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Crave Weight Loss Center seeks to 'transform lives'

Posted: June 10, 2012 at 6:14 pm

Since Crave Weight Loss Center at 622 N. Webb Road opened in late February, business has been booming.

Tracy Gardner is the owner and developer of the Crave Weight Loss program. She is a Grand Island native and a member of the Bosselman family, where she worked for 20 years before deciding to make a career of helping other people make a transformation in their lives when it comes to their appearance, how they feel about themselves and improving their health. She is a certified personal trainer and weight loss coach.

"I knew I wanted to make a difference in people's lives," Gardner said.

She went back to school to focus her talents in nutrition and become a certified personal trainer to help people make that transformation in their lives.

Prior to opening her business, Gardner was working with clients, but she wanted to expand her business, which has more than doubled since opening her new store in Grand Island in February and continues to grow.

Gardner said her passion is nutrition and fitness, but that was not always the case as she struggled with her weight as a young girl.

"I lost my first weight when I was in the eighth grade, and I have battled it along," she said. "It has been an up and down battle. I really have learned to take care of myself and eat the right foods. I was pre-diabetic, so I decided to go down the nutrition and fitness route so I could help transform people's lives."

That struggle as a youth with her weight and the hard work and dedication to turn that around in her personal life, has given her the perspective of being in that person's shoes and knowing where they are coming from as she helps others successfully make that life affirming transformation.

"That is important as I also specialize in emotional and mindful eating as that ties so closely into it," Gardner said.

That attitude has led Gardner to make Crave Weight Loss Center more than just a "diet."

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Crave Weight Loss Center seeks to 'transform lives'

Diartis' Positive Clinical Results of VRS-859 for Type 2 Diabetes Presented at ADA Annual Scientific Meeting

Posted: June 9, 2012 at 11:12 pm

PHILADELPHIA, PA--(Marketwire -06/09/12)- Diartis Pharmaceuticals, Inc. today presented positive data from its recently completed Phase 1 multicenter clinical trial of VRS-859 (exenatide-XTEN) at the American Diabetes Association's 72nd Scientific Sessions, which began yesterday in Philadelphia. VRS-859, a long-acting glucagon-like peptide-1 (GLP-1) analog, is being developed as a once monthly treatment for patients with type 2 diabetes mellitus (T2DM). The Diartis poster -- "Safety, Pharmacokinetics, and Pharmacodynamics of a Single Subcutaneous Administration of VRS-859 in Patients with Type 2 Diabetes" -- was presented today, June 9, in the 11:30 am to 12:30 pm Clinical Therapeutics/NewTechnology session (Poster Presentation 1105-P).

Jeffrey L. Cleland, Ph.D., Diartis Chief Executive Officer, was present at the poster session to discuss the recently completed safety, pharmacokinetic (PK) and pharmacodynamics (PD) results from the company's Phase 1 clinical trial in T2DM patients. The Phase 1 multicenter, blinded, placebo-controlled, single-ascending dose study was designed to evaluate the safety and tolerability of VRS-859 as well as the ability to maintain glycemic control for one month in T2DM patients after a single dose.

"We are very encouraged by the robust results seen in this initial Phase 1 study, most notably the statistically significant reductions in HbA1c levels at 30 days after only a single 200 mg dose of VRS-859," commented Dr. Cleland. "We are also quite pleased by the dose-proportional decreases in body weight observed within 30 days after a single treatment."

The Phase 1 results in T2DM patients demonstrate that all doses administered (up to 200 mg) were well tolerated and no unexpected adverse events were noted. Furthermore, the PK of VRS-859 in these patients was dose linear and comparable to the profile predicted from preclinical studies, validating the half-life extension capability of the XTEN technology and supporting a once monthly dosing regimen for VRS-859.

The Phase 1 Trial The primary objective of the study was to determine the safety and tolerability of a single subcutaneous dose of VRS-859 in patients with T2DM. Secondary objectives included single dose pharmacokinetics, assessment to evaluate evidence of VRS-859 activity by measurement of fasting plasma glucose and response to oral glucose tolerance tests at selected times post-dose, as well as to evaluate post-challenge glucose excursions. Seventy T2DM patients concurrently on metformin were enrolled in the study: 18 patients received placebo and 52 patients received one of six dose levels: 12.5, 25, 50, 100, 150 and 200 mg.

