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Election pledges: Food, farming and climate – Wicked Leeks

Posted: December 7, 2019 at 11:45 am

Action on the climate crisis has become central to the 2019 election campaign, with all major parties vastly expanding the scope of their ambition to protect the environment.

Theres been a bidding war on tree planting numbers, with 2 billion, 700 million, 60m and 30m trees pledged by Labour, the Greens, Lib Dems and Tories respectively.

There was the pledge to end fracking until there is evidence it can be done safely by the Conservatives, bowing down to years of fierce environmentalist pressure.

And perhaps most dramatically, there was a no-show by party leaders Boris Johnson and Nigel Farage at Channel 4s Climate Debate, with the pair instead replaced by melting ice sculptures.

The tone of the campaign reflects public pressure for government to act on the environment with intensity never before seen in UK politics. A YouGov poll at the beginning of the election period listed climate change as the fourth most important issue, with 25 per cent of Brits placing it in one of their top three, up from the eight per cent recorded at the same point in the 2017 election.

Eating habits have themselves become part of the climate debate, with the Intergovernmental Panel on Climate Change (IPCC) calling for people to buy less meat, milk, cheese and butter and eat more locally-sourced seasonal food.

The general election takes place on Thursday 12 December. Image Flickr/Michael D Beckwith.

Due to the close connection between food, farming and the climate, these policies are interlinked, as well as being important in their own right, covering farm subsidies, support for agroecological farming, food security, and local food economies.

On food, farming and the environment, the top four parties are, however, promising very different agendas and timetables. Here is a round up of their headline manifesto pledges on all three areas:


Read the full Conservative manifesto here.


Labours full manifesto can be found here.

Liberal Democrats:

Read the full Lib Dem manifesto here.

Green Party:

Read the full Green Party manifesto here.

Election pledges: Food, farming and climate - Wicked Leeks

25 Incredible Weight-Loss Transformations You Just HAVE To See – Pulse Nigeria

Posted: December 7, 2019 at 11:44 am

It also means that you could use a serious dose of inspo from ladies who have stuck out their journey long enough to see real success. Because let's face it: Losing weight is hard, and it's even harder for women than men, thanks to metabolic and hormonal differences, research shows.

Most of the weight-loss warriors here tried multiple avenues, from going vegan to intermittent fasting to at-home Pilates workouts, before finding the methods and eating regimes that worked with their lifestyles. And part of their success was being realistic about what was achievable in the long run. Take it from one wise woman: "I promised in the beginning that I wouldnt want to eat or do anything while losing weight that I wouldnt want to eat or do once I hit [my] goal, even if that meant it took a little bit longer," says @ashleys_officially_lost_it.

Finding a workout routine you love can also help keep you on track throughout the ups and downs. As one woman, @kaitlynesse, says, "Truly all of my weight loss came from working out to feel better and not to look a certain way. I just found this passion for it weightlifting I never had before," she says, noting that lifting helped her fight through a bout of depression after a breakup.

One more nugget of advice? Don't underestimate the small stuff, since any effort is better than no effort. "Even when you think those 30 minutes of walking wont add up to anything, trust meit will," @branjay24 says. You have to keep telling yourself, "'Yes, you are worth it!'" she adds.

Together, these powerful women lost more than 2,500 poundsand gained so much strength along the waywhich youll see in these dramatic before-and-afters. Take them in as needed to stay focused, inspired, and invested in your journey toward achieving your own health goals. If they can do it, so can you.

@stellaisstriving lost 243 poundsmore than 42 percent of her starting body weightby overhauling her eating habits with the keto diet and focusing on fat loss (not just losing pounds).

@_jens_journey_ started out doing keto but didn't feel that it worked for her, so she stuck with intermittent fasting, a sugar-free diet, and keeping her carbs down. She dropped more than 100 poundsthen gained back about 15 of those pounds to feel her healthiest, she previously told Women's Health .

It was WW that got @sweet_pea_leigh to a place of kicking her food addiction , which had been causing her to keep gaining weight as well as numerous body aches and pains. She's lost over 150 pounds.

The Couch to 5K app was hugely transformative for @lizzy_rockzsoon after hopping on the app, she started triathlon training and subsequently ran four marathons. Meal prepping with lots of protein and few carbs was huge for her, too, in her journey to lose about 150 pounds.

@rachellsharp93 went down a little more than 100 pounds, starting with her own version of alternate-day fasting , consuming small amounts of food in between days, and then segueing into another type of intermittent fasting.

Down about 220 pounds, @losing_for_health started out doing keto, then continued to count her macros with a free online calculator.

Originally through gastric bypass surgery , @kathleeng1112 shed 179 pounds, but she kept it up by eating tons of protein and few carbs. She stays active with Pilates, yoga, and at-home workouts.

@gessisfitnessjourney hit her goal of losing 124 pounds first by trying going vegan, then vegetarian, and low-carb, but she ultimately succeeded by tracking everythingcalories, stepson her Fitbit .

It was a combination of keto and intermittent fasting that helped @gritandgrace__ lose more than 50 pounds and her status as prediabetic. Once she cut out sugar, her PCOS symptoms were more manageable, too.

@hannah_day28's big turnaround came from BeachBody toning workouts . She also began practicing clean eating and portion control. She still eats buffalo chicken, but in a zucchini boat rather than fried.

She started out with VSG surgery , but @cam_bree_uhhh kept off 148 pounds by eating a vegan diet. She now belongs to two different gyms to stick with her love of weight lifting and doing circuits.

@carlywontquit lost 108 pounds with a strict policy of no added sugar , even in her coffee. She's also a cardio fanatic and can't get enough of Zumba or Total Body Pump.

Realizing the power of a nutritious home-cooked meal turned @_iwokeupinbeastmode;s nutrition around, helping her to lose a total of 130 pounds. She started out tracking every macro, but after hitting her goal, she stopped counting calories and focused on just eating clean instead.

@laurenlosing did VSG surgery in 2013 as a tool to change her lifestyle. She kept going with eating a high-protein diet, counting macros, and weight lifting.

