being provided is changing my lifestyle. Now I am aware of different food options and I'm armed with new knowledge on nutrition regarding what our body needs for success. I'll be the first ...

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Whole Cuisine Getting Runners Ready For The 10K One Meal At A Time - Vancouver Sun

Finding reliable online self-help programs – Idaho Statesman

Posted: April 24, 2017 at 5:42 pm


Idaho Statesman
Finding reliable online self-help programs
Idaho Statesman
There are tens of thousands of online self-help programs and businesses with apps and websites that tout their DIY approach to managing everything from addiction and depression to chronic pain and insomnia. A 2015 study found that around 15,000 ...

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Finding reliable online self-help programs - Idaho Statesman

The Monday Extract: The ballerina who was hospitalised with anorexia – The Spinoff

Posted: April 24, 2017 at 5:42 pm

Massey University creative writing graduate Sacha Joneswas a principal dancer in the Sydney City Ballet after surviving a teenage diet of cake and laxatives on Saturdays. Her memoir takes a tragi-comic look back at her early dance career.

Kelly Barden, a fledgling young dancer, was lithe and lovely and very much built for ballet, as I was not. But her technique was weak and undeveloped where mine was strong. When she was awarded first prize in the Stuyvesant, Australias premier ballet competition, against every prediction of the teachers and other dancers at the Opera House on the night, and I was awarded runner-up for the second time, I thought it was the end of my world, and in a way it was. It was the end of my childhood, and the beginning of the end of my dance career, though I didnt know that then. I planned to go to London to win the top ballet competition there, the Adeline Gene. That would show them.

The company returned from Tasmania a few days later and I make myself go in to meet them in the studio. They are buzzing with the success of the tour; the best ever, they all agreed, which doesnt exactly help. But it does help to have the studio alive again. You dont look too good, someone tells me, and I shrug. I dont feel too good. The SeptemberNovember edition of Dance Australia comes out with a full-page article and photo of Kelly, still wearing that stolen golden smile, her arms laden with her winners bounty of flowers, trophy and $4000 cheque. There are a few words dedicated to the runner-up.

Another production of The Nutcracker to be performed for schools by day and the general public by night is planned for late November, early December, to finish a few days before I leave. I am going to London despite the Stuyvesant loss and because of it, in a way.

I have enough saved in my little blue bank book for a one-way ticket and after the Stuyvesant I have no more doubts about leaving, possibly never to return.

Between rehearsals for The Nutcracker, for which I am dancing the part of Clara, I must learn the two Gene variations from a video and manual. This is a gruelling process undertaken awkwardly with Mrs Ps help in the smaller studio next to the one in which Hassan runs rehearsals of the second act, which doesnt involve Clara much. The piano accompaniment for the Gene dances is clunky and uninspiring next to Tchaikovskys passionate Nutcracker score, and the steps are so technical that I cant muster much enthusiasm for them.

The truth of the matter is thatIm not as fit as I was for the Stuyvesant. In just a few weeks I have lost condition, returning to abusing laxatives on an ever more regular basis, and extending my binges beyond a few spoonfuls of pie. On my way home from the studio one evening, the custard cannoli in the window of the Italian bakery at Central Station that I have successfully resisted for approximately 700 days finally wins out and I dont stop there.

That night the laxatives dont work, possibly because my body is getting used to them, or perhaps laxatives dont work on custard cannoli. Whatever the case, waking up with all those cloying calories weighing me down the next morning is more depressing than losing the Stuyvesant almost. I starve myself the next day, not even eating breakfast, and again the following day, then break out with another binge the day after that.

And so the vicious cycle begins and continues until one day Mrs P, taking me through my Gene variations, tells me I have put on weight and need to lose it before the Gene. She leads me to the mirror and says: Here, pinching the fat on my upper arm, and here, pinching my upper inner thigh, which is not the first time she has touched that part of me ballet teachers have a free pass to the whole body but it is the first time she has done it for the purpose of finding fat. I have finally failed the pinch test.

Sacha Jones as a teenage ballerina, Sydney,1982 (Image: Supplied)

Im a miserable wreck. I charge headlong into a carrot-and- TAB-only diet that I intend to stay on for the remaining weeks till I leave for London. It lasts precisely three long days; not quite long enough for Mrs P to notice any improvement or say anything if she does, but long enough that Im so ravenous I could eat an entire Italian bakery and almost do. My battalion of laxatives comes out in full force that night and this time they do work. By the time I get into the studio the next morning, I am light-headed and dizzy from a very draining night. And its not over yet. After another visit to the studio bathrooms I collapse unconscious on the floor fortunately just beyond the toilet cubicle.

When I come to, I am being carried through the streets of Sydney in Daryns arms. Later on I find out that he insisted on being the one to carry me to the hospital, although Hassan, a much bigger man, offered.

I spent that day after collapsing in the museum bathrooms in intensive care at Sydney Hospital being tested for drugs and diseases, questioned by a psychiatrist (I admitted nothing), given a sedative and finally diagnosed with anorexia in its early stages. I was deeply ashamed of those early stages. I had always taken inspiration from Karen Carpenters battle with anorexia, even if she had just died of the disease earlier in the year, but early stages anorexia feels like being runner-up in the Stuyvesant.