The study demonstrated that a single dose of VRS-859 achieved very high plasma concentrations and provided statistically significant and persistent improvements in glycemic control. There were no reported SAEs in the study. Adverse events, including those related to GI tolerability, were primarily mild and transient. These results support the company's plan to conduct a 6-month repeat dose study to determine a safe and efficacious subcutaneous dose of VRS-859 in patients with T2DM. It is hoped that upon successful development of this compound, VRS-859 may allow T2DM patients to safely manage their glucose with a therapy that is superior to current treatments for diabetes.

About Diabetes TreatmentTreatment of diabetes involves lowering blood glucose levels. Despite the availability of current therapies, more than 60 percent of people with diabetes do not achieve their target levels with their current treatment regimen. In addition, approximately 80 percent of type 2 diabetes patients are either overweight or obese. After diagnosis, type 2 diabetes patients are often placed on a diet and exercise program to control blood glucose levels and reduce body weight, but these patients usually progress to oral drug therapy, metformin and/or sulfonylurea. However it has been demonstrated that many patients are still unable to achieve adequate glycemic control on diet and exercise plus these oral therapies.

About VRS-859The compound has been designed to provide improved therapeutic outcomes for T2DM patients including robust and sustained improvements in HbA1c, improved tolerability, prolonged half-life (up to monthly dosing), as well as enhanced administration of a liquid formulation via a fine-gauge needle. The development goal is to satisfy the unmet needs of T2DM patients as well as contribute to treatment of the worldwide healthcare problem of obesity.

About Diartis PharmaceuticalsDiartis Pharmaceuticals, Inc. is a privately held biopharmaceutical company with headquarters in Redwood City, CA. Diartis develops novel biologics with enhanced properties to provide improved therapeutic outcomes to patients with metabolic diseases. The company's initial focus is the development of a long-acting GLP-1 receptor agonist that conveniently delivers maximum glucose control, aids compliance and adherence via less frequent administrations, and has improved GI tolerability. Diartis acquired the VRS-859 (exenatide-XTEN) program from Versartis, Inc. and continues its development for T2DM.

XTEN is a novel hydrophilic sequence of natural amino acids and is expressed as a fusion protein with a therapeutically active peptide or protein. New compounds developed by Diartis using the XTEN technology are expected to provide improved therapeutic outcomes such as enhanced efficacy/compliance, fewer side effects, prolonged half-life (up to monthly dosing), as well as low-cost production and enhanced stability. Further information on Diartis can be found at http://www.diartispharma.com.

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Diartis' Positive Clinical Results of VRS-859 for Type 2 Diabetes Presented at ADA Annual Scientific Meeting

J&J diabetes drug tops older therapies in studies

Posted: June 9, 2012 at 11:11 pm

* Better glucose control than Januvia or glimepiride

* Significant weight loss seen with J&J's canagliflozin

* Far less hypoglycemia than glimepiride with canagliflozin

* Canagliflozin has been submitted to FDA for approval decision

June 9 (Reuters) - An experimental treatment for type 2 diabetes developed by Johnson & Johnson (TLO: JNJ-U.TI - news) demonstrated greater reduction in blood sugar than Merck (Xetra: A0YD8Q - news) & Co's Januvia and an older common treatment, glimepiride, according to data from a pair of late stage clinical trials.

The J&J drug, canagliflozin, also led to significantly greater weight loss than both of the other drugs and far fewer incidents of hypoglycemia, or potentially dangerous drops in blood sugar levels, than glimepiride, a member of the sulfonylurea class of medicines.

Weight loss is an especially attractive effect as obesity is a leading cause of type 2 diabetes and some older medicines cause weight gain.

Canagliflozin, belongs to a new class of diabetes treatments called SGLT2 inhibitors that work by blocking reabsorption of glucose by the kidney and increases glucose excretion in the urine to lower blood sugar.

The data from the two 52-week studies, presented on Saturday at the American Diabetes Association (ADA (Paris: FR0000053076 - news) ) meeting in Philadelphia, are part of a massive approval application J&J submitted to the U.S. Food and Drug Administration last week that comprised nine separate Phase III trials involving more than 10,000 patients. If approved it would be the giant healthcare conglomerate's first diabetes medicine.

"There are clearly some unmet needs in diabetes to get glucose control. Hypoglycemia is a big limitation and right now we don't have effective weight loss therapy, so this class of drugs clearly provides clinical benefits," said Dr. William Cefalu, the primary researcher on the glimepiride study.