A new-found love of lifting heavy was a major transforming factor for @kaitlynesse. She lost 80 pounds in about a year, focusing on squats and deadlifts, which she says made her feel strong and powerful. She also put on about 10 pounds of solid muscle in the process.

Keto and kickboxing were the power duo for @thestairlady. She went down 100 pounds in a year without giving up her favorite food, pizza.

@healthylivinislife's weight-loss journey started with VSG surgery. She continued to drop 120 pounds through the keto diet, and then a general low-carb eating plan. She also supplemented with a hot-yoga routine to help with her anxiety and started running and amping up her core workouts, too.

Struggling with symptoms of both PCOS and IBS, @get_moefit first cut carbs and started going beast mode in the gym, and then worked with a nutritionist to do an elimination diet. She cut out some cruciferous veggies that bothered her, as well as beef and pork (but kept other types of lean meat) to reduce GI issues and lose 80 pounds.

Starting with gastric-sleeve surgery, @gi_sciortino shed 120 pounds and kept it off with intense strength-training and HIIT workouts.

Counting calories with the My Fitness Pal app was a factor for @hayleysweightlossjourneyx to lose 70 pounds. "It was the simple science of tracking calories in vs. out, mixed with self-discipline and self belief," she says.

@journeytoslimsyddie dropped 140 pounds between VSG surgery, three to five weekly hard-core workouts in the gym, and eating mindfully (with a low-carb and high-protein diet).

It all started with a fun, competitive "biggest loser" challenge at work for @branjay24. She lost 105 pounds by cutting out carbs and sweets and exercised six times a week. Another major factor for her? Taking care of her mental health throughout.

@wokeuplikedez dropped 150 pounds after having gastric-bypass surgery, and then continued the momentum with a high-protein diet. She kept consuming fewer calories and working out more consistently than she had in the past, too.

In the beginning, @ashleys_officially_lost_it tried losing weight simply by counting calories, but she needed more accountability and support, she says. She jumped on the WW (formerly Weight Watchers) bandwagon and later became an ambassador in the midst of her 120-pound weight loss, which she's maintained for almost two years. Her transformation was mostly accomplished via healthier food swapsshe loves to make cleaner versions of favorite fast-food dishes, like a chipotle chicken avocado sandwich from Panera.

Down 80 pounds from clean eating and at-home workouts, @beast_girl_22 toned up using BeachBody Body Beast. She also made a major change in her eating routine: switching from eating three healthy meals a day to eating smaller healthy meals every two to three hours, with lots of water.

Read more here:
25 Incredible Weight-Loss Transformations You Just HAVE To See - Pulse Nigeria

How to lose weight and get fit like this 43-year-old Ironman triathlete and open water swimmer – GQ India – What a man’s got to do

Posted: December 7, 2019 at 11:44 am

Weight loss is easy. There are multiple clever and fail-proof tricks and tips that can help you lose weight without ever going on a crash diet or starving yourself. But, heres the real kicker just by losing weight or your bodys excess fat, youll not automatically become fit.

Fit is not a destination. It is a journey. If you dont incorporate fitness as part and parcel of your daily life, you will fall back into your old patterns (and inches) sooner than you can even imagine. 43-year-old Nikhil Kanodia an entrepreneur, Ironman triathlete and open water swimmer tells us that three years ago, he decided to whip himself shape to become the fittest version of himself in his 40s. I started my journey in Jan 2016 and I weighed ~92 kgs, he says.

I dropped around 20 kgs in 3 months (went from 92 kgs to 72 kgs) by following a whole foods diet, he adds.

A whole foods diet is a lifestyle change that emphasises on the consumption of whole or minimally processed foods as your meals. Plants, including vegetables, fruits, whole grains, legumes, seeds and nuts make up this diet.

Kanodia outlines his whole foods diet plan as a combination of proteins, good fats, low glycemic carbs and fibre. To successfully follow a whole foods diet, cut out salt, sugar, refined carbs and processed foods from your meals. Actually, here's a quick note on salt: my rationale was to get rid of my body's water retention. I added salt back into my diet a year after starting my journey.

Post this initial fat loss of 20 kgs, I got into triathlons (Ironman) and as my endurance increased, while training for them, my weight further decreased and trimmed to my present weight - 68 kgs. And, on that note, here's another kicker, as your body's needs change, you need to adapt for diet as well.

Consequently, Kanodia also updated his diet and started following a dedicated weekly training schedule.

"Currently, I am on a Low Carb High Fat (LCHF) diet wherein my daily calorie intake comprises 60-70% fat, less than 130g of carbs and protein. This diet has helped me maintain a more normalised blood sugar level through the day and made me better at fat oxidation also which in turn has enabled me to first and foremost race cramp-free and also work on improving my performance in long-distance triathlons."

I train 10 hours (on average) per week for a Half Ironman race (also known as Ironman 70.3 that includes swimming (1.9 km) + cycling (90 km) + running (21.1 km). And about 15 hours (on average) per week for a Full Ironman race (also known as Ironman Triathlon that comprises swimming (3.86 km) + cycling (180.25 km) + running (42.20 km).

This is what my weekly training schedule includes:

3 swims (Endurance swim, Strength swim, Technique swim)

3-4 runs (Fartlek/ Hill interval run, Tempo run, Endurance run and Brick run)

2-3 bike rides (High gear strength/ Tempo bike, Endurance bike, Recovery bike)

1-2 strength workouts (usually HIIT with focus on legs, core and upper body)

I train hard 6 days a week! Monday is typically a rest day or light strength and stretching session.

Notably, Kanodia participates in 2-3 Half Ironman races per year along with participating in 1 Full Ironman race.

