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Western diet may increase risk of gut inflammation, infection Washington University School of Medicine in St. Louis – Washington University School of…

Posted: May 23, 2021 at 1:53 am

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Diet rich in sugar, fat damages immune cells in digestive tracts of mice

A tiny, 3D model of the intestines formed from anti-inflammatory cells known as Paneth cells (green and red) and other intestinal cells (blue) is seen in the image above. Researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic used such models, called organoids, to understand why a Western-style diet rich in fat and sugar damages Paneth cells and disrupts the gut immune system.

Eating a Western diet impairs the immune system in the gut in ways that could increase risk of infection and inflammatory bowel disease, according to a study from researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic.

The study, in mice and people, showed that a diet high in sugar and fat causes damage to Paneth cells, immune cells in the gut that help keep inflammation in check. When Paneth cells arent functioning properly, the gut immune system is excessively prone to inflammation, putting people at risk of inflammatory bowel disease and undermining effective control of disease-causing microbes. The findings, published May 18 in Cell Host & Microbe, open up new approaches to regulating gut immunity by restoring normal Paneth cell function.

Inflammatory bowel disease has historically been a problem primarily in Western countries such as the U.S., but its becoming more common globally as more and more people adopt Western lifestyles, said lead author Ta-Chiang Liu, MD, PhD, an associate professor of pathology & immunology at Washington University. Our research showed that long-term consumption of a Western-style diet high in fat and sugar impairs the function of immune cells in the gut in ways that could promote inflammatory bowel disease or increase the risk of intestinal infections.

Paneth cell impairment is a key feature of inflammatory bowel disease. For example, people with Crohns disease, a kind of inflammatory bowel disease characterized by abdominal pain, diarrhea, anemia and fatigue, often have Paneth cells that have stopped working.

Liu and senior author Thaddeus Stappenbeck, MD, PhD chair of the Department of Inflammation and Immunity at Cleveland Clinic, and former co-director of the Division of Laboratory and Genomic Medicine at Washington University set out to find the cause of Paneth cell dysfunction in people. They analyzed a database containing demographic and clinical data on 400 people, including an assessment of each persons Paneth cells. The researchers found that high body mass index (BMI) was associated with Paneth cells that looked abnormal and unhealthy under a microscope. The higher a persons BMI, the worse his or her Paneth cells looked. The association held for healthy adults and people with Crohns disease.

To better understand this connection, the researchers studied two strains of mice that are genetically predisposed to obesity. Such mice chronically overeat because they carry mutations that prevent them from feeling full even when fed a regular diet. To the researchers surprise, the obese mice had Paneth cells that looked normal.

In people, obesity is frequently the result of eating a diet rich in fat and sugar. So the scientists fed normal mice a diet in which 40% of the calories came from fat or sugar, similar to the typical Western diet. After two months on this chow, the mice had become obese and their Paneth cells looked decidedly abnormal.

Obesity wasnt the problem per se, Liu said. Eating too much of a healthy diet didnt affect the Paneth cells. It was the high-fat, high-sugar diet that was the problem.

The Paneth cells returned to normal when the mice were put back on a healthy mouse diet for four weeks. Whether people who habitually eat a Western diet can improve their gut immunity by changing their diet remains to be seen, Liu said.

This was a short-term experiment, just eight weeks, Liu said. In people, obesity doesnt occur overnight or even in eight weeks. People have a suboptimal lifestyle for 20, 30 years before they become obese. Its possible that if you have a Western diet for so long, you cross a point of no return and your Paneth cells dont recover even if you change your diet. Wed need to do more research before we can say whether this process is reversible in people.

Further experiments showed that a molecule known as deoxycholic acid, a secondary bile acid formed as a byproduct of the metabolism of gut bacteria, forms the link between a Western diet and Paneth cell dysfunction. The bile acid increases the activity of two immune molecules farnesoid X receptor and type 1 interferon that inhibit Paneth cell function.

Liu and colleagues now are investigating whether fat or sugar plays the primary role in impairing Paneth cells. They also have begun studying ways to restore normal Paneth cell function and improve gut immunity by targeting the bile acid or the two immune molecules.