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J&J diabetes drug tops older therapies in studies

Maria Sharapova Weight Loss 2012 Maria Sharapova Diet Programs

Posted: June 9, 2012 at 11:11 pm

Maria Sharapova Weight Loss 2012 Maria Sharapova Diet Programs - Isn't amazing how all of the celebrities you see have a celebrity diet plan for weight loss to maintain their weight. Some of them are shapely and healthy looking, and look good on camera. Others look like they haven't eaten in weeks, like they just got back from the famine in Ethiopia for a few weeks. Like they had been starving themselves to lose weight, and that is probably what they have been doing. You see it in all the tabloids, this person lost 100 pounds again, this one gained 100 pounds, and then lost 150 pounds. Some are not as dramatic; this one lost 40 pounds and is a television spokesperson, because the previous celebrity diet spokesperson gained the weight back. The fact is they may be starving themselves to lose weight, fasting like they are going through a famine.

Celebrities make dieting look so easy, don't they? One month they're on the cover of US Weekly for gaining too much weight and the next they're headlining the "sexiest beach bods" story. It is true that seriously overweight people can lose large amounts of fat in a quick amount of time, because of the large fat content in their cells. But those that are only a few pounds overweight, losing 40 pounds in a month, is not only starvation, it is malnutrition and can have serious side effects. Our body weight can fluctuate day to day and the best diets take the weight off gradually, the way it came on.

Researches indicate that individuals who indulge in a weight loss program by taking prepared meals end up losing an additional 31% weight as against those who cook their own meals. With help, losing weight is made easier and at times much faster as against doing it on your own.Diet delivery is gaining popularity in a big way as it is fairly affordable by even the common man, roughly around $20 a day with an increasing variety to choose from. A few of which include: Zone-compliant meal, low carbs plan, veggie meals, and gourmet too.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

With the rapidly increasing epidemic of obesity and increasing BMI levels, there is an array of products and diet plan to aid in combating obesity. Celebrity slim diet, the basic idea is to educate people and not to depict food as an enemy. Like a lot of famous diets in Hollywood, if your body thinks you are starving, it is going to hold on to every calorie you take in to keep you from starving to death instead of burning them for energy. When you follow a properly balanced weight loss diet, your metabolism will hardly notice the decrease in calories and continue to burn fat it doesn't need to store. This is a more long-term weight loss strategy.

Celebrities do not have secrets about dieting. They are normal people like the rest of us but, unlike most of us, they have people working for them such as diet advisors and personal trainers. Celebrity diets involve a level of commitment and dedication which we struggle with. The best celebrity diets involve eating sensibly and limiting our calorie intake. Having these factors in mind will allow you to have safe and easy weight loss that will provide you with short term and long term consistent results.

Original post:
Maria Sharapova Weight Loss 2012 Maria Sharapova Diet Programs

Danny Welbeck Weight Loss 2012 Danny Welbeck Diet Programs

Posted: June 9, 2012 at 11:11 pm

Danny Welbeck Weight Loss 2012 Danny Welbeck Diet Programs - Isn't amazing how all of the celebrities you see have a celebrity diet plan for weight loss to maintain their weight. Some of them are shapely and healthy looking, and look good on camera. Others look like they haven't eaten in weeks, like they just got back from the famine in Ethiopia for a few weeks. Like they had been starving themselves to lose weight, and that is probably what they have been doing. You see it in all the tabloids, this person lost 100 pounds again, this one gained 100 pounds, and then lost 150 pounds. Some are not as dramatic; this one lost 40 pounds and is a television spokesperson, because the previous celebrity diet spokesperson gained the weight back. The fact is they may be starving themselves to lose weight, fasting like they are going through a famine.

Celebrities make dieting look so easy, don't they? One month they're on the cover of US Weekly for gaining too much weight and the next they're headlining the "sexiest beach bods" story. It is true that seriously overweight people can lose large amounts of fat in a quick amount of time, because of the large fat content in their cells. But those that are only a few pounds overweight, losing 40 pounds in a month, is not only starvation, it is malnutrition and can have serious side effects. Our body weight can fluctuate day to day and the best diets take the weight off gradually, the way it came on.

Researches indicate that individuals who indulge in a weight loss program by taking prepared meals end up losing an additional 31% weight as against those who cook their own meals. With help, losing weight is made easier and at times much faster as against doing it on your own.Diet delivery is gaining popularity in a big way as it is fairly affordable by even the common man, roughly around $20 a day with an increasing variety to choose from. A few of which include: Zone-compliant meal, low carbs plan, veggie meals, and gourmet too.