QUICK READ: Swimming workouts: what to know before diving in

When I am on Ironman training I follow this LCHF diet plan:

Breakfast: 1 whole egg + an omelette made from 2 egg whites/ fried egg (sunny side up) + an avocado or vegetable salad (200g) + a cup of black coffee

Mid-morning snack: Papaya/melon (200g)

Lunch: Indian meal comprising 1 vegetable curry (150g) + a serving of sauted vegetables (100g) + 1 chicken preparation (200g) + 3-4 chapatis made from flour of nuts/seeds

Snacks: A cup of black coffee and berries (150g)

Dinner: Grilled chicken, fish or lamb (200g) with sauted vegetables (200g)

When I am not training, I eat much lesser than this and also follow an intermittent fasting pattern of eating on certain days.

Intermittent Fasting (IF) is an eating pattern that cycles between periods of fasting and eating. It doesnt specify which foods you can or cannot eat. It only focuses on when you should eat them.

There are many IF plans and patterns that you can follow, but the most effective one, according to studies is the 16:8 IF diet. The 16:8 IF diet entails one to observe a 16-hour fasting period, followed by an 8-hour eating window.

How to follow the 16:8 diet plan to lose weight?

You can commence a 16-hour fast at 10:00 pm in the night, after you eat your last meal of the day and go to sleepthats 7-8 hours gone right there. You can break the 16-hour fast at 2:00 pm with your lunch and eat small meals till 10:00 pmthis makes up the 8-hour eating window. Alternatively, you can also begin your fast at 8 pm and break it at 12 pm, the next day.

Healthy living is not about building 6-pack abs! Getting those were easy, now that I look back on how far I have come. It only took me 3 months to transform from having a belly to seeing abs and another 3-4 months to see a proper 6-pack. However, only once I started training for endurance events (marathons, triathlons, long-distance open water swimming races and long bike tours) I realised that real fitness takes time to develop...and it still feels Ive just started. Train, eat, recover and repeat! Do that repeatedly day after day and that's how you'll be able to imbibe real fitness in your life."

Let me elaborate the above statement with this one example: despite achieving the best-ever aesthetics (for me), early on in my journey, my body would still cramp during every single endurance event I'd participate in be it a Half Marathon race or an Olympic distance triathlon or Half/Full Ironman. When I Googled the reasons for these sudden cramping, I came to the following conclusions: insufficient electrolytes, insufficient carbs and/or insufficient training."

"I explored all these areas individually but the cramps never went away. Until I finally read a research paper that pointed towards the benefits of fat for fuel. Our bodies can carry a max of 2000 calories as glycogen (energy from carbs). That's about 2-2.5 hours of energy depending on intensity. Our stomachs cannot effectively digest more than 60 calories per hour. If you are totally carb-dependent in a long race, it is only a matter of time before muscle glycogen runs out and cramps/ bonking happens. The good news is that there are around 40,000-50,000 calories of fat even in the most lean physiques. That's almost unlimited energy provided we teach our bodies to tap into it!"

The only race I have successfully completed (till now) without any cramps was the Full Ironman that I'd participated in earlier this year a 3.8km swim, 180 km bike and 42.2km run. The reason I was able to do was by following a LCHF diet! I am really excited to see how much faster I can get on the LCHF diet!

We also reached out Golds Gym where Kanodia works out on a daily basis to understand how the LCHF diet works. According to Golds Gym Maharani Baghs head trainer, Sachin Mavi, the low carb high fat diet (LCHF) body activates ketones. Hence the body starts taking energy from fats instead of glucose that we get from carbohydrates. When we start reducing our carb intake we push are body to start using fat as fuel which in turn leads to weight loss.

Disclaimer: The diet and workout routines shared by the respondents may or may not be approved by diet and fitness experts. GQ India doesn't encourage or endorse the weight loss tips & tricks shared by the person in the article. Please consult an authorised medical professional before following any specific diet or workout routine mentioned above.


Everything you need to know before you decide on running a marathon

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Continued here:
How to lose weight and get fit like this 43-year-old Ironman triathlete and open water swimmer - GQ India - What a man's got to do

Not Seeing Results With Keto? This M.D. Says "Sneaky Carbs" May Be To Blame –

Posted: December 7, 2019 at 11:44 am

Unfortunately, carbohydrate-rich plant foods just don't fit into most keto plans. Eating them can knock you out of ketosis. Yes, these foods have their merits; they come loaded with plant compounds such as flavonoids, carotenoids, phytoestrogens, and glucosinolates and other vitamins and minerals. But, if you are looking to go keto, you'll have to skip them.

Let's look at some frequent offenders that trip people up on their keto plan:

Starchier veggies. Sweet potatoes, beets, pumpkin, and butternut or spaghetti squash are nutrient powerhouses. But along with those nutrients and fiber comes a hefty carbohydrate load that can knock you right out of ketosis.

Legumes. This broad category of plant foods includes alfalfa, beans, carob, chickpeas, lentils, peas, soybeans, tamarind, and peanuts. Legumes are high in carbohydrates. (Read: keto-unfriendly in even small amounts.) They also contain lectins, anti-nutrients that can lead to inflammation in some people.

Fruit. Apples and other fruits are nutrient rock stars with gut-healing nutrients and fiber. But fruit tastes sweet and can be easy to overeat for a reason: Most kinds are high in sugar. Even a little bit of fruit can stall weight loss on a keto diet.

Even when you're avoiding these higher-carbohydrate plant foods, you might still be getting carbs from other sources that sabotage your keto plan.