Liu TC, Kern JT, Jain U, Sonnek NM, Xiong S, Simpson KF, VanDussen KL, Winkler ES, Haritunians T, Lu Q, Sasaki Y, Storer C, Diamond MS, Head RD, McGovern DPB, Stappenbeck TS. Western Diet Induces Paneth Cell Defects through FXR and Type I Interferon. Cell Host & Microbe. May 18, 2021. DOI: 10.1016/j.chom.2021.04.004

The study was supported by the National Institutes of Health (NIH), grant numbers U01DK062413, R01 DK125296, R01 DK124274, DK109081, R01 AI143673, R01 AI127513 and R01 AI123348; the Helmsley Charitable Trust, grant number 2014PGIBD010; and Washington Universitys Genome Technology Access Center and Digestive Disease Research Core Center.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, consistently ranking among the top medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

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Western diet may increase risk of gut inflammation, infection Washington University School of Medicine in St. Louis - Washington University School of...

Post-Covid Diet: Here’s What You Should Eat Post Covid Recovery – Expert Reveals – NDTV Food

Posted: May 23, 2021 at 1:53 am

Congratulations you defeated the Coronavirus! For the last 15-20 days or more if you had some complications, your body has been fighting against an invader. It used all its strength and ammunition available to push back, so though the infection is gone but the damages have to be repaired. Lost energy, lost muscle mass, lost appetite has to be built up again while dealing with the aftereffects of strong medication and the psychological trauma you went through. Eating is the best tool to overcome post-COVID malnutrition and weakness, which is easier said than done because there is loss of appetite, reduced energy levels and weakness which in themselves are a deterrent to eating, and on top of that, to cater to your own meals seems like a Herculean task.

Let's simplify the journey to health post Covid!

Energy is the most important need of our body, and energy that is easily utilised and takes minimum effort on the part of our metabolism is Carbohydrate. Rich sources of carbs are cereal grains, pulses, fruits, vegetables, roots and tubers. Right now, just sticking to whole grains may not be very important, easy to cook rava, or semolina, maybe a good idea. Ready-to-eat breads and breakfast cereals will also conserve effort and provide easy to digest options. As you get better, start introducing healthier choices once more.

Also Read:Which Carbs Are Good For Your Body (and Which Aren't)

Post-Covid Diet: Try avocado, some cheese, nuts and seeds or olives for snacks.

Proteins. These are the building blocks of our body. During illness, there is a loss of muscle mass which needs to be replenished. Adding protein to every meal is critical to rebuilding the body. Depleted proteins also mean lowered immunity. Eating proteins all in one meal will not work as the body may not be able to utilise a large amount at one go; spread it through the day. Muscle proteins replenishment will be better with this strategy.

In case you find it difficult to eat, then speak to your nutritionist for a supplement that will help you tide over. In hospitals, clinical meal supplements are used for very sick people and these are safe and make a difference to your recovery period.

Your discharge advice would also have certain vitamins and mineral supplements. These are recommended to support your recovery and are prescribed for a period. In addition, the same vitamins should be consciously included in daily meals to enhance recovery.

Also Read:6 Excellent Sources Of Vegetarian Protein For Your Daily Diet

Post-Covid Diet: Protein-rich foods can help recover from the loss of muscle.

Vitamin C is a strong antioxidant that is specific to lung health. Foods rich in Vitamin C are citrus fruits, spinach, papaya, kiwi, tomato, mango and strawberries are a few good sources. Being a water-soluble vitamin, you need to consume adequate amounts daily.

Zinc is another critical nutrient that supports immune health. Overdosing may cause problems so stick to the supplemental amount as per your prescription. Good food sources of Zinc include Rajma, Lobia, Chana, almonds, Pumpkin seeds, Chicken, Milk and Cheese.

Also Read:Top 7 Zinc-Rich Foods For Immunity You Can Include In Your Diet

Post-Covid Diet: Zinc-rich foods boost our immunity.

Vitamin D is not just a vitamin, but it functions as a hormone and is closely involved with the immune system. Several studies have found a positive correlation between Vitamin D and better COVID outcomes. So get out into the sun (not without your mask). It's summers and will be warm in midday; try to get some early morning sunshine for at least 20 minutes or divide the same into two or three exposures. Sunlight also releases Nitric Oxide from our skin stores and that is known to be beneficial and protective to heart health, another reason to soak up the sunshine.

Also Read:7 Healthy Vitamin D Foods You Must Eat To Avoid Vitamin D Deficiency

Other than these post-Covid diet tips, you need all the nutrients that are necessary for your health. Recovery post-COVID will take some time, you need to eat, rest a lot and also put all the bad experiences behind you for becoming truly healthy.

Eat, sleep, meditate and hydrate! Stay safe!

Disclaimer: The opinions expressed within this article are the personal opinions of the author. NDTV is not responsible for the accuracy, completeness, suitability, or validity of any information on this article. All information is provided on an as-is basis. The information, facts or opinions appearing in the article do not reflect the views of NDTV and NDTV does not assume any responsibility or liability for the same.