But the show must go on. I was out of intensive care and onto the stage dancing the role of Clara quicker than you could say Nutcracker. Three days after my collapse, we opened at the Capitol Theatre (the Regent being prepared for demolition by that stage), with the dress rehearsal the very next day.

Three weeks later I am on the plane to London. And it is this goal that saves me, I think, as well as my brief stay in intensive care, which was a bit of a wake-up call. After that, I put away the laxatives and got back to my much more balanced breakfast-only, no-cannoli diet. By the end of those three weeks I was down to 41kilograms, roughly my goal weight, and felt more or less recovered. I could lose those last two kilos in London.

More cautious parents may well have wanted to keep their slightly unstable, recently hospitalised teen at home for a while longer before sending her off to the other side of the world unsupervised. So it was just as well that my parents were not the cautious type. In fact, in those three weeks Mum and Dad had taken themselves off to their favourite guesthouse in Bowral where Mum, according to her diary, sank a 20-foot putt, and Dad bought her an eternity ring to celebrate twenty years of marriage while waiting to hear back from Oxford University Press who had sent him some encouraging letters on his book.

As soon as I take my seat on the flight to London, I plug in The Man from Snowy River (in my ears) for a bit of premature nostalgia as the plane clears that vast brown continent of fake forests and improbable fruits, heading north over the bright, blushing blue sea. A box of Colon Care is tucked safely in the hold just in case. They might not have laxatives in Narnia.

From The Grass Was Always Browner, a memoir by Sacha Jones (Finch Publishing,$32.99),available at Unity Books. Sacha will compete tonight (Monday) at the Classic Comedy Club in Auckland for a place in the semi-finals of the Raw Quest. All the best Sacha!

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The Monday Extract: The ballerina who was hospitalised with anorexia - The Spinoff

Your mother’s diet may influence your liver’s health – Medical News Today

Posted: April 24, 2017 at 5:42 pm

Non-alcoholic fatty liver disease is a serious and growing problem. Previously linked with obesity, a new study also connects it to maternal obesity - meaning that what your mother ate during pregnancy may affect your future liver health.

Non-alcoholic fatty liver disease (NAFLD) is characterized by a buildup of fat within the cells of the liver. Although having fat in the liver is normal, if there is an excessive amount, it can lead to liver scarring and cirrhosis.

Cirrhosis describes a process during which liver cells are gradually replaced by scar tissue, hindering the liver's capacity to work effectively.

NAFLD is estimated to affect 20 to 30 percent of people in the Western world, and this level appears to be on the rise.

Individuals with type 2 diabetes and morbid obesity are among the worst affected; in these groups, the rates of NAFLD are 70 and 90 percent, respectively.

Although some of the risk factors are understood, it is not always clear why one person develops NAFLD while another, similar person, does not. Because of the rising prevalence of NAFLD, a great deal of research is currently under way that attempts to generate an understanding of the pathways behind the condition.

The latest research comes from a team headed up by Dr. Michael Thompson, Ph.D., a pediatric endocrinology fellow at Nationwide Children's Hospital in Ohio. The results are presented today at the Experimental Biology 2017 meeting, held in Chicago, IL.

Using a mouse model, the research explores the effect, if any, of a maternal high-fat diet on the offspring's liver health.

Dr. Thompson explains the reasons for his decision to embark on the current project: "Complications of obesity are a significant cost burden for the medical system, especially given the prevalence of obesity. Understanding how maternal exposures impact obesity-related disease such as non-alcoholic fatty liver disease will allow us to develop lower-cost preventative therapies to utilize up front rather than awaiting complications down the road."

Once the data had been analyzed, they found that exposure to a high-fat diet during development produced changes in the liver that persisted through to adulthood. These changes remained even if the offspring were fed a low-fat diet after birth.

If this effect is confirmed in humans, it would mean that someone of a healthy weight could still be at risk for NAFLD if their mother had been obese during pregnancy.

When the team looked further into the data, they found that levels of bile acid and the genes involved in its regulation were altered in the offspring of obese mothers. This suggests that the offspring might have cholestasis, a condition in which the normal flow of bile is interrupted.

"If human offspring from obese mothers have a similar risk for developing fibrosis as we see in mice, we may be able to predict who is going to develop more serious disease.

Knowing who is most at risk for more serious disease will guide us on which patients should be treated more aggressively. Furthermore, understanding the biological mechanisms involved in this increased risk could lead to preventative therapies."

Dr. Michael Thompson

The results will need to be confirmed, but they open the door to a raft of new questions. Thompson and his team are now planning research to further investigate the risk of disease progression. Using the same mouse model, they are also designing studies that will examine preventative therapies able to be administered during pregnancy or shortly after birth.

Due to the rising rates of NAFLD, research in this vein is likely to continue at breakneck pace. Preventing or slowing this condition could have huge health benefits for the population at large.

Learn how eating meat may increase the risk of developing NAFLD.

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Your mother's diet may influence your liver's health - Medical News Today


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