Read more from the original source:
Not Seeing Results With Keto? This M.D. Says "Sneaky Carbs" May Be To Blame -

Karyopharm Reports New and Updated XPOVIO (Selinexor) Data in Relapsed or Refractory Multiple Myeloma at the American Society of Hematology 2019…

Posted: December 7, 2019 at 11:44 am

-- All Oral Regimen of Once Weekly Selinexor in Combination with Daily Pomalyst and Low Dose Dexamethasone Demonstrates 56% Overall Response Rate in Pomalyst-Nave and Revlimid-Relapsed or -Refractory Myeloma with Progression-Free Survival of 12.2 Months --

-- Selinexor and Low Dose Dexamethasone Either Alone or in Combination with Velcade or Kyprolis Results in Responses in Six of Seven Patients Whose Myeloma Has Progressed Following Experimental CAR-T Therapy --

NEWTON, Mass., Dec. 07, 2019 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), an oncology-focused pharmaceutical company, today announced that two presentations highlighting new and updated data relating to XPOVIO(selinexor), the Companys first-in-class, oral Selective Inhibitor of Nuclear Export (SINE) compound, will be given at the American Society of Hematology (ASH) 2019 Annual Meeting taking place December 7-10, 2019 in Orlando. The first study, which will be featured in an oral presentation, describes updated data from the Phase 1b/2 STOMP study evaluating the all oral regimen of selinexor in combination with Pomalyst (pomalidomide) and low-dose dexamethasone (dex) (SPd) in patients with relapsed or refractory multiple myeloma. The second abstract, which will be featured in a poster presentation, describes new data on the use of selinexor and dexamethasone, either alone or in combination with standard approved therapies, in patients with multiple myeloma whose disease has progressed following experimental chimeric antigen receptor T-cell (CAR-T) therapy.

We continue to be pleased with the efficacy and safety observed in the all oral selinexor plus Pomalyst arm of the Phase 1b/2 STOMP study, where patients with Pomalyst-nave and Revlimid (lenalidomide)-relapsed or -refractory myeloma achieved a 56% overall response rate (ORR) and a 12-month progression free survival (PFS), said Sharon Shacham, PhD, MBA, Founder, President and Chief Scientific Officer of Karyopharm. Another key study this year is the presentation of new data from patients treated with selinexor-based regimens after their myeloma had progressed following experimental CAR-T therapy. Although these data are early, six of seven patients whose disease relapsed after CAR-T achieved a response when treated with selinexor and dexamethasone alone or in combination with either Velcade (bortezomib) or Kyprolis (carfilzomib). There is currently very limited data regarding treatment options for patients whose disease has progressed following experimental CAR-T therapy, and we believe these encouraging results further reinforce the therapeutic activity of selinexor in patients with relapsed or refractory disease.

Updated Data from Phase 1b/2 STOMP Study Evaluating Selinexor in Combination with Pomalyst and Low-dose Dexamethasone (SPd)

In this arm of the Phase 1b/2 STOMP study, oral selinexor is being evaluated in combination with Pomalyst (3 or 4mg orally, once daily) and low dose dexamethasone (orally, 40mg once weekly or 20mg twice weekly) in patients with relapsed or refractory multiple myeloma who received at least three prior lines of therapy, including a proteasome inhibitor (PI) and an immunomodulatory drug (IMiD), or patients with myeloma refractory to both a PI and an IMiD. The following table is a summary of the efficacy results:

Key: ORR=Overall Response Rate (VGPR+PR); VGPR=Very Good Partial Response; PR=Partial Response1 Responses were adjudicated according to the International Myeloma Working Group criteria2 Based on interim unaudited data3 Five patients not evaluable for response: one death unrelated to myeloma, one non-compliance with study procedures, one withdrawal of consent before disease follow up, one death related to progressive disease (PD), one PD before C2D14 One unconfirmed VGPR

Among the patients evaluated for safety as of the data cutoff date, the most common treatment-related adverse events (AEs) were cytopenias, along with gastrointestinal and constitutional symptoms; most were manageable with dose modifications and/or standard supportive care. The most common non-hematologic treatment-related AEs were nausea (52%), fatigue (52%) and weight loss (39%). As expected, the most common treatment-related Grade 3 and 4 AEs were neutropenia (58%), thrombocytopenia (27%) and anemia (27%).

Based on these Phase 2 results, a Phase 3 study investigating the SPd combination is planned.

In parallel with the ongoing Phase 1b/2 STOMP study, Karyopharm is conducting the pivotal, randomized Phase 3 BOSTON study evaluating once-weekly selinexor in combination with the PI Velcade and dexamethasone (SVd) for the treatment of patients with multiple myeloma who have had one to three prior lines of therapy. Enrollment in the BOSTON study is complete and top-line data are expected in early 2020 contingent upon the occurrence of PFS events, the primary endpoint of the study. Data from the BOSTON study, if positive, are expected to be used to support regulatory submissions to the U.S. Food and Drug Administration and the European Medicines Agency requesting the use of selinexor in combination with Velcade and dexamethasone in patients with multiple myeloma who have received at least one prior therapy.

New Data from Study Evaluating Selinexor in Patients with Multiple Myeloma Following CAR-T Therapy

In this study, seven patients were identified from selinexor myeloma trials who had received an active dose of CAR-T cell therapy (>108 CAR-positive cells targeting B-cell maturation antigen) as treatment for their multiple myeloma prior to being enrolled in a trial using a selinexor-containing regimen. One patient was treated with selinexor (starting at 80 mg twice-weekly) and dexamethasone (20 mg twice weekly), one patient was treated with the regimen currently being investigated in the ongoing Phase 3 BOSTON study, a combination of selinexor (100 mg once-weekly), Velcade (1.3 mg/m2 once-weekly for 4 of 5 weeks) and dexamethasone (40 mg once-weekly), and five patients were treated with a combination of selinexor (100 mg once-weekly), Kyprolis (20/56 mg/m2 or 20/70 mg/m2) and dexamethasone (40 mg once weekly or 20 mg twice weekly). Patients had a median of ten prior therapeutic regimens (range: 5-15), all had high-risk cytogenetics, and six of the seven had rapidly progressing disease as indicated by the percent increase in paraprotein (17-91%) between screening and Cycle 1 Day 1 (range: 7-22 days).

The following table is a summary of the efficacy results:

Key: ORR=Overall Response Rate (CR+VGPR+PR); sCR=Stringent Complete Response1 Responses were adjudicated according to the International Myeloma Working Group criteria2 Based on interim unaudited data

Of the six patients who responded (PR), the duration of response ranged from 1.4 months to 7.4 months, with two patients still on therapy and responding. Adverse events were consistent with what has previously been reported with selinexor-containing regimens in heavily-pretreated patients with multiple myeloma and included nausea, fatigue, thrombocytopenia, neutropenia, and anemia.