Post-Covid Diet: Here's What You Should Eat Post Covid Recovery - Expert Reveals - NDTV Food

Thinking of how to combat climate change? Check what you eat | Daily Sabah – Daily Sabah

Posted: May 23, 2021 at 1:53 am

If you are looking for a way to help combat climate change, other than the well-known facts like using public transport and careful use of water, you might want to take a closer look at your eating habits.

Eating less meat and buying organic food sums it up, says Michael Bilharz of Germany's Federal Environment Agency. "We should definitely eat less meat," says author Malte Rubach, though he adds, "no one has to become an ascetic."

For people in the West, food can account for up to a third of a household's carbon footprint. In a European country like Germany, the average carbon footprint for food is around 1.7 tons per person per year, of those who eat a mixed diet, says Bilharz.

That figure falls to 1.3 to 1.4 tons for vegetarians, and to 1 ton for vegans, he says.

The most carbon is released by products made from ruminants, meaning mainly beef but also cheese and other dairy products, followed by pork and chicken.

For anyone who's interested, the Planetary Health Diet can serve as a guide. It's designed to make sure everyone can get enough to eat without pushing the planet to its limits.

The diet suggests a daily maximum of 300 grams of meat per person, ideally poultry or pork. The German Nutrition Society, meanwhile, suggests no more than 300 to 600 grams per week. "Above all, the meat should be produced regionally," says Rubach.

The planetary diet foresees one and a half to three liters of milk or up to 300 grams of cheese and three to four eggs per week.

The diet upgrades legumes and grain to become people's main source of protein, Bilharz says.

It isn't easy and Bilharz acknowledges that consumers could also reach their limits trying to work out where each and every single product comes from. Even the experts struggle to work out every single detail.

He warns against making food a big problem, saying from anorexia to obesity, it's already a source of difficulties for many.

But climate-friendly and healthy eating can go hand in hand, Bilharz says. "Eat a plant-based diet as much as possible, make sure you have fiber, reduce animal fats and eat lots of vegetables and fruits, preferably organic."

Organic products are better as there are tougher restrictions on the ingredients and additives, Bilharz says, including meat or dairy substitutes.

If you're in the European Union, then the EU organic label can make life more straightforward for shoppers. Consumers who want to dive deeper into the issue can compare the different criteria covered by different labeling.

Also, it's a good idea to drink tap water, for those in countries where it's safe, says Bilharz. Drinks often come second, after meat, in terms of contributors to carbon emissions.

But environmental protection is not a solely individual task, but one that is shared, says Bilharz. What counts is less what each individual eats than the overall results at the end of the year.

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Thinking of how to combat climate change? Check what you eat | Daily Sabah - Daily Sabah

Protect your lung health with smart diet and exercise choices – Starts at 60

Posted: May 23, 2021 at 1:53 am

Lung capacity refers to the maximum amount of air that your lungs can hold, which is a feature youd typically associate with being physically fit. Meanwhile, lung function refers to how well youre breathing; for example, how quickly you can inhale and exhale air from your lungs and how effectively your lungs both oxygenate and remove carbon dioxide from your blood.

If your lungs are either not able to hold enough air or move oxygen into the blood quick enough to meet the demand of your body, a common physiological response is being short of breath, Curran says.

Shortness of breath, also known as dyspnoea, can be caused by a variety of health conditions affecting the lungs, heart or other health systems. For example, shortness of breath is a common symptom of COPD. But breathlessness can be associated with age, weight or just a lack of fitness, rather than a lung condition.

That said, while lung function may decline with age, Curran says if youre experiencing any new, persistent and unexplained symptoms such as breathlessness, dont ignore them. She advises using the Lung Health Checklist, which takes just two minutes to complete online, to help you better understand your symptoms.

If you get out of breath more easily than others your own age, or experience any sudden difficulties in breathing, its really important that you discuss it further with your GP, she says. You can download your checklist results from the Lung Foundation Australia website and take it to your doctor to help you start a conversation about your lung health.

Curran says getting regular exercise can improve lung function in those with or without a lung condition, and reduce breathlessness in people with chronic lung conditions. To put it simply, the more you exercise, the easier itll become to breathe freely while exercising. In fact, the Australian physical activity guidelines recommend that people aged 60 and above ensure theyre active on most days (preferably all), by doing at least 30 minutes of moderate activity.

Curran recommends doing aerobic exercises such as walking or swimming most days of the week, and strength-based exercises twice a week. Dont know where to start on strength training? Curran recommends introducing squats, step-ups, wall push-ups and bicep curls into your routine.