"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"

With the rapidly increasing epidemic of obesity and increasing BMI levels, there is an array of products and diet plan to aid in combating obesity. Celebrity slim diet, the basic idea is to educate people and not to depict food as an enemy. Like a lot of famous diets in Hollywood, if your body thinks you are starving, it is going to hold on to every calorie you take in to keep you from starving to death instead of burning them for energy. When you follow a properly balanced weight loss diet, your metabolism will hardly notice the decrease in calories and continue to burn fat it doesn't need to store. This is a more long-term weight loss strategy.

Celebrities do not have secrets about dieting. They are normal people like the rest of us but, unlike most of us, they have people working for them such as diet advisors and personal trainers. Celebrity diets involve a level of commitment and dedication which we struggle with. The best celebrity diets involve eating sensibly and limiting our calorie intake. Having these factors in mind will allow you to have safe and easy weight loss that will provide you with short term and long term consistent results.

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Danny Welbeck Weight Loss 2012 Danny Welbeck Diet Programs

joongangusa.com

Posted: June 9, 2012 at 11:11 pm

By using our site, you consent to this privacy policy: This website allows third-party advertising companies for the purpose of reporting website traffic, statistics, advertisements, "click-throughs" and/or other activities to use Cookies and /or Web Beacons and other monitoring technologies to serve ads and to compile anonymous statistics about you when you visit this website. Cookies are small text files stored on your local internet browser cache. A Web Beacon is an often-transparent graphic image, usually no larger than 1 pixel x 1 pixel that is placed on a Web site. Both are created for the main purpose of helping your browser process the special features of websites that use Cookies or Web Beacons. The gathered information about your visits to this and other websites are used by these third party companies in order to provide advertisements about goods and services of interest to you. The information do not include any personal data like your name, address, email address, or telephone number. If you would like more information about this practice and to know your choices about not having this information used by these companies, click here.

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Sick of Diets? This Works Better! Free Workshop |704-412-8013|Charlotte|28213|28262|28269|NC – Video

Posted: June 9, 2012 at 6:14 am

07-06-2012 11:56 (704) 412-8013 -- Call for more info or to attend our free workshop. Do you need to lose weight? Have you tried diets, and they don't work? Are you exercising and not seeing any results? Have you tried the same diets as your friends, but they didn't work for you? Have you had weight loss,...

Originally posted here:
Sick of Diets? This Works Better! Free Workshop |704-412-8013|Charlotte|28213|28262|28269|NC - Video

Lose Weight With a Diet That Works – Free Workshop |704-412-8013|Charlotte|28213|28262|28269|NC – Video

Posted: June 9, 2012 at 6:14 am

07-06-2012 11:56 (704) 412-8013 -- Call for more info or to attend our free workshop. Do you need to lose weight? Have you tried diets, and they don't work? Are you exercising and not seeing any results? Have you tried the same diets as your friends, but they didn't work for you? Have you had weight loss,...

Follow this link:
Lose Weight With a Diet That Works - Free Workshop |704-412-8013|Charlotte|28213|28262|28269|NC - Video

This Dukan Diet Alternative Works– Free Workshop|704-412-8013|Charlotte|28213|28262|28269|NC – Video

Posted: June 9, 2012 at 6:14 am

07-06-2012 11:56 (704) 412-8013 -- Call for more info or to attend our free workshop. Do you need to lose weight? Have you tried diets, and they don't work? Are you exercising and not seeing any results? Have you tried the same diets as your friends, but they didn't work for you? Have you had weight loss,...

Excerpt from:
This Dukan Diet Alternative Works-- Free Workshop|704-412-8013|Charlotte|28213|28262|28269|NC - Video

This Detox Diet Alternative Works– Free Workshop|704-412-8013|Charlotte|28213|28262|28269|NC – Video

Posted: June 9, 2012 at 6:14 am

07-06-2012 11:56 (704) 412-8013 -- Call for more info or to attend our free workshop. Do you need to lose weight? Have you tried diets, and they don't work? Are you exercising and not seeing any results? Have you tried the same diets as your friends, but they didn't work for you? Have you had weight loss,...

See the rest here:
This Detox Diet Alternative Works-- Free Workshop|704-412-8013|Charlotte|28213|28262|28269|NC - Video


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