These preliminary data suggest that selinexor-dexamethasone alone or in combination with Velcade or Kyprolis may offer a therapeutic option for patients who have exhausted other available treatments, have rapidly progressing disease, and who have progressed after CAR-T therapy.

Details for these two ASH 2019 presentations are as follows:

Oral Presentation

Title: Selinexor, Pomalidomide, and Dexamethasone (SPd) in Patients with Relapsed or Refractory Multiple MyelomaPresenter: Christine Chen, Princess Margaret Cancer CentreAbstract #: 141Session: 653. Myeloma: Therapy, excluding Transplantation: New Approaches in the Treatment of Relapsed/Refractory Plasma Cell DiscrasiasDate and Time: Saturday, December 7, 2019; 9:30-11:00 AM ETLocation: Orange County Convention Center, Hall E1Poster Presentation Company-Sponsored Studies

Title: Selinexor-Containing Regimens for the Treatment of Patients with Multiple Myeloma Refractory to Chimeric Antigen Receptor T-Cell (CAR-T) TherapyPresenter: Ajai Chari, Icahn School of Medicine at Mount SinaiAbstract #: 1854Session: 653. Myeloma: Therapy, excluding Transplantation: Poster IDate and Time: Saturday, December 7, 2019; 5:30-7:30 PM ETLocation: Orange County Convention Center, Hall B

PDF copies of these presentations will be available here following conclusion of the presentations at the meeting.

About XPOVIO (selinexor)

XPOVIO is a first-in-class, oral Selective Inhibitor of Nuclear Export (SINE) compound. XPOVIO functions by selectively binding to and inhibiting the nuclear export protein exportin 1 (XPO1, also called CRM1). XPOVIO blocks the nuclear export of tumor suppressor, growth regulatory and anti-inflammatory proteins, leading to accumulation of these proteins in the nucleus and enhancing their anti-cancer activity in the cell. The forced nuclear retention of these proteins can counteract a multitude of the oncogenic pathways that, unchecked, allow cancer cells with severe DNA damage to continue to grow and divide in an unrestrained fashion. In addition to receiving accelerated FDA approval of XPOVIO in July 2019 in combination with dexamethasone for the treatment of adult patients with relapsed refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is refractory to at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody, Karyopharm has also submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) with a request for conditional approval of selinexor. Selinexor is also being studied in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). In 2018, Karyopharm reported positive top-line results from the Phase 2b SADAL study evaluating selinexor in patients with relapsed or refractory DLBCL after at least two prior multi-agent therapies and who are ineligible for transplantation, including high dose chemotherapy with stem cell rescue. Selinexor has received Fast Track designation from the FDA for the patient population evaluated in the SADAL study. Selinexor is also being evaluated in several other mid-and later-phase clinical trials across multiple cancer indications, including in multiple myeloma in a pivotal, randomized Phase 3 study in combination with Velcade (bortezomib) and low-dose dexamethasone (BOSTON), as a potential backbone therapy in combination with approved therapies (STOMP), in liposarcoma (SEAL), in recurrent gliomas (KING) and in endometrial cancer (SIENDO), among others. Additional Phase 1, Phase 2 and Phase 3 studies are ongoing or currently planned, including multiple studies in combination with approved therapies in a variety of tumor types to further inform Karyopharm's clinical development priorities for selinexor. Additional clinical trial information for selinexor is available at



XPOVIO can cause thrombocytopenia, leading to potentially fatal hemorrhage. Thrombocytopenia was reported as an adverse reaction in 74% of patients, and severe (Grade 3-4) thrombocytopenia occurred in 61% of patients treated with XPOVIO. The median time to onset of the first event was 22 days. Bleeding occurred in 23% of patients with thrombocytopenia, clinically significant bleeding occurred in 5% of patients with thrombocytopenia and fatal hemorrhage occurred in <1% of patients.

Monitor platelet counts at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Institute platelet transfusion and/or other treatments as clinically indicated. Monitor patients for signs and symptoms of bleeding and evaluate promptly. Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.


XPOVIO can cause neutropenia, potentially increasing the risk of infection. Neutropenia was reported as an adverse reaction in 34% of patients, and severe (Grade 3-4) neutropenia occurred in 21% of patients treated with XPOVIO. The median time to onset of the first event was 25 days. Febrile neutropenia was reported in 3% of patients.

Obtain neutrophil counts at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Monitor patients for signs and symptoms of concomitant infection and evaluate promptly. Consider supportive measures including antimicrobials for signs of infection and use of growth factors (e.g., G-CSF). Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.

Gastrointestinal Toxicity

Gastrointestinal toxicities occurred in patients treated with XPOVIO.


Nausea was reported as an adverse reaction in 72% of patients, and Grade 3 nausea occurred in 9% of patients treated with XPOVIO. The median time to onset of the first nausea event was 3 days.

Vomiting was reported in 41% of patients, and Grade 3 vomiting occurred in 4% of patients treated with XPOVIO. The median time to onset of the first vomiting event was 5 days.

Provide prophylactic 5-HT3 antagonists and/or other anti-nausea agents, prior to and during treatment with XPOVIO. Manage nausea/vomiting by dose interruption, reduction, and/or discontinuation. Administer intravenous fluids and replace electrolytes to prevent dehydration in patients at risk. Use additional anti-nausea medications as clinically indicated.


Diarrhea was reported as an adverse reaction in 44% of patients, and Grade 3 diarrhea occurred in 6% of patients treated with XPOVIO. The median time to onset of diarrhea was 15 days.

Manage diarrhea by dose modifications and/or standard anti-diarrheal agents; administer intravenous fluids to prevent dehydration in patients at risk.

Anorexia/Weight Loss

Anorexia was reported as an adverse reaction in 53% of patients, and Grade 3 anorexia occurred in 5% of patients treated with XPOVIO. The median time to onset of anorexia was 8 days.

Weight loss was reported as an adverse reaction in 47% of patients, and Grade 3 weight loss occurred in 1% of patients treated with XPOVIO. The median time to onset of weight loss was 15 days.