To help you ease into strength training, Lung Foundation Australia has a Maintaining Movement Series of instructional videos for easy exercises you can do at home all you need is your bodyweight and a little bit of space. Of course, its important to talk to your doctor before starting any new exercise program or if you are looking to increase your current level of activity, especially if you have an existing lung condition.

Older people who live a much more sedentary lifestyle might find embarking on an exercise program difficult, so Curran recommends some strategies to reduce your sedentary time. This can be as simple as finding ways to include incidental activities throughout your day, such as marching on the spot whilst the kettle is boiling, walking around the clothesline a few times when hanging the washing out or doing a few extra laps of the shopping centre. Remember to think of all types of activity as a chance to improve your health, she advises.

And if youre not a fan of working out at home, Lung Foundation Australia also runs community-based exercise maintenance classes all over the country for people who have completed pulmonary rehabilitation. Lungs in Action classes provide exercise training for people with chronic lung conditions or heart failure.

Lungs in Action is a great way to stay connected and keep on top of your exercise regime, Curran says.

IMPORTANT LEGAL INFO This article is of a general nature and FYI only, because it doesnt take into account your personal health requirements or existing medical conditions. That means its not personalised health advice and shouldnt be relied upon as if it is. Before making a health-related decision, you should work out if the info is appropriate for your situation and get professional medical advice.

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Protect your lung health with smart diet and exercise choices - Starts at 60

7 Foods and Drinks That May Cause Cloudy Urine – Healthline

Posted: May 23, 2021 at 1:53 am

Cloudy urine refers to pee thats murky and no longer transparent. It can result from many underlying causes, including certain foods and drinks.

Some causes of cloudy urine are harmless, while others may require medical attention.

Here are 7 foods and drinks that may cause cloudy urine.

Some people may get cloudy urine after eating large amounts of foods that are high in phosphorus and purines, such as milk and dairy products (1).

Phosphorus is a mineral thats necessary for optimal bone health and many bodily functions (2).

When you consume high amounts of phosphorus, your body may release it in your urine, causing murky pee. However, this is uncommon among generally healthy people.

Dairy is particularly rich in bone-building calcium. For most people, eating milk and dairy products in moderation is not a concern. In fact, they can be a nutritious addition to your diet (3).

More often, urine thats high in phosphorus may be a sign of kidney disease, high vitamin D levels, or a thyroid condition caused by too much parathyroid hormone in the body (4, 5).

These conditions require medical attention.

Consuming too much milk or dairy could temporarily cause cloudy urine as your body works to excrete excess phosphorus. However, more often, urine thats high in phosphorus is the result of an underlying condition.

Meat, including poultry and beef, is also high in phosphorus.

As is the case with dairy products, consuming too much meat may cause your body to excrete excess phosphorus via urine. As a result, your pee may turn from transparent to opaque (1).

However, having cloudy pee as a result of a high phosphorus diet is uncommon.

Its more likely that eating too much of certain types of meat contributes to other causes of cloudy urine.

Highly processed or cured meats, such as bacon, sausage, salami, and pepperoni, may be high in salt.

Consuming too much salt can increase thirst and contribute to dehydration, which in turn may cause your urine to be darker, more concentrated, and cloudier (6).

To reap the benefits of meat without unwanted side effects, including cloudy urine, eat meat in moderation and limit high salt varieties, in particular.

Consuming too much meat could increase urinary phosphorus excretion and lead to cloudy urine. Processed and cured meats are also high in salt, which may contribute to dehydration and make cloudy urine even cloudier.

Some types of seafood, especially anchovies, shellfish, and sardines, are high in purines, a group of compounds that the body turns into uric acid.

When some people eat a lot of purine-rich foods, it can lead to high levels of uric acid in their urine. This is also known as hyperuricosuria. As a result, urine may appear cloudy (7, 8).

However, seafood provides a ton of health benefits. Its rich in lean protein, several minerals, and omega-3 fatty acids, which fight inflammation and promote heart health (9).

For most people, the benefits of consuming seafood outweigh the possible downsides. If youre concerned about your purine intake or a healthcare professional has advised you to limit purines, opt for seafood thats lower in purines, such as salmon, flounder, and halibut.

Other high purine foods to limit include red meat, meat gravies, organ meats, alcohol, and foods that contain high fructose corn syrup.

In addition to a high purine diet, certain medical conditions can lead to excess uric acid in the urine. These conditions include gout, insulin resistance, and certain genetic conditions (8).