Monitor patient weight at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Manage anorexia and weight loss with dose modifications, appetite stimulants, and nutritional support.


XPOVIO can cause hyponatremia; 39% of patients treated with XPOVIO experienced hyponatremia, 22% of patients experienced Grade 3 or 4 hyponatremia. The median time to onset of the first event was 8 days.

Monitor sodium level at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Correct sodium levels for concurrent hyperglycemia (serum glucose >150 mg/dL) and high serum paraprotein levels. Treat hyponatremia per clinical guidelines (intravenous saline and/or salt tablets), including dietary review. Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.


In patients receiving XPOVIO, 52% of patients experienced any grade of infection. Upper respiratory tract infection of any grade occurred in 21%, pneumonia in 13%, and sepsis in 6% of patients. Grade 3 infections were reported in 25% of patients, and deaths resulting from an infection occurred in 4% of patients. The most commonly reported Grade 3 infections were pneumonia in 9% of patients, followed by sepsis in 6%. The median time to onset was 54 days for pneumonia and 42 days for sepsis. Most infections were not associated with neutropenia and were caused by non-opportunistic organisms.

Neurological Toxicity

Neurological toxicities occurred in patients treated with XPOVIO.

Neurological adverse reactions including dizziness, syncope, depressed level of consciousness, and mental status changes (including delirium and confusional state) occurred in 30% of patients, and severe events (Grade 3-4) occurred in 9% of patients treated with XPOVIO. Median time to the first event was 15 days.

Optimize hydration status, hemoglobin level, and concomitant medications to avoid exacerbating dizziness or mental status changes.

Embryo-Fetal Toxicity

Based on data from animal studies and its mechanism of action, XPOVIO can cause fetal harm when administered to a pregnant woman. Selinexor administration to pregnant animals during organogenesis resulted in structural abnormalities and alterations to growth at exposures below those occurring clinically at the recommended dose.

Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential and males with a female partner of reproductive potential to use effective contraception during treatment with XPOVIO and for 1 week after the last dose.


The most common adverse reactions (incidence 20%) are thrombocytopenia, fatigue, nausea, anemia, decreased appetite, decreased weight, diarrhea, vomiting, hyponatremia, neutropenia, leukopenia, constipation, dyspnea, and upper respiratory tract infection.

The treatment discontinuation rate due to adverse reactions was 27%; 53% of patients had a reduction in the XPOVIO dose, and 65.3% had the dose of XPOVIO interrupted. The most frequent adverse reactions requiring permanent discontinuation in 4% or greater of patients who received XPOVIO included fatigue, nausea, and thrombocytopenia. The rate of fatal adverse reactions was 8.9%.

Please see XPOVIO Full Prescribing Information available at

About Karyopharm Therapeutics

Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is an oncology-focused pharmaceutical company dedicated to the discovery, development, and commercialization of novel first-in-class drugs directed against nuclear export and related targets for the treatment of cancer and other major diseases. Karyopharm's SINE compounds function by binding with and inhibiting the nuclear export protein XPO1 (or CRM1). Karyopharms lead compound, XPOVIO (selinexor), received accelerated approval from the FDA in July 2019 in combination with dexamethasone as a treatment for patients with heavily pretreated multiple myeloma. A Marketing Authorization Application for selinexor is also currently under review by the European Medicines Agency (EMA). In addition to single-agent and combination activity against a variety of human cancers, SINE compounds have also shown biological activity in models of neurodegeneration, inflammation, autoimmune disease, certain viruses and wound-healing. Karyopharm has several investigational programs in clinical or preclinical development. For more information, please visit

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding Karyopharms expectations relating to XPOVIO for the treatment of patients with heavily pretreated multiple myeloma, commercialization of XPOVIO or any of its drug candidates, submissions to, and the review and potential approval of selinexor by, regulatory authorities, including the anticipated availability of data to support such submissions, timing of such submissions and actions by regulatory authorities and the potential availability of accelerated approval pathways, and the therapeutic potential of and potential clinical development plans for Karyopharm's drug candidates, especially selinexor. Such statements are subject to numerous important factors, risks and uncertainties, many of which are beyond Karyopharm's control, that may cause actual events or results to differ materially from Karyopharm's current expectations. For example, there can be no guarantee that Karyopharm will successfully commercialize XPOVIO; that regulators will agree that selinexor qualifies for conditional approval in the E.U. as a result of data from the STORM study or confirmatory approval in the U.S. or EU based on the BOSTON study in patients with relapsed or refractory multiple myeloma, or that any of Karyopharm's drug candidates, including selinexor, will successfully complete necessary clinical development phases or that development of any of Karyopharm's drug candidates will continue. Further, there can be no guarantee that any positive developments in the development or commercialization of Karyopharm's drug candidate portfolio will result in stock price appreciation. Management's expectations and, therefore, any forward-looking statements in this press release could also be affected by risks and uncertainties relating to a number of other factors, including the following: adoption of XPOVIO in the commercial marketplace, the timing and costs involved in commercializing XPOVIO or any of Karyopharms drug candidates that receive regulatory approval; the ability to retain regulatory approval of XPOVIO or any of Karyopharms drug candidates that receive regulatory approval; Karyopharm's results of clinical trials and preclinical studies, including subsequent analysis of existing data and new data received from ongoing and future studies; the content and timing of decisions made by the U.S. Food and Drug Administration and other regulatory authorities, investigational review boards at clinical trial sites and publication review bodies, including with respect to the need for additional clinical studies; the ability of Karyopharm or its third party collaborators or successors in interest to fully perform their respective obligations under the applicable agreement and the potential future financial implications of such agreement; Karyopharm's ability to obtain and maintain requisite regulatory approvals and to enroll patients in its clinical trials; unplanned cash requirements and expenditures; development of drug candidates by Karyopharm's competitors for diseases in which Karyopharm is currently developing its drug candidates; and Karyopharm's ability to obtain, maintain and enforce patent and other intellectual property protection for any drug candidates it is developing. These and other risks are described under the caption "Risk Factors" in Karyopharm's Quarterly Report on Form 10-Q for the quarter ended September 30, 2019, which was filed with the Securities and Exchange Commission (SEC) on November 4, 2019, and in other filings that Karyopharm may make with the SEC in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and, except as required by law, Karyopharm expressly disclaims any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.