Certain types of seafood are high in purines, which get broken down into uric acid in your body and may cause cloudy urine in some people.

Cloudy urine can also result from a high sugar intake.

In particular, high fructose intake is linked to hyperuricosuria. Your bodys metabolism of fructose promotes the formation of uric acid (1, 10, 11, 12).

As such, eating a lot of fructose can lead to excess uric acid in your pee, resulting in cloudy urine.

Fructose is naturally found in fruit, honey, and molasses. Its also the main component of high fructose corn syrup, which is used in sodas and sugary drinks, candy and packaged desserts, salad dressing and condiments, certain granola bars, and some breads and crackers.

If you consume a lot of fructose, you may experience cloudy urine, but not everyone experiences this effect. Individuals with type 2 diabetes, obesity, or metabolic syndrome are more likely to have hyperuricosuria (13).

Besides their possible effect on urine cloudiness, foods and drinks high in fructose often offer little nutritional value. Its best to limit these items on a balanced diet.

High fructose intake from sugary foods and drinks may lead to high urine levels of uric acid and result in cloudiness.

Salty foods like chips, canned soups, cured and deli meats, and salted popcorn may be behind your murky pee.

Eating too much salt can affect your bodys fluid balance and cause your kidneys to hold onto water.

If you eat a lot of salt and dont drink enough water, you can become dehydrated. This can lead to dark, cloudy urine and fewer trips to the bathroom (6).

Whats more, many foods that are high in salt contain other unhealthy ingredients and dont provide many beneficial nutrients.

Most experts recommend keeping salt intake around 2,300 mg per day, or the equivalent of 1 teaspoon (6 grams) of salt, in addition to consuming plenty of water to stay hydrated (14).

Consuming excess salt can cause your body to hold onto water and may contribute to dehydration. This can result in concentrated, cloudy urine.

Having an occasional alcoholic beverage doesnt usually cause problems, but drinking too much alcohol may contribute to cloudy urine.

Alcohol is considered a diuretic, meaning it causes your kidneys to release more water by suppressing the hormone that usually stops urination (15).

As a result, alcohol consumption can lead to dehydration. After a night of drinking, you may find that your urine is darker and cloudier than usual.

To prevent cloudy urine from alcohol-related dehydration, remember to drink water alongside alcoholic beverages.

Excess alcohol intake may also increase your risk of heart disease, liver disease, some cancers, and several other health issues. Experts recommend limiting your alcohol consumption to one drink per day for women and two drinks per day for men (16).

Drinking too much alcohol can lead to dehydration, which can result in cloudy urine. Remember to consume alcohol in moderation and drink water with it to prevent dehydration.

Coffee and tea are two possible culprits behind cloudy urine.

Coffee and some teas, such as green, black, and oolong, contain caffeine. When you consume caffeine, it causes several diuretic effects on the kidneys and increases urine excretion (17).

Drinking a lot of caffeinated drinks may lead to dehydration and urine cloudiness or color changes.

However, plain coffee and green and black teas also provide health benefits. Theyre loaded with compounds that act as antioxidants and help prevent cell damage related to disease development (19).

Still, its important to drink these beverages in moderation to avoid dehydration. Be sure to drink plenty of water after consuming caffeinated coffee or tea.

Coffee and teas that contain caffeine can have diuretic effects and lead to dehydration and cloudy urine. Though they provide beneficial compounds, its best to drink them in moderation along with plenty of water.

Cloudy urine can be harmless, but it may also be a sign of a medical condition or serious underlying cause.

Some conditions associated with cloudy urine include urinary tract infections, kidney stones, prostate problems, and sexually transmitted infections.

See a doctor if your cloudy urine does not go away or is accompanied by a foul smell, blood, pain, vomiting, or discharge. These may indicate an infection or other issue.

Cloudy urine is often harmless, but this isnt always the case. Seek medical attention if you have other symptoms alongside cloudy urine, or if it doesnt go away.

Some foods and drinks may contribute to cloudy urine.

These include foods that are high in phosphorus, purines, refined sugars, and salt, as well as alcohol and caffeine.

However, sometimes cloudy urine is a sign of something more serious. Consult a medical professional if you experience other symptoms alongside cloudy urine.

Continued here:
7 Foods and Drinks That May Cause Cloudy Urine - Healthline

Weight loss story: "I had stuffed paranthas and rice every day and still went from XXL to S. Here’s how" | The Times of India – Times of…

Posted: May 23, 2021 at 1:53 am

I believe the true beauty of following a quantified nutrition plan is not having to give up anything- you can have everything and anything as long as it falls within your macros. Believe it or not, during this 6-pack-abs journey of mine, I had stuffed parathas, biryani, chicken curry, rice, omelettes, ice cream almost daily and still maintained my 1600 calorie limit. I also ensure that my protein intake is minimum 1.2-1.5 grams of body weight.