Velcade is a registered trademark of Takeda Pharmaceutical Company LimitedRevlimid and Pomalyst are registered trademarks of Celgene CorporationKyprolis is a registered trademark of Onyx Pharmaceuticals, Inc.


Investors: Karyopharm Therapeutics Inc. Ian Karp, Vice President, Investor and Public Relations857-297-2241 |

Media:FTI ConsultingSimona Kormanikova or Robert Stanislaro212-850-5600 | or

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Karyopharm Reports New and Updated XPOVIO (Selinexor) Data in Relapsed or Refractory Multiple Myeloma at the American Society of Hematology 2019...

7 foods that the world’s longest-living people swear by, from wine to nuts – Business Insider

Posted: December 7, 2019 at 11:43 am


Olive oil is eaten with bread, salads, and veggies, in addition to being used to cook nearly everything in Blue Zones, Buettner noted in the cookbook.

It is rich in monounsaturated fatty acids, which has been found to lower "bad" LDL cholesterol and in turn reduce the risk of heart disease.

It's also anti-inflammatory and packed with antioxidants. This can help reduce the risk of many types of chronic illnesses, like cancer, diabetes, Alzheimer's, metabolic syndrome, and even arthritis.

Even though olive oil high in fat and calories, it's also been linked to weight loss.

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7 foods that the world's longest-living people swear by, from wine to nuts - Business Insider

Weight loss: The best probiotics to lose weight easily! – Times of India

Posted: December 7, 2019 at 11:43 am

What probiotics can also do is induce satiety in your diet. This is one thing many do not know. Certain probiotics which have Bifidobacterium in them release an essential hormone, GLP-1, which works as an appetite suppressant, makes you feel fuller for longer and burn those calories. Bifidobacterium is believed to help us digest fiber and other tough carbs that our body cant digest on its own.

In fact, they can also help prevent further weight gain, after you have reached that weight loss plateau. Hence, including probiotics in the diet can help manage obesity. However, as tough as it sounds, sourcing them is not that difficult. For optimum weight loss and results, try adding these four food types:

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Weight loss: The best probiotics to lose weight easily! - Times of India

Cancer: The four nutrients proven to help fight cancer – what are they? – Express

Posted: December 7, 2019 at 11:43 am

Cancer is a worldwide epidemic taking millions of lives each year. Latest global cancer data states that one in five men and one in six women worldwide develop cancer during their lifetime and one in eight men and one in 11 women die from the disease. With these worrying statistics, finding ways to help stave off the disease is crucial. Scientists have revealed the four nutrients that should be part of everyones diet.

Antioxidant rich apples

According to Dr Vincent, a diet rich in phenolic antioxidants is important to help rid the body of free radicals before they are able to do damage to the body.

Dr Vincent said: Phenolics are plant-based compounds that when activated in their absorbable forms may help prevent inflammation, cardiovascular diseases and infections.

Scientific evidence has shown one of the most promising sources of phenolics has been found in apples.


Foods rich in folate

Folate is one of the B vitamins naturally present in many foods and its primary job is to help create new red blood cells.

Dr Vincent said: Folate, better known as B9, should be included as part of a healthy diet as it many help protect against cancers of the colon rectum and breast.

"The best way to get folate is not from a tablet but by eating enough fruits, vegetables and enriched grain products.

"Naturally occurring folate is better absorbed by the body.

Foods high in fibre

Eating food that is high in fibre is essential for good digestion and a healthy gut.

Dr Vincent said: High fibre foods can also hep to prevent some cancers. Some studies have shown a positive link between eating a diet that is high in legumes and a lowered risk of colorectal cancer.

Sources of fibre include dark leafy vegetables like bok choy, lettuce, spinach as well as cruciferous vegetables including broccoli, cauliflower and Brussels sprouts.

Foods with essential fatty acids

Essential fatty acids (EFAs) are types of good fat and essential for maintaining excellent health.

Dr Vincent explained this group of nutrients, Omega 3 and 6, can only be ingested through food and should be included as part of a diet as a preventative measure.

Foods high in essential fatty acids include oily fish like salmon, sardines, trout, flaxseeds, walnuts and soybean.

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Cancer: The four nutrients proven to help fight cancer - what are they? - Express

How Technology Is Disrupting The Fitness Industry – Entrepreneur

Posted: December 7, 2019 at 11:43 am

From wearables to fitness apps, new technological innovations have changed the way we exercise and associate with our daily fitness

December7, 20194 min read

Opinions expressed by Entrepreneur contributors are their own.

You're reading Entrepreneur India, an international franchise of Entrepreneur Media.

Technology today has disrupted every business. It is strategically integrated into every industry and has helped advance it, be it health, education or automobile. Fitness industry is no exception.

New technological innovations are regularly changing the way we exercise, which then over time creates a transformation within the health and fitness industry. People today who work out are not satisfied by only knowing their weight, height, waist line etc. They are interested in knowing more about their day to day progress, food macro and calorie consumption, body-fat percentage, sleep quality, calories burned, heart rate, etc. It is exciting and motivating when then receive this knowledge about themselves. With continuously checking their cardio machines screens to calculate time and calories burnt, they want to keep a tab on themselves throughout the day, even when they are not at the gym or working out. These people are not only avid gym-goers, athletes or bodybuilders, but also include regular people who desire to be fit and exercise to maintain a balanced weight and active lifestyle.

To meet this demand, many technological innovations have disrupted the fitness industry and changed the way we exercise and associate with our daily fitness.