It was only after I started coaching under experts did I realize that the reason I wasn't losing weight before was my bad metabolism. My calorie intake was way less than my BMR and that's the reason I was not reducing weight so we started working on it and gradually increased food intake from 1400 cals to 2600 cals diet over a period of 3 months along with basic weight training.

My metabolism recovered and that was the perfect time to cut down that extra mass so we started reducing calories and came down to 1600 in 3 months with a regular workout. You know I have only reduced 4 KGs of weight during this period but have lost 4 inches from waist another miracle.. the extra fat converts into muscle mass .

Pre-workout meal: A black coffee

Post-workout meal: Nothing as such

P.S.- My dinner is always the heaviest meal (700+ calories) and that too after 8:30 P.M.

I indulge in (What you eat on your cheat days): I can have all my favourites at home so having a specific cheat day is absolutely not required.

Low-calorie recipes I swear by: No food is bad food until its fitting into your macros, still, I like the white eggs and chicken breast most as it has good protein when compared to its total calorie and price index.

I also have 5L of water every day.

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Weight loss story: "I had stuffed paranthas and rice every day and still went from XXL to S. Here's how" | The Times of India - Times of...

How Noom Won 2020, a Banner Year for Wellness and Weight-Loss Apps – Inc.

Posted: May 23, 2021 at 1:53 am

For health care platform Noom, 2020 was a banner year. The company generated $400 million in revenue, thanks to millions of people looking to shed pandemic-fueled pounds. The artificial intelligence-driven app integrates fitness tracking, nutrition, and sleep and stress management to form a one-stop shop for health and wellness. But it took a lot of trial and error for the 13-year-old company, founded by Korean entrepreneur Saeju Jeong and Ukrainian Artem Petakov, to become a success story. Noom is atwo-time honoree on the Inc. 5000 ranking of the fastest-growing U.S. private companies and on the Inc. Best Workplaces roster. AccordingtoBloombergthe companyhas just closed a mega-round of private-equity investment at a $4 billion valuation and plans an initial public offeringin the next year.

Jeong spoke with Tom Foster, an Inc.editor-at-large, in an exclusive stream eventon Tuesday about lessons learned from the company's early stumbles and how it finally found a healthy balance. Here are the biggest takeaways for entrepreneurs from the session.

1. Finding the right product-market fit takes time.

Long before Pelotonbecame popular, Noom experimented with a connected bike that integrated with its fitness platform. The company planned to corner at-home gym users by selling them a platform that would gamify exercise and motivate them to work out. But it turnedout that people weren't quite ready yet for the CardioTrainer back in 2008.

"After two years, we couldn't sell the product or raise capital," saysJeong. At a time when only a fraction of Americans were getting enough exercise, the market for a connected bike was already small to begin with. The company would need to expand its audience to fulfillits mission, which was to apply technology in a way that would make people's lives healthier.

"We made so many mistakes ... I learned the painful way that it's almost inevitable," says Jeong.

Noom eventually launched its weight-loss and tracking app in 2010, which allowed users to track nutrition as well as their fitness according to an activity of their choice. It found that roughly 90 percent of its users were using the app for its pedometer feature, or to track steps. The founders were then curious about why more users weren't opting for more high-intensity exercise like running or cycling. After doing some research, the company discovered the main reason many users weren't engaging in more physically strenuousactivity:excess weight.

Jeong sayshe realized then that there was a huge opportunity in the weight-loss and nutrition market. The next step was to create a product that would allow users to accomplish both their weight-loss goals and their fitness goals.

2. Stay focused on customers.

Noom's founders realized earlier on that they had to take a holistic approach to improving the user's overall health. They realized that their customer's journey to better health wasn't just about shedding pounds or logging more steps. To ensure that users metweight-loss goals, Noom had to integrate everything itlearned in the past about health and fitness. The foundersalso realized they had to incorporate psychology in the mix as wellto effectively change user behavior.

"A lot of us will have a bad habit. There's a reason why we cannot get out from a bad routine," saysJeong.

The company decided to make human coaching a core part of the Noom service. While the app was already utilizing A.I. in order to assess a user's fitness and nutrition profile, A.I. could only do so much.

"Empathy is not a thing you can generate out of A.I. technology," saysJeong.