These are activity-trackers, they monitor fitness-related metrics that play a significant role in your fitness journey, such as distance covered in a run, the number of steps completed, heart rate, calories burnt, etc. They provide valuable data about progress and developments. These sync with your smartphone and store the collected data. They are usually in the form of wristbands or armbands and have gained immense popularity. Now even smartwatches possess the features of a fitness wearable and serve as a stylish accessory. Even when people are not working out they are using their fitness bands to track data.

Initially, these fitness wearable were expensive, but today several tech gadget brands are offering budget-friendly and powerful wearables to meet the demand of the consumers.

Various applications are the highlight of smartphones. You have likely heard the saying, There is an app for everything! that is because its true. These applications have taken smartphone usage to the next level and are giving people an experience that they demand. One such is the demand for fitness applications. From diet trackers to workout guides to drinking water reminders, people have been downloading and using such apps every day. They are seeking one-stop health and fitness apps that provide holistic information, help track fitness metrics, give nutrition and diet plans, be their fitness partner and also help them shop of fitness-related goods. Several gyms, fitness centers, sports apparel brands, etc. have now joined the league and launched their fitness apps.

With the demand for fitness wearables increasing, tech accessory brands are introducing AI-enabled wearable technology. It is developed to increase the functionality as well as end-user experience and to provide them with instantaneous metrics and insights while also guiding them towards making better fitness choices. This innovation is presently trending and will be utilized extensively in future. AI-assisted CRM software provides an added advantage to gymnasiums. It can help improve operational efficiencies, increase customer conversion, and improve personalization for the sales department and provide multiple other benefits. IoT has changed how people workout now, with continuously collecting and providing data, it is used to track personal growth.

One of the best ways the fitness industry has adopted IoT is through enabling group fitness activities. Here, such workout groups are using wireless IoT fitness trackers to showcase the progress of every participant and helping design training solutions as per the unique requirements by analyzing and visualizing them on equipment consoles or mobile devices.

Another offering of AI is the chatbot. With its convenience and features, it is now being used primarily in almost every business that communicates with their existing and potential customers online. Chatbots can serve as digital assistants and are one of the most important technological innovation developed for businesses. It has become a powerful tool and the fitness industry is utilizing it to enhance the experience for their customers. Here, chatbots can assist as nutritional consultants, workout partners, personal trainers and also as customer service redresser. It can resolve customers needs and create a personalized diet and fitness plan, schedule and deliver reminders to customers for their workout and food needs, serve as educational content providers and act as motivators for customers through encouragement.

These are some of the technological trends that are playing a pivotal role in the ever-evolving fitness industry. These will be utilized to its full potential in times to come. Businesses that are in the health and fitness domain are sure to benefit from technology and should welcome such advancement in the near future.

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How Technology Is Disrupting The Fitness Industry - Entrepreneur

Want to lose weight quickly? Add spice to your life – TheHealthSite

Posted: December 7, 2019 at 11:42 am

So, you have finally decided to lose weight. Exercise and diet are on your mind. Nothing can compensate for a regular exercise regime and a well-balanced diet. To lose weight, you have to exercise regularly. You also have to watch what you are eating and control your portion size. The entire process can be quite challenging. But if you know a few tricks, you can make it a fast process. All you need to do is look in your kitchen cabinet. Most Indian kitchens are well-stocked with all kinds of spices. There are many common spices that can make you lose weight faster. It does so by raising your body heat. This, in turn, makes the body burn more calories when it tries to cool down. It basically boosts your metabolism. Just add these spices to your food and watch the extra kilos burn away.

Here, let us take a look at a few spices that can help you lose weight fast and in a safe manner.

Capsaicin, the major component in cayenne, provides the thermogenic property. The heat that results from digesting the pepper could boost metabolism and help the body burn more fat. Specialists say that adding a dash of cayenne to a meal may help you burn an additional 100 calories. It could also help curb hunger, reduce the level of fat in the blood and reduce the build-up of fat in the body. Add a dash of cayenne to eggs, soups or roasted nuts for a kick in flavour and weight loss benefits.

Cumin, a commonly used spice in Indian cuisine, may have the ability to help the body burn fat. Cumin may also reduce cholesterol levels by providing phytosterols that regulate the bodys absorption of cholesterol and support blood sugar levels in those with type 2 diabetes. Apart from aiding weight loss, cumin could also support memory and reduce stress. It is a versatile spice and can be added to sauteed vegetables, soups, dressings and more.

Ginger has numerous medicinal properties and can help suppress appetite, increase metabolism and promote fat burn. Gingerol, one of its components, may also support healthy blood sugar levels and increase the amount of good cholesterol in the body. Ginger also promotes the production of leptin, the protein that signals the brain that the body has enough stored fat and energy, thus encouraging it to burn excess fat. Add ginger to salad dressings, teas, curries and more.

With amazing fat-burning properties, black pepper may also be able to inhibit the formation of fat cells. It contains piperine, which could prevent weight gain. Black pepper also has the ability to improve the bodys absorption of other spices like turmeric that can aid in weight loss. Pepper can be added to salads, soups and dishes containing turmeric for added benefits.

Turmeric has, in recent times, gained a lot of popularity due to its numerous health benefits. Its main component, curcumin, could help prevent obesity, increase metabolism, help prevent conditions like Alzheimers and even fight cancer. Curcumin may also control the formation of fat tissues and help reduce the fat currently stored in the body.

Cinnamon is not just for the holidays this warming spice has the ability to regulate blood sugar levels, suppress hunger, boost metabolism and help control cholesterol levels too. Apart from promoting weight loss, cinnamon may also support cardiovascular health. While a gooey cinnamon roll may not be the best way to ingest cinnamon, you can always add a pinch to your breakfast oatmeal, tea or favorite holiday drink.

Indian cuisine has a lot of uses for this aromatic spice that imparts a mellow aroma and fruity flavor to both savory and sweet dishes. Cardamom also has many health benefits and is known to boost metabolism, reduce the occurrence of gas build up in the abdomen and digest toxins that are left in the body due to poor digestion.

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Published : December 7, 2019 1:14 pm | Updated:December 7, 2019 1:17 pm

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Want to lose weight quickly? Add spice to your life - TheHealthSite

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