3. Deliver great value.

It's no secret that health care is a saturated market. Jeong saysthat he had astrong belief that if Noom was able to deliver great value to its users, the business would follow. During the app's early days, it topped the charts in both the Android and iOS stores. He saysthe company had multiple opportunities to easily generate revenue by simplifying the app to focus on just fitness trackingor calorie counting.

"There are many fitness tracking applications that are doing good business. Calorie counting, same," saysJeong.

But neither calorie counting nor fitness tracking fulfilled the company's mission, which was to improve the overall health of a wider population. Instead, Jeong saysNoom took more than a decade to figure out the best way to approach the health of its users in a holistic way.

"We found a tough way to deliver our mission," saysJeong.

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How Noom Won 2020, a Banner Year for Wellness and Weight-Loss Apps - Inc.

Study: Combining Minimally Invasive Bariatric Surgery With Semaglutide Increases Weight Loss – Pharmacy Times

Posted: May 23, 2021 at 1:53 am

Pairing semaglutide, a drug used to treat diabetes, with a minimally invasive endoscopic sleeve gastroplasty (ESG) can provide significant weight loss benefits for patients who are not candidates for invasive weight loss surgery, according to a study presented at Digestive Disease Week 2021.

For the double-blind study, the researchers randomized 61 patients undergoing ESG into 2 groups: 1 receiving semaglutidean injectable glucagon-like peptide-1 receptor that has been found to stimulate weight loss1 month after the procedure, and the other receiving a placebo administered through look-alike injector pens. Participants were monitored each month for body weight and body composition, with blood panels taken every 3 months.

According to the authors of the study, patients receiving semaglutide lost 26.7% of their total body weight on average, compared to 19.6% in the control group. The semaglutide group lost 86.3% of their excess weight (the amount of weight the participants needed to lose to reach normal BMI) compared to 60.4% for the control group. Additionally, body fat by weight decreased by 12.7% in the semaglutide group versus 9% in the control group, and glycated hemoglobin levels fell 0.95 for the semaglutide group and 0.61 for the controls.

As the worldwide obesity rate continues to climb, so do the number of people seeking bariatric surgery to treat their condition, said Anna Carolina Hoff, MD, lead researcher on the study and founder and clinical director of Angioskope Brazil, So Jos dos Campos, in a press release. Surgical procedures are some of the most successful ways to help patients lose weight, but they can eventually come with complications. Our study shows that patients may not have to undergo invasive surgery to get similar results.

More invasive surgical procedures, such as laparoscopic sleeve gastrectomy, come with increased costs and a higher risk for complications, such as gastroesophageal reflux disease. These procedures are normally restricted to patients with a BMI of at least 35 with comorbidities, or a BMI above 40.

ESG can be performed at an earlier stage of disease and at a lower BMI, allowing more patients to get the treatment they need before their disease progresses. Providing earlier treatment to patients with obesity can reduce the risk of mortality and comorbidities, as well as lower costs associated with treatment.

ESG has been available to patients for years, but it has not always been as successful as surgical options in helping patients lose weight, Hoff said in the release. We now have a minimally invasive procedure that can be just as successful when combined with semaglutide and can be made available to even more people looking to lose a significant amount of weight.

ESG is performed through guiding a device through the patients throat into the stomach, where an endoscopist uses sutures to decrease the size of the stomach. This assists in weight loss by limiting the amount that a patient can eat. Patients are candidates for ESG if they have a BMI at or above 30, and diet and exercise have not helped them lose weight, or if they are not a candidate for surgery, or do not wish to pursue surgery.

Long-term durability of the treatment still has yet to be determined, according to the researchers.


Pairing bariatric procedure with diabetes drug increases weight loss [news release]. EurekAlert; May 14, 2021. Accessed May 17, 2021.

See the article here:
Study: Combining Minimally Invasive Bariatric Surgery With Semaglutide Increases Weight Loss - Pharmacy Times

Five common mistakes people make while trying to lose weight – The Indian Express

Posted: May 23, 2021 at 1:53 am

One of the evergreen themes on social media has been weight loss. People like to post images of workouts, healthy recipes, and foods that they are cooking or eating. However, this can also promote negative body image issues by making some people feel self-conscious about looking good, having a chiseled body or toned abs. In the attempt to reach these goals, they are misguided by diet fads and misinformation that can cause more harm than good, said Rohit Shelatkar, fitness and nutrition expert and VP at Vitabiotics.

Losing weight requires the right amount of foods packed with all essential nutrients, the correct form of exercise, good sleep, and most importantly, the consciousness to actually commit to being fit and looking fit, he told

Below, he listed the five common mistakes people tend to make while on their fitness journey:

Focusing on cardio and ignoring strength training: Some exercise is better than no exercise at all. But if your cardio workout is not showing any result despite watching your diet and leading an overall healthy lifestyle, it may be due to a lack of strength training. This misconception is quite common among women who think lifting weights will bulk them. On the contrary, resistance training or strength training will not only help build muscles but also boost your metabolism and promote belly fat loss. Weight loss is just an added bonus. One should combine cardio and resistance training for the best results.

Skipping meals: This is a common mistake. Many people skip meals in order to consume fewer calories. Not only are you losing out on essential nutritional intake, but your metabolism also slows down drastically, sending your body into survival mode. This actually makes it harder to lose weight and may even cause weight gain in the short term. One should consume 4-5 small/controlled portions through day which packed with nutrients. If one feels hungry, switch to healthier options like dry fruits, yogurt, and makhanas, he shared.

Not consuming enough protein: Getting enough protein is extremely important if youre trying to lose weight. Protein has been shown to help with weight loss in several ways. It can reduce appetite, increase feelings of fullness, decrease calorie intake, increase metabolic rate, and protect muscle mass during weight loss. Hence, high-protein food is recommended in weight-loss diets to make it more effective. Foods like paneer, chicken, eggs are great sources of protein. People with a plant-based diet can opt for lentils, chickpeas, peanuts quinoa, and soy-based products like tofu and tempeh.

Drinking sugar: Most people exercising diet control remove soft drinks and other sweetened beverages to lose weight. However, they still continue to take packaged drinking fruit juice. Even 100 per cent fruit juice is loaded with sugar and may lead to health and weight problems similar to those caused by sugar-sweetened beverages. One should instead consume 4-5 litres of water. You can add lemon or mint leaves to give it a different flavour. Unsweetened green tea is another suitable alternative, he shared.

Not getting enough sleep: Sleep deprivation can lead to a reduction of leptin (the fullness hormone) while boosting the production of ghrelin (the hunger hormone). As a result, when one is up late night or binge-watching one tends to always feel hungry. Besides, the less sleep one is getting, the more one craves high-fat and high-carb foods. Make sure to get enough sleep. Adults should get at least seven-nine hours of sleep in order to stay healthy.

While you may lose weight in the short term by certain quick-fix methods, like following a fad diet, sustained weight loss is a journey and must be seen more as a quest for good health, he concluded.

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Five common mistakes people make while trying to lose weight - The Indian Express

WWE: Mark Henry reveals body transformation and huge weight loss goal –

Posted: May 23, 2021 at 1:53 am

The Worlds Strongest Man is in the shape of his life (Photo: WWE)

WWE legend Mark Henry has revealed his epic body transformation and hes got more to go.

The Worlds Strongest Man who still holds the WDFPF world records in the squat, deadlift and total looks to be in incredible shape as he posed for the camera with a huge smile on his face.

Revealing his current target, he tweeted: 20 pounds to go.

Henry whose most recent in-ring appearance came in the Andre the Giant Memorial Battle Royal at WrestleMania 33 in 2017 got plenty of messages of support from friends and fans alike.

Renee Paquette replied: Go Mark!! You look amazing!

Natalya one half of the Womens Tag Team Champions with Tamina added: Proud of you!

And giant Omos who holds the Raw Tag Team Titles with AJ Styles tweeted: Looking good big homie!! (sic)

The 49-year-old Hall of Famer retired from the business in 2017, but earlier this month he revealed hes keen to get back in the ring for one more run.

Appearing on Booker Ts podcast, he said: Theres a lot of kids that didnt get to see me wrestle. They only saw me on YouTube. Its been enough time that has passed.

Also, I quit before I had a last match, before I waved at everybody and said, Ok. I had the pink jacket on. Im sorry I lied to you all that I was leaving and retiring. I own it.

But, I did not get that match where you go and pay tribute to the fans and you go and you wrestle somebody thats up and coming thats talented and you give them, what we call, the rub.

I didnt do that, and I feel guilty. Thats why Im doing it.

To get himself back in shape, the former world champion had already dropped almost six stone before revealing his latest milestone.

Listen, Im going to go out there in really good shape. Im already 80 pounds lighter than I was when I had my last match, he added.

Im going to be in really good shape. Its going to take a good man to beat me, but it might not take him long.

At 50, they dont expect me to go out there and have a 20 minute, five-star match, just to be honest. Im telling you that right now.

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WWE: Mark Henry reveals body transformation and huge weight loss goal